Details of the Target

General Information of Target

Target ID LDTP04140
Target Name Large ribosomal subunit protein eL29 (RPL29)
Gene Name RPL29
Gene ID 6159
Synonyms
Large ribosomal subunit protein eL29; 60S ribosomal protein L29; Cell surface heparin-binding protein HIP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQAN
NAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCR
PKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL29 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P47914
Ensemble ID
ENST00000294189.11
HGNC ID
HGNC:10331

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.32  LDD0402  [1]
P3
 Probe Info  		1.64  LDD0450  [2]
TH211
 Probe Info  		Y98(10.28)  LDD0260  [3]
TH216
 Probe Info  		Y98(20.00)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		K33(0.00); K38(0.00); K149(0.00); K156(0.00)  LDD0273  [5]
Probe 1
 Probe Info  		Y98(6.10)  LDD3495  [6]
HHS-482
 Probe Info  		Y98(1.04)  LDD0285  [7]
HHS-475
 Probe Info  		Y98(0.78)  LDD0264  [8]
IA-alkyne
 Probe Info  		C119(0.60)  LDD2182  [9]
HHS-465
 Probe Info  		Y98(10.00)  LDD2237  [10]
AMP probe
 Probe Info  		N.A.  LDD0200  [11]
ATP probe
 Probe Info  		K149(0.00); K33(0.00); K82(0.00); K84(0.00)  LDD0199  [11]
2PCA
 Probe Info  		N.A.  LDD0034  [12]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
NHS
 Probe Info  		K134(0.00); K73(0.00); K63(0.00); K149(0.00)  LDD0010  [14]
OSF
 Probe Info  		N.A.  LDD0029  [15]
SF
 Probe Info  		K149(0.00); Y29(0.00); Y98(0.00); K103(0.00)  LDD0028  [15]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
AOyne
 Probe Info  		8.30  LDD0443  [19]
NAIA_5
 Probe Info  		N.A.  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		17.75  LDD1865  [21]
C191
 Probe Info  		10.85  LDD1868  [21]
C193
 Probe Info  		6.19  LDD1869  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 12.92  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0625  F8 Ramos C119(5.46)  LDD2187  [9]
 LDCM0573  Fragment11 Ramos C119(0.07)  LDD2190  [9]
 LDCM0576  Fragment14 Ramos C119(0.29)  LDD2193  [9]
 LDCM0586  Fragment28 Ramos C119(1.11)  LDD2198  [9]
 LDCM0566  Fragment4 Ramos C119(0.68)  LDD2184  [9]
 LDCM0569  Fragment7 Ramos C119(0.42)  LDD2186  [9]
 LDCM0116  HHS-0101 DM93 Y98(0.78)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y98(1.79)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y98(0.61)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y98(2.26)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y98(1.98)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0123  JWB131 DM93 Y98(1.04)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y98(0.86)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y98(1.04)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y98(2.98)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y98(2.21)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y98(1.32)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y98(0.52)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y98(0.63)  LDD0292  [7]
 LDCM0022  KB02 Ramos C119(0.60)  LDD2182  [9]
 LDCM0023  KB03 Ramos C119(0.57)  LDD2183  [9]
 LDCM0024  KB05 Ramos C119(0.27)  LDD2185  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [18]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Unveiling the Multifaceted Capabilities of Endophytic Aspergillus flavus Isolated from Annona squamosa Fruit Peels against Staphylococcus Isolates and HCoV 229E-In Vitro and In Silico Investigations. Pharmaceuticals (Basel). 2024 May 19;17(5):656. doi: 10.3390/ph17050656.
Mass spectrometry data entry: PXD013019
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.