Details of the Target

General Information of Target

Target ID LDTP03765
Target Name Myosin-10 (MYH10)
Gene Name MYH10
Gene ID 4628
Synonyms
Myosin-10; Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQRTGLEDPERYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEAASIKEERGDEVMV
ELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGL
FCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGES
GAGKTENTKKVIQYLAHVASSHKGRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSS
RFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLL
LEGFNNYRFLSNGYIPIPGQQDKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNIS
FKKERNTDQASMPENTVAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTKEQADFA
VEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTN
EKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECW
FPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLN
DNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLYKES
LTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIV
FQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLEE
ERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTK
VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET
ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD
EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE
KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE
LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ
KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR
HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ
VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT
QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV
DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR
QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE
EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED
AKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKK
KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEK
KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQ
LEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAK
LQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVED
ERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSRE
VSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQSE
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Subcellular location
Cell projection, lamellipodium
Function
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
Uniprot ID
P35580
Ensemble ID
ENST00000269243.8
HGNC ID
HGNC:7568
ChEMBL ID
CHEMBL4105746

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		2.85  LDD0215  [2]
C-Sul
 Probe Info  		7.90  LDD0066  [3]
TH211
 Probe Info  		Y1467(20.00); Y407(12.73)  LDD0257  [4]
TH216
 Probe Info  		Y22(6.98)  LDD0259  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
BTD
 Probe Info  		C1238(0.16)  LDD1699  [6]
ONAyne
 Probe Info  		K442(0.00); K1411(0.00)  LDD0273  [7]
IPM
 Probe Info  		C1238(0.00); C176(0.00); C382(0.00); C1011(0.00)  LDD0241  [8]
OPA-S-S-alkyne
 Probe Info  		K1782(1.76)  LDD3494  [9]
Probe 1
 Probe Info  		Y13(12.62); Y761(10.54)  LDD3495  [10]
DBIA
 Probe Info  		C759(3.24); C398(4.17)  LDD3311  [11]
AHL-Pu-1
 Probe Info  		C95(2.28); C1238(2.17)  LDD0168  [12]
HHS-482
 Probe Info  		Y13(0.74); Y1868(1.31); Y22(0.96); Y407(0.92)  LDD0285  [13]
HHS-475
 Probe Info  		Y1657(0.69); Y1467(0.79); Y22(0.80); Y13(0.82)  LDD0264  [14]
HHS-465
 Probe Info  		Y13(10.00); Y1467(10.00); Y22(10.00); Y407(9.59)  LDD2237  [15]
ATP probe
 Probe Info  		K1532(0.00); K1813(0.00); K1809(0.00); K1811(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C678(0.00); C1238(0.00); C1011(0.00); C797(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C1011(0.00); C1238(0.00); C823(0.00); C701(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		C678(0.00); C701(0.00); C576(0.00); C95(0.00)  LDD0030  [19]
IPIAA_L
 Probe Info  		C95(0.00); C678(0.00); C176(0.00); C576(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C678(0.00); C1238(0.00); C1011(0.00); C797(0.00)  LDD0037  [17]
WYneO
 Probe Info  		C176(0.00); C95(0.00); C1238(0.00)  LDD0022  [20]
1d-yne
 Probe Info  		K1082(0.00); K1088(0.00)  LDD0356  [21]
Compound 10
 Probe Info  		C1238(0.00); C95(0.00)  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
ENE
 Probe Info  		C176(0.00); C701(0.00); C1238(0.00)  LDD0006  [20]
NHS
 Probe Info  		K1452(0.00); K1394(0.00); K1399(0.00); K1216(0.00)  LDD0010  [20]
PPMS
 Probe Info  		N.A.  LDD0008  [20]
SF
 Probe Info  		Y22(0.00); Y13(0.00); K1619(0.00); K809(0.00)  LDD0028  [23]
STPyne
 Probe Info  		K1809(0.00); K1256(0.00); K1452(0.00)  LDD0009  [20]
TFBX
 Probe Info  		C1011(0.00); C823(0.00); C576(0.00); C678(0.00)  LDD0148  [24]
VSF
 Probe Info  		C176(0.00); C701(0.00); C1011(0.00); C95(0.00)  LDD0007  [20]
YN-1
 Probe Info  		D1038(0.00); E1041(0.00)  LDD0446  [5]
1c-yne
 Probe Info  		K1234(0.00); K1761(0.00); K1724(0.00); K1308(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		C95(0.00); C176(0.00); H777(0.00); H693(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		H693(0.00); C176(0.00); C576(0.00); C1011(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C95(0.00); C176(0.00); C1011(0.00); C576(0.00)  LDD0218  [25]
W1
 Probe Info  		C1011(0.00); C1238(0.00)  LDD0236  [8]
NAIA_5
 Probe Info  		C678(0.00); C797(0.00); C747(0.00); C1011(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.73  LDD1779  [27]
FFF probe11
 Probe Info  		6.16  LDD0471  [28]
FFF probe12
 Probe Info  		8.34  LDD0473  [28]
FFF probe13
 Probe Info  		12.74  LDD0475  [28]
FFF probe14
 Probe Info  		16.46  LDD0477  [28]
FFF probe3
 Probe Info  		5.17  LDD0464  [28]
FFF probe6
 Probe Info  		5.30  LDD0467  [28]
STS-1
 Probe Info  		N.A.  LDD0136  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1238(0.90)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1238(1.07)  LDD2130  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1238(0.81)  LDD2103  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1238(1.33)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C95(2.28); C1238(2.17)  LDD0168  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C95(2.14); C1238(2.18)  LDD0169  [12]
 LDCM0214  AC1 HEK-293T C678(0.85); C1238(0.88); C176(0.93); C576(1.04)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C678(0.96); C1238(0.91); C176(1.00); C576(0.93)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C678(0.96); C1238(0.92); C176(1.04); C576(0.99)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C678(0.94); C1238(0.88); C176(1.00); C576(0.99)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C678(0.93); C1238(0.92); C176(1.08); C576(1.12)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C678(0.97); C1238(0.85); C176(0.98); C576(0.96)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C678(0.98); C1238(0.95); C176(1.00); C576(1.09)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C678(0.95); C1238(0.97); C176(1.09); C576(0.96)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C678(0.95); C1238(0.92); C176(1.04); C576(0.99)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C678(0.98); C1238(0.94); C176(1.01); C576(1.03)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C678(1.06); C1238(0.93); C176(0.98); C576(1.04)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C678(1.09); C1238(0.91); C176(1.01); C576(0.99)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C678(0.91); C1238(0.97); C176(0.99); C576(1.11)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C678(0.97); C1238(0.92); C176(0.93); C576(1.01)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C678(0.97); C1238(0.95); C176(0.98); C576(0.97)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C678(0.91); C1238(0.94); C176(1.00); C576(1.02)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C678(0.89); C1238(0.96); C176(1.11); C576(1.00)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C678(0.99); C1238(0.91); C176(1.09); C576(1.03)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C678(0.92); C1238(0.92); C176(1.05); C576(1.07)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C678(1.05); C1238(0.94); C176(1.03); C576(1.01)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C678(0.99); C1238(0.94); C176(1.00); C576(1.04)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C678(0.94); C1238(0.96); C176(1.03); C576(1.13)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C678(1.10); C1238(0.92); C176(0.97); C576(1.00)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C678(0.88); C1238(0.99); C176(0.91); C576(0.98)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C678(0.85); C1238(0.87); C176(0.91); C576(1.00)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C678(0.90); C1238(0.88); C176(0.99); C576(0.97)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C678(0.90); C1238(0.86); C176(0.99); C576(1.05)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C678(0.96); C1238(0.82); C176(0.95); C576(1.04)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C678(1.00); C1238(0.86); C176(0.99); C576(1.02)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C678(0.96); C1238(0.88); C176(1.02); C576(1.14)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C678(0.89); C1238(0.84); C176(0.90); C576(0.94)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C678(1.04); C1238(0.85); C176(1.07); C576(1.06)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C678(0.94); C1238(0.89); C176(1.00); C576(0.96)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C678(0.78); C1238(0.86); C176(0.96); C576(0.98)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C678(0.95); C1238(0.85); C176(1.04); C576(0.90)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C678(0.90); C1238(0.84); C176(0.98); C576(1.02)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C678(0.92); C1238(0.82); C176(0.96); C576(0.97)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C678(1.04); C1238(0.86); C176(0.92); C576(0.96)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C678(0.84); C1238(0.89); C176(0.99); C576(1.08)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C678(0.85); C1238(0.85); C176(0.93); C576(0.95)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C678(0.96); C1238(0.90); C176(1.00); C576(0.95)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C678(0.95); C1238(0.86); C176(0.88); C576(0.99)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C678(1.00); C1238(1.01); C176(0.98); C576(1.04)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C678(0.93); C1238(0.88); C176(0.94); C576(0.95)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C678(0.94); C1238(0.94); C176(1.01); C576(1.07)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C678(0.98); C1238(0.88); C176(0.95); C576(0.97)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C678(1.07); C1238(0.94); C176(0.98); C576(1.00)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C678(0.85); C1238(0.95); C176(0.98); C576(1.04)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C678(0.94); C1238(0.87); C176(0.91); C576(0.93)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C678(0.97); C1238(0.95); C176(0.97); C576(0.96)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C678(0.88); C1238(0.89); C176(0.87); C576(1.00)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C678(0.89); C1238(0.88); C176(0.97); C576(0.97)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C678(0.91); C1238(0.87); C176(1.01); C576(1.03)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C678(0.95); C1238(0.92); C176(1.05); C576(1.06)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C678(0.93); C1238(0.90); C176(0.98); C576(0.99)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C678(0.99); C1238(0.94); C176(0.96); C576(0.92)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C678(0.85); C1238(0.93); C176(0.96); C576(1.08)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C678(0.98); C1238(0.88); C176(0.96); C576(0.95)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C678(0.96); C1238(0.93); C176(0.91); C576(0.96)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C678(0.98); C1238(0.90); C176(0.97); C576(1.00)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C678(1.00); C1238(0.96); C176(1.00); C576(1.02)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C1238(1.01)  LDD2138  [6]
 LDCM0248  AKOS034007472 HEK-293T C678(1.09); C1238(0.96); C176(1.04); C576(0.96)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C678(0.92); C1238(0.91); C176(0.97); C576(0.99)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C678(0.96); C1238(0.92); C176(0.97); C576(0.95)  LDD1514  [30]
 LDCM0108  Chloroacetamide HeLa C95(0.00); C176(0.00); C576(0.00); H693(0.00)  LDD0222  [25]
 LDCM0367  CL1 HEK-293T C678(0.84); C1238(0.86); C176(0.90); C576(1.02)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C678(0.82); C1238(0.80); C176(1.17); C576(0.66)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C678(0.96); C1238(0.87); C176(0.88); C576(0.91)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C678(0.85); C1238(0.94); C176(0.93); C576(1.00)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C678(0.91); C1238(0.86); C176(1.01); C576(0.89)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C678(0.88); C1238(0.86); C176(0.96); C576(0.89)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C678(0.88); C1238(0.87); C176(0.89); C576(1.00)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C678(0.90); C1238(0.95); C176(0.97); C576(1.03)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C678(0.96); C1238(0.87); C176(1.02); C576(0.92)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C678(1.02); C1238(0.95); C176(0.97); C576(0.96)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C678(0.94); C1238(1.02); C176(0.99); C576(1.01)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C678(0.89); C1238(0.90); C176(0.92); C576(1.03)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C678(0.85); C1238(0.80); C176(1.38); C576(0.76)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C678(0.89); C1238(0.82); C176(1.10); C576(0.91)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C678(0.94); C1238(0.90); C176(0.99); C576(0.95)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C678(0.90); C1238(0.92); C176(0.92); C576(0.93)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C678(0.93); C1238(0.87); C176(0.94); C576(0.99)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C678(0.91); C1238(0.77); C176(0.95); C576(0.86)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C678(0.96); C1238(0.82); C176(0.99); C576(0.94)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C678(0.86); C1238(0.85); C176(0.89); C576(0.94)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C678(0.89); C1238(0.86); C176(0.90); C576(0.99)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C678(0.85); C1238(0.85); C176(1.01); C576(0.86)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C678(0.90); C1238(0.79); C176(0.93); C576(0.93)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C678(0.89); C1238(0.97); C176(1.76); C576(0.73)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C678(0.92); C1238(0.85); C176(0.94); C576(0.97)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C678(0.89); C1238(0.91); C176(0.90); C576(1.06)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C678(0.86); C1238(0.89); C176(0.92); C576(0.95)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C678(0.96); C1238(0.75); C176(0.94); C576(0.92)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C678(0.90); C1238(0.88); C176(0.91); C576(0.94)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C678(0.90); C1238(0.84); C176(0.84); C576(1.07)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C678(0.86); C1238(0.89); C176(0.95); C576(0.89)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C678(0.92); C1238(0.84); C176(0.90); C576(0.93)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C678(0.94); C1238(0.88); C176(0.95); C576(0.95)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C678(0.86); C1238(0.85); C176(0.97); C576(0.99)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C678(0.83); C1238(0.86); C176(1.07); C576(0.85)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C678(0.91); C1238(0.69); C176(1.14); C576(0.92)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C678(0.85); C1238(0.86); C176(0.99); C576(0.91)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C678(0.81); C1238(0.76); C176(1.03); C576(0.92)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C678(0.87); C1238(0.81); C176(1.25); C576(0.84)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C678(0.91); C1238(0.98); C176(1.53); C576(0.82)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C678(0.79); C1238(0.93); C176(1.05); C576(0.90)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C678(0.99); C1238(0.85); C176(1.13); C576(0.75)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C678(1.09); C1238(0.90); C176(1.50); C576(0.85)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C678(0.87); C1238(1.04); C176(1.32); C576(0.58)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C678(0.92); C1238(0.86); C176(1.28); C576(0.71)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C678(0.93); C1238(1.00); C176(1.81); C576(0.70)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C678(0.89); C1238(0.87); C176(0.85); C576(1.07)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C678(0.84); C1238(0.91); C176(1.12); C576(0.93)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C678(0.93); C1238(0.90); C176(1.07); C576(0.89)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C678(0.93); C1238(0.94); C176(0.98); C576(0.97)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C678(1.02); C1238(0.94); C176(1.01); C576(0.97)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C678(1.05); C1238(0.80); C176(1.11); C576(0.97)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C678(1.03); C1238(0.94); C176(1.20); C576(0.88)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C678(0.95); C1238(1.03); C176(1.32); C576(0.83)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C678(1.04); C1238(0.94); C176(1.08); C576(0.76)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C678(1.06); C1238(0.86); C176(1.47); C576(0.95)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C678(0.88); C1238(0.96); C176(1.27); C576(0.59)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C678(0.88); C1238(0.92); C176(1.31); C576(0.69)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C678(0.97); C1238(0.92); C176(1.89); C576(0.68)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C678(0.92); C1238(0.92); C176(0.86); C576(1.06)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C678(0.94); C1238(0.86); C176(0.94); C576(0.91)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C678(0.88); C1238(0.87); C176(0.95); C576(0.95)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C678(0.92); C1238(0.94); C176(1.03); C576(0.99)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C678(0.99); C1238(0.88); C176(1.09); C576(0.96)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C678(1.01); C1238(0.91); C176(1.26); C576(0.79)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C678(0.99); C1238(0.95); C176(1.32); C576(0.77)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C678(0.99); C1238(0.92); C176(1.13); C576(0.81)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C678(1.12); C1238(0.90); C176(1.42); C576(0.83)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C678(1.06); C1238(0.98); C176(1.33); C576(0.58)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C678(1.01); C1238(0.91); C176(1.37); C576(0.68)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C678(0.97); C1238(0.96); C176(1.55); C576(0.62)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C678(0.81); C1238(0.82); C176(0.86); C576(0.98)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C678(0.87); C1238(0.90); C176(1.10); C576(0.98)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C678(0.82); C1238(0.82); C176(0.92); C576(0.93)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C678(0.98); C1238(0.87); C176(0.97); C576(1.01)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C678(0.84); C1238(0.75); C176(1.03); C576(0.92)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C678(1.02); C1238(0.69); C176(1.10); C576(0.84)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C678(0.89); C1238(1.00); C176(1.42); C576(0.76)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C678(0.90); C1238(0.82); C176(1.08); C576(0.74)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C678(1.08); C1238(0.82); C176(1.47); C576(0.86)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C678(0.96); C1238(0.90); C176(1.31); C576(0.60)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C678(0.97); C1238(0.82); C176(1.30); C576(0.71)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C678(0.97); C1238(0.73); C176(1.07); C576(0.90)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C678(0.92); C1238(0.86); C176(1.93); C576(0.67)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C678(0.80); C1238(0.88); C176(0.83); C576(1.04)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C678(0.84); C1238(0.81); C176(1.01); C576(0.87)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C678(0.85); C1238(0.82); C176(0.98); C576(0.94)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C678(0.93); C1238(0.80); C176(0.98); C576(0.95)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C678(0.77); C1238(0.86); C176(0.95); C576(0.90)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C678(0.89); C1238(0.84); C176(1.14); C576(0.81)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C678(0.88); C1238(0.94); C176(1.30); C576(0.86)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C678(1.00); C1238(0.83); C176(1.09); C576(0.77)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C678(0.98); C1238(0.91); C176(1.32); C576(0.90)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C678(0.89); C1238(0.96); C176(1.32); C576(0.86)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C678(0.99); C1238(0.93); C176(1.23); C576(0.63)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C678(0.92); C1238(0.87); C176(1.24); C576(0.71)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C678(0.94); C1238(0.92); C176(1.53); C576(0.72)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C678(0.84); C1238(0.89); C176(0.89); C576(1.06)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C678(0.85); C1238(0.90); C176(1.03); C576(0.88)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C678(0.90); C1238(0.91); C176(0.93); C576(0.97)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C678(0.85); C1238(0.82); C176(1.01); C576(0.95)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C678(0.99); C1238(0.88); C176(1.11); C576(0.88)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C678(0.95); C1238(0.96); C176(1.23); C576(0.86)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C678(0.96); C1238(0.64); C176(0.97); C576(0.89)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C678(1.07); C1238(0.88); C176(1.15); C576(0.82)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C678(1.05); C1238(0.95); C176(1.41); C576(0.85)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C678(0.95); C1238(0.94); C176(1.27); C576(0.70)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C678(1.08); C1238(0.84); C176(1.20); C576(0.78)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C678(0.98); C1238(0.88); C176(1.36); C576(0.80)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C678(0.88); C1238(0.82); C176(0.81); C576(1.05)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C678(0.82); C1238(0.85); C176(0.90); C576(0.88)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C678(0.89); C1238(0.76); C176(0.80); C576(0.84)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C678(0.89); C1238(0.81); C176(0.89); C576(0.94)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C678(0.78); C1238(0.83); C176(0.94); C576(0.99)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C678(1.04); C1238(1.04); C176(1.51); C576(0.86)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C678(0.94); C1238(0.62); C176(1.02); C576(0.96)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C678(0.88); C1238(0.91); C176(1.08); C576(0.90)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C678(0.92); C1238(0.71); C176(0.94); C576(0.92)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C678(0.97); C1238(0.87); C176(1.18); C576(0.89)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C678(0.91); C1238(0.90); C176(1.11); C576(0.77)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C678(0.99); C1238(0.70); C176(1.06); C576(0.85)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C678(0.96); C1238(0.84); C176(1.04); C576(0.86)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C678(0.90); C1238(0.89); C176(0.90); C576(1.06)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C678(0.95); C1238(0.88); C176(1.03); C576(0.96)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C678(0.97); C1238(0.86); C176(0.96); C576(0.96)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C678(0.93); C1238(0.79); C176(0.88); C576(0.86)  LDD1698  [30]
 LDCM0573  Fragment11 Ramos C1238(20.00)  LDD2190  [31]
 LDCM0576  Fragment14 Ramos C1238(1.11)  LDD2193  [31]
 LDCM0468  Fragment33 HEK-293T C678(0.96); C1238(0.83); C176(1.00); C576(0.91)  LDD1671  [30]
 LDCM0566  Fragment4 Ramos C1238(0.57)  LDD2184  [31]
 LDCM0427  Fragment51 HEK-293T C678(0.82); C1238(0.91); C176(1.00); C576(0.95)  LDD1631  [30]
 LDCM0569  Fragment7 Ramos C1238(0.55)  LDD2186  [31]
 LDCM0116  HHS-0101 DM93 Y1657(0.69); Y1467(0.79); Y22(0.80); Y13(0.82)  LDD0264  [14]
 LDCM0117  HHS-0201 DM93 Y1657(0.67); Y1467(0.76); Y1868(0.82); Y407(0.88)  LDD0265  [14]
 LDCM0118  HHS-0301 DM93 Y22(0.54); Y1467(0.61); Y13(0.64); Y407(0.68)  LDD0266  [14]
 LDCM0119  HHS-0401 DM93 Y1467(0.71); Y1657(0.73); Y22(0.76); Y1868(0.87)  LDD0267  [14]
 LDCM0120  HHS-0701 DM93 Y1467(0.61); Y22(0.85); Y1657(0.85); Y1868(0.88)  LDD0268  [14]
 LDCM0107  IAA HeLa C176(0.00); H693(0.00); H777(0.00); C1011(0.00)  LDD0221  [25]
 LDCM0123  JWB131 DM93 Y13(0.74); Y1868(1.31); Y22(0.96); Y407(0.92)  LDD0285  [13]
 LDCM0124  JWB142 DM93 Y13(0.59); Y1868(1.17); Y22(0.94); Y407(0.71)  LDD0286  [13]
 LDCM0125  JWB146 DM93 Y13(0.68); Y1868(1.42); Y22(1.00); Y407(0.93)  LDD0287  [13]
 LDCM0126  JWB150 DM93 Y13(1.40); Y1868(5.47); Y22(3.57); Y407(2.84)  LDD0288  [13]
 LDCM0127  JWB152 DM93 Y13(1.25); Y1868(4.01); Y22(1.96); Y407(1.93)  LDD0289  [13]
 LDCM0128  JWB198 DM93 Y13(0.38); Y1868(2.56); Y22(0.83); Y407(1.28)  LDD0290  [13]
 LDCM0129  JWB202 DM93 Y13(0.44); Y1868(1.04); Y22(0.59); Y407(0.59)  LDD0291  [13]
 LDCM0130  JWB211 DM93 Y13(0.90); Y1868(1.50); Y22(0.93); Y407(1.02)  LDD0292  [13]
 LDCM0022  KB02 HEK-293T C678(0.98); C1238(0.99); C576(0.94); C382(0.86)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C678(0.92); C1238(1.01); C576(0.98); C382(0.94)  LDD1497  [30]
 LDCM0024  KB05 G361 C759(3.24); C398(4.17)  LDD3311  [11]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1238(0.77)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1238(0.94)  LDD2121  [6]
 LDCM0109  NEM HeLa C176(0.00); H693(0.00); H1438(0.00); H579(0.00)  LDD0223  [25]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1238(1.10)  LDD2094  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1238(0.65)  LDD2100  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1238(1.04)  LDD2105  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1238(0.95)  LDD2110  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1238(2.36)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1238(1.00)  LDD2120  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1238(0.97)  LDD2127  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1238(0.86)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1238(1.18)  LDD2136  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1238(0.86)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1238(0.70)  LDD2141  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1238(3.12)  LDD2145  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1238(0.34)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1238(0.41)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C1238(0.30)  LDD2151  [6]

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
14 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578