Details of the Target

General Information of Target

Target ID LDTP01456
Target Name Pre-mRNA-processing factor 6 (PRPF6)
Gene Name PRPF6
Gene ID 24148
Synonyms
C20orf14; Pre-mRNA-processing factor 6; Androgen receptor N-terminal domain-transactivating protein 1; ANT-1; PRP6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQM
KKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERR
EQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLT
PVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDM
RKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKS
VRETNPHHPPAWIASARLEEVTGKLQVARNLIMKGTEMCPKSEDVWLEAARLQPGDTAKA
VVAQAVRHLPQSVRIYIRAAELETDIRAKKRVLRKALEHVPNSVRLWKAAVELEEPEDAR
IMLSRAVECCPTSVELWLALARLETYENARKVLNKARENIPTDRHIWITAAKLEEANGNT
QMVEKIIDRAITSLRANGVEINREQWIQDAEECDRAGSVATCQAVMRAVIGIGIEEEDRK
HTWMEDADSCVAHNALECARAIYAYALQVFPSKKSVWLRAAYFEKNHGTRESLEALLQRA
VAHCPKAEVLWLMGAKSKWLAGDVPAARSILALAFQANPNSEEIWLAAVKLESENDEYER
ARRLLAKARSSAPTARVFMKSVKLEWVQDNIRAAQDLCEEALRHYEDFPKLWMMKGQIEE
QKEMMEKAREAYNQGLKKCPHSTPLWLLLSRLEEKIGQLTRARAILEKSRLKNPKNPGLW
LESVRLEYRAGLKNIANTLMAKALQECPNSGILWSEAIFLEARPQRRTKSVDALKKCEHD
PHVLLAVAKLFWSQRKITKAREWFHRTVKIDSDLGDAWAFFYKFELQHGTEEQQEEVRKR
CESAEPRHGELWCAVSKDIANWQKKIGDILRLVAGRIKNTF
Target Bioclass
Other
Subcellular location
Nucleus, nucleoplasm
Function
Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Uniprot ID
O94906
Ensemble ID
ENST00000266079.5
HGNC ID
HGNC:15860

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.E447K DBIA    Probe Info 
CAL27 SNV: p.R761Ter DBIA    Probe Info 
CCK81 SNV: p.S853N DBIA    Probe Info 
COLO678 SNV: p.E475K DBIA    Probe Info 
HCT15 SNV: p.K667N DBIA    Probe Info 
HEC1B SNV: p.I377T .
JURKAT SNV: p.H541Y Compound 10    Probe Info 
LS123 SNV: p.E475K DBIA    Probe Info 
LS180 SNV: p.R31Q DBIA    Probe Info 
MCC26 SNV: p.I466F DBIA    Probe Info 
MELHO SNV: p.E475K DBIA    Probe Info 
MOLT4 SNV: p.R302W IA-alkyne    Probe Info 
NCIH23 SNV: p.A602S DBIA    Probe Info 
NCIH446 SNV: p.Q505H; p.W506L DBIA    Probe Info 
PF382 SNV: p.G335E DBIA    Probe Info 
REH SNV: p.R457W DBIA    Probe Info 
TE4 SNV: p.K710M DBIA    Probe Info 
TGBC1TKB SNV: p.E753Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.65  LDD0402  [1]
A-EBA
 Probe Info  		2.54  LDD0215  [2]
TH211
 Probe Info  		Y446(20.00); Y732(8.24)  LDD0257  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
Probe 1
 Probe Info  		Y131(50.31); Y446(64.65); Y582(32.94); Y658(17.61)  LDD3495  [6]
BTD
 Probe Info  		C604(1.78); C522(1.78); C339(1.37)  LDD1700  [7]
Jackson_1
 Probe Info  		10.37  LDD0121  [8]
AHL-Pu-1
 Probe Info  		C901(8.72); C739(20.00)  LDD0170  [9]
HHS-475
 Probe Info  		Y222(1.33)  LDD0264  [10]
DBIA
 Probe Info  		C913(0.84)  LDD0078  [11]
ATP probe
 Probe Info  		K540(0.00); K710(0.00); K573(0.00); K574(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C698(0.00); C522(0.00); C807(0.00); C837(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C913(0.00); C698(0.00); C339(0.00); C513(0.00)  LDD0032  [14]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C522(0.00); C807(0.00); C429(0.00); C430(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneN
 Probe Info  		C604(0.00); C698(0.00); C913(0.00)  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
Compound 10
 Probe Info  		C698(0.00); C913(0.00)  LDD2216  [20]
IPM
 Probe Info  		C837(0.00); C913(0.00); C604(0.00)  LDD0005  [19]
NHS
 Probe Info  		N.A.  LDD0010  [19]
STPyne
 Probe Info  		K683(0.00); K324(0.00)  LDD0009  [19]
VSF
 Probe Info  		C837(0.00); C913(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C604(0.00); C807(0.00); C739(0.00)  LDD0018  [21]
Ox-W18
 Probe Info  		W157(0.00); W686(0.00)  LDD2175  [22]
1c-yne
 Probe Info  		K606(0.00); K683(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C550(0.00); C513(0.00); C698(0.00); H190(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C513(0.00); C698(0.00); C913(0.00); C522(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C513(0.00); C698(0.00); C522(0.00); C913(0.00)  LDD0218  [24]
W1
 Probe Info  		C698(0.00); C513(0.00); C913(0.00); C339(0.00)  LDD0236  [25]
AOyne
 Probe Info  		12.00  LDD0443  [26]
NAIA_5
 Probe Info  		C698(0.00); C522(0.00); C807(0.00); C837(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y131(0.69)  LDD2239  [27]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.39  LDD0472  [28]
FFF probe13
 Probe Info  		6.03  LDD0476  [28]
FFF probe3
 Probe Info  		12.25  LDD0464  [28]
STS-1
 Probe Info  		N.A.  LDD0136  [29]
VE-P
 Probe Info  		N.A.  LDD0396  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C901(0.65)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C901(0.72)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C604(0.75)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C604(0.88)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C604(1.05); C339(1.27); C522(0.89); C901(1.02)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C604(1.20); C522(1.00); C901(1.10)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C901(0.70)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C604(0.66)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C604(0.78)  LDD2131  [7]
 LDCM0025  4SU-RNA DM93 C901(8.72); C739(20.00)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C739(3.00)  LDD0173  [9]
 LDCM0214  AC1 HCT 116 C339(1.50); C513(0.93); C550(1.23); C558(1.19)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C513(0.72); C522(1.08); C550(0.99); C558(0.96)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C339(0.50); C513(0.34); C522(0.83); C550(0.61)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C339(0.54); C513(0.37); C522(0.91); C550(0.60)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C339(0.64); C513(0.34); C522(1.00); C550(0.60)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C339(0.42); C513(0.33); C522(0.96); C550(0.60)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C339(0.50); C513(0.30); C522(0.82); C550(0.60)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C339(0.46); C513(0.32); C522(0.92); C550(0.63)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C339(0.59); C513(0.35); C522(0.95); C550(0.64)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C339(0.43); C513(0.36); C522(0.88); C550(0.63)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C339(0.59); C513(0.51); C522(0.88); C550(0.65)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C339(0.65); C513(0.53); C522(0.97); C550(0.59)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C513(0.66); C522(1.44); C550(1.01); C558(1.01)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C339(0.58); C513(0.45); C522(0.90); C550(0.59)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C339(0.63); C513(0.48); C522(0.88); C550(0.61)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C339(0.55); C513(0.35); C522(0.81); C550(0.56)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C339(1.29); C429(0.94); C430(0.94); C513(1.12)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C339(1.10); C429(0.73); C430(0.73); C513(0.85)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C339(0.99); C429(0.45); C430(0.45); C513(0.72)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C339(1.31); C429(0.34); C430(0.34); C513(0.82)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C339(1.32); C429(0.52); C430(0.52); C513(0.99)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C339(1.25); C429(0.59); C430(0.59); C513(1.01)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C339(1.38); C429(0.45); C430(0.45); C513(1.04)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C513(0.87); C522(1.21); C550(0.96); C558(0.95)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C339(1.21); C429(0.53); C430(0.53); C513(0.91)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C339(1.11); C429(0.51); C430(0.51); C513(1.15)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C339(1.18); C429(0.87); C430(0.87); C513(1.22)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C339(1.08); C429(1.10); C430(1.10); C513(1.38)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C339(1.43); C429(1.23); C430(1.23); C513(1.12)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C339(1.46); C429(0.46); C430(0.46); C513(0.91)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C339(1.54); C429(0.31); C430(0.31); C513(0.91)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C339(1.30); C429(0.35); C430(0.35); C513(0.99)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C339(0.93); C513(1.42); C550(1.30); C558(1.29)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C339(0.99); C513(1.23); C550(1.11); C558(1.17)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C339(0.98); C513(1.09); C550(1.23); C558(1.31)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C339(0.95); C513(1.04); C550(0.97); C558(1.00)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C339(1.20); C513(1.24); C550(1.12); C558(1.21)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C339(0.98); C513(1.12); C550(1.18); C558(1.29)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C339(0.97); C513(0.93); C550(1.14); C558(1.12)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C339(0.95); C513(1.10); C550(1.15); C558(1.21)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C339(1.01); C513(0.98); C550(1.15); C558(1.17)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C339(1.02); C513(1.02); C550(1.05); C558(1.08)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C339(0.86); C513(0.88); C550(1.07); C558(1.09)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C339(1.02); C513(1.00); C550(1.18); C558(1.23)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C513(0.90); C522(1.19); C550(0.85); C558(0.85)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C339(0.98); C513(0.98); C550(1.13); C558(1.19)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C339(1.00); C513(0.90); C550(1.06); C558(1.07)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C339(1.25); C513(1.34); C550(1.21); C558(1.30)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C339(0.72); C513(0.73); C698(0.75); C550(0.79)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C339(0.31); C513(0.39); C550(0.74); C558(0.80)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C513(0.48); C339(0.57); C604(0.78); C550(0.82)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C339(0.42); C513(0.46); C698(0.77); C550(0.82)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C339(0.30); C513(0.40); C550(0.72); C558(0.76)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C339(0.27); C513(0.52); C558(1.05); C550(1.11)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C339(0.30); C513(0.43); C698(0.64); C550(0.81)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C513(0.62); C550(0.79); C558(0.80); C837(0.90)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C513(0.49); C339(0.65); C550(0.76); C913(0.79)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C513(0.51); C339(0.66); C550(0.70); C698(0.77)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C339(0.27); C513(0.45); C550(0.82); C558(0.89)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C339(0.28); C513(0.56); C698(0.66); C550(1.06)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C339(0.37); C513(0.37); C550(0.67); C558(0.80)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C339(0.40); C513(0.41); C550(0.89); C558(0.94)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C339(0.74); C513(0.62); C550(0.86); C558(0.98)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C339(0.67); C513(0.72); C550(0.74); C558(0.91)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C339(0.54); C550(0.70); C513(0.71); C558(0.79)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C339(0.30); C513(0.53); C550(0.83); C558(0.88)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C339(0.54); C513(0.58); C550(0.77); C604(0.80)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C837(0.89); C513(0.96); C913(1.02); C558(1.04)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C339(0.57); C513(0.70); C550(0.70); C604(0.75)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C339(0.52); C513(0.67); C550(0.69); C558(0.73)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C339(0.65); C550(0.83); C604(0.85); C558(0.90)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C339(0.53); C513(0.66); C550(0.72); C558(0.76)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C604(0.77); C550(0.79); C339(0.79); C558(0.83)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C513(0.60); C558(0.78); C550(0.79); C913(0.79)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C513(0.61); C913(0.64); C550(0.77); C558(0.77)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C513(0.48); C550(0.72); C558(0.72); C913(0.73)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C513(0.58); C550(0.76); C604(0.77); C558(0.77)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C513(0.63); C913(0.65); C558(0.66); C550(0.72)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C513(0.83); C837(0.87); C913(1.07); C339(1.08)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C513(0.57); C913(0.68); C604(0.69); C558(0.72)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C513(0.65); C913(0.68); C604(0.80); C837(0.83)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C513(0.54); C913(0.67); C558(0.73); C550(0.79)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C513(0.53); C558(0.72); C913(0.73); C604(0.75)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C513(0.49); C558(0.73); C913(0.76); C550(0.81)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C901(0.61); C837(0.83); C913(0.93); C550(0.97)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C901(0.73); C913(0.79); C837(0.81); C604(0.92)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C837(0.78); C913(0.91); C901(0.95); C604(0.95)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C604(0.91); C913(0.93); C837(0.93); C558(0.95)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C837(0.80); C901(0.85); C913(0.97); C604(1.02)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C513(0.75); C837(0.96); C913(1.16); C604(1.28)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C339(0.85); C837(0.87); C913(0.90); C604(1.03)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C837(0.74); C901(0.78); C913(0.79); C604(0.88)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C913(0.87); C604(0.90); C837(0.90); C339(0.93)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C913(0.81); C837(0.83); C604(0.91); C513(0.97)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C837(0.81); C339(0.87); C604(0.99); C913(1.02)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C339(0.80); C837(0.88); C913(1.00); C901(1.06)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C698(0.81); C901(0.83); C913(0.90); C604(0.91)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C901(0.89); C339(0.95); C837(0.97); C913(0.99)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C901(0.72); C698(0.74); C837(0.92); C913(1.00)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C339(0.61); C901(0.68); C698(0.79); C913(0.90)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C513(0.84); C837(0.96); C339(0.99); C913(1.15)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C339(0.66); C901(0.74); C698(0.78); C513(0.88)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C901(0.70); C698(0.85); C604(0.88); C837(0.91)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C901(0.69); C604(0.86); C339(0.87); C513(0.91)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C339(0.69); C513(0.76); C913(0.87); C698(0.92)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C339(0.69); C901(0.72); C698(0.89); C513(0.92)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C339(0.61); C698(0.77); C513(0.88); C913(0.92)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C339(0.70); C901(0.78); C698(0.92); C913(1.08)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C429(0.24); C430(0.24); C339(0.63); C550(0.83)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C429(0.33); C430(0.33); C339(0.59); C901(0.95)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C429(0.23); C430(0.23); C339(0.51); C513(0.87)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C513(0.60); C837(0.82); C550(0.86); C558(0.87)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C429(0.24); C430(0.24); C339(0.51); C837(0.89)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C429(0.33); C430(0.33); C339(0.63); C837(0.87)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C429(0.20); C430(0.20); C339(0.48); C901(0.99)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C429(0.21); C430(0.21); C339(0.44); C550(0.83)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C429(0.18); C430(0.18); C339(0.42); C513(0.78)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C429(0.17); C430(0.17); C339(0.50); C513(0.91)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C429(0.23); C430(0.23); C339(0.53); C513(0.90)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C429(0.13); C430(0.13); C339(0.49); C901(0.79)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C429(0.58); C430(0.58); C901(0.84); C698(0.94)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C429(0.69); C430(0.69); C698(0.91); C513(1.00)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C513(0.72); C837(0.81); C558(0.90); C550(0.91)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C429(0.38); C430(0.38); C901(0.88); C513(0.93)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C429(0.74); C430(0.74); C550(0.97); C558(0.98)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C429(0.69); C430(0.69); C901(0.84); C558(0.94)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C429(0.55); C430(0.55); C698(0.80); C901(0.95)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C429(0.57); C430(0.57); C901(0.97); C698(0.98)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C429(0.60); C430(0.60); C698(0.77); C901(0.86)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C429(0.47); C430(0.47); C698(0.95); C513(0.99)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C429(0.57); C430(0.57); C901(0.78); C698(0.87)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C901(0.98); C429(0.99); C430(0.99); C698(1.03)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C429(0.73); C430(0.73); C901(0.87); C698(0.87)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C513(0.62); C837(0.81); C550(0.83); C558(0.86)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C429(0.62); C430(0.62); C513(0.99); C698(0.99)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C429(0.63); C430(0.63); C698(0.94); C837(1.04)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C429(0.56); C430(0.56); C698(0.99); C901(1.20)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C513(0.58); C901(0.71); C837(0.81); C339(0.96)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C901(0.63); C513(0.63); C837(0.80); C339(0.92)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C837(0.69); C513(0.71); C901(0.78); C339(0.78)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C513(0.61); C837(0.70); C604(0.73); C901(0.87)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C837(0.77); C513(0.77); C604(0.86); C901(0.86)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C513(0.59); C604(0.75); C837(0.78); C901(0.87)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C513(0.62); C837(0.71); C604(0.77); C901(0.81)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C837(0.71); C513(0.90); C604(0.90); C901(0.98)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C837(0.71); C513(0.89); C901(0.89); C339(0.99)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C837(0.75); C513(0.76); C901(0.77); C604(0.94)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C513(0.60); C837(0.79); C604(0.83); C558(0.85)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C901(0.77); C837(0.86); C558(0.88); C513(0.91)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C837(0.72); C901(0.91); C913(0.94); C604(0.98)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C901(0.84); C558(0.89); C339(0.89); C513(0.89)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C513(0.60); C837(0.65); C604(0.82); C901(0.82)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C513(0.36); C339(0.44); C604(0.69); C837(0.69)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C513(0.53); C604(0.57); C837(0.59); C550(0.63)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C604(0.43); C901(0.23)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C522(0.92)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C513(1.12); C522(1.08); C550(1.09); C558(1.11)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C513(0.74); C837(0.80); C913(0.87); C550(0.91)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C513(0.68); C837(0.90); C550(0.97); C558(0.98)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C913(0.84)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C604(0.38); C339(0.63); C901(0.22); C913(0.27)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C513(0.00); H190(0.00); H465(0.00); H307(0.00)  LDD0222  [24]
 LDCM0071  Cisar_cp14 MDA-MB-231 10.37  LDD0121  [8]
 LDCM0632  CL-Sc Hep-G2 C913(2.42); C807(1.66); C698(1.35); C837(0.99)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C901(0.63); C698(0.79); C550(0.84); C558(0.84)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C901(0.59); C429(0.60); C430(0.60); C339(0.65)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C513(0.60); C837(0.96); C558(0.99); C550(1.04)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C513(0.59); C837(0.78); C558(0.81); C550(0.82)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C837(0.70); C513(0.72); C550(0.85); C558(0.86)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C513(0.70); C837(0.79); C522(0.81); C558(0.85)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C513(0.79); C837(0.82); C550(0.84); C558(0.87)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C339(0.40); C513(0.58); C550(0.83); C558(0.88)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C339(0.28); C513(0.62); C550(0.89); C558(0.95)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C339(0.26); C513(0.51); C550(0.82); C558(0.91)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C339(0.24); C513(0.55); C550(0.89); C558(0.98)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C339(0.43); C513(0.55); C604(0.70); C550(0.80)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C429(0.57); C430(0.57); C339(0.61); C901(0.68)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C339(0.33); C513(0.52); C604(0.79); C550(0.84)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C339(0.45); C513(0.59); C522(0.60); C550(0.75)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C513(0.63); C913(0.71); C837(0.78); C558(0.81)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C513(0.55); C913(0.68); C558(0.75); C901(0.76)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C913(0.62); C558(0.65); C837(0.69); C513(0.70)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C913(0.64); C604(0.69); C901(0.70); C558(0.71)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C513(0.60); C837(0.71); C558(0.73); C604(0.73)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C339(0.67); C913(0.90); C837(1.07); C513(1.10)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C837(0.83); C913(0.88); C339(0.91); C901(0.93)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C913(0.80); C901(0.83); C837(0.87); C339(0.88)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C429(0.48); C430(0.48); C339(0.56); C901(0.74)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C837(0.74); C913(0.85); C901(0.93); C604(0.94)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C604(0.67); C698(0.67); C339(0.74); C513(0.78)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C901(0.72); C698(0.89); C913(0.97); C604(0.99)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C339(0.56); C901(0.68); C698(0.89); C513(0.90)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C339(0.54); C901(0.81); C513(0.84); C913(0.95)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C429(0.36); C430(0.36); C339(0.68); C837(0.84)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C429(0.25); C430(0.25); C339(0.59); C837(0.73)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C429(0.41); C430(0.41); C339(0.69); C837(0.85)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C429(0.16); C430(0.16); C339(0.56); C513(0.74)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C901(0.68); C339(0.74); C429(0.80); C430(0.80)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C901(0.71); C339(0.80); C522(0.82); C550(0.85)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C901(0.70); C698(0.72); C339(0.85); C837(0.97)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C339(0.59); C513(0.60); C429(0.82); C430(0.82)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C339(0.50); C513(0.85); C604(0.94); C913(0.97)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C339(0.80); C837(1.00); C604(1.03); C913(1.08)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C339(0.64); C513(0.71); C429(0.72); C430(0.72)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C698(0.75); C901(0.78); C513(0.87); C550(0.90)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C339(0.46); C429(0.54); C430(0.54); C513(0.59)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C339(0.39); C429(0.40); C430(0.40); C513(0.70)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C339(0.48); C429(0.53); C430(0.53); C513(1.15)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C339(0.48); C513(0.61); C429(0.69); C430(0.69)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C339(0.41); C429(0.41); C430(0.41); C513(0.79)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C339(0.35); C429(0.41); C430(0.41); C513(0.70)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C339(0.43); C429(0.74); C430(0.74); C513(0.69)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C339(0.51); C429(0.48); C430(0.48); C513(0.68)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C339(0.45); C429(0.63); C430(0.63); C513(0.72)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C339(0.55); C429(0.55); C430(0.55); C513(0.70)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C339(0.86); C429(1.33); C430(1.33); C513(0.83)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C339(0.58); C429(1.09); C430(1.09); C513(0.94)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C339(0.68); C429(0.64); C430(0.64); C513(0.82)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C339(0.99); C429(1.45); C430(1.45); C513(1.72)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C339(0.71); C429(0.71); C430(0.71); C513(0.79)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C339(0.40); C429(0.38); C430(0.38); C513(0.89)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C339(0.34); C429(0.54); C430(0.54); C513(0.71)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C339(0.39); C429(0.36); C430(0.36); C513(0.92)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C339(0.35); C429(0.32); C430(0.32); C513(1.06)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C339(0.40); C429(0.37); C430(0.37); C513(0.79)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C339(0.87); C429(0.97); C430(0.97); C513(0.81)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C339(0.38); C429(0.41); C430(0.41); C513(0.78)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C339(0.44); C429(0.47); C430(0.47); C513(0.84)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C339(0.36); C429(0.37); C430(0.37); C513(1.14)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C339(0.36); C429(0.45); C430(0.45); C513(1.06)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C339(0.51); C429(0.59); C430(0.59); C513(1.03)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C339(0.41); C429(0.37); C430(0.37); C513(1.27)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C429(2.81); C430(2.81); C513(0.87); C522(1.08)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C429(2.05); C430(2.05); C513(0.85); C522(1.27)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C429(2.37); C430(2.37); C513(0.93); C522(1.22)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C429(1.98); C430(1.98); C513(1.00); C522(1.00)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C339(0.83); C429(1.02); C430(1.02); C513(0.88)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C429(1.65); C430(1.65); C513(0.98); C522(1.02)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C429(2.17); C430(2.17); C513(0.79); C522(1.04)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C429(1.56); C430(1.56); C513(0.91); C522(1.11)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C429(2.52); C430(2.52); C513(0.99); C522(1.13)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C429(2.05); C430(2.05); C513(1.04); C522(1.09)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C429(2.30); C430(2.30); C513(0.93); C522(1.07)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C429(1.24); C430(1.24); C513(1.14); C522(0.89)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C429(1.61); C430(1.61); C513(1.07); C522(0.90)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C429(2.64); C430(2.64); C513(1.01); C522(0.99)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C429(1.60); C430(1.60); C513(0.92); C522(0.82)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C339(1.00); C429(0.90); C430(0.90); C513(0.99)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C429(1.32); C430(1.32); C513(0.91); C522(0.92)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C339(0.83); C429(0.50); C430(0.50); C513(0.75)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C339(0.84); C429(0.35); C430(0.35); C513(0.89)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C339(0.77); C429(0.28); C430(0.28); C513(0.79)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C339(0.43); C429(0.26); C430(0.26); C513(0.84)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C339(0.74); C429(0.34); C430(0.34); C513(0.90)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C339(0.33); C429(0.16); C430(0.16); C513(0.96)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C339(0.39); C429(0.24); C430(0.24); C513(0.85)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C339(0.60); C429(0.24); C430(0.24); C513(0.70)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C339(1.22); C429(1.07); C430(1.07); C513(0.87)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C339(0.65); C429(0.47); C430(0.47); C513(1.11)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C339(0.66); C429(0.45); C430(0.45); C513(0.98)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C339(0.50); C429(0.25); C430(0.25); C513(0.86)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C339(1.02); C429(0.54); C430(0.54); C513(0.71)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C339(0.55); C429(0.32); C430(0.32); C513(0.79)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C339(0.49); C429(0.29); C430(0.29); C513(0.74)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C339(0.73); C513(0.96); C550(0.99); C558(0.99)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C339(0.58); C513(0.66); C550(0.83); C558(0.83)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C339(0.61); C513(0.67); C550(0.82); C558(0.82)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C339(0.33); C513(0.69); C550(0.86); C558(0.86)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C339(0.51); C429(0.56); C430(0.56); C513(0.83)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C339(1.04); C513(1.14); C550(1.00); C558(1.00)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C339(0.48); C513(0.62); C550(0.90); C558(0.90)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C339(0.30); C513(0.75); C550(1.22); C558(1.22)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C339(0.31); C513(0.83); C550(1.10); C558(1.10)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C339(0.29); C513(0.98); C550(1.36); C558(1.36)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C339(0.48); C513(0.80); C550(0.92); C558(0.92)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C339(0.70); C513(0.78); C550(0.96); C558(0.96)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C339(0.43); C513(0.73); C550(0.96); C558(0.96)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C339(0.33); C513(0.80); C550(1.01); C558(1.01)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C339(0.33); C513(1.10); C550(1.30); C558(1.30)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C339(0.63); C429(0.87); C430(0.87); C513(0.79)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C339(1.08); C513(0.95); C550(0.87); C558(0.87)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C339(0.58); C513(0.79); C550(1.07); C558(1.08)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C339(0.92); C513(0.84); C550(0.92); C558(0.86)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C339(0.73); C513(0.66); C550(0.99); C558(0.92)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C339(1.31); C513(0.56); C550(0.92); C558(0.84)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C339(0.79); C513(0.62); C550(0.99); C558(0.92)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C339(0.83); C513(0.56); C550(0.98); C558(0.99)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C339(0.82); C513(0.71); C550(1.05); C558(1.02)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C339(0.96); C513(0.69); C550(1.21); C558(1.28)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C339(0.96); C513(0.69); C550(1.09); C558(1.16)  LDD0811  [11]
 LDCM0190  Compound 34 HEK-293T 9.88  LDD0510  [28]
 LDCM0192  Compound 35 HEK-293T 4.04  LDD0509  [28]
 LDCM0193  Compound 36 HEK-293T 7.85  LDD0511  [28]
 LDCM0634  CY-0357 Hep-G2 C698(1.17)  LDD2228  [18]
 LDCM0495  E2913 HEK-293T C901(1.05); C604(0.91); C522(1.02); C837(1.06)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C913(5.49); C522(2.83); C698(2.05)  LDD1702  [7]
 LDCM0625  F8 Ramos C604(1.57); C901(1.13); C913(0.88); C698(0.69)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C604(2.34); C901(1.52); C913(0.70); C698(1.03)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C604(0.78); C901(2.74); C913(1.24); C698(4.65)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C604(5.62); C901(1.63); C913(1.03); C698(1.27)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C913(0.92); C698(1.12); C522(1.34); C513(0.73)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C604(3.13); C901(0.93); C913(1.04); C698(2.22)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C604(5.03); C913(1.87); C698(1.22); C522(1.21)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C604(1.72); C913(1.19); C698(0.98); C522(1.43)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C604(0.71); C901(0.67); C913(0.71); C698(0.92)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C604(1.06); C901(0.62); C913(0.77); C698(0.90)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C604(1.15); C901(0.41); C913(1.11); C698(0.81)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C604(2.81); C901(0.88); C913(1.11); C698(1.01)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C604(1.25); C901(0.69); C913(0.80); C698(1.04)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C604(4.53); C901(0.88); C913(1.16); C698(1.27)  LDD2201  [32]
 LDCM0468  Fragment33 HCT 116 C339(0.54); C429(0.26); C430(0.26); C513(0.81)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C901(1.13); C913(3.12); C698(0.88); C522(1.28)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C604(4.62); C901(1.31); C913(1.06); C698(0.84)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C339(0.36); C429(0.45); C430(0.45); C513(1.12)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C913(0.92); C698(2.21); C522(1.43); C513(1.19)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C604(1.62); C901(1.67); C913(0.91); C698(1.19)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C604(3.98); C901(0.89); C913(1.60); C698(0.83)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C604(4.49); C901(1.36); C913(1.13); C698(1.39)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y222(1.33)  LDD0264  [10]
 LDCM0120  HHS-0701 DM93 Y222(2.88)  LDD0268  [10]
 LDCM0107  IAA HeLa H190(0.00); H704(0.00); C513(0.00); C698(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C550(3.57); C558(3.57); C837(1.81); C698(1.25)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C550(3.58); C558(3.58); C837(2.05); C698(1.43)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C550(2.31); C558(2.31); C837(1.70); C698(1.44)  LDD0082  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C901(0.81)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C604(0.44); C339(0.91); C901(0.33)  LDD2121  [7]
 LDCM0109  NEM HeLa H465(0.00); H368(0.00); H399(0.00); H190(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C339(0.61); C522(0.38); C901(0.32); C698(0.92)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C339(0.78)  LDD2090  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C604(1.28); C339(1.18); C522(0.91)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C901(0.72)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C604(0.44); C522(0.38)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C913(1.02)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C604(1.06); C339(1.14); C522(0.71); C913(0.89)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C339(0.98)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C339(0.64); C522(1.08); C901(0.58)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C339(0.43); C901(0.84)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C901(0.99); C913(1.37)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C339(0.58)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C604(0.92); C339(1.06); C522(0.98); C913(0.88)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C901(0.82)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C604(0.91); C339(0.60); C522(1.28); C901(0.61)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C901(0.73)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C604(1.05); C339(1.20); C522(0.97)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C901(0.78)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C522(0.55); C901(0.51)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C604(0.72)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C604(0.66)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C604(2.60); C339(2.37); C522(2.06)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C604(0.93); C339(0.89)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C604(0.53); C913(0.57)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C604(0.97); C339(0.97); C522(1.12); C901(0.57)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C604(0.51); C901(1.02)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C604(0.87); C339(0.95); C522(1.07); C901(0.62)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C604(1.12); C339(1.17); C522(0.85); C901(0.86)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C339(1.01)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C604(1.00); C339(1.45); C522(0.98); C901(0.49)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C522(1.05)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C522(0.68); C901(0.95)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C604(1.02); C339(1.61); C522(1.18); C901(0.69)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C604(1.31); C339(1.11); C522(1.03); C901(0.87)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C604(1.01); C339(1.15); C522(0.86); C901(0.74)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C604(1.78); C522(1.78); C339(1.37)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C604(0.82); C339(0.82); C522(0.90)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C901(0.86)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C604(1.55); C339(0.98); C901(1.30)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C604(2.55); C339(3.11); C522(2.17); C901(2.35)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C604(1.01); C339(0.96); C522(0.72); C901(0.54)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C339(2.59)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C604(1.12); C522(0.60)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C604(0.56)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C604(0.33); C339(0.50); C901(0.25)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C604(1.48); C339(0.69)  LDD2151  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C739(2.79); C698(1.14); C807(1.12); C913(0.85)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C604(2.36); C739(1.25); C913(0.84); C807(0.78)  LDD2207  [33]
 LDCM0021  THZ1 HCT 116 C837(1.11); C913(0.97)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin-like protein 4A (TXNL4A) DIM1 family P83876
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200) Helicase family O75643
Serine/threonine-protein kinase A-Raf (ARAF) TKL Ser/Thr protein kinase family P10398
Polycomb complex protein BMI-1 (BMI1) . P35226
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
U4/U6.U5 tri-snRNP-associated protein 1 (SART1) SNU66/SART1 family O43290
CD2 antigen cytoplasmic tail-binding protein 2 (CD2BP2) . O95400
Pre-mRNA-processing factor 6 (PRPF6) . O94906
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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Mass spectrometry data entry: PXD044402
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