Details of the Target

General Information of Target

Target ID LDTP02544
Target Name Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)
Gene Name SLC2A1
Gene ID 6513
Synonyms
GLUT1; Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWVHRYGESILPTT
LTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFE
MLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVVGILIAQVFGLDSIM
GNKDLWPLLLSIIFIPALLQCIVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHD
LQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEK
AGVQQPVYATIGSGIVNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAILMTIALALLEQ
LPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGM
CFQYVEQLCGPYVFIIFTVLLVLFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPE
ELFHPLGADSQV
Target Type
Preclinical
Target Bioclass
Transporter and channel
Family
Major facilitator superfamily, Sugar transporter (TC 2.A.1.1) family, Glucose transporter subfamily
Subcellular location
Cell membrane
Function
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation.
TTD ID
T89458
Uniprot ID
P11166
DrugMap ID
TT79TKF
Ensemble ID
ENST00000426263.10
HGNC ID
HGNC:11005
ChEMBL ID
CHEMBL2535

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		6.21  LDD0318  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
YN-1
 Probe Info  		3.82  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
ONAyne
 Probe Info  		K245(0.80)  LDD0274  [4]
STPyne
 Probe Info  		K245(9.54); K255(8.36); K256(7.97); K477(8.61)  LDD0277  [4]
AZ-9
 Probe Info  		E462(10.00)  LDD2209  [5]
DBIA
 Probe Info  		C133(1.76)  LDD3365  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.73  LDD1733  [8]
C063
 Probe Info  		10.48  LDD1760  [8]
C158
 Probe Info  		11.55  LDD1838  [8]
C159
 Probe Info  		8.63  LDD1839  [8]
C160
 Probe Info  		7.36  LDD1840  [8]
C161
 Probe Info  		15.14  LDD1841  [8]
C212
 Probe Info  		5.94  LDD1886  [8]
C246
 Probe Info  		13.93  LDD1919  [8]
C310
 Probe Info  		11.63  LDD1977  [8]
FFF probe13
 Probe Info  		5.71  LDD0476  [9]
FFF probe3
 Probe Info  		7.90  LDD0465  [9]
STS-1
 Probe Info  		N.A.  LDD0136  [10]
STS-2
 Probe Info  		N.A.  LDD0138  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C133(0.95)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C133(0.91)  LDD1508  [12]
 LDCM0259  AC14 HEK-293T C133(1.10)  LDD1512  [12]
 LDCM0276  AC17 HEK-293T C133(0.92)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C133(0.86)  LDD1516  [12]
 LDCM0279  AC2 HEK-293T C133(1.09)  LDD1518  [12]
 LDCM0281  AC21 HEK-293T C133(0.83)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C133(1.00)  LDD1521  [12]
 LDCM0285  AC25 HEK-293T C133(0.96)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C133(0.89)  LDD1525  [12]
 LDCM0289  AC29 HEK-293T C133(0.76)  LDD1528  [12]
 LDCM0291  AC30 HEK-293T C133(1.25)  LDD1530  [12]
 LDCM0294  AC33 HEK-293T C133(0.92)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C133(0.90)  LDD1534  [12]
 LDCM0298  AC37 HEK-293T C133(0.95)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C133(1.13)  LDD1538  [12]
 LDCM0303  AC41 HEK-293T C133(0.96)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C133(0.83)  LDD1543  [12]
 LDCM0307  AC45 HEK-293T C133(1.19)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C133(1.07)  LDD1547  [12]
 LDCM0311  AC49 HEK-293T C133(0.98)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C133(1.01)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C133(0.87)  LDD1552  [12]
 LDCM0316  AC53 HEK-293T C133(0.85)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C133(0.93)  LDD1556  [12]
 LDCM0320  AC57 HEK-293T C133(0.92)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C133(0.98)  LDD1560  [12]
 LDCM0323  AC6 HEK-293T C133(0.83)  LDD1562  [12]
 LDCM0325  AC61 HEK-293T C133(0.97)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C133(1.16)  LDD1565  [12]
 LDCM0248  AKOS034007472 HEK-293T C133(0.93)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C133(1.04)  LDD1570  [12]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0368  CL10 HEK-293T C133(1.17)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C133(0.88)  LDD1573  [12]
 LDCM0373  CL104 HEK-293T C133(0.95)  LDD1577  [12]
 LDCM0377  CL108 HEK-293T C133(0.84)  LDD1581  [12]
 LDCM0382  CL112 HEK-293T C133(0.93)  LDD1586  [12]
 LDCM0386  CL116 HEK-293T C133(1.08)  LDD1590  [12]
 LDCM0391  CL120 HEK-293T C133(0.91)  LDD1595  [12]
 LDCM0395  CL124 HEK-293T C133(0.85)  LDD1599  [12]
 LDCM0399  CL128 HEK-293T C133(0.92)  LDD1603  [12]
 LDCM0403  CL16 HEK-293T C133(0.97)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C133(1.10)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C133(0.91)  LDD1609  [12]
 LDCM0409  CL21 HEK-293T C133(0.91)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C133(1.15)  LDD1614  [12]
 LDCM0416  CL28 HEK-293T C133(0.90)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C133(1.02)  LDD1621  [12]
 LDCM0419  CL30 HEK-293T C133(0.77)  LDD1623  [12]
 LDCM0422  CL33 HEK-293T C133(0.94)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C133(1.41)  LDD1627  [12]
 LDCM0429  CL4 HEK-293T C133(0.99)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C133(0.83)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C133(1.04)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C133(0.93)  LDD1636  [12]
 LDCM0435  CL45 HEK-293T C133(0.79)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C133(1.13)  LDD1640  [12]
 LDCM0440  CL5 HEK-293T C133(0.99)  LDD1644  [12]
 LDCM0443  CL52 HEK-293T C133(0.95)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C133(1.01)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C133(0.95)  LDD1648  [12]
 LDCM0448  CL57 HEK-293T C133(1.01)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C133(1.14)  LDD1652  [12]
 LDCM0451  CL6 HEK-293T C133(1.13)  LDD1654  [12]
 LDCM0456  CL64 HEK-293T C133(0.79)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C133(1.01)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C133(0.83)  LDD1661  [12]
 LDCM0461  CL69 HEK-293T C133(0.87)  LDD1664  [12]
 LDCM0463  CL70 HEK-293T C133(1.77)  LDD1666  [12]
 LDCM0469  CL76 HEK-293T C133(0.80)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C133(0.93)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C133(0.81)  LDD1674  [12]
 LDCM0475  CL81 HEK-293T C133(0.82)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C133(1.03)  LDD1679  [12]
 LDCM0482  CL88 HEK-293T C133(1.09)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C133(1.01)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C133(1.14)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C133(1.17)  LDD1688  [12]
 LDCM0488  CL93 HEK-293T C133(1.05)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C133(1.27)  LDD1692  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C133(1.08)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C133(1.10)  LDD1497  [12]
 LDCM0024  KB05 OVCAR-3 C133(1.76)  LDD3365  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) Sugar transporter (TC 2.A.1.1) family P11166

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126
Butabarbital Small molecular drug DB00237
Etomidate Small molecular drug DB00292
Glucosamine Small molecular drug DB01296
Carboxymethylcellulose . DB11059
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Wzb-117 Small molecular drug DCL8J5
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Resveratrol Small molecular drug DB02709

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402