Details of the Target

General Information of Target

Target ID LDTP05742
Target Name Acetyl-CoA carboxylase 1 (ACACA)
Gene Name ACACA
Gene ID 31
Synonyms
ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC1; EC 6.4.1.2; Acetyl-Coenzyme A carboxylase alpha; ACC-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEPSPLAQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLS
DLGISSLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEK
VLIANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPG
GPNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWAL
GDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDGLQA
AEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQSRHLEV
QILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAKMVGYVSA
GTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLYRIKDIRMMY
GVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQELNFRSNKNVWGY
FSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLIKLLET
ESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLRNSVSNFLHSLERGQV
LPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDG
SSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGKLIQYIVEDGGHVFAGQCYA
EIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQLDNPSKVQQAELHTGSLPRIQ
STALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSKVKDWVERLMKTLRDPSLPLLELQ
DIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQFPSQQIANILDSHAATLNRKSEREV
FFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQYLRVETQFQNGHYDKCVFALREENKSD
MNTVLNYIFSHAQVTKKNLLVTMLIDQLCGRDPTLTDELLNILTELTQLSKTTNAKVALR
ARQVLIASHLPSYELRHNQVESIFLSAIDMYGHQFCIENLQKLILSETSIFDVLPNFFYH
SNQVVRMAALEVYVRRAYIAYELNSVQHRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRM
SFSSNLNHYGMTHVASVSDVLLDNSFTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSP
PQSPTFPEAGHTSLYDEDKVPRDEPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLV
DHGIRRLTFLVAQKDFRKQVNYEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQ
LELNRMRNFDLTAIPCANHKMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFE
YLQNEGERLLLEAMDELEVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYG
SRLWKLRVLQAELKINIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQA
YGDKQGPLHGMLINTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQA
FLPSPPLPSDMLTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVI
GNDITYRIGSFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVD
PEDPYKGYRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGS
GMIAGESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGR
EVYTSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPID
RIIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLGG
IPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREGLPL
MVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVVIDSSI
NPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGTPELSTAE
RKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTSRTFFYWRLR
RLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKDLAEWLEKQLTE
EDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHISPTQRAEVIRILST
MDSPST
Target Bioclass
Enzyme
Subcellular location
Cytoplasm, cytosol
Function
Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
Uniprot ID
Q13085
Ensemble ID
ENST00000611803.2
HGNC ID
HGNC:84
ChEMBL ID
CHEMBL3351

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.83  LDD0215  [2]
C-Sul
 Probe Info  		3.26  LDD0066  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
Probe 1
 Probe Info  		Y1342(27.63); Y1715(22.46); Y2027(32.39); Y2262(14.18)  LDD3495  [5]
DA-P3
 Probe Info  		11.46  LDD0183  [6]
AHL-Pu-1
 Probe Info  		C701(3.08)  LDD0168  [7]
DBIA
 Probe Info  		C1297(66.51); C743(18.14)  LDD0209  [8]
HHS-482
 Probe Info  		Y2027(0.55)  LDD0285  [9]
AMP probe
 Probe Info  		K2127(0.00); K323(0.00)  LDD0200  [10]
ATP probe
 Probe Info  		K2127(0.00); K323(0.00); K386(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C500(0.00); C813(0.00); C1297(0.00); C1470(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C1176(0.00); C407(0.00); C500(0.00); C1396(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C1176(0.00); C934(0.00); C1396(0.00); C813(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
BTD
 Probe Info  		N.A.  LDD0004  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
IPM
 Probe Info  		C813(0.00); C1297(0.00)  LDD0005  [13]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		K2127(0.00); K323(0.00)  LDD0009  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Acrolein
 Probe Info  		C1769(0.00); C407(0.00); H2146(0.00); C1297(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C1769(0.00); C1297(0.00)  LDD0218  [17]
W1
 Probe Info  		C500(0.00); C1297(0.00); C813(0.00); C1470(0.00)  LDD0236  [18]
NAIA_5
 Probe Info  		C1297(0.00); C813(0.00); C634(0.00)  LDD2223  [14]
HHS-465
 Probe Info  		K323(0.00); K1759(0.00); K2009(0.00)  LDD2240  [19]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		2.50  LDD0137  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C813(0.64)  LDD2095  [21]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C813(0.79)  LDD2130  [21]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C813(1.03)  LDD2117  [21]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C813(1.15)  LDD2152  [21]
 LDCM0025  4SU-RNA HEK-293T C701(3.08)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C701(5.30); C1049(2.77)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C813(0.93); C1470(0.96); C1116(0.95); C448(1.14)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C1769(1.11); C813(0.94); C1176(0.89); C1470(0.97)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C1769(0.87); C813(1.05); C1470(1.07); C1116(0.95)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C1769(1.07); C813(0.98); C1176(1.09); C1470(0.91)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C1769(1.22); C813(0.99); C1176(0.91); C1470(1.09)  LDD1512  [22]
 LDCM0270  AC15 HEK-293T C1769(0.96); C813(0.98); C1470(1.13); C1116(1.05)  LDD1513  [22]
 LDCM0276  AC17 HEK-293T C813(0.93); C1470(0.94); C1116(1.05); C448(1.12)  LDD1515  [22]
 LDCM0277  AC18 HEK-293T C1769(1.14); C813(1.03); C1176(1.10); C1470(1.03)  LDD1516  [22]
 LDCM0278  AC19 HEK-293T C1769(0.86); C813(0.98); C1470(0.93); C1116(0.88)  LDD1517  [22]
 LDCM0279  AC2 HEK-293T C1769(1.07); C813(0.91); C1176(0.87); C1470(1.11)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C1769(1.10); C813(0.97); C1176(0.86); C1470(1.14)  LDD1519  [22]
 LDCM0281  AC21 HEK-293T C1769(1.03); C813(0.95); C1176(0.92); C1470(1.02)  LDD1520  [22]
 LDCM0282  AC22 HEK-293T C1769(1.07); C813(0.95); C1176(1.04); C1470(0.83)  LDD1521  [22]
 LDCM0283  AC23 HEK-293T C1769(0.95); C813(0.97); C1470(1.10); C1116(1.04)  LDD1522  [22]
 LDCM0284  AC24 HEK-293T C1769(1.01); C813(0.98); C1176(0.98); C1470(1.09)  LDD1523  [22]
 LDCM0285  AC25 HEK-293T C813(0.92); C1470(1.06); C1116(1.04); C448(1.13)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C1769(1.15); C813(0.96); C1176(1.03); C1470(0.99)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C1769(0.95); C813(0.97); C1470(0.94); C1116(0.94)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C1769(1.02); C813(0.93); C1176(0.87); C1470(0.87)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C1769(1.10); C813(0.97); C1176(0.89); C1470(1.02)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C1769(1.02); C813(1.03); C1470(1.00); C1116(1.01)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C1769(1.22); C813(0.96); C1176(0.86); C1470(0.89)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C1769(0.84); C813(1.02); C1470(0.99); C1116(0.98)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C1769(1.16); C813(0.98); C1176(0.88); C1470(0.84)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C813(0.91); C1470(1.04); C1116(1.01); C448(1.10)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C1769(1.13); C813(0.93); C1176(0.84); C1470(1.02)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C1769(1.03); C813(1.03); C1470(1.02); C1116(0.98)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C1769(1.30); C813(0.99); C1176(0.83); C1470(1.01)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C1769(1.30); C813(0.93); C1176(0.99); C1470(1.03)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C1769(1.09); C813(0.92); C1176(0.82); C1470(1.01)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C1769(0.95); C813(0.93); C1470(1.02); C1116(1.02)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C1769(0.95); C813(0.99); C1176(0.98); C1470(0.87)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C1769(1.00); C813(0.91); C1176(1.02); C1470(0.95)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C813(0.95); C1470(1.01); C1116(1.09); C448(1.08)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C1769(1.04); C813(1.01); C1176(1.14); C1470(0.93)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C1769(1.05); C813(1.00); C1470(1.03); C1116(0.93)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C1769(0.93); C813(1.02); C1176(1.05); C1470(1.02)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C1769(1.26); C813(0.94); C1176(1.06); C1470(1.03)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C1769(1.08); C813(0.96); C1176(0.92); C1470(0.93)  LDD1547  [22]
 LDCM0309  AC47 HEK-293T C1769(0.87); C813(0.99); C1470(1.05); C1116(1.07)  LDD1548  [22]
 LDCM0310  AC48 HEK-293T C1769(0.90); C813(0.94); C1176(0.97); C1470(1.17)  LDD1549  [22]
 LDCM0311  AC49 HEK-293T C813(0.91); C1470(1.02); C1116(0.94); C448(0.87)  LDD1550  [22]
 LDCM0312  AC5 HEK-293T C1769(0.96); C813(1.02); C1176(0.78); C1470(0.93)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C1769(1.04); C813(0.97); C1176(1.00); C1470(0.95)  LDD1552  [22]
 LDCM0314  AC51 HEK-293T C1769(0.95); C813(0.96); C1470(1.07); C1116(0.97)  LDD1553  [22]
 LDCM0315  AC52 HEK-293T C1769(1.05); C813(0.98); C1176(0.93); C1470(0.89)  LDD1554  [22]
 LDCM0316  AC53 HEK-293T C1769(1.09); C813(1.04); C1176(0.95); C1470(1.07)  LDD1555  [22]
 LDCM0317  AC54 HEK-293T C1769(1.08); C813(0.93); C1176(0.91); C1470(1.01)  LDD1556  [22]
 LDCM0318  AC55 HEK-293T C1769(0.84); C813(0.99); C1470(1.17); C1116(0.99)  LDD1557  [22]
 LDCM0319  AC56 HEK-293T C1769(0.95); C813(0.93); C1176(1.02); C1470(0.93)  LDD1558  [22]
 LDCM0320  AC57 HEK-293T C813(0.94); C1470(0.92); C1116(0.98); C448(0.96)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C1769(1.05); C813(0.98); C1176(1.06); C1470(1.00)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C1769(0.89); C813(1.01); C1470(1.04); C1116(0.93)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C1769(1.00); C813(1.00); C1176(0.73); C1470(0.97)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C1769(0.98); C813(0.95); C1176(1.01); C1470(0.94)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C1769(1.03); C813(1.01); C1176(1.02); C1470(0.83)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C1769(0.88); C813(1.00); C1176(0.95); C1470(0.91)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C1769(0.90); C813(1.02); C1470(1.07); C1116(0.97)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C1769(0.80); C813(0.91); C1176(0.92); C1470(0.98)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C1769(0.76); C813(1.01); C1470(1.06); C1116(1.00)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C1769(0.97); C813(0.98); C1176(1.10); C1470(0.94)  LDD1569  [22]
 LDCM0545  Acetamide MDA-MB-231 C813(0.37)  LDD2138  [21]
 LDCM0520  AKOS000195272 MDA-MB-231 C813(0.56)  LDD2113  [21]
 LDCM0248  AKOS034007472 HEK-293T C1769(1.06); C813(1.06); C1176(1.03); C1470(1.00)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C813(0.97); C1470(1.07); C1116(1.05); C448(1.32)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C1769(0.83); C813(0.97); C1176(1.02); C1470(1.04)  LDD1514  [22]
 LDCM0108  Chloroacetamide HeLa C500(0.00); C1769(0.00); C634(0.00); C1297(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C407(20.00); C1297(0.36)  LDD2227  [14]
 LDCM0367  CL1 HEK-293T C1769(0.84); C813(0.91); C1176(0.98); C1470(1.36)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C1769(1.05); C813(1.15); C1176(0.98); C1470(1.29)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C1769(1.00); C813(1.03); C1470(0.90); C1116(0.97)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C1769(0.93); C813(0.98); C1176(0.36); C1470(1.16)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C1769(1.07); C813(0.97); C1176(1.12); C1470(0.85)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C1769(0.87); C813(0.89); C1470(0.98); C1116(1.08)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C1769(0.92); C813(0.92); C1470(1.00); C1116(0.99)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C1769(1.00); C813(1.01); C1176(1.07); C1470(1.06)  LDD1578  [22]
 LDCM0375  CL106 HEK-293T C1769(0.88); C813(0.99); C1176(1.18); C1470(0.98)  LDD1579  [22]
 LDCM0376  CL107 HEK-293T C1769(0.58); C813(0.94); C1470(0.94); C1116(0.89)  LDD1580  [22]
 LDCM0377  CL108 HEK-293T C1769(0.98); C813(0.92); C1470(0.92); C1116(0.95)  LDD1581  [22]
 LDCM0378  CL109 HEK-293T C1769(1.01); C813(0.98); C1176(1.27); C1470(0.98)  LDD1582  [22]
 LDCM0379  CL11 HEK-293T C1769(0.66); C813(1.15); C1470(1.14); C1116(1.41)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C1769(0.88); C813(0.96); C1176(1.07); C1470(0.90)  LDD1584  [22]
 LDCM0381  CL111 HEK-293T C1769(0.73); C813(0.93); C1470(0.97); C1116(0.97)  LDD1585  [22]
 LDCM0382  CL112 HEK-293T C1769(0.95); C813(0.97); C1470(0.97); C1116(0.99)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C1769(1.00); C813(0.95); C1176(1.14); C1470(0.96)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C1769(1.16); C813(1.07); C1176(1.09); C1470(0.94)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C1769(0.75); C813(0.93); C1470(0.97); C1116(1.00)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C1769(1.03); C813(0.89); C1470(1.07); C1116(1.05)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C1769(1.09); C813(0.96); C1176(0.99); C1470(1.19)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C1769(0.93); C813(0.95); C1176(1.18); C1470(1.00)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C1769(0.90); C813(0.88); C1470(0.95); C1116(1.06)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C1769(0.85); C813(1.01); C1176(1.18); C1470(0.89)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C1769(1.03); C813(0.93); C1470(0.90); C1116(0.95)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C1769(0.88); C813(0.94); C1176(0.44); C1470(1.05)  LDD1596  [22]
 LDCM0393  CL122 HEK-293T C1769(0.94); C813(0.98); C1176(1.29); C1470(0.98)  LDD1597  [22]
 LDCM0394  CL123 HEK-293T C1769(0.56); C813(0.92); C1470(0.83); C1116(0.89)  LDD1598  [22]
 LDCM0395  CL124 HEK-293T C1769(0.93); C813(0.92); C1470(1.05); C1116(0.76)  LDD1599  [22]
 LDCM0396  CL125 HEK-293T C1769(0.71); C813(0.97); C1176(1.31); C1470(1.16)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C1769(0.82); C813(1.06); C1176(1.23); C1470(0.97)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C1769(0.58); C813(0.96); C1470(0.99); C1116(0.93)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C1769(0.86); C813(0.96); C1470(0.95); C1116(0.97)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C1769(0.86); C813(0.92); C1176(1.20); C1470(1.00)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C1769(1.13); C813(0.98); C1176(1.22); C1470(1.13)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C1769(0.58); C813(1.01); C1470(0.99); C1116(1.04)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C1769(1.01); C813(0.98); C1470(0.87); C1116(0.94)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C813(0.98); C1470(0.95); C1116(1.11); C448(1.06)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C1769(1.06); C813(0.96); C1176(1.27); C1470(1.09)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C1769(0.96); C813(1.02); C1470(1.16); C1116(1.12)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C1769(1.19); C813(1.05); C1176(1.25); C1470(1.04)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C1769(1.02); C813(1.07); C1176(1.00); C1470(0.81)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C1769(1.01); C813(1.11); C1176(0.97); C1470(0.97)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C1769(0.85); C813(1.16); C1176(0.75); C1470(1.09)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C1769(0.91); C813(1.10); C1470(1.22); C1116(1.36)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C1769(0.87); C813(1.02); C1176(1.08); C1470(1.15)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C1769(0.69); C813(0.95); C1176(0.91); C1470(0.83)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C1769(0.96); C813(1.08); C1176(0.86); C1470(0.96)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C1769(0.77); C813(0.94); C1470(0.94); C1116(0.93)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C1769(0.93); C813(1.02); C1470(0.80); C1116(0.99)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C813(0.91); C1470(1.09); C1116(0.98); C448(0.93)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C1769(0.67); C813(0.94); C1470(0.92); C1116(0.96)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C1769(1.11); C813(1.01); C1176(1.05); C1470(1.03)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C1769(0.86); C813(1.15); C1470(1.01); C1116(0.95)  LDD1624  [22]
 LDCM0421  CL32 HEK-293T C1769(0.78); C813(1.10); C1176(1.08); C1470(0.95)  LDD1625  [22]
 LDCM0422  CL33 HEK-293T C1769(0.89); C813(1.08); C1176(0.90); C1470(0.99)  LDD1626  [22]
 LDCM0423  CL34 HEK-293T C1769(1.00); C813(1.10); C1176(0.79); C1470(1.06)  LDD1627  [22]
 LDCM0424  CL35 HEK-293T C1769(0.82); C813(1.08); C1470(1.21); C1116(1.23)  LDD1628  [22]
 LDCM0425  CL36 HEK-293T C1769(0.81); C813(1.09); C1176(1.18); C1470(1.13)  LDD1629  [22]
 LDCM0426  CL37 HEK-293T C1769(1.00); C813(0.89); C1176(0.84); C1470(0.83)  LDD1630  [22]
 LDCM0428  CL39 HEK-293T C1769(0.71); C813(0.99); C1470(0.91); C1116(0.95)  LDD1632  [22]
 LDCM0429  CL4 HEK-293T C1769(0.94); C813(0.98); C1470(0.89); C1116(0.98)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C1769(1.20); C813(0.95); C1470(0.92); C1116(1.00)  LDD1634  [22]
 LDCM0431  CL41 HEK-293T C813(0.95); C1470(0.99); C1116(1.07); C448(0.92)  LDD1635  [22]
 LDCM0432  CL42 HEK-293T C1769(0.86); C813(1.06); C1176(0.85); C1470(1.00)  LDD1636  [22]
 LDCM0433  CL43 HEK-293T C1769(0.93); C813(1.08); C1470(1.01); C1116(0.94)  LDD1637  [22]
 LDCM0434  CL44 HEK-293T C1769(0.87); C813(1.03); C1176(0.93); C1470(1.17)  LDD1638  [22]
 LDCM0435  CL45 HEK-293T C1769(0.83); C813(1.07); C1176(0.93); C1470(1.04)  LDD1639  [22]
 LDCM0436  CL46 HEK-293T C1769(0.89); C813(1.10); C1176(0.82); C1470(1.16)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C1769(0.96); C813(1.10); C1470(1.09); C1116(1.19)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C1769(0.84); C813(1.05); C1176(1.06); C1470(1.07)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C1769(0.81); C813(0.88); C1176(0.92); C1470(1.16)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C813(0.99); C1470(1.09); C1116(1.14); C448(1.09)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C1769(1.12); C813(0.99); C1176(0.92); C1470(1.07)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C1769(1.21); C813(0.92); C1470(0.97); C1116(0.93)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C813(0.92); C1470(0.95); C1116(0.99); C448(0.95)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C1769(0.92); C813(0.96); C1176(0.95); C1470(1.02)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C1769(0.97); C813(1.06); C1470(0.99); C1116(1.00)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C1769(1.13); C813(1.03); C1176(0.76); C1470(1.10)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C1769(0.97); C813(1.15); C1176(0.99); C1470(0.96)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C1769(0.82); C813(1.04); C1176(0.83); C1470(1.05)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C1769(0.86); C813(1.14); C1470(1.27); C1116(1.26)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C1769(0.84); C813(0.94); C1176(1.03); C1470(1.01)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C1769(0.82); C813(1.02); C1176(1.28); C1470(1.21)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C1769(0.83); C813(0.96); C1176(1.11); C1470(1.14)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C1769(0.98); C813(1.04); C1176(1.06); C1470(1.00)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C1769(0.51); C813(0.92); C1470(0.97); C1116(0.99)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C1769(0.86); C813(0.91); C1470(0.93); C1116(0.94)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C813(0.91); C1470(1.04); C1116(1.01); C448(1.37)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C1769(1.01); C813(0.96); C1176(1.07); C1470(0.94)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C1769(0.94); C813(1.03); C1470(1.05); C1116(0.99)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C1769(0.92); C813(1.03); C1176(1.11); C1470(0.94)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C1769(0.93); C813(1.08); C1176(0.97); C1470(1.05)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C1769(0.92); C813(0.99); C1470(1.08); C1116(1.04)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C1769(0.92); C813(1.04); C1176(1.09); C1470(1.10)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C1769(0.59); C813(1.05); C1470(1.15); C1116(1.33)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C1769(1.11); C813(1.01); C1176(1.22); C1470(1.01)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C1769(0.87); C813(0.99); C1176(1.06); C1470(0.87)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C1769(1.02); C813(1.00); C1176(1.03); C1470(0.97)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C1769(0.93); C813(0.84); C1470(0.93); C1116(0.96)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C813(0.96); C1470(0.88); C1116(0.94); C448(0.98)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C1769(1.08); C813(0.97); C1176(1.01); C1470(0.96)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C1769(0.86); C813(1.04); C1470(1.13); C1116(0.95)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C1769(0.66); C813(1.05); C1176(0.89); C1470(1.10)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C1769(0.95); C813(1.01); C1176(1.18); C1470(0.95)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C1769(1.05); C813(1.01); C1176(0.97); C1470(1.08)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C1769(1.03); C813(1.05); C1176(1.06); C1470(1.10)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C1769(0.64); C813(1.04); C1470(1.07); C1116(1.20)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C1769(0.78); C813(0.97); C1176(0.94); C1470(1.20)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C1769(0.68); C813(0.92); C1176(1.06); C1470(1.23)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C1769(0.83); C813(0.96); C1176(1.08); C1470(0.92)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C1769(0.55); C813(0.97); C1470(0.91); C1116(1.05)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C1769(0.75); C813(1.00); C1470(0.92); C1116(1.01)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C813(0.91); C1470(1.08); C1116(1.01); C448(1.08)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C1769(0.87); C813(1.09); C1176(0.92); C1470(0.97)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C1769(0.71); C813(0.97); C1176(0.97); C1470(1.02)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C1769(0.70); C813(1.08); C1470(1.04); C1116(0.84)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C1769(0.76); C813(1.03); C1176(1.07); C1470(0.85)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C1769(0.92); C813(1.11); C1176(1.06); C1470(1.07)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C1769(0.85); C813(0.94); C1176(1.07); C1470(1.25)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C1769(0.71); C813(1.03); C1470(1.04); C1116(1.09)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C1769(0.66); C813(1.01); C1176(0.97); C1470(1.02)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C1769(0.85); C813(0.91); C1176(0.94); C1470(1.00)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C1769(1.06); C813(1.06); C1176(1.02); C1470(0.93)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C1769(0.45); C813(1.00); C1470(0.97); C1116(1.02)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C1769(0.62); C813(0.98); C1470(1.03); C1116(0.88)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C813(4.40); C1009(3.59); C1396(1.32)  LDD1702  [21]
 LDCM0031  Epigallocatechin gallate HEK-293T 11.46  LDD0183  [6]
 LDCM0625  F8 Ramos C1297(1.53); C813(0.98)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C1297(2.20); C813(0.71)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C1297(1.28); C813(0.07)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C1297(1.17); C813(1.74)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C1297(1.38); C813(0.90)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C1297(1.15); C813(0.65)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C1297(1.52); C813(1.26)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C1297(1.26); C813(0.73)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C1297(1.89); C813(1.15)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C1297(1.26); C813(1.04)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C1297(1.00); C813(0.65)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C1297(1.24); C813(1.14)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C1297(1.19); C813(0.83)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C1297(1.66); C813(1.03)  LDD2201  [23]
 LDCM0468  Fragment33 HEK-293T C1769(0.62); C813(0.93); C1470(0.96); C1116(0.92)  LDD1671  [22]
 LDCM0596  Fragment38 Ramos C1297(0.83); C813(0.99)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C1297(1.44); C813(0.63)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C1769(0.95); C813(0.96); C1176(1.39); C1470(1.00)  LDD1631  [22]
 LDCM0610  Fragment52 Ramos C1297(1.11); C813(1.49)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C1297(0.90); C813(1.26)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C1297(1.90); C813(0.49)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C1297(1.47); C813(1.30)  LDD2188  [23]
 LDCM0107  IAA HeLa C1769(0.00); H1322(0.00); H653(0.00); H504(0.00)  LDD0221  [17]
 LDCM0123  JWB131 DM93 Y2027(0.55)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y2027(0.44)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y2027(0.63)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y2027(0.53)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y2027(1.41)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y2027(0.89)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y2027(0.92)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y2027(0.62)  LDD0292  [9]
 LDCM0022  KB02 HEK-293T C1769(1.01); C813(0.94); C1297(1.02); C500(1.05)  LDD1492  [22]
 LDCM0023  KB03 Jurkat C1297(66.51); C743(18.14)  LDD0209  [8]
 LDCM0024  KB05 HMCB C1213(2.44); C850(2.70)  LDD3312  [24]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C813(0.72)  LDD2121  [21]
 LDCM0109  NEM HeLa H653(0.00); H1322(0.00); H2146(0.00); H1287(0.00)  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C813(0.60)  LDD2089  [21]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C813(1.59)  LDD2090  [21]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C813(0.87)  LDD2092  [21]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C813(1.16)  LDD2093  [21]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C813(0.99)  LDD2094  [21]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C813(1.24)  LDD2096  [21]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C813(0.94)  LDD2098  [21]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C813(0.98)  LDD2099  [21]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C813(0.78)  LDD2109  [21]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C813(1.03)  LDD2111  [21]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C813(0.93)  LDD2116  [21]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C813(0.93)  LDD2123  [21]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C813(0.94)  LDD2125  [21]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C813(1.30)  LDD2127  [21]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C813(1.28)  LDD2128  [21]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C813(0.99)  LDD2129  [21]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C813(1.00)  LDD2137  [21]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C813(0.89)  LDD2143  [21]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C813(0.91)  LDD2146  [21]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C813(1.99)  LDD2147  [21]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C813(1.31)  LDD2151  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aldo-keto reductase family 1 member B10 (AKR1B10) Aldo/keto reductase family O60218
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) Sirtuin family Q96EB6
Acetyl-CoA carboxylase 1 (ACACA) . Q13085
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-I (APOC1) Apolipoprotein C1 family P02654

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840