Details of the Target

General Information of Target

Target ID LDTP15505
Target Name Choline dehydrogenase, mitochondrial (CHDH)
Gene Name CHDH
Gene ID 55349
Synonyms
Choline dehydrogenase, mitochondrial; CDH; CHD; EC 1.1.99.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGPGSNRRRPTQGERGPGSPGEPMEKYQVLYQLNPGALGVNLVVEEMETKVKHVIKQVE
CMDDHYASQALEELMPLLKLRHAHISVYQELFITWNGEISSLYLCLVMEFNELSFQEVIE
DKRKAKKIIDSEWMQNVLGQVLDALEYLHHLDIIHRNLKPSNIILISSDHCKLQDLSSNV
LMTDKAKWNIRAEEDPFRKSWMAPEALNFSFSQKSDIWSLGCIILDMTSCSFMDGTEAMH
LRKSLRQSPGSLKAVLKTMEEKQIPDVETFRNLLPLMLQIDPSDRITIKDVVHITFLRGS
FKSSCVSLTLHRQMVPASITDMLLEGNVASILEVMQKFSGWPEVQLRAMKRLLKMPADQL
GLPWPPELVEVVVTTMELHDRVLDVQLCACSLLLHLLGQALVHHPEAKAPCNQAITSTLL
SALQSHPEEEPLLVMVYSLLAITTTQESESLSEELQNAGLLEHILEHLNSSLESRDVCAS
GLGLLWALLLDGIIVNKAPLEKVPDLISQVLATYPADGEMAEASCGVFWLLSLLGCIKEQ
QFEQVVALLLQSIRLCQDRALLVNNAYRGLASLVKVSELAAFKVVVQEEGGSGLSLIKET
YQLHRDDPEVVENVGMLLVHLASYEEILPELVSSSMKALLQEIKERFTSSLVSDSSAFSK
PGLPPGGSPQLGCTTSGGLE
Target Bioclass
Enzyme
Family
GMC oxidoreductase family
Subcellular location
Mitochondrion inner membrane
Uniprot ID
Q8NE62
Ensemble ID
ENST00000315251.11
HGNC ID
HGNC:24288

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
IPM
 Probe Info  		C163(0.00); C242(0.00); C516(0.00); C106(0.00)  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C242(2.86)  LDD0172  [3]
HPAP
 Probe Info  		3.13  LDD0062  [4]
DBIA
 Probe Info  		C99(0.94)  LDD0531  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Phosphinate-6
 Probe Info  		C242(0.00); C363(0.00)  LDD0018  [7]
W1
 Probe Info  		N.A.  LDD0236  [2]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		C163(0.00); C242(0.00)  LDD2223  [9]
TPP-AC
 Probe Info  		N.A.  LDD0427  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C407
 Probe Info  		15.78  LDD2064  [11]
A-DA
 Probe Info  		3.25  LDD0331  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C242(2.86)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C242(2.64)  LDD0173  [3]
 LDCM0214  AC1 HCT 116 C99(0.94)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C242(1.13); C363(0.90)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C242(1.00); C363(1.00)  LDD1509  [13]
 LDCM0230  AC113 HCT 116 C242(1.02)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C242(1.00)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C242(0.96)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C242(1.07)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C242(0.94)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C242(0.97)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C242(0.99)  LDD0553  [5]
 LDCM0237  AC12 HEK-293T C242(1.06); C53(0.82); C363(0.88)  LDD1510  [13]
 LDCM0238  AC120 HCT 116 C242(1.46)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C242(1.23)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C242(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C242(1.33)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C242(1.07)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C242(1.17)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C242(1.25)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C242(1.05)  LDD0562  [5]
 LDCM0259  AC14 HEK-293T C242(1.08); C53(0.97); C363(1.05)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C242(0.94); C53(0.96); C363(0.92); C200(1.06)  LDD1513  [13]
 LDCM0276  AC17 HCT 116 C242(0.98); C99(1.15)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C242(0.87); C99(1.03)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C242(0.95); C99(1.69)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C99(0.77)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C242(1.17); C99(1.23)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C242(1.27); C99(1.37)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C242(0.92); C99(1.09)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C242(0.94); C99(1.21)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C242(0.90); C99(1.40)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C242(1.24)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C242(1.24)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C242(1.22)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C242(0.96)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C242(1.21)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C99(0.75)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C242(1.16)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C242(1.06)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C242(1.07)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C242(1.53)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C242(1.32)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C99(0.59)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C99(0.80)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C99(0.87)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C99(0.75)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C99(0.67)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C99(0.67)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C99(0.76)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C99(0.77)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C99(0.98)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C99(0.91)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C99(0.62)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C99(0.68)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C99(1.18)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C99(0.92)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C99(1.05)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C99(0.94)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C99(0.70)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C99(1.01)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C99(0.96)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C99(0.99)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C99(0.96)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C99(0.89)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C99(1.07)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C99(1.16)  LDD0636  [5]
 LDCM0320  AC57 HEK-293T C242(0.62); C325(0.62)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C242(0.52); C325(0.52)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C242(0.45); C325(0.45)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C242(0.97); C53(0.95); C363(0.99)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C242(0.44); C325(0.44)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C242(0.63); C325(0.63)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C242(0.56); C325(0.56)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C242(0.43); C325(0.43)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C242(0.36); C325(0.36)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C242(0.49); C325(0.49)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C242(0.63); C325(0.63)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C242(0.44); C325(0.44)  LDD0929  [5]
 LDCM0334  AC7 HEK-293T C242(0.96); C53(0.89); C363(0.99); C200(0.88)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C242(1.30); C363(1.05); C106(1.02)  LDD1569  [13]
 LDCM0349  AC83 HCT 116 C242(1.11)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C242(1.13)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C242(1.11)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C242(1.14)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C242(1.04)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C242(1.19)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C242(1.21)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C242(1.21)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C242(1.32)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C242(1.27)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C242(1.14)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C242(1.22)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C242(1.18)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C242(1.20)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C242(1.34)  LDD0681  [5]
 LDCM0248  AKOS034007472 HEK-293T C242(1.02); C53(1.05); C363(1.00); C106(0.97)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C242(0.94); C53(1.56); C363(1.03); C200(1.15)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C242(1.16); C363(0.98); C106(1.11)  LDD1514  [13]
 LDCM0020  ARS-1620 HCC44 C242(0.97)  LDD2171  [5]
 LDCM0632  CL-Sc Hep-G2 C242(1.41)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C242(1.10)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C242(0.92)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C99(0.96)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C242(1.08); C53(0.82); C363(0.97)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C242(1.08); C53(1.29); C363(1.15)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C242(1.02); C53(1.16); C363(0.93); C106(1.08)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C242(0.83); C363(1.07); C514(0.99)  LDD1577  [13]
 LDCM0374  CL105 HCT 116 C99(0.99); C242(1.14)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C99(0.80); C242(1.06)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C99(1.00); C242(1.15)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C99(0.97); C242(1.02)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C242(1.15); C99(1.15)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C242(1.01)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C242(0.79); C99(1.00)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C242(0.90); C99(1.00)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C242(0.88)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C242(1.17)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C242(1.13)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C242(1.29)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C242(1.05)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C99(0.80)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C99(0.78)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C99(0.94)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C242(0.89)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C99(0.68)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C99(0.76)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C99(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C99(1.02)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C99(1.01)  LDD0712  [5]
 LDCM0396  CL125 HEK-293T C242(0.44); C325(0.44)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C242(0.67); C325(0.67)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C242(0.44); C325(0.44)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C242(0.57); C325(0.57)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C242(0.99)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C242(1.07)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C242(1.02)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C99(1.44)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C242(1.05); C99(1.09)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C99(0.90); C242(0.93)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C242(0.86); C99(1.04)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C242(0.91)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C242(0.87); C99(1.12)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C242(0.89); C99(1.29)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C242(1.03); C99(1.45)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C242(0.94); C99(1.03)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C242(0.94); C99(1.05)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C242(0.86); C99(1.18)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C242(0.86); C99(1.61)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C242(0.98); C99(1.26)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C242(0.88); C99(1.42)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C242(0.80); C99(1.17)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C242(0.94)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C242(0.57); C99(1.45)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C242(0.87)  LDD0737  [5]
 LDCM0421  CL32 HEK-293T C242(0.90); C325(0.90)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C242(1.05); C325(1.05)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C242(0.85); C325(0.85)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C242(0.84); C325(0.84)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C242(0.88); C325(0.88)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C242(1.50); C325(1.50)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C242(1.44); C325(1.44)  LDD1026  [5]
 LDCM0429  CL4 HCT 116 C242(1.11)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C242(1.01); C325(1.01)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C242(0.94); C325(0.94)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C242(1.26); C325(1.26)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C242(1.15); C325(1.15)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C242(0.76); C325(0.76)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C242(1.29); C325(1.29)  LDD1033  [5]
 LDCM0436  CL46 HCT 116 C242(0.70)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C242(0.72)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C242(0.68)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C242(0.76)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C242(1.03)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C242(0.83)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C242(0.61)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C242(0.67)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C242(1.33)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C242(0.83)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C242(0.78)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C242(1.04)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C242(0.90)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C242(0.76)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C242(0.80)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C242(1.02)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C242(0.71)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C242(1.11)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C242(1.13)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C242(1.33)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C242(1.16)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C242(1.28)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C242(1.01)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C242(1.59)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C242(2.38)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C242(1.65)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C242(1.02)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C242(1.43)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C242(1.65)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C242(1.37)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C242(1.61)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C242(1.75)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C242(1.14)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C242(1.38)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C242(1.13)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C242(0.93)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C242(1.11)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C242(1.19)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C242(1.14)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C242(1.39)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C242(1.03)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C242(1.07)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C242(1.30)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C242(1.15)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C242(1.18)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C242(1.49)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C242(1.25)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C242(1.06)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C242(1.42)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C99(0.90)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C99(0.82)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C99(0.82)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C99(0.70)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C99(0.88)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C99(1.13)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C99(0.88)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C99(0.95)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C99(0.77)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C242(1.04); C53(1.28); C363(1.02); C106(0.91)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C242(1.18)  LDD0785  [5]
 LDCM0427  Fragment51 HEK-293T C242(0.82); C325(0.82)  LDD1025  [5]
 LDCM0022  KB02 HEK-293T C242(0.99); C363(0.93)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C242(1.00); C363(1.00)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C242(2.05)  LDD3310  [14]
 LDCM0014  Panhematin HEK-293T 3.13  LDD0062  [4]
 LDCM0137  SR-4995 HEK-293T 3.25  LDD0331  [12]
 LDCM0021  THZ1 HCT 116 C242(0.97)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Small molecular drug DB00122
Choline Salicylate Small molecular drug DB14006

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840