Details of the Target

General Information of Target

Target ID LDTP05560
Target Name Peroxisomal bifunctional enzyme (EHHADH)
Gene Name EHHADH
Gene ID 1962
Synonyms
ECHD; Peroxisomal bifunctional enzyme; PBE; PBFE; L-bifunctional protein; LBP; Multifunctional enzyme 1; MFE1) [Includes: Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; EC 4.2.1.17; EC 5.3.3.8; 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEYTRLHNALALIRLRNPPVNAISTTLLRDIKEGLQKAVIDHTIKAIVICGAEGKFSAG
ADIRGFSAPRTFGLTLGHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQV
GLPEVTLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNSDPVEE
AIRFAQRVSDQPLESRRLCNKPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAA
VQYPYEVGIKKEEELFLYLLQSGQARALQYAFFAERKANKWSTPSGASWKTASARPVSSV
GVVGLGTMGRGIVISFARARIPVIAVDSDKNQLATANKMITSVLEKEASKMQQSGHPWSG
PKPRLTSSVKELGGVDLVIEAVFEEMSLKKQVFAELSAVCKPEAFLCTNTSALDVDEIAS
STDRPHLVIGTHFFSPAHVMKLLEVIPSQYSSPTTIATVMNLSKKIKKIGVVVGNCFGFV
GNRMLNPYYNQAYFLLEEGSKPEEVDQVLEEFGFKMGPFRVSDLAGLDVGWKSRKGQGLT
GPTLLPGTPARKRGNRRYCPIPDVLCELGRFGQKTGKGWYQYDKPLGRIHKPDPWLSKFL
SRYRKTHHIEPRTISQDEILERCLYSLINEAFRILGEGIAASPEHIDVVYLHGYGWPRHK
GGPMFYASTVGLPTVLEKLQKYYRQNPDIPQLEPSDYLKKLASQGNPPLKEWQSLAGSPS
SKL
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family
Subcellular location
Peroxisome
Function
Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway. Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA. Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species (Probable). Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity. Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways. Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation.
Uniprot ID
Q08426
Ensemble ID
ENST00000231887.8
HGNC ID
HGNC:3247

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HSC4 Substitution: p.I321H DBIA    Probe Info 
MDAMB468 SNV: p.G35V .
NCIH1993 Substitution: p.W595F .
ONS76 SNV: p.E54D .
SUDHL6 SNV: p.G499S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K605(4.91)  LDD0277  [1]
IPM
 Probe Info  		C227(0.00); C623(0.00); C51(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C227(0.35); C233(0.35); C476(1.02); C559(0.35)  LDD0531  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		C623(0.00); C199(0.00); C559(0.00)  LDD0162  [5]
W1
 Probe Info  		N.A.  LDD0236  [2]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C407
 Probe Info  		11.39  LDD2064  [6]
C409
 Probe Info  		5.43  LDD2066  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C227(0.35); C233(0.35); C476(1.02); C559(0.35)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C227(0.76); C233(0.76); C476(0.98)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C227(1.05); C233(1.05); C476(0.88); C559(0.90)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C227(0.85); C233(0.85); C476(0.87); C559(0.72)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C227(1.06); C233(1.06); C476(0.95); C559(0.71)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C227(0.92); C233(0.92); C476(0.90); C559(0.36)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C227(1.18); C233(1.18); C476(1.02); C559(0.64)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C227(1.00); C233(1.00); C476(0.83); C559(0.39)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C227(1.01); C233(1.01); C476(0.90); C559(0.42)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C227(1.03); C233(1.03); C476(0.90); C559(0.50)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C227(0.98); C233(0.98); C476(0.81); C559(0.78)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C227(1.25); C233(1.25); C476(0.98); C559(0.68)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C227(0.53); C233(0.53); C476(1.09)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C227(1.00); C233(1.00); C476(0.84); C559(0.68)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C227(0.80); C233(0.80); C476(0.90); C559(0.89)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C227(0.86); C233(0.86); C476(0.86); C559(0.53)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C227(1.33); C233(1.33); C559(1.43); C566(1.43)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C227(0.91); C233(1.00); C559(0.91); C566(0.91)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C227(0.83); C233(0.92); C559(0.52); C566(0.52)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C227(0.83); C233(0.83); C559(0.53); C566(0.53)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C227(0.99); C233(0.88); C559(0.85); C566(0.85)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C227(0.90); C233(0.93); C559(0.99); C566(0.99)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C227(1.05); C233(1.08); C559(0.69); C566(0.69)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C227(0.80); C233(0.80); C476(1.18)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C227(0.82); C233(0.92); C559(0.84); C566(0.84)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C227(1.20); C233(0.99); C559(1.13); C566(1.13)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C227(0.63); C233(0.71); C559(0.56); C566(0.56)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C227(1.08); C233(0.96); C559(1.46); C566(1.46)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C227(1.26); C233(1.10); C559(1.17); C566(1.17)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C227(0.88); C233(1.00); C559(0.90); C566(0.90)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C227(0.83); C233(0.91); C559(0.68); C566(0.68)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C227(0.85); C233(0.86); C559(0.66); C566(0.66)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C476(1.42); C559(0.32); C566(0.32)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C476(1.36); C559(1.24); C566(1.24)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C476(1.33); C559(0.44); C566(0.44)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C476(1.32); C559(1.13); C566(1.13)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C476(1.20); C559(1.20); C566(1.20)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C476(1.32); C559(0.69); C566(0.69)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C476(1.18); C559(0.63); C566(0.63)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C476(1.18); C559(0.62); C566(0.62)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C476(1.15); C559(0.84); C566(0.84)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C476(1.11); C559(0.82); C566(0.82)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C476(1.03); C559(0.70); C566(0.70)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C476(1.03); C559(1.04); C566(1.04)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C227(0.67); C233(0.67); C476(0.93)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C476(1.09); C559(0.81); C566(0.81)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C476(1.13); C559(0.87); C566(0.87)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C476(1.17); C559(0.94); C566(0.94)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C227(1.18); C233(1.18); C476(0.95); C559(0.83)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C559(0.33); C566(0.33); C476(1.00); C227(1.30)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C559(0.55); C566(0.55); C476(1.09); C227(1.61)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C559(0.36); C566(0.36); C476(0.98); C227(1.15)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C559(0.29); C566(0.29); C476(1.07); C227(1.18)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C559(0.12); C566(0.12); C476(0.70); C227(1.16)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C559(0.32); C566(0.32); C476(0.82); C227(0.93)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C227(0.80); C233(0.80); C476(0.89)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C476(1.02); C227(1.26); C233(1.26); C559(1.43)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C559(0.86); C566(0.86); C476(1.07); C227(1.33)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C559(0.23); C566(0.23); C476(0.98); C227(1.34)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C559(0.11); C566(0.11); C476(0.78); C227(1.09)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C227(1.42); C233(1.42); C476(0.99); C559(0.37)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C227(1.91); C233(1.91); C476(1.13); C559(0.52)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C227(1.23); C233(1.23); C476(1.05); C559(1.06)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C227(1.43); C233(1.43); C476(1.08); C559(0.84)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C559(0.86); C566(0.86); C476(1.07); C227(1.08)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C559(0.44); C566(0.44); C227(0.75); C233(0.75)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C476(1.03); C559(1.04); C566(1.04); C227(1.12)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C227(0.72); C233(0.72); C559(0.80); C566(0.80)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C559(1.08); C566(1.08); C476(1.09); C227(1.36)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C559(0.92); C566(0.92); C227(1.01); C233(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C476(0.96); C559(1.16); C566(1.16); C227(1.31)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C476(0.88); C227(1.03); C233(1.03); C559(1.11)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C476(1.14); C559(1.26); C566(1.26); C227(1.53)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C227(0.82); C233(0.82)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C227(0.66); C233(0.66)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C227(0.67); C233(0.67)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C227(0.63); C233(0.63)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C227(0.60); C233(0.60)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C559(0.64); C566(0.64); C227(0.82); C233(0.82)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C227(0.56); C233(0.56)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C227(0.61); C233(0.61)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C227(0.46); C233(0.46)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C227(0.60); C233(0.60)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C227(0.62); C233(0.62)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C476(0.85); C227(1.50); C233(1.52); C559(1.62)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C476(0.94); C233(1.10); C227(1.11); C559(1.63)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C233(1.12); C227(1.12); C476(1.15); C559(1.27)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C476(0.96); C227(1.01); C233(1.05); C559(1.18)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C476(0.96); C559(1.05); C566(1.05); C233(1.07)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C559(0.54); C566(0.54); C227(0.71); C233(0.71)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C559(0.75); C566(0.75); C476(0.87); C227(0.93)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C227(0.97); C233(0.98); C476(1.00); C559(1.09)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C559(0.92); C566(0.92); C476(0.98); C233(1.04)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C233(0.76); C227(0.82); C559(0.84); C566(0.84)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C476(0.93); C559(1.00); C566(1.00); C233(1.03)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C559(0.66); C566(0.66); C233(0.94); C227(0.98)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C476(0.74); C227(0.90); C233(0.90); C559(0.90)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C559(0.88); C566(0.88); C476(0.90); C227(1.02)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C233(0.42); C559(0.51); C566(0.51); C227(0.60)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C559(0.35); C566(0.35); C233(0.46); C227(0.71)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C559(0.55); C566(0.55); C227(0.67); C233(0.67)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C559(0.44); C566(0.44); C233(0.61); C227(0.78)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C476(0.93); C559(1.08); C566(1.08); C227(1.10)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C476(0.79); C559(0.98); C566(0.98); C227(1.06)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C559(0.56); C566(0.56); C233(0.66); C227(0.75)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C559(0.58); C566(0.58); C233(0.82); C227(0.90)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C559(0.37); C566(0.37); C233(0.52); C227(0.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C559(0.26); C566(0.26); C233(0.27); C227(0.58)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C559(0.28); C566(0.28); C227(0.30); C233(0.30)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C559(0.23); C566(0.23); C227(0.24); C233(0.24)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C227(0.29); C233(0.29); C559(0.33); C566(0.33)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C227(0.70); C233(0.70); C476(0.78)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C227(0.18); C233(0.18); C559(0.28); C566(0.28)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C227(0.14); C233(0.14); C559(0.20); C566(0.20)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C559(0.24); C566(0.24); C227(0.26); C233(0.26)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C227(0.18); C233(0.18); C559(0.24); C566(0.24)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C227(0.21); C233(0.21); C559(0.22); C566(0.22)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C227(0.24); C233(0.24); C559(0.30); C566(0.30)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C227(0.21); C233(0.21); C559(0.30); C566(0.30)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C227(0.10); C233(0.10); C559(0.11); C566(0.11)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C559(0.61); C566(0.61); C227(0.65); C233(0.65)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C227(0.64); C233(0.64); C559(0.73); C566(0.73)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C227(0.78); C233(0.78); C476(0.81)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C227(0.45); C233(0.45); C559(0.53); C566(0.53)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C227(0.73); C233(0.73); C476(0.99); C559(1.00)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C559(0.68); C566(0.68); C476(0.75); C227(0.80)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C227(0.28); C233(0.28); C559(0.54); C566(0.54)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C227(0.34); C233(0.34); C476(0.61); C559(0.74)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C227(0.22); C233(0.22); C559(0.59); C566(0.59)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C227(0.65); C233(0.65); C476(0.80); C559(0.86)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C227(0.57); C233(0.57); C559(0.58); C566(0.58)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C227(0.39); C233(0.39); C559(0.69); C566(0.69)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C559(0.79); C566(0.79); C476(0.94); C227(0.98)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C227(0.67); C233(0.67); C476(0.88)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C559(0.71); C566(0.71); C476(0.81); C227(1.26)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C476(0.63); C559(0.64); C566(0.64); C227(0.73)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C227(0.27); C233(0.27); C476(0.62); C559(0.73)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C227(0.68); C233(0.68)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C227(0.68); C233(0.68)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C227(0.72); C233(0.72)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C227(0.75); C233(0.75)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C227(0.68); C233(0.68)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C227(1.00); C233(1.00)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C227(0.75); C233(0.75)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C227(0.98); C233(0.98)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C227(0.91); C233(0.91)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C227(0.78); C233(0.78)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C227(0.88); C233(0.88)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C227(1.02); C233(1.02)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C227(0.56); C233(0.56)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C227(1.08); C233(1.08)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C227(0.70); C233(0.70)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C559(0.11); C566(0.11); C227(0.76); C233(0.76)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C476(0.82); C227(0.91); C233(0.91); C559(1.09)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C227(0.79); C233(0.79); C476(0.99)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C227(0.54); C233(0.54); C476(0.82)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C227(0.63); C233(0.63); C476(0.75)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C227(0.75)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C476(0.84); C559(1.02); C566(1.02); C227(1.20)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C559(0.33); C566(0.33); C227(0.54); C233(0.54)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C559(0.50); C566(0.50); C227(0.62); C233(0.62)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C227(0.78); C233(0.78); C476(0.94)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C227(0.82); C233(0.82); C476(0.93)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C227(0.88); C233(0.88); C476(1.16)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C227(0.82); C233(0.82); C476(1.00)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C559(0.80); C566(0.80); C227(0.83); C233(0.83)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C559(0.28); C566(0.28); C227(0.33); C233(0.33)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C559(0.52); C566(0.52); C227(0.78); C233(0.78)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C559(0.42); C566(0.42); C227(0.59); C233(0.59)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C559(0.70); C566(0.70); C227(0.87); C233(0.87)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C559(0.27); C566(0.27); C227(0.55); C233(0.55)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C559(0.55); C566(0.55); C227(0.73); C233(0.73)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C559(0.75); C566(0.75); C227(0.93); C233(0.93)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C227(0.82); C233(0.82)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C227(0.51); C233(0.51)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C227(0.56); C233(0.56)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C227(0.60); C233(0.60)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C227(0.56); C233(0.56)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C559(0.31); C566(0.31); C233(0.65); C227(0.69)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C233(0.89); C476(0.92); C227(0.96); C559(0.98)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C559(0.77); C566(0.77); C476(0.91); C233(0.92)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C559(0.31); C566(0.31); C227(0.62); C233(0.62)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C476(0.82); C233(1.01); C227(1.02); C559(1.22)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C559(0.64); C566(0.64); C476(0.75); C227(1.33)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C233(0.49); C559(0.64); C566(0.64); C227(0.68)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C559(0.55); C566(0.55); C476(0.68); C233(0.74)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C559(0.45); C566(0.45); C233(0.61); C227(0.73)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C227(0.71); C233(0.71); C476(0.90); C559(0.94)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C227(0.40); C233(0.40); C559(0.68); C566(0.68)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C227(0.45); C233(0.45); C559(0.54); C566(0.54)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C227(0.39); C233(0.39); C559(0.39); C566(0.39)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C559(0.31); C566(0.31); C227(0.58); C233(0.58)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C559(0.66); C566(0.66); C227(0.79); C233(0.79)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C559(0.39); C566(0.39); C227(0.68); C233(0.68)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C233(0.56); C476(0.64); C559(0.80); C566(0.80)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C559(0.54); C566(0.54); C227(1.01); C233(1.03)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C559(0.33); C566(0.33); C476(0.71); C233(0.78)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C559(0.47); C566(0.47); C476(0.89); C233(1.02)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C476(0.96); C227(1.10); C233(1.10); C559(1.22)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C559(0.48); C566(0.48); C233(0.66); C227(1.01)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C559(0.35); C566(0.35); C227(0.80); C233(0.93)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C559(0.23); C566(0.23); C227(0.69); C233(0.76)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C233(0.56); C559(0.67); C566(0.67); C476(0.87)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C559(0.37); C566(0.37); C233(0.57); C227(0.66)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C227(0.68); C233(0.41); C476(0.76); C559(0.47)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C227(0.90); C233(0.49); C476(0.73); C559(0.61)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C227(1.09); C233(0.66); C476(0.84); C559(0.81)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C227(0.68); C233(0.48); C476(0.66); C559(0.52)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C227(0.91); C233(0.70); C476(0.85); C559(0.52)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C227(0.96); C233(0.96); C476(0.92); C559(0.97)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C227(0.87); C233(0.56); C476(0.80); C559(0.82)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C227(0.85); C233(0.85); C476(0.98); C559(0.68)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C227(0.44); C233(0.44); C476(0.78); C559(0.25)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C227(0.58); C233(0.58); C476(0.84); C559(0.33)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C227(0.78); C233(0.78); C476(0.89); C559(0.31)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C227(0.72); C233(0.72); C476(0.92); C559(0.31)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C227(0.87); C233(0.87); C476(1.03); C559(0.38)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C227(0.80); C233(0.80); C476(1.00); C559(0.28)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C227(0.69); C233(0.69); C476(0.94); C559(0.46)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C227(1.00); C233(1.00); C476(0.93); C559(0.79)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C227(0.87); C233(0.87); C476(0.95); C559(0.37)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C227(0.76); C233(0.76); C476(1.09); C559(0.51)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C227(0.47); C233(0.47); C476(0.71); C559(0.16)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C227(0.57); C233(0.57); C476(0.81); C559(0.20)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C227(0.69); C233(0.69); C476(0.85); C559(0.22)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C227(0.61); C233(0.61); C476(0.77); C559(0.25)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C227(1.53); C233(1.53)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C227(1.32); C233(1.32)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C227(1.51); C233(1.51)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C227(1.31); C233(1.31)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C227(0.93); C233(0.93); C476(0.82); C559(0.78)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C227(1.29); C233(1.29)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C227(1.48); C233(1.48)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C227(1.26); C233(1.26)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C227(1.43); C233(1.43)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C227(1.57); C233(1.57)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C227(1.81); C233(1.81)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C227(1.27); C233(1.27)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C227(1.46); C233(1.46)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C227(1.45); C233(1.45)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C227(1.56); C233(1.56)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C227(0.62); C233(0.62); C476(0.81); C559(0.39)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C227(1.18); C233(1.18)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C476(1.28); C559(0.87); C566(0.87)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C476(1.28); C559(0.91); C566(0.91)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C476(1.22); C559(0.85); C566(0.85)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C476(1.37); C559(0.67); C566(0.67)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C476(1.39); C559(0.90); C566(0.90)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C476(1.12); C559(0.40); C566(0.40)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C476(1.65); C559(0.57); C566(0.57)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C476(1.18); C559(0.43); C566(0.43)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C476(1.23); C559(0.50); C566(0.50)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C227(0.63); C233(0.63); C476(1.01); C559(0.43)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C476(1.10); C559(0.49); C566(0.49)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C476(1.27); C559(0.77); C566(0.77)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C476(1.23); C559(1.29); C566(1.29)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C476(1.24); C559(0.73); C566(0.73)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C476(1.43); C559(0.71); C566(0.71)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C227(0.89); C233(0.89); C476(1.07); C559(0.37)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C227(0.86); C233(0.86); C476(0.93); C559(0.64)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C227(0.86); C233(0.86); C476(1.00); C559(0.45)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C227(1.03); C233(1.03); C476(0.82); C559(0.40)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C227(0.77); C233(0.77); C476(0.68); C559(0.29)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C227(0.67); C233(0.67); C476(0.89); C559(0.33)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C227(1.02); C233(1.02); C476(1.18); C559(0.56)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C227(1.12); C233(1.12); C476(0.92); C559(0.25)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C227(0.98); C233(0.98); C476(0.90); C559(0.24)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C227(0.75); C233(0.75); C476(0.95); C559(0.15)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C227(0.95); C233(0.95); C476(0.90); C559(0.57)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C227(1.08); C233(1.08); C476(0.91); C559(0.71)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C227(1.14); C233(1.14); C476(1.00); C559(0.50)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C227(1.21); C233(1.21); C476(0.82); C559(0.25)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C227(0.66); C233(0.66); C476(0.89); C559(0.14)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C227(0.87); C233(0.87); C476(0.87); C559(0.69)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C227(1.17); C233(1.17); C476(0.75); C559(0.94)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C227(0.72); C233(0.72); C476(0.89); C559(0.62)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C227(0.83); C233(0.83); C476(0.91); C559(0.74)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C227(0.80); C233(0.80); C476(1.05); C559(0.59)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C227(0.54); C233(0.54); C476(1.24); C559(0.44)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C227(0.60); C233(0.60); C476(0.94); C559(0.50)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C227(0.73); C233(0.73); C476(1.01); C559(0.55)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C227(0.59); C233(0.59); C476(0.99); C559(0.44)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C227(0.82); C233(0.82); C476(0.88); C559(0.52)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C227(0.75); C233(0.75); C476(1.03); C559(0.44)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C51(0.96); C227(1.24); C559(0.68)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C476(1.17); C559(0.78); C566(0.78)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C227(0.59); C233(0.59); C476(0.71); C559(0.19)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C199(1.03); C227(1.09)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C199(0.98); C227(1.14)  LDD1497  [7]
 LDCM0024  KB05 G361 C51(2.12)  LDD3311  [8]
 LDCM0021  THZ1 HCT 116 C227(0.75)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin, cytoplasmic 1 (ACTB) Actin family P60709
Actin, cytoplasmic 2 (ACTG1) Actin family P63261
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Alanine--tRNA ligase, mitochondrial (AARS2) Class-II aminoacyl-tRNA synthetase family Q5JTZ9
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Protein mab-21-like 3 (MAB21L3) Mab-21 family Q8N8X9
Prostaglandin E synthase (PTGES) MAPEG family O14684
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Tripeptidyl-peptidase 2 (TPP2) Peptidase S8 family P29144
Dual specificity protein kinase CLK2 (CLK2) CMGC Ser/Thr protein kinase family P49760
Epidermal retinol dehydrogenase 2 (SDR16C5) Short-chain dehydrogenases/reductases (SDR) family Q8N3Y7
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
E3 ubiquitin-protein ligase TRIM63 (TRIM63) . Q969Q1
Germ cell-less protein-like 1 (GMCL1) . Q96IK5
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane progestin receptor beta (PAQR8) ADIPOR family Q8TEZ7
Claudin-5 (CLDN5) Claudin family O00501
Derlin-3 (DERL3) Derlin family Q96Q80
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
Syncytin-2 (ERVFRD-1) Gamma type-C retroviral envelope protein family P60508
Huntingtin-interacting protein 1 (HIP1) SLA2 family O00291
Transmembrane protein 17 (TMEM17) TMEM17 family Q86X19
Urea transporter 2 (SLC14A2) Urea transporter family Q15849
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Leucine zipper transcription factor-like protein 1 (LZTFL1) LZTFL1 family Q9NQ48
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
High mobility group protein 20A (HMG20A) . Q9NP66
Nucleus accumbens-associated protein 1 (NACC1) . Q96RE7
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Zinc finger and BTB domain-containing protein 9 (ZBTB9) . Q96C00
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) Chemokine-like factor family Q9NX76
Tumor necrosis factor receptor superfamily member 3 (LTBR) . P36941
Other
Click To Hide/Show 49 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cofilin-2 (CFL2) Actin-binding proteins ADF family Q9Y281
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Claudin-18 (CLDN18) Claudin family P56856
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
Endoplasmic reticulum-Golgi intermediate compartment protein 1 (ERGIC1) ERGIC family Q969X5
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Armadillo repeat-containing X-linked protein 3 (ARMCX3) Eutherian X-chromosome-specific Armcx family Q9UH62
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Protein HID1 (HID1) Hid-1 family Q8IV36
Desmin (DES) Intermediate filament family P17661
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 4-11 (KRTAP4-11) KRTAP type 4 family Q9BYQ6
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
ORM1-like protein 1 (ORMDL1) ORM family Q9P0S3
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) PRKRA family O75569
Protein reprimo (RPRM) Reprimo family Q9NS64
RUS family member 1 (RUSF1) RUS1 family Q96GQ5
Beta-sarcoglycan (SGCB) Sarcoglycan beta/delta/gamma/zeta family Q16585
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
Synaptogyrin-3 (SYNGR3) Synaptogyrin family O43761
Transmembrane protein 121 (TMEM121) TMEM121 family Q9BTD3
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
BTB/POZ domain-containing protein KCTD6 (KCTD6) . Q8NC69
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Coiled-coil domain-containing protein 13 (CCDC13) . Q8IYE1
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
Ly6/PLAUR domain-containing protein 5 (LYPD5) . Q6UWN5
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
Protein phosphatase 1 regulatory subunit 12C (PPP1R12C) . Q9BZL4
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Small integral membrane protein 5 (SMIM5) . Q71RC9
TNF receptor-associated factor 1 (TRAF1) . Q13077
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Uncharacterized protein C1orf50 (C1orf50) . Q9BV19
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840