Details of the Target

General Information of Target

Target ID LDTP12544
Target Name Serine incorporator 1 (SERINC1)
Gene Name SERINC1
Gene ID 57515
Synonyms
KIAA1253; TDE1L; TDE2; Serine incorporator 1; Tumor differentially expressed protein 1-like; Tumor differentially expressed protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKV
SGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTW
ANDGY
Target Bioclass
Other
Family
TDE1 family
Subcellular location
Endoplasmic reticulum membrane
Function Enhances the incorporation of serine into phosphatidylserine and sphingolipids.
Uniprot ID
Q9NRX5
Ensemble ID
ENST00000339697.5
HGNC ID
HGNC:13464

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		7.35  LDD0043  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
YN-4
 Probe Info  		100.00  LDD0445  [2]
DBIA
 Probe Info  		C72(2.39)  LDD3312  [3]
BTD
 Probe Info  		C72(0.53)  LDD2100  [4]
IPM
 Probe Info  		C72(4.21); C81(3.23)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0227  [5]
AOyne
 Probe Info  		8.90  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C310
 Probe Info  		26.35  LDD1977  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C81(0.44); C72(1.15)  LDD2117  [4]
 LDCM0214  AC1 HEK-293T C28(1.22); C29(1.22)  LDD0812  [8]
 LDCM0215  AC10 HEK-293T C81(0.96); C72(0.99); C29(1.10)  LDD1508  [9]
 LDCM0216  AC100 HEK-293T C28(0.92)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C28(0.91)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C28(0.98)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C28(1.03)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C28(1.11)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C28(0.85)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C28(0.80)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C28(0.84)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C28(0.88)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C28(0.89)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C81(0.99); C72(1.00)  LDD1509  [9]
 LDCM0227  AC110 HEK-293T C28(1.14)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C28(1.11)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C28(1.20)  LDD0827  [8]
 LDCM0230  AC113 PaTu 8988t C28(0.79); C29(0.79)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C28(0.84); C29(0.84)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C28(0.90); C29(0.90)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C28(1.12); C29(1.12)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C28(0.69); C29(0.69)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C28(0.78); C29(0.78)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C28(0.95); C29(0.95)  LDD1115  [8]
 LDCM0237  AC12 HEK-293T C81(1.05); C72(1.03)  LDD1510  [9]
 LDCM0238  AC120 PaTu 8988t C28(1.07); C29(1.07)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C28(0.88); C29(0.88)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C28(0.69); C29(0.69)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C28(0.72); C29(0.72)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C28(1.07); C29(1.07)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C28(1.14); C29(1.14)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C28(0.84); C29(0.84)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C28(1.03); C29(1.03)  LDD1124  [8]
 LDCM0259  AC14 HEK-293T C81(1.02); C72(0.97)  LDD1512  [9]
 LDCM0263  AC143 PaTu 8988t C28(0.76); C29(0.76)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C28(0.83); C29(0.83)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C28(0.71); C29(0.71)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C28(0.67); C29(0.67)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C28(0.91); C29(0.91)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C28(0.74); C29(0.74)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C28(0.99); C29(0.99)  LDD1148  [8]
 LDCM0270  AC15 HEK-293T C81(0.98)  LDD1513  [9]
 LDCM0271  AC150 PaTu 8988t C28(0.84); C29(0.84)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C28(1.05); C29(1.05)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C28(0.95); C29(0.95)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C28(0.95); C29(0.95)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C28(0.92); C29(0.92)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C28(0.82); C29(0.82)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C28(1.02); C29(1.02)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C28(0.94); C29(0.94)  LDD2169  [8]
 LDCM0276  AC17 HEK-293T C28(1.00); C29(1.00)  LDD0874  [8]
 LDCM0277  AC18 HEK-293T C28(0.69); C29(0.69)  LDD0875  [8]
 LDCM0278  AC19 HEK-293T C28(0.95); C29(0.95)  LDD0876  [8]
 LDCM0279  AC2 HEK-293T C28(0.92); C29(0.92)  LDD0877  [8]
 LDCM0280  AC20 HEK-293T C28(0.91); C29(0.91)  LDD0878  [8]
 LDCM0281  AC21 HEK-293T C28(1.01); C29(1.01)  LDD0879  [8]
 LDCM0282  AC22 HEK-293T C28(1.11); C29(1.11)  LDD0880  [8]
 LDCM0283  AC23 HEK-293T C28(1.10); C29(1.10)  LDD0881  [8]
 LDCM0284  AC24 HEK-293T C28(0.84); C29(0.84)  LDD0882  [8]
 LDCM0285  AC25 HEK-293T C28(1.20)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C28(1.19)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C28(1.30)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C28(1.60)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C28(1.27)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C28(1.15); C29(1.15)  LDD0888  [8]
 LDCM0291  AC30 HEK-293T C28(1.21)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C28(1.12)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C28(1.10)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C28(1.17)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C28(1.06)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C28(0.98)  LDD0894  [8]
 LDCM0297  AC36 HEK-293T C28(0.98)  LDD0895  [8]
 LDCM0298  AC37 HEK-293T C28(1.04)  LDD0896  [8]
 LDCM0299  AC38 HEK-293T C28(1.01)  LDD0897  [8]
 LDCM0300  AC39 HEK-293T C28(1.05)  LDD0898  [8]
 LDCM0301  AC4 HEK-293T C28(1.08); C29(1.08)  LDD0899  [8]
 LDCM0302  AC40 HEK-293T C28(0.93)  LDD0900  [8]
 LDCM0303  AC41 HEK-293T C28(1.13)  LDD0901  [8]
 LDCM0304  AC42 HEK-293T C28(1.16)  LDD0902  [8]
 LDCM0305  AC43 HEK-293T C28(1.05)  LDD0903  [8]
 LDCM0306  AC44 HEK-293T C28(1.04)  LDD0904  [8]
 LDCM0307  AC45 HEK-293T C28(0.87)  LDD0905  [8]
 LDCM0308  AC46 HEK-293T C28(1.16)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C28(1.19)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C28(1.17)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C28(1.09)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C28(0.93); C29(0.93)  LDD0910  [8]
 LDCM0313  AC50 HEK-293T C28(1.19)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C28(1.16)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C28(1.24)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C28(1.01)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C28(1.23)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C28(1.33)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C28(1.14)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C28(0.62); C29(0.62)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C28(1.05); C29(1.05)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C28(0.73); C29(0.73)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C81(1.08); C72(1.03)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C28(0.39); C29(0.39)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C28(1.06); C29(1.06)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C28(1.18); C29(1.18)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C28(1.07); C29(1.07)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C28(0.91); C29(0.91)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C28(0.95); C29(0.95)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C28(1.02); C29(1.02)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C28(0.97); C29(0.97)  LDD0929  [8]
 LDCM0332  AC68 HEK-293T C28(1.17); C29(1.31)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C28(1.31); C29(1.54)  LDD0931  [8]
 LDCM0334  AC7 HEK-293T C81(1.05)  LDD1568  [9]
 LDCM0335  AC70 HEK-293T C28(1.06); C29(1.08)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C28(1.00); C29(0.95)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C28(1.35); C29(1.33)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C28(1.10); C29(0.84)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C28(1.18); C29(1.01)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C28(1.03); C29(0.88)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C28(1.16); C29(1.36)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C28(1.18); C29(1.29)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C28(1.19); C29(1.22)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C28(1.31); C29(1.51)  LDD0942  [8]
 LDCM0345  AC8 HEK-293T C81(1.04); C72(0.95)  LDD1569  [9]
 LDCM0346  AC80 HEK-293T C28(1.25); C29(1.28)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C28(1.15); C29(1.28)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C28(1.47); C29(1.65)  LDD0946  [8]
 LDCM0349  AC83 HEK-293T C28(0.96)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C28(1.28)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C28(1.05)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C28(1.03)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C28(1.04)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C28(1.09)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C28(1.41)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C28(1.07)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C28(1.12)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C28(1.14)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C28(1.07)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C28(1.29)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C28(1.24)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C28(1.19)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C28(1.39)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C28(0.80)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C28(0.76)  LDD0964  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C72(0.74)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C81(1.01); C72(0.99)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C81(0.98); C72(0.96)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C81(1.05); C72(0.97)  LDD1514  [9]
 LDCM0367  CL1 PaTu 8988t C28(1.70); C29(1.70)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C28(2.58); C29(2.58)  LDD1247  [8]
 LDCM0369  CL100 HEK-293T C28(0.90); C29(0.90)  LDD0967  [8]
 LDCM0370  CL101 HEK-293T C81(1.05); C72(0.93)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C81(1.26); C72(0.99); C28(1.16)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C81(1.00); C72(1.04)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C81(1.00); C72(0.88)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C28(1.08); C29(1.08)  LDD0972  [8]
 LDCM0375  CL106 HEK-293T C28(1.28); C29(1.28)  LDD0973  [8]
 LDCM0376  CL107 HEK-293T C28(0.89); C29(0.89)  LDD0974  [8]
 LDCM0377  CL108 HEK-293T C28(0.79); C29(0.79)  LDD0975  [8]
 LDCM0378  CL109 HEK-293T C28(1.35); C29(1.35)  LDD0976  [8]
 LDCM0379  CL11 PaTu 8988t C28(1.30); C29(1.30)  LDD1258  [8]
 LDCM0380  CL110 HEK-293T C28(1.08); C29(1.08)  LDD0978  [8]
 LDCM0381  CL111 HEK-293T C28(0.90); C29(0.90)  LDD0979  [8]
 LDCM0382  CL112 HEK-293T C28(1.20)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C28(1.14)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C28(1.26)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C28(1.16)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C28(1.27)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C28(0.86)  LDD0985  [8]
 LDCM0388  CL118 HEK-293T C28(0.84)  LDD0986  [8]
 LDCM0389  CL119 HEK-293T C28(0.99)  LDD0987  [8]
 LDCM0390  CL12 PaTu 8988t C28(1.24); C29(1.24)  LDD1269  [8]
 LDCM0391  CL120 HEK-293T C28(1.12)  LDD0989  [8]
 LDCM0392  CL121 HEK-293T C28(1.28)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C28(1.13)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C28(1.01)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C28(1.18)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C28(0.77); C29(0.77)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C28(0.59); C29(0.59)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C28(0.72); C29(0.72)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C28(0.86); C29(0.86)  LDD0997  [8]
 LDCM0400  CL13 PaTu 8988t C28(2.02); C29(2.02)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C28(2.51); C29(2.51)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C28(1.59); C29(1.59)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C28(1.10); C29(1.10)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C28(1.53); C29(1.53)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C28(1.42); C29(1.42)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C28(1.31); C29(1.31)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C28(1.30); C29(1.30)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C28(1.67); C29(1.67)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C28(1.96); C29(1.96)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C28(1.70); C29(1.70)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C28(1.84); C29(1.84)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C28(1.61); C29(1.61)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C28(1.11); C29(1.11)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C28(1.70); C29(1.70)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C28(1.48); C29(1.48)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C28(1.52); C29(1.52)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C28(2.31); C29(2.31)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C28(1.68); C29(1.68)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C28(1.35); C29(1.35)  LDD1298  [8]
 LDCM0420  CL31 HEK-293T C29(0.84)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C29(1.09)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C29(3.09)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C29(1.30)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C29(1.69)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C29(1.75)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C29(2.22)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C29(1.89)  LDD1026  [8]
 LDCM0429  CL4 PaTu 8988t C28(1.11); C29(1.11)  LDD1308  [8]
 LDCM0430  CL40 HEK-293T C29(2.58)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C29(2.13)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C29(2.49)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C29(2.10)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C29(1.87)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C29(2.68)  LDD1033  [8]
 LDCM0436  CL46 PaTu 8988t C28(1.44); C29(1.44)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C28(1.01); C29(1.01)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C28(1.08); C29(1.08)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C28(1.24); C29(1.24)  LDD1318  [8]
 LDCM0440  CL5 PaTu 8988t C28(2.14); C29(2.14)  LDD1319  [8]
 LDCM0441  CL50 PaTu 8988t C28(1.18); C29(1.18)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C28(1.13); C29(1.13)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C28(1.29); C29(1.29)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C28(1.50); C29(1.50)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C28(1.81); C29(1.81)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C28(1.21); C29(1.21)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C28(1.21); C29(1.21)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C28(1.49); C29(1.49)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C28(1.35); C29(1.35)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C28(1.07); C29(1.07)  LDD1329  [8]
 LDCM0451  CL6 PaTu 8988t C28(1.99); C29(1.99)  LDD1330  [8]
 LDCM0452  CL60 PaTu 8988t C28(1.04); C29(1.04)  LDD1331  [8]
 LDCM0453  CL61 PaTu 8988t C28(1.26); C29(1.26)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C28(1.10); C29(1.10)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C28(1.11); C29(1.11)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C28(1.41); C29(1.41)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C28(1.05); C29(1.05)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C28(0.96); C29(0.96)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C28(1.48); C29(1.48)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C28(2.06); C29(2.06)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C28(1.44); C29(1.44)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C28(1.87); C29(1.87)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C28(1.39); C29(1.39)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C28(0.90); C29(0.90)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C28(1.21); C29(1.21)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C28(1.54); C29(1.54)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C28(1.17); C29(1.17)  LDD1346  [8]
 LDCM0469  CL76 HEK-293T C81(1.01); C72(0.88)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C81(1.30); C72(1.02)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C81(0.90); C72(1.15); C29(1.05)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C81(1.04); C72(1.15)  LDD1675  [9]
 LDCM0473  CL8 PaTu 8988t C28(1.75); C29(1.75)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C81(1.06); C72(1.16)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C81(1.17); C72(1.12)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C81(1.26); C72(1.21)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C81(1.50)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C81(1.72); C72(1.28)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C81(1.23); C72(1.00)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C81(1.21); C72(0.98); C28(1.22)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C81(1.15); C72(1.28)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C81(1.05); C72(0.94)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C81(1.11); C72(1.00)  LDD1686  [9]
 LDCM0484  CL9 PaTu 8988t C28(1.55); C29(1.55)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C81(2.70); C72(2.12); C29(6.46)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C28(1.15); C29(1.15)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C28(0.89); C29(0.89)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C28(1.89); C29(1.89)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C28(0.86); C29(0.86)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C28(1.28); C29(1.28)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C28(0.70); C29(0.70)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C28(1.01); C29(1.01)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C28(1.08); C29(1.08)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C28(1.00); C29(1.00)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C81(1.00); C72(1.11)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C81(4.02); C72(1.55)  LDD1702  [4]
 LDCM0468  Fragment33 PaTu 8988t C28(1.24); C29(1.24)  LDD1347  [8]
 LDCM0427  Fragment51 HEK-293T C29(1.81)  LDD1025  [8]
 LDCM0022  KB02 HEK-293T C81(0.79); C72(1.19)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C81(0.86); C72(1.16)  LDD1497  [9]
 LDCM0024  KB05 HMCB C72(2.39)  LDD3312  [3]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C72(0.53)  LDD2100  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C81(0.49)  LDD2107  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C72(0.36)  LDD2115  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C81(0.39); C72(0.92)  LDD2125  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C72(0.46)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C81(0.51)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C72(1.21)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C81(0.50)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C72(0.91)  LDD2140  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C81(0.72); C72(0.59)  LDD2148  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-9 (AQP9) MIP/aquaporin (TC 1.A.8) family O43315
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paired box protein Pax-8 (PAX8) . Q06710
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 3 (FFAR3) G-protein coupled receptor 1 family O14843
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402