Details of the Target

General Information of Target

Target ID LDTP01630
Target Name Vesicle transport protein SFT2B (SFT2D2)
Gene Name SFT2D2
Gene ID 375035
Synonyms
Vesicle transport protein SFT2B; SFT2 domain-containing protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDKLKKVLSGQDTEDRSGLSEVVEASSLSWSTRIKGFIACFAIGILCSLLGTVLLWVPRK
GLHLFAVFYTFGNIASIGSTIFLMGPVKQLKRMFEPTRLIATIMVLLCFALTLCSAFWWH
NKGLALIFCILQSLALTWYSLSFIPFARDAVKKCFAVCLA
Target Bioclass
Other
Family
SFT2 family
Subcellular location
Membrane
Function May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
Uniprot ID
O95562
Ensemble ID
ENST00000271375.7
HGNC ID
HGNC:25140

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
STPyne
 Probe Info  		K6(10.00)  LDD0277  [2]
IA-alkyne
 Probe Info  		1.47  LDD2187  [3]
DBIA
 Probe Info  		C158(1.07)  LDD1507  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C158(1.07)  LDD1507  [4]
 LDCM0215  AC10 HEK-293T C158(1.06)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C158(1.06)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C158(0.97)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C158(1.14)  LDD1512  [4]
 LDCM0270  AC15 HEK-293T C158(0.96)  LDD1513  [4]
 LDCM0276  AC17 HEK-293T C158(1.04)  LDD1515  [4]
 LDCM0277  AC18 HEK-293T C158(0.99)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C158(1.12)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C158(0.97)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C158(0.92)  LDD1519  [4]
 LDCM0282  AC22 HEK-293T C158(1.10)  LDD1521  [4]
 LDCM0283  AC23 HEK-293T C158(1.10)  LDD1522  [4]
 LDCM0284  AC24 HEK-293T C158(0.97)  LDD1523  [4]
 LDCM0285  AC25 HEK-293T C158(1.09)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C158(1.12)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C158(0.88)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C158(1.10)  LDD1527  [4]
 LDCM0290  AC3 HEK-293T C158(0.96)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C158(1.09)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C158(1.04)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C158(0.95)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C158(1.09)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C158(1.17)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C158(1.01)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C158(1.08)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C158(1.00)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C158(1.12)  LDD1539  [4]
 LDCM0301  AC4 HEK-293T C158(0.81)  LDD1540  [4]
 LDCM0302  AC40 HEK-293T C158(1.01)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C158(1.13)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C158(1.08)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C158(1.05)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C158(1.03)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C158(1.18)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C158(1.00)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C158(0.95)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C158(1.07)  LDD1550  [4]
 LDCM0313  AC50 HEK-293T C158(1.05)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C158(0.93)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C158(1.06)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C158(1.08)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C158(1.02)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C158(1.06)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C158(1.19)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C158(1.10)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C158(0.95)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C158(1.07)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C158(1.08)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C158(1.13)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C158(1.01)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C158(1.04)  LDD1567  [4]
 LDCM0334  AC7 HEK-293T C158(0.99)  LDD1568  [4]
 LDCM0345  AC8 HEK-293T C158(0.91)  LDD1569  [4]
 LDCM0356  AKOS034007680 HEK-293T C158(1.09)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C158(1.00)  LDD1514  [4]
 LDCM0367  CL1 HEK-293T C158(0.95)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C158(1.13)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C158(0.98)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C158(1.03)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C158(0.88)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C158(0.98)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C158(1.03)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C158(1.00)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C158(1.01)  LDD1582  [4]
 LDCM0379  CL11 HEK-293T C158(0.85)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C158(1.08)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C158(0.91)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C158(1.05)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C158(1.15)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C158(1.06)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C158(1.02)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C158(1.05)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C158(0.88)  LDD1593  [4]
 LDCM0390  CL12 HEK-293T C158(0.90)  LDD1594  [4]
 LDCM0392  CL121 HEK-293T C158(1.10)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C158(0.94)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C158(0.97)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C158(1.02)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C158(1.14)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C158(0.97)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C158(1.02)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C158(1.07)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C158(0.96)  LDD1606  [4]
 LDCM0404  CL17 HEK-293T C158(1.22)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C158(1.10)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C158(0.95)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C158(0.95)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C158(1.09)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C158(1.11)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C158(1.03)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C158(0.88)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C158(1.18)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C158(1.02)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C158(0.92)  LDD1619  [4]
 LDCM0417  CL29 HEK-293T C158(1.12)  LDD1621  [4]
 LDCM0418  CL3 HEK-293T C158(0.91)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C158(1.00)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C158(1.10)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C158(0.95)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C158(1.19)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C158(0.91)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C158(1.05)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C158(0.95)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C158(0.92)  LDD1632  [4]
 LDCM0431  CL41 HEK-293T C158(1.04)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C158(1.11)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C158(0.88)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C158(1.14)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C158(1.16)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C158(1.00)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C158(1.00)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C158(0.91)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C158(1.03)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C158(0.99)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C158(1.06)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C158(1.18)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C158(0.95)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C158(0.96)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C158(1.17)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C158(0.96)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C158(1.19)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C158(0.96)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C158(1.02)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C158(0.90)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C158(0.96)  LDD1658  [4]
 LDCM0457  CL65 HEK-293T C158(1.09)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C158(1.14)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C158(1.07)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C158(0.94)  LDD1663  [4]
 LDCM0462  CL7 HEK-293T C158(0.94)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C158(1.04)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C158(1.09)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C158(1.01)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C158(1.31)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C158(0.97)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C158(1.24)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C158(1.18)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C158(0.95)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C158(1.62)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C158(1.03)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C158(1.21)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C158(0.99)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C158(0.91)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C158(0.84)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C158(0.99)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C158(1.03)  LDD1684  [4]
 LDCM0483  CL89 HEK-293T C158(1.03)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C158(1.39)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C158(0.94)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C158(1.11)  LDD1690  [4]
 LDCM0489  CL94 HEK-293T C158(1.21)  LDD1692  [4]
 LDCM0490  CL95 HEK-293T C158(1.24)  LDD1693  [4]
 LDCM0491  CL96 HEK-293T C158(0.97)  LDD1694  [4]
 LDCM0492  CL97 HEK-293T C158(0.98)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C158(1.09)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C158(0.89)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C158(0.86)  LDD1698  [4]
 LDCM0625  F8 Ramos 1.47  LDD2187  [3]
 LDCM0573  Fragment11 Ramos 20.00  LDD2190  [3]
 LDCM0586  Fragment28 Ramos 0.49  LDD2198  [3]
 LDCM0468  Fragment33 HEK-293T C158(0.84)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C158(1.12)  LDD1631  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Very long chain fatty acid elongase 4 (ELOVL4) ELO family Q9GZR5
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
Inositol polyphosphate 5-phosphatase K (INPP5K) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q9BT40
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) . Q12982
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Hepatic sodium/bile acid cotransporter (SLC10A1) Bile acid:sodium symporter (BASS) family Q14973
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) Tim44 family O43615
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Taste receptor type 2 member 5 (TAS2R5) G-protein coupled receptor T2R family Q9NYW4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon gamma receptor 2 (IFNGR2) Type II cytokine receptor family P38484
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 2 (REEP2) DP1 family Q9BRK0
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
MOB kinase activator 2 (MOB2) MOB1/phocein family Q70IA6
Perilipin-2 (PLIN2) Perilipin family Q99541
Perilipin-3 (PLIN3) Perilipin family O60664
Transmembrane protein 143 (TMEM143) . Q96AN5
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402