Details of the Target

General Information of Target

Target ID LDTP04187
Target Name CD151 antigen (CD151)
Gene Name CD151
Gene ID 977
Synonyms
TSPAN24; CD151 antigen; GP27; Membrane glycoprotein SFA-1; Platelet-endothelial tetraspan antigen 3; PETA-3; Tetraspanin-24; Tspan-24; CD antigen CD151
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLAT
AYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNT
ELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVV
PDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIF
TCCLYRSLKLEHY
Target Bioclass
Transporter and channel
Family
Tetraspanin (TM4SF) family
Subcellular location
Membrane
Function
Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.; (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
Uniprot ID
P48509
Ensemble ID
ENST00000322008.9
HGNC ID
HGNC:1630

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.74  LDD0197  [1]
FBPP2
 Probe Info  		5.51  LDD0318  [2]
CHEMBL5175495
 Probe Info  		9.28  LDD0196  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		K249(1.11)  LDD0274  [6]
STPyne
 Probe Info  		K249(1.36)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K132(2.32); K127(2.32); K186(6.68)  LDD3494  [7]
BTD
 Probe Info  		C192(1.71); C185(0.96); C184(0.84)  LDD1700  [8]
IPM
 Probe Info  		C192(5.02); C15(2.48)  LDD1701  [8]
DBIA
 Probe Info  		C184(0.90); C185(0.91); C192(0.88)  LDD0531  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
ENE
 Probe Info  		N.A.  LDD0006  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		C192(0.00); C184(0.00)  LDD0218  [12]
AOyne
 Probe Info  		9.90  LDD0443  [13]
NAIA_5
 Probe Info  		C208(0.00); C192(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DR-1
 Probe Info  		2.19  LDD0398  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C184(0.73)  LDD2142  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C185(1.02); C184(0.91); C208(0.52)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C185(1.21); C184(1.35); C208(0.91); C192(1.01)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C185(0.76); C184(0.54); C208(0.51); C192(0.66)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C185(1.17); C184(1.01); C208(0.82); C192(0.93)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C185(0.59); C208(0.39); C192(0.37)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C185(0.83); C208(0.59)  LDD2131  [8]
 LDCM0214  AC1 HCT 116 C184(0.90); C185(0.91); C192(0.88)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C184(1.04); C185(1.04); C192(1.46)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C192(1.06)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C192(1.11)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C192(0.86)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C192(0.77)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C192(0.88)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C192(0.69)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C192(0.81)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C192(0.87)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C192(0.83)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C192(0.77)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C184(0.76); C185(0.76); C192(1.22)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C192(0.98)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C192(0.94)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C192(0.97)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C184(1.09); C185(1.12)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C184(0.80); C185(0.84)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C184(0.72); C185(0.70)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C184(0.74); C185(0.77)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C184(0.95); C185(0.88)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C184(0.94); C185(0.91)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C184(0.95); C185(0.97)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C184(1.07); C185(1.07); C192(1.41)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C184(0.83); C185(0.85)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C184(1.12); C185(1.00)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C184(0.93); C185(0.92)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C184(1.16); C185(1.03)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C184(1.08); C185(1.04)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C184(0.90); C185(0.91)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C184(0.78); C185(0.79)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C184(0.84); C185(0.79)  LDD0562  [9]
 LDCM0246  AC128 HEK-293T C184(0.92); C185(0.92)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C184(0.94); C185(0.94)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C184(0.85); C185(0.85)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C184(0.96); C185(0.96)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C184(0.88); C185(0.88)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C184(0.82); C185(0.82)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C184(0.95); C185(0.95)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C184(0.94); C185(0.94)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C184(1.17); C185(1.17)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C184(0.95); C185(0.95)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C184(0.81); C185(0.81)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C184(0.89); C185(0.89)  LDD0856  [9]
 LDCM0259  AC14 HCT 116 C184(0.93); C185(0.93); C192(1.31)  LDD0576  [9]
 LDCM0260  AC140 HEK-293T C184(0.82); C185(0.82)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C184(0.97); C185(0.97)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C184(0.88); C185(0.88)  LDD0860  [9]
 LDCM0263  AC143 HCT 116 C184(0.90); C185(0.91)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C185(0.84); C184(0.87)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C185(0.83); C184(0.86)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C185(0.80); C184(0.92)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C185(0.75); C184(0.79)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C185(0.74); C184(0.82)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C185(0.83); C184(0.89)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C184(0.92); C185(0.92); C192(1.25)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C185(1.12); C184(1.22)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C185(1.20); C184(1.29)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C185(0.78); C184(0.87)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C185(0.79); C184(0.96)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C184(0.92); C185(0.83)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C184(1.10); C185(1.01)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C184(1.17); C185(1.08)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C184(1.42); C185(1.29)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C184(0.91); C185(0.97); C192(1.15)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C185(0.82); C184(0.92); C192(1.78)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C184(0.98); C185(1.01); C192(1.31)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C192(0.71); C185(0.87); C184(0.89)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C184(0.96); C192(1.21); C185(1.32)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C185(0.92); C184(0.94); C192(1.43)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C185(0.88); C184(1.20); C192(1.25)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C185(0.92); C184(1.03); C192(1.10)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C185(0.94); C184(1.02); C192(1.16)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C184(0.88); C185(0.88)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C184(0.75); C185(0.75)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C184(0.68); C185(0.68)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C184(0.70); C185(0.70)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C184(0.74); C185(0.74)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C192(0.75); C185(0.97); C184(1.04)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C184(0.71); C185(0.71)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C184(0.65); C185(0.65)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C184(0.55); C185(0.55)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C184(0.58); C185(0.58)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C184(0.56); C185(0.56)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C11(0.93); C15(0.93); C185(0.98); C184(1.12)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C185(0.80); C11(0.87); C15(0.87); C184(1.11)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C185(0.74); C11(0.82); C15(0.82); C184(1.05)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C185(0.81); C11(0.83); C15(0.83); C184(1.11)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C185(0.91); C11(0.96); C15(0.96); C184(1.09)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C192(0.83); C185(0.90); C184(0.98)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C185(0.74); C11(0.80); C15(0.80); C184(0.93)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C185(0.69); C11(0.79); C15(0.79); C184(1.17)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C185(0.70); C11(0.86); C15(0.86); C184(1.07)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C185(0.66); C184(0.88); C11(0.89); C15(0.89)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C185(0.67); C11(0.91); C15(0.91); C184(1.04)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C185(0.73); C11(0.91); C15(0.91); C184(1.07)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C184(0.88); C185(0.88)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C184(0.92); C185(0.92)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C184(0.79); C185(0.79)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C184(0.68); C185(0.68)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C185(0.91); C184(0.98); C192(0.98)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C184(0.67); C185(0.67)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C184(0.90); C185(0.90)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C184(0.87); C185(0.87)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C184(0.91); C185(0.91)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C184(0.85); C185(0.85)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C184(0.91); C185(0.91)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C184(0.62); C185(0.62)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C11(1.94)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C11(2.05)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C11(1.47)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C184(0.88); C185(0.88); C192(1.08)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C11(1.30)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C11(1.63)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C11(1.58)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C11(1.77)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C11(1.46)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C11(2.29)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C11(1.46)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C11(2.08)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C184(1.03); C185(1.03)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C184(0.96); C185(0.96)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C184(1.00); C185(1.00); C192(1.30)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C184(0.92); C185(0.92)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C184(1.19); C185(1.19)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C184(1.00); C185(1.00)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C184(0.76); C185(0.76)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C184(0.73); C185(0.73)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C184(0.75); C185(0.75)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C184(0.94); C185(0.94)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C184(0.88); C185(0.88)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C184(0.98); C185(0.98)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C184(0.94); C185(0.94)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C184(0.88); C185(0.88); C192(1.14)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C184(1.07); C185(1.07)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C184(1.44); C185(1.44)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C184(0.64); C185(0.64)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C184(0.71); C192(0.73); C185(0.76); C15(1.01)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C184(0.73); C185(0.77); C192(0.78); C15(0.97)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C184(0.88); C185(0.91); C192(0.93); C15(1.03)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C184(0.94); C185(0.96); C192(1.12); C15(1.13)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C15(0.96); C192(1.02); C11(1.17); C184(1.21)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C15(0.90); C185(0.92); C184(0.92); C192(1.00)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C184(0.85); C185(0.85); C192(0.85); C15(0.99)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C15(1.12); C184(1.16); C185(1.16); C192(1.34)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C192(0.73); C184(0.79); C185(0.80); C15(1.03)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C192(0.78); C185(0.89); C184(0.92); C15(1.07)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C192(0.89); C15(1.03); C185(1.07); C184(1.08)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C192(0.97); C184(1.04); C185(1.05); C11(1.13)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C15(0.84); C185(0.93); C184(0.93); C192(1.10)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C192(0.84); C184(0.96); C185(0.96); C11(1.09)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C184(0.82); C185(0.85); C15(0.91); C192(0.91)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C192(0.27)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C192(0.86)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C185(0.75); C184(1.00); C208(0.21); C192(0.47)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C185(1.47); C184(2.00)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C184(1.05); C185(1.05); C192(1.11)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C184(0.93); C185(0.93); C192(1.63)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C184(0.78); C185(0.78); C192(1.38)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C185(0.92); C192(1.01)  LDD2171  [9]
 LDCM0498  BS-3668 MDA-MB-231 C185(1.00); C184(0.88); C208(0.42); C192(0.63)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa H219(0.00); C192(0.00); C184(0.00)  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C192(1.23); C185(1.26); C184(1.28)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C192(0.85); C185(0.86); C184(0.92)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C184(0.85); C192(0.86); C185(0.86)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C184(1.03); C185(1.03); C192(1.59)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C184(1.10); C185(1.10); C192(1.43)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C184(1.06); C185(1.06); C192(1.31)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C184(1.07); C185(1.07); C192(1.36)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C185(0.80); C184(0.84); C192(1.39)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C184(0.48); C185(0.78); C192(1.17)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C184(0.80); C185(0.88); C192(1.40)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C184(0.70); C185(0.84); C192(1.57)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C185(0.77); C184(0.81); C192(1.28)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C192(0.81); C185(0.94); C184(1.07)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C184(0.62); C185(0.93); C192(1.32)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C184(0.78); C185(0.79); C192(1.39)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C184(1.01); C185(1.01)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C184(0.62); C185(0.62)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C184(0.86); C185(0.86)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C184(0.80); C185(0.80)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C184(0.75); C185(0.75)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C185(0.71); C184(0.84); C11(0.88); C15(0.88)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C185(0.88); C184(1.07); C11(1.15); C15(1.15)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C185(0.83); C184(0.92); C11(1.03); C15(1.03)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C185(0.93); C192(0.99); C184(1.01)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C185(0.72); C184(0.91); C11(0.98); C15(0.98)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C184(1.32); C185(1.32)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C184(0.76); C185(0.76)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C184(0.91); C185(0.91)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C184(0.78); C185(0.78)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C11(0.79)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C11(1.17)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C11(0.85)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C11(1.13)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C192(0.78); C184(0.82); C185(0.83)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C185(1.03); C184(1.04); C192(1.15)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C192(0.55); C185(0.96); C184(0.98)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C184(1.04); C185(1.04); C192(1.05); C11(1.05)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C184(0.87); C185(0.87); C192(0.94); C11(1.48)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C11(0.85); C15(0.85); C184(0.90); C185(0.90)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C184(0.80); C185(0.80); C192(0.82); C11(0.90)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C185(1.22); C184(1.25); C192(1.32)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C184(0.74); C185(0.74); C192(0.85); C11(0.95)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C192(0.80); C184(0.81); C185(0.81); C11(2.57)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C192(0.64); C184(0.67); C185(0.67); C11(1.20)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C192(0.77); C184(0.82); C185(0.82); C11(0.89)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C184(0.81); C185(0.81); C192(0.81); C11(1.08)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C11(1.62); C15(1.62); C184(0.94); C185(0.94)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C11(1.08); C15(1.08); C184(0.89); C185(0.89)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C11(1.02); C15(1.02); C184(0.94); C185(0.94)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C11(1.07); C15(1.07); C184(0.74); C185(0.74)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C11(1.22); C15(1.22); C184(0.71); C185(0.71)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C184(1.08); C185(1.07); C192(1.10)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C11(1.06); C15(1.06); C184(0.99); C185(0.99)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C11(0.98); C184(1.08); C185(1.13); C192(1.27)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C11(1.56); C184(0.88); C185(1.05); C192(1.10)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C11(1.84); C184(0.89); C185(0.92); C192(0.75)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C11(1.56); C184(0.72); C185(0.89); C192(0.86)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C11(1.77); C184(0.81); C185(0.96); C192(0.92)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C11(1.39); C184(0.90); C185(0.95); C192(0.92)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C11(1.43); C184(0.78); C185(0.98); C192(0.90)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C11(1.66); C184(0.83); C185(1.09); C192(1.11)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C184(1.06); C185(1.01); C192(1.14)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C11(1.33); C184(0.88); C185(0.91); C192(1.02)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C11(1.20); C184(0.81); C185(1.31); C192(1.05)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C11(1.94); C184(0.92); C185(0.97); C192(0.78)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C11(1.65); C184(0.93); C185(0.99); C192(0.89)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C11(1.47); C184(0.92); C185(1.02); C192(1.00)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C11(1.45); C184(0.90); C185(0.93); C192(0.77)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C11(1.47); C15(1.47); C184(0.99); C185(1.05)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C11(1.38); C15(1.38); C184(1.09); C185(1.04)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C11(1.42); C15(1.42); C184(0.86); C185(0.91)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C11(1.41); C15(1.41); C184(1.17); C185(1.08)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C184(1.09); C185(1.02); C192(0.96)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C11(1.18); C15(1.18); C184(0.94); C185(0.99)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C11(2.04); C15(2.04); C184(1.01); C185(1.00)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C11(1.69); C15(1.69); C184(1.02); C185(1.04)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C11(1.30); C15(1.30); C184(0.89); C185(0.91)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C11(2.09); C15(2.09); C184(0.93); C185(0.94)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C11(1.12); C15(1.12); C184(1.24); C185(1.03)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C11(0.92); C15(0.92); C184(0.99); C185(0.96)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C11(1.51); C15(1.51); C184(1.25); C185(1.07)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C11(1.18); C15(1.18); C184(0.98); C185(0.98)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C11(1.20); C15(1.20); C184(1.03); C185(0.96)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C184(0.96); C185(0.90); C192(0.95)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C11(1.44); C15(1.44); C184(1.07); C185(1.05)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C11(1.19); C15(1.19); C184(0.89); C185(0.89)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C11(1.02); C15(1.02); C184(0.91); C185(0.91)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C11(1.07); C15(1.07); C184(0.91); C185(0.91)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C11(2.58); C15(2.58); C184(0.84); C185(0.84)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C11(1.44); C15(1.44); C184(0.88); C185(0.88)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C11(1.28); C15(1.28); C184(0.81); C185(0.81)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C11(1.52); C15(1.52); C184(0.84); C185(0.84)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C11(1.50); C15(1.50); C184(0.72); C185(0.72)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C11(1.14); C15(1.14); C184(0.98); C185(0.98)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C184(0.98); C185(0.90); C192(0.82)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C11(1.35); C15(1.35); C184(0.76); C185(0.76)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C11(1.35); C15(1.35); C184(0.84); C185(0.84)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C11(0.93); C15(0.93); C184(0.91); C185(0.91)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C11(1.22); C15(1.22); C184(0.79); C185(0.79)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C11(1.42); C15(1.42); C184(0.82); C185(0.82)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C11(0.92); C15(0.92); C184(0.97); C185(0.97)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C11(0.94); C15(0.94); C184(1.17); C185(1.17)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C11(1.24); C15(1.24); C184(1.01); C185(1.01)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C11(0.69); C15(0.69); C184(1.07); C185(1.07)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C184(0.73); C185(0.80); C192(0.84)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C11(0.81); C15(0.81); C184(1.06); C185(1.06)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C11(0.92); C15(0.92); C184(1.04); C185(1.04)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C11(1.12); C15(1.12); C184(1.21); C185(1.21)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C11(0.95); C15(0.95); C184(1.04); C185(1.04)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C11(0.90); C15(0.90); C184(0.80); C185(0.80)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C11(0.76); C15(0.76); C184(0.93); C185(0.93)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C11(0.83); C15(0.83); C184(0.97); C185(0.97)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C11(1.01); C15(1.01); C184(1.20); C185(1.20)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C11(0.82); C15(0.82); C184(1.00); C185(1.00)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C11(0.83); C15(0.83); C184(0.82); C185(0.82)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C184(1.07); C185(1.01); C192(0.98)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C11(2.07); C15(2.07); C184(1.09); C185(1.09)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C184(0.95); C185(0.91); C192(1.08)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C184(1.09); C185(0.99); C192(1.09)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C184(1.08); C185(0.99); C192(0.94)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C184(1.00); C185(0.92); C192(1.00)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C184(1.09); C185(0.96); C192(1.03)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C184(0.99); C185(0.94); C192(1.27)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C184(0.94); C185(0.87); C192(1.06)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C184(0.86); C185(0.86); C192(0.96)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C184(0.89); C185(0.89); C192(0.93)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C192(1.13); C185(0.87)  LDD1698  [17]
 LDCM0468  Fragment33 HCT 116 C11(1.17); C15(1.17); C184(0.91); C185(0.91)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C11(2.13); C184(0.98); C185(0.93); C192(0.83)  LDD0744  [9]
 LDCM0107  IAA HeLa H219(0.00); H197(0.00)  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C192(0.89); C185(1.04)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C192(1.03); C185(0.99)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C192(4.45)  LDD3310  [18]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C185(0.99); C208(0.43); C192(0.81)  LDD2121  [8]
 LDCM0109  NEM HeLa H219(0.00); H197(0.00)  LDD0223  [12]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C185(1.02); C184(1.20); C208(0.39); C192(0.76)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C185(0.99)  LDD2090  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C185(0.79); C184(0.60); C208(0.70); C192(0.82)  LDD2093  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C184(1.07)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C185(0.85); C184(0.81); C208(0.83); C192(0.90)  LDD2099  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C185(1.59); C184(1.79); C208(1.36)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C185(0.99)  LDD2104  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C208(0.75)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C185(0.89); C184(0.63); C208(0.60); C192(0.63)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C185(1.49); C184(1.15); C208(1.04)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C185(0.93); C184(0.73); C208(0.97)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C184(0.90)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C185(0.82); C184(0.97); C208(0.88); C192(0.62)  LDD2115  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C185(1.27); C184(1.43); C192(1.75)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C192(0.65)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C185(0.71); C184(0.52); C208(0.52); C192(0.59)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C185(0.57); C184(0.50); C208(0.50); C192(0.61)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C185(0.57); C184(0.44); C208(0.87)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C184(0.57); C192(0.87)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C185(1.58); C184(1.71); C208(1.47); C192(0.85)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C185(1.16); C184(1.28); C208(0.91)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C185(1.07); C184(0.93); C208(0.84); C192(1.06)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C185(0.87); C184(0.84); C208(0.62)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C185(0.69); C184(0.59); C208(0.86); C192(0.69)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C192(1.71); C185(0.96); C184(0.84)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C184(0.70); C208(0.57); C192(0.57)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C192(0.92)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C185(1.98); C208(2.79)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C185(0.81); C184(0.58); C208(0.69); C192(0.62)  LDD2146  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C185(0.85); C184(0.82); C208(0.81); C192(0.44)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C185(1.08); C208(0.50); C192(0.54)  LDD2150  [8]
 LDCM0021  THZ1 HCT 116 C185(0.92); C192(1.01)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Aster-C (GRAMD1C) . Q8IYS0
Transmembrane protein 139 (TMEM139) . Q8IV31
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin alpha-3 (ITGA3) Integrin alpha chain family P26006
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
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Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
15 Quantitative Proteomics Reveals Cellular Off-Targets of a DDR1 Inhibitor. ACS Med Chem Lett. 2020 Feb 5;11(4):535-540. doi: 10.1021/acsmedchemlett.9b00658. eCollection 2020 Apr 9.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840