Details of the Target
General Information of Target
| Target ID | LDTP07378 | |||||
|---|---|---|---|---|---|---|
| Target Name | Small ubiquitin-related modifier 4 (SUMO4) | |||||
| Gene Name | SUMO4 | |||||
| Gene ID | 387082 | |||||
| Synonyms |
SMT3H4; Small ubiquitin-related modifier 4; SUMO-4; Small ubiquitin-like protein 4 |
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| 3D Structure | ||||||
| Sequence |
MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSVKQIRF
RFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY |
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| Target Bioclass |
Other
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| Family |
Ubiquitin family, SUMO subfamily
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| Function |
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
YN-1 Probe Info |
 |
100.00 | LDD0444 | [1] | |
|
YN-4 Probe Info |
 |
100.00 | LDD0445 | [1] | |
|
1c-yne Probe Info |
 |
N.A. | LDD0228 | [2] | |
|
HHS-465 Probe Info |
 |
N.A. | LDD2240 | [3] | |
References