Details of the Target

General Information of Target

Target ID LDTP03728
Target Name Large ribosomal subunit protein eL22 (RPL22)
Gene Name RPL22
Gene ID 6146
Synonyms
Large ribosomal subunit protein eL22; 60S ribosomal protein L22; EBER-associated protein; EAP; Epstein-Barr virus small RNA-associated protein; Heparin-binding protein HBp15
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGV
VTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQD
EEEEEDED
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL22 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P35268
Ensemble ID
ENST00000234875.9
HGNC ID
HGNC:10315

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		1.86  LDD0451  [1]
N1
 Probe Info  		4.83  LDD0242  [2]
C-Sul
 Probe Info  		3.81  LDD0066  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
AZ-9
 Probe Info  		E64(0.86)  LDD2208  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
IPM
 Probe Info  		N.A.  LDD0241  [7]
OPA-S-S-alkyne
 Probe Info  		K107(2.29); K80(2.72); K52(7.72)  LDD3494  [8]
DBIA
 Probe Info  		C25(0.88)  LDD3310  [9]
THZ1-DTB
 Probe Info  		C25(1.04)  LDD0460  [10]
W1
 Probe Info  		K10(0.84)  LDD0237  [7]
ATP probe
 Probe Info  		K84(0.00); K80(0.00); K107(0.00); K69(0.00)  LDD0199  [11]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [13]
ATP probe
 Probe Info  		K107(0.00); K80(0.00)  LDD0035  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [17]
NHS
 Probe Info  		K52(0.00); K107(0.00); K69(0.00)  LDD0010  [18]
SF
 Probe Info  		K69(0.00); K10(0.00)  LDD0028  [19]
STPyne
 Probe Info  		K52(0.00); K69(0.00)  LDD0009  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [20]
Acrolein
 Probe Info  		C25(0.00); H27(0.00)  LDD0217  [21]
AOyne
 Probe Info  		9.00  LDD0443  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.15  LDD0137  [23]
STS-2
 Probe Info  		4.65  LDD0138  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C25(1.02)  LDD1507  [24]
 LDCM0215  AC10 PaTu 8988t C25(0.73)  LDD1094  [25]
 LDCM0226  AC11 PaTu 8988t C25(0.71)  LDD1105  [25]
 LDCM0237  AC12 PaTu 8988t C25(0.73)  LDD1116  [25]
 LDCM0259  AC14 PaTu 8988t C25(0.85)  LDD1138  [25]
 LDCM0270  AC15 PaTu 8988t C25(0.81)  LDD1149  [25]
 LDCM0276  AC17 HEK-293T C25(0.99)  LDD1515  [24]
 LDCM0277  AC18 HEK-293T C25(1.09)  LDD1516  [24]
 LDCM0278  AC19 HEK-293T C25(1.06)  LDD1517  [24]
 LDCM0279  AC2 HEK-293T C25(1.09)  LDD1518  [24]
 LDCM0280  AC20 HEK-293T C25(1.16)  LDD1519  [24]
 LDCM0281  AC21 HEK-293T C25(0.96)  LDD1520  [24]
 LDCM0282  AC22 HEK-293T C25(1.20)  LDD1521  [24]
 LDCM0283  AC23 HEK-293T C25(0.96)  LDD1522  [24]
 LDCM0284  AC24 HEK-293T C25(1.03)  LDD1523  [24]
 LDCM0285  AC25 PaTu 8988t C25(0.97)  LDD1164  [25]
 LDCM0286  AC26 PaTu 8988t C25(1.16)  LDD1165  [25]
 LDCM0287  AC27 PaTu 8988t C25(1.01)  LDD1166  [25]
 LDCM0288  AC28 PaTu 8988t C25(1.02)  LDD1167  [25]
 LDCM0289  AC29 PaTu 8988t C25(1.27)  LDD1168  [25]
 LDCM0290  AC3 HEK-293T C25(1.04)  LDD1529  [24]
 LDCM0291  AC30 PaTu 8988t C25(1.18)  LDD1170  [25]
 LDCM0292  AC31 PaTu 8988t C25(0.98)  LDD1171  [25]
 LDCM0293  AC32 PaTu 8988t C25(0.91)  LDD1172  [25]
 LDCM0294  AC33 PaTu 8988t C25(1.03)  LDD1173  [25]
 LDCM0295  AC34 PaTu 8988t C25(1.12)  LDD1174  [25]
 LDCM0296  AC35 PaTu 8988t C25(1.18)  LDD1175  [25]
 LDCM0297  AC36 PaTu 8988t C25(1.23)  LDD1176  [25]
 LDCM0298  AC37 PaTu 8988t C25(1.04)  LDD1177  [25]
 LDCM0299  AC38 PaTu 8988t C25(1.16)  LDD1178  [25]
 LDCM0300  AC39 PaTu 8988t C25(1.43)  LDD1179  [25]
 LDCM0301  AC4 HEK-293T C25(1.12)  LDD1540  [24]
 LDCM0302  AC40 PaTu 8988t C25(1.23)  LDD1181  [25]
 LDCM0303  AC41 PaTu 8988t C25(0.93)  LDD1182  [25]
 LDCM0304  AC42 PaTu 8988t C25(0.76)  LDD1183  [25]
 LDCM0305  AC43 PaTu 8988t C25(1.13)  LDD1184  [25]
 LDCM0306  AC44 PaTu 8988t C25(1.17)  LDD1185  [25]
 LDCM0307  AC45 PaTu 8988t C25(0.98)  LDD1186  [25]
 LDCM0308  AC46 HEK-293T C25(1.12)  LDD1547  [24]
 LDCM0309  AC47 HEK-293T C25(1.03)  LDD1548  [24]
 LDCM0310  AC48 HEK-293T C25(1.09)  LDD1549  [24]
 LDCM0311  AC49 HEK-293T C25(1.09)  LDD1550  [24]
 LDCM0312  AC5 HEK-293T C25(1.03)  LDD1551  [24]
 LDCM0313  AC50 HEK-293T C25(1.01)  LDD1552  [24]
 LDCM0314  AC51 HEK-293T C25(1.01)  LDD1553  [24]
 LDCM0315  AC52 HEK-293T C25(1.11)  LDD1554  [24]
 LDCM0316  AC53 HEK-293T C25(0.98)  LDD1555  [24]
 LDCM0317  AC54 HEK-293T C25(1.04)  LDD1556  [24]
 LDCM0318  AC55 HEK-293T C25(0.98)  LDD1557  [24]
 LDCM0319  AC56 HEK-293T C25(1.04)  LDD1558  [24]
 LDCM0320  AC57 HEK-293T C25(1.05)  LDD1559  [24]
 LDCM0321  AC58 HEK-293T C25(1.04)  LDD1560  [24]
 LDCM0322  AC59 HEK-293T C25(1.12)  LDD1561  [24]
 LDCM0323  AC6 PaTu 8988t C25(1.03)  LDD1202  [25]
 LDCM0324  AC60 HEK-293T C25(1.14)  LDD1563  [24]
 LDCM0325  AC61 HEK-293T C25(0.98)  LDD1564  [24]
 LDCM0326  AC62 HEK-293T C25(1.06)  LDD1565  [24]
 LDCM0327  AC63 HEK-293T C25(1.00)  LDD1566  [24]
 LDCM0328  AC64 HEK-293T C25(1.02)  LDD1567  [24]
 LDCM0334  AC7 PaTu 8988t C25(0.75)  LDD1213  [25]
 LDCM0345  AC8 PaTu 8988t C25(0.80)  LDD1224  [25]
 LDCM0248  AKOS034007472 PaTu 8988t C25(1.27)  LDD1127  [25]
 LDCM0356  AKOS034007680 PaTu 8988t C25(0.63)  LDD1235  [25]
 LDCM0275  AKOS034007705 PaTu 8988t C25(0.79)  LDD1154  [25]
 LDCM0630  CCW28-3 231MFP C25(1.11)  LDD2214  [26]
 LDCM0108  Chloroacetamide HeLa C25(0.00); H27(0.00)  LDD0222  [21]
 LDCM0367  CL1 HEK-293T C25(1.13)  LDD1571  [24]
 LDCM0368  CL10 HEK-293T C25(1.01)  LDD1572  [24]
 LDCM0369  CL100 HEK-293T C25(1.05)  LDD1573  [24]
 LDCM0370  CL101 PaTu 8988t C25(0.85)  LDD1249  [25]
 LDCM0371  CL102 PaTu 8988t C25(0.73)  LDD1250  [25]
 LDCM0372  CL103 PaTu 8988t C25(0.83)  LDD1251  [25]
 LDCM0373  CL104 PaTu 8988t C25(0.87)  LDD1252  [25]
 LDCM0374  CL105 HEK-293T C25(1.01)  LDD1578  [24]
 LDCM0375  CL106 HEK-293T C25(1.04)  LDD1579  [24]
 LDCM0376  CL107 HEK-293T C25(1.00)  LDD1580  [24]
 LDCM0377  CL108 HEK-293T C25(1.01)  LDD1581  [24]
 LDCM0378  CL109 HEK-293T C25(1.06)  LDD1582  [24]
 LDCM0379  CL11 HEK-293T C25(1.01)  LDD1583  [24]
 LDCM0380  CL110 HEK-293T C25(1.01)  LDD1584  [24]
 LDCM0381  CL111 HEK-293T C25(1.04)  LDD1585  [24]
 LDCM0382  CL112 PaTu 8988t C25(1.05)  LDD1261  [25]
 LDCM0383  CL113 PaTu 8988t C25(1.18)  LDD1262  [25]
 LDCM0384  CL114 PaTu 8988t C25(0.91)  LDD1263  [25]
 LDCM0385  CL115 PaTu 8988t C25(0.69)  LDD1264  [25]
 LDCM0386  CL116 PaTu 8988t C25(1.13)  LDD1265  [25]
 LDCM0387  CL117 PaTu 8988t C25(1.17)  LDD1266  [25]
 LDCM0388  CL118 PaTu 8988t C25(0.92)  LDD1267  [25]
 LDCM0389  CL119 PaTu 8988t C25(1.39)  LDD1268  [25]
 LDCM0390  CL12 HEK-293T C25(1.05)  LDD1594  [24]
 LDCM0391  CL120 PaTu 8988t C25(1.26)  LDD1270  [25]
 LDCM0392  CL121 HEK-293T C25(1.02)  LDD1596  [24]
 LDCM0393  CL122 HEK-293T C25(0.99)  LDD1597  [24]
 LDCM0394  CL123 HEK-293T C25(0.96)  LDD1598  [24]
 LDCM0395  CL124 HEK-293T C25(1.07)  LDD1599  [24]
 LDCM0396  CL125 HEK-293T C25(1.06)  LDD1600  [24]
 LDCM0397  CL126 HEK-293T C25(1.03)  LDD1601  [24]
 LDCM0398  CL127 HEK-293T C25(1.04)  LDD1602  [24]
 LDCM0399  CL128 HEK-293T C25(0.99)  LDD1603  [24]
 LDCM0400  CL13 HEK-293T C25(1.06)  LDD1604  [24]
 LDCM0401  CL14 HEK-293T C25(1.15)  LDD1605  [24]
 LDCM0402  CL15 HEK-293T C25(0.99)  LDD1606  [24]
 LDCM0403  CL16 HEK-293T C25(1.01)  LDD1607  [24]
 LDCM0404  CL17 HEK-293T C25(0.80)  LDD1608  [24]
 LDCM0405  CL18 HEK-293T C25(1.19)  LDD1609  [24]
 LDCM0406  CL19 HEK-293T C25(0.99)  LDD1610  [24]
 LDCM0407  CL2 HEK-293T C25(1.02)  LDD1611  [24]
 LDCM0408  CL20 HEK-293T C25(1.15)  LDD1612  [24]
 LDCM0409  CL21 HEK-293T C25(1.00)  LDD1613  [24]
 LDCM0410  CL22 HEK-293T C25(1.05)  LDD1614  [24]
 LDCM0411  CL23 HEK-293T C25(0.96)  LDD1615  [24]
 LDCM0412  CL24 HEK-293T C25(1.06)  LDD1616  [24]
 LDCM0413  CL25 HEK-293T C25(1.04)  LDD1617  [24]
 LDCM0414  CL26 HEK-293T C25(0.98)  LDD1618  [24]
 LDCM0415  CL27 HEK-293T C25(1.00)  LDD1619  [24]
 LDCM0416  CL28 HEK-293T C25(0.95)  LDD1620  [24]
 LDCM0417  CL29 HEK-293T C25(1.04)  LDD1621  [24]
 LDCM0418  CL3 HEK-293T C25(0.85)  LDD1622  [24]
 LDCM0419  CL30 HEK-293T C25(1.09)  LDD1623  [24]
 LDCM0420  CL31 PaTu 8988t C25(1.18)  LDD1299  [25]
 LDCM0421  CL32 PaTu 8988t C25(1.19)  LDD1300  [25]
 LDCM0422  CL33 PaTu 8988t C25(0.80)  LDD1301  [25]
 LDCM0423  CL34 PaTu 8988t C25(1.14)  LDD1302  [25]
 LDCM0424  CL35 PaTu 8988t C25(1.03)  LDD1303  [25]
 LDCM0425  CL36 PaTu 8988t C25(0.33)  LDD1304  [25]
 LDCM0426  CL37 PaTu 8988t C25(0.92)  LDD1305  [25]
 LDCM0428  CL39 PaTu 8988t C25(1.02)  LDD1307  [25]
 LDCM0429  CL4 HEK-293T C25(1.06)  LDD1633  [24]
 LDCM0430  CL40 PaTu 8988t C25(1.01)  LDD1309  [25]
 LDCM0431  CL41 PaTu 8988t C25(1.04)  LDD1310  [25]
 LDCM0432  CL42 PaTu 8988t C25(0.99)  LDD1311  [25]
 LDCM0433  CL43 PaTu 8988t C25(1.08)  LDD1312  [25]
 LDCM0434  CL44 PaTu 8988t C25(1.15)  LDD1313  [25]
 LDCM0435  CL45 PaTu 8988t C25(0.94)  LDD1314  [25]
 LDCM0436  CL46 PaTu 8988t C25(1.04)  LDD1315  [25]
 LDCM0437  CL47 PaTu 8988t C25(0.84)  LDD1316  [25]
 LDCM0438  CL48 PaTu 8988t C25(0.85)  LDD1317  [25]
 LDCM0439  CL49 PaTu 8988t C25(0.93)  LDD1318  [25]
 LDCM0440  CL5 HEK-293T C25(1.00)  LDD1644  [24]
 LDCM0441  CL50 PaTu 8988t C25(0.71)  LDD1320  [25]
 LDCM0442  CL51 PaTu 8988t C25(1.00)  LDD1321  [25]
 LDCM0443  CL52 PaTu 8988t C25(0.85)  LDD1322  [25]
 LDCM0444  CL53 PaTu 8988t C25(1.00)  LDD1323  [25]
 LDCM0445  CL54 PaTu 8988t C25(0.84)  LDD1324  [25]
 LDCM0446  CL55 PaTu 8988t C25(0.86)  LDD1325  [25]
 LDCM0447  CL56 PaTu 8988t C25(0.97)  LDD1326  [25]
 LDCM0448  CL57 PaTu 8988t C25(0.90)  LDD1327  [25]
 LDCM0449  CL58 PaTu 8988t C25(0.85)  LDD1328  [25]
 LDCM0450  CL59 PaTu 8988t C25(0.99)  LDD1329  [25]
 LDCM0451  CL6 HEK-293T C25(1.09)  LDD1654  [24]
 LDCM0452  CL60 PaTu 8988t C25(0.90)  LDD1331  [25]
 LDCM0453  CL61 PaTu 8988t C25(0.83)  LDD1332  [25]
 LDCM0454  CL62 PaTu 8988t C25(1.28)  LDD1333  [25]
 LDCM0455  CL63 PaTu 8988t C25(1.00)  LDD1334  [25]
 LDCM0456  CL64 PaTu 8988t C25(1.04)  LDD1335  [25]
 LDCM0457  CL65 PaTu 8988t C25(0.90)  LDD1336  [25]
 LDCM0458  CL66 PaTu 8988t C25(0.88)  LDD1337  [25]
 LDCM0459  CL67 PaTu 8988t C25(0.80)  LDD1338  [25]
 LDCM0460  CL68 PaTu 8988t C25(1.06)  LDD1339  [25]
 LDCM0461  CL69 PaTu 8988t C25(0.94)  LDD1340  [25]
 LDCM0462  CL7 HEK-293T C25(1.08)  LDD1665  [24]
 LDCM0463  CL70 PaTu 8988t C25(0.91)  LDD1342  [25]
 LDCM0464  CL71 PaTu 8988t C25(0.88)  LDD1343  [25]
 LDCM0465  CL72 PaTu 8988t C25(1.09)  LDD1344  [25]
 LDCM0466  CL73 PaTu 8988t C25(1.20)  LDD1345  [25]
 LDCM0467  CL74 PaTu 8988t C25(0.81)  LDD1346  [25]
 LDCM0469  CL76 PaTu 8988t C25(1.01)  LDD1348  [25]
 LDCM0470  CL77 PaTu 8988t C25(0.90)  LDD1349  [25]
 LDCM0471  CL78 PaTu 8988t C25(1.07)  LDD1350  [25]
 LDCM0472  CL79 PaTu 8988t C25(1.16)  LDD1351  [25]
 LDCM0473  CL8 HEK-293T C25(1.07)  LDD1676  [24]
 LDCM0474  CL80 PaTu 8988t C25(1.00)  LDD1353  [25]
 LDCM0475  CL81 PaTu 8988t C25(0.81)  LDD1354  [25]
 LDCM0476  CL82 PaTu 8988t C25(1.11)  LDD1355  [25]
 LDCM0477  CL83 PaTu 8988t C25(1.25)  LDD1356  [25]
 LDCM0478  CL84 PaTu 8988t C25(0.96)  LDD1357  [25]
 LDCM0479  CL85 PaTu 8988t C25(0.87)  LDD1358  [25]
 LDCM0480  CL86 PaTu 8988t C25(0.82)  LDD1359  [25]
 LDCM0481  CL87 PaTu 8988t C25(1.01)  LDD1360  [25]
 LDCM0482  CL88 PaTu 8988t C25(1.12)  LDD1361  [25]
 LDCM0483  CL89 PaTu 8988t C25(1.10)  LDD1362  [25]
 LDCM0484  CL9 HEK-293T C25(1.01)  LDD1687  [24]
 LDCM0485  CL90 PaTu 8988t C25(0.84)  LDD1364  [25]
 LDCM0486  CL91 HEK-293T C25(1.11)  LDD1689  [24]
 LDCM0487  CL92 HEK-293T C25(1.02)  LDD1690  [24]
 LDCM0488  CL93 HEK-293T C25(1.01)  LDD1691  [24]
 LDCM0489  CL94 HEK-293T C25(1.04)  LDD1692  [24]
 LDCM0490  CL95 HEK-293T C25(0.86)  LDD1693  [24]
 LDCM0491  CL96 HEK-293T C25(1.04)  LDD1694  [24]
 LDCM0492  CL97 HEK-293T C25(1.03)  LDD1695  [24]
 LDCM0493  CL98 HEK-293T C25(0.96)  LDD1696  [24]
 LDCM0494  CL99 HEK-293T C25(0.95)  LDD1697  [24]
 LDCM0495  E2913 HEK-293T C25(0.96)  LDD1698  [24]
 LDCM0625  F8 Ramos C25(0.68)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C25(0.50)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C25(0.27)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C25(0.31)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C25(0.41)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C25(1.05)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C25(0.21)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C25(0.61)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C25(0.54)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C25(0.59)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C25(0.26)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C25(0.56)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C25(0.50)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C25(0.44)  LDD2201  [27]
 LDCM0468  Fragment33 PaTu 8988t C25(0.87)  LDD1347  [25]
 LDCM0596  Fragment38 Ramos C25(0.10)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C25(0.79)  LDD2184  [27]
 LDCM0427  Fragment51 PaTu 8988t C25(1.14)  LDD1306  [25]
 LDCM0610  Fragment52 Ramos C25(0.35)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C25(0.23)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C25(0.65)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C25(0.24)  LDD2188  [27]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C25(0.97)  LDD1492  [24]
 LDCM0023  KB03 HEK-293T C25(0.99)  LDD1497  [24]
 LDCM0024  KB05 COLO792 C25(0.88)  LDD3310  [9]
 LDCM0109  NEM HeLa N.A.  LDD0226  [21]
 LDCM0131  RA190 MM1.R C25(1.16)  LDD0304  [28]
 LDCM0021  THZ1 HeLa S3 C25(1.04)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 K10(0.84)  LDD0237  [7]
 LDCM0111  W14 Hep-G2 K10(0.58); S106(0.85)  LDD0238  [7]
 LDCM0113  W17 Hep-G2 K10(0.57)  LDD0240  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Huntingtin (HTT) Huntingtin family P42858
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Cancer/testis antigen family 45 member A1 (CT45A1) CT45 family Q5HYN5
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Large ribosomal subunit protein eL22 (RPL22) Eukaryotic ribosomal protein eL22 family P35268
Fibroblast growth factor 11 (FGF11) Heparin-binding growth factors family Q92914
Surfeit locus protein 6 (SURF6) SURF6 family O75683
SH3 and cysteine-rich domain-containing protein 3 (STAC3) . Q96MF2
Syntenin-2 (SDCBP2) . Q9H190
Zinc finger CCHC domain-containing protein 10 (ZCCHC10) . Q8TBK6

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.