Details of the Target

General Information of Target

Target ID LDTP10999
Target Name Histone H2A type 1-J (H2AC14)
Gene Name H2AC14
Gene ID 8331
Synonyms
H2AFE; HIST1H2AJ; Histone H2A type 1-J; Histone H2A/e
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEPSKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSSK
Target Bioclass
Other
Family
Histone H2A family
Subcellular location
Nucleus
Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Uniprot ID
Q99878
Ensemble ID
ENST00000333151.5
HGNC ID
HGNC:4727

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P1
 Probe Info  		2.89  LDD0448  [1]
P2
 Probe Info  		3.03  LDD0449  [1]
P8
 Probe Info  		1.99  LDD0451  [1]
FBPP2
 Probe Info  		2.50  LDD0318  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
AZ-9
 Probe Info  		E92(1.09)  LDD2208  [4]
ATP probe
 Probe Info  		K96(0.00); K119(0.00); K120(0.00)  LDD0199  [5]
W1
 Probe Info  		K120(0.00); K96(0.00); K119(0.00); H83(0.00)  LDD0236  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0111  W14 Hep-G2 H83(1.11)  LDD0238  [6]

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.