Details of the Target

General Information of Target

Target ID LDTP05163
Target Name 4-aminobutyrate aminotransferase, mitochondrial (ABAT)
Gene Name ABAT
Gene ID 18
Synonyms
GABAT; 4-aminobutyrate aminotransferase, mitochondrial; EC 2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; EC 2.6.1.22; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMK
QLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQ
NASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYR
SKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPS
FDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGG
DNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMM
TGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLL
DLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVF
RDHHAHLFLNIFSDILADFK
Target Type
Successful
Target Bioclass
Enzyme
Family
Class-III pyridoxal-phosphate-dependent aminotransferase family
Subcellular location
Mitochondrion matrix
Function
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
TTD ID
T59045
Uniprot ID
P80404
DrugMap ID
TTT2LD9
Ensemble ID
ENST00000268251.13
HGNC ID
HGNC:23
ChEMBL ID
CHEMBL2044

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
YN-4
 Probe Info  		100.00  LDD0445  [1]
IPM
 Probe Info  		C440(0.00); C269(0.00); C224(0.00); C334(0.00)  LDD0241  [2]
Probe 1
 Probe Info  		Y41(15.73); Y84(44.18); Y376(47.35); Y426(26.41)  LDD3495  [3]
DBIA
 Probe Info  		C224(1.31)  LDD3313  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C269(0.00); C467(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C269(0.00); C440(0.00); C467(0.00); C224(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C269(0.00); C224(0.00); C467(0.00)  LDD0037  [5]
W1
 Probe Info  		N.A.  LDD0236  [2]
NAIA_5
 Probe Info  		C269(0.00); C440(0.00); C467(0.00); C224(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C467(0.81)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C467(0.82); C224(1.06)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C467(0.97); C224(0.97)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C467(0.95); C224(1.02)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C224(0.73)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C467(0.96); C224(1.03)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C467(0.96)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C467(0.88); C224(1.03)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C467(1.00); C224(0.93)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C467(0.84); C224(1.11)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C467(1.02); C224(0.97)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C467(0.86); C224(1.01)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C224(0.82)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C467(0.92); C224(0.98)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C467(0.94); C224(0.98)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C467(0.96)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C467(0.81); C224(1.10)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C467(1.13); C224(1.04)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C467(0.96); C224(1.06)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C467(0.95); C224(1.09)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C467(0.93); C224(1.04)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C224(1.09)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C467(1.03); C224(1.10)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C467(1.01); C224(1.06)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C467(0.93)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C467(0.92); C224(0.88)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C467(1.05); C224(1.09)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C467(0.92); C224(0.79)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C467(0.97); C224(1.06)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C224(0.85)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C467(0.89); C224(1.04)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C467(0.91); C224(1.18)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C467(0.93); C224(1.03)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C467(0.90)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C467(0.87); C224(1.02)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C467(0.94); C224(1.07)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C467(1.05); C224(0.83)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C467(0.91); C224(1.06)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C224(0.79)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C467(0.99); C224(1.11)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C467(0.98); C224(1.00)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C467(0.86)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C467(0.95); C224(0.98)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C467(0.92); C224(1.27)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C467(0.92); C224(0.98)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C467(0.93); C224(0.86)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C467(0.98); C224(1.05)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C224(0.91)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C467(1.03); C224(1.03)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C467(0.97); C224(1.02)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C467(0.92)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C467(0.88); C224(1.09)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C467(1.11); C224(1.00)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C224(0.93)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C467(0.96); C224(0.97)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C467(0.93); C224(1.05)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C224(0.90)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C467(0.95); C224(1.07)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C467(0.93); C224(1.05)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C467(0.98); C224(1.00)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C467(1.06); C224(0.99)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C467(0.86); C224(1.03)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C467(1.01)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C467(0.99); C224(1.08)  LDD1514  [7]
 LDCM0632  CL-Sc Hep-G2 C269(20.00); C224(1.60)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C467(1.03)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C224(0.79)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C467(1.02); C224(0.99)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C467(0.99)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C467(0.82); C224(0.89)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C467(1.00); C224(1.05)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C467(0.93); C224(1.10)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C467(1.08)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C467(0.89); C224(1.00)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C467(1.00); C224(1.09)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C467(0.80); C224(0.95)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C467(1.12)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C467(1.01); C224(0.95)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C467(0.94); C224(0.98)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C467(0.96); C224(1.01)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C467(0.82); C224(0.97)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C467(0.94)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C467(0.88); C224(1.41)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C467(1.01); C224(1.15)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C467(0.82); C224(1.14)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C467(1.03)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C467(0.95); C224(1.01)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C467(1.11); C224(1.09)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C467(0.92); C224(0.96)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C467(0.83); C224(1.20)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C467(1.00)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C467(0.90); C224(0.79)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C467(0.96); C224(1.00)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C467(0.79); C224(1.01)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C467(0.93)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C467(0.87); C224(1.00)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C467(0.98); C224(1.05)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C467(0.78); C224(1.13)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C467(0.98)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C467(0.90); C224(0.93)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C467(0.85); C224(0.96)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C467(0.85); C224(1.03)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C467(0.78)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C467(0.84); C224(0.85)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C467(0.98); C224(1.00)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C467(1.11); C224(1.06)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C467(0.95); C224(0.79)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C467(0.91); C224(1.05)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C224(0.87)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C467(1.00); C224(0.93)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C467(1.08); C224(0.99)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C467(0.89)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C467(0.91); C224(0.90)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C467(1.12); C224(1.06)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C467(1.00); C224(1.02)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C467(0.87)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C467(0.92); C224(0.98)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C467(0.88); C224(0.93)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C467(1.27); C224(0.99)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C467(1.09); C224(0.88)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C467(0.99); C224(0.97)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C224(0.88)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C467(0.96); C224(0.92)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C467(1.04); C224(0.98)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C467(1.00)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C467(1.00); C224(1.00)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C467(0.92); C224(1.06)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C467(0.86); C224(1.02)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C467(0.90)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C467(0.85); C224(1.01)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C467(1.00); C224(0.96)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C467(1.02); C224(0.79)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C467(0.86); C224(0.94)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C224(0.79)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C467(1.06); C224(0.93)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C467(0.96); C224(0.98)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C467(1.07)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C467(1.06)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C467(1.02); C224(0.85)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C467(0.78); C224(1.20)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C467(0.76)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C467(0.78); C224(0.89)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C467(1.09); C224(0.97)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C467(0.98); C224(0.76)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C467(1.03); C224(1.04)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C224(0.80)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C467(0.84); C224(0.99)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C467(0.78); C224(0.82)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C467(1.07); C224(0.95)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C467(1.07)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C467(0.94); C224(0.85)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C467(1.10); C224(1.07)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C467(0.74); C224(1.00)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C467(1.00)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C467(0.90); C224(0.81)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C467(1.20); C224(0.95)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C467(0.95); C224(0.78)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C467(0.91); C224(1.03)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C467(1.12); C224(0.98)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C224(0.75)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C467(0.81); C224(0.90)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C467(1.03); C224(1.05)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C467(1.00)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C467(1.03); C224(0.88)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C467(0.87); C224(1.02)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C467(0.82)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C467(0.85); C224(0.82)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C467(1.02); C224(1.07)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C467(0.46); C224(0.75)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C467(1.00); C224(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C467(0.95); C224(1.03)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C224(0.85)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C467(0.97); C224(0.97)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C467(0.98); C224(0.95)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C467(0.95)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C467(0.87); C224(0.99)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C467(1.05); C224(1.13)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C467(0.84); C224(1.18)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C467(0.94)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C467(1.04); C224(1.02)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C467(0.62); C224(0.69)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C467(0.91); C224(1.10)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C467(0.93); C224(0.81)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C467(0.96); C224(1.03)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C224(0.93)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C467(0.93); C224(0.88)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C467(0.99); C224(1.01)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C467(1.00)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C467(0.90); C224(0.86)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C467(1.03); C224(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C467(1.05); C224(1.17)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C467(1.01); C224(1.02)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C467(0.90); C224(0.95)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C224(0.99); C467(1.03)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C224(1.06); C467(0.90)  LDD1497  [7]
 LDCM0024  KB05 Hs 936.T C224(1.31)  LDD3313  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 8 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Divalproex Sodium Small molecular drug D03LGY
Glutamic Acid Small molecular drug DB00142
L-alanine Small molecular drug D09PUL
Phenelzine Small molecular drug DB00780
Pyridoxal Phosphate Small molecular drug D06JGH
Pyridoxal Phosphate Small molecular drug DB00114
Pyruvic Acid Small molecular drug D0G4JI
Vigabatrin Small molecular drug D0R3QY
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cpp-115 Small molecular drug D0EJ7U
K-828-ab . D0YC4F
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cpp -15 . D0TP1P
Investigative
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(4e)-4-aminohex-4-enoic Acid Small molecular drug D05TEW
1-(4-hydroxyphenyl)Prop-2-en-1-one Small molecular drug D0L7RB
3-chloro-1-(4-hydroxyphenyl)Propan-1-one Small molecular drug D0UT2X
4-amino Hexanoic Acid Small molecular drug D0L5IN
4-hydroxy-3-nitrobenzaldehyde Small molecular drug D03VZF
4-hydroxybenzylamine Small molecular drug D07ZBH
Acetate Ion Small molecular drug D0F2ME
Alanine Small molecular drug DB00160
Gamma-acetylenic Gaba Small molecular drug D09IHN
Nipecotic Acid Small molecular drug D0RF2M
Oxamate Small molecular drug D0LP2H
Sodium Valproate Small molecular drug D0R5HK
Patented
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-hydroxybenzaldehyde Small molecular drug D00BRD
T83193 Small molecular drug D0B5YS

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402