Details of the Target

General Information of Target

Target ID LDTP13992
Target Name RNA-splicing ligase RtcB homolog (RTCB)
Gene Name RTCB
Gene ID 51493
Synonyms
C22orf28; RNA-splicing ligase RtcB homolog; EC 6.5.1.8; 3'-phosphate/5'-hydroxy nucleic acid ligase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKG
AVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQ
DKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSL
NFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVA
GGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTY
GLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA
Target Bioclass
Enzyme
Family
RtcB family
Subcellular location
Nucleus
Function
Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. {|HAMAP-Rule:MF_03144}.
Uniprot ID
Q9Y3I0
Ensemble ID
ENST00000216038.6
HGNC ID
HGNC:26935

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.78  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y475(20.00); Y184(11.69)  LDD0257  [3]
TH214
 Probe Info  		Y184(20.00)  LDD0258  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
Probe 1
 Probe Info  		Y5(38.52); Y184(28.17); Y306(47.56); Y316(12.36)  LDD3495  [5]
m-APA
 Probe Info  		11.82  LDD0403  [6]
BTD
 Probe Info  		C255(2.26)  LDD1700  [7]
Curcusone 37
 Probe Info  		4.05  LDD0188  [8]
AHL-Pu-1
 Probe Info  		C295(8.17)  LDD0169  [9]
HHS-482
 Probe Info  		Y475(2.70)  LDD0287  [10]
DBIA
 Probe Info  		C485(0.98)  LDD0080  [11]
5E-2FA
 Probe Info  		H150(0.00); H267(0.00); H486(0.00); H80(0.00)  LDD2235  [12]
AMP probe
 Probe Info  		K492(0.00); K493(0.00)  LDD0200  [13]
ATP probe
 Probe Info  		K492(0.00); K493(0.00); K366(0.00); K279(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C193(0.00); C255(0.00); C485(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C485(0.00); C193(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C193(0.00); C485(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C193(0.00); C255(0.00); C295(0.00); C485(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
WYneN
 Probe Info  		N.A.  LDD0021  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
IPM
 Probe Info  		C485(0.00); C295(0.00)  LDD0147  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [19]
STPyne
 Probe Info  		K492(0.00); K493(0.00)  LDD0009  [19]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [21]
1c-yne
 Probe Info  		K465(0.00); K67(0.00); K308(0.00); K158(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C193(0.00); H267(0.00); H150(0.00); C485(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		C193(0.00); C255(0.00); C485(0.00); C295(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C193(0.00); C485(0.00); C255(0.00)  LDD0218  [22]
W1
 Probe Info  		C193(0.00); C485(0.00)  LDD0236  [23]
NAIA_5
 Probe Info  		C295(0.00); C193(0.00); C255(0.00); C19(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C485(0.29)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C485(0.64)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C255(0.80); C485(0.62)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C485(0.73)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C255(0.95); C485(1.12)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C255(1.14); C485(1.07)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C485(0.81)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C485(0.50); C193(0.54)  LDD2132  [7]
 LDCM0025  4SU-RNA DM93 C193(5.25); C485(2.27)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C295(8.17)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C485(0.89)  LDD0531  [11]
 LDCM0215  AC10 HEK-293T C255(0.86); C408(0.86); C427(1.15); C485(0.94)  LDD0813  [11]
 LDCM0216  AC100 HCT 116 C193(0.82); C485(0.70)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C193(0.57); C485(0.60)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C193(0.50); C485(0.63)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C193(0.30); C485(0.35)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C193(0.41); C485(0.45)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C193(0.34); C485(0.38)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C193(0.40); C485(0.39)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C193(0.26); C485(0.51)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C193(0.60); C485(0.45)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C193(0.71); C485(0.36)  LDD0542  [11]
 LDCM0226  AC11 HEK-293T C255(1.14); C408(1.14); C427(1.13); C485(1.16)  LDD0824  [11]
 LDCM0227  AC110 HCT 116 C193(0.64); C485(0.35)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C193(0.61); C485(0.32)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C193(0.40); C485(0.43)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C193(0.79); C485(1.04)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C193(0.72); C485(0.78)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C193(0.58); C485(0.67)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C193(0.52); C485(0.71)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C193(0.71); C485(0.95)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C193(0.95); C485(0.99)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C193(0.77); C485(0.79)  LDD0553  [11]
 LDCM0237  AC12 HEK-293T C255(1.23); C408(1.23); C427(1.27); C485(1.07)  LDD0835  [11]
 LDCM0238  AC120 HCT 116 C193(0.83); C485(0.72)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C193(0.84); C485(1.02)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C193(0.73); C485(0.82)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C193(0.85); C485(1.38)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C193(0.93); C485(0.88)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C193(0.79); C485(0.79)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C193(0.55); C485(0.73)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C193(0.55); C485(0.76)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C485(0.74)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C485(0.83)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C485(0.76)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C485(0.89)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C485(0.93)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C485(0.85)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C485(0.82)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C485(0.79)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C485(0.83)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C485(0.94)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C485(0.70)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C485(0.79)  LDD0575  [11]
 LDCM0259  AC14 HEK-293T C255(0.92); C408(0.92); C427(1.14); C485(0.91)  LDD0857  [11]
 LDCM0260  AC140 HCT 116 C485(0.69)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C485(0.71)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C485(0.91)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C193(0.97); C485(1.11)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C193(0.45); C485(0.72)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C193(0.81); C485(0.96)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C193(0.59); C485(0.66)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C193(0.50); C485(0.58)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C193(0.19); C485(0.28)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C193(0.43); C485(0.52)  LDD0586  [11]
 LDCM0270  AC15 HEK-293T C255(0.87); C408(0.87); C427(1.05); C485(0.76)  LDD0868  [11]
 LDCM0271  AC150 HCT 116 C193(1.05); C485(1.19)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C193(0.85); C485(1.16)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C193(0.35); C485(0.51)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C193(0.17); C485(0.26)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C193(0.62); C485(0.66)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C193(0.61); C485(0.66)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C193(0.94); C485(1.03)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C193(0.78); C485(0.87)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C193(1.12)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C193(0.93)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C193(1.01)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C485(0.92)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C193(1.09)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C193(1.13)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C193(1.24)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C193(1.01)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C193(0.96)  LDD0601  [11]
 LDCM0285  AC25 HEK-293T C255(0.88); C408(0.63); C427(2.52); C485(0.97)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C255(0.84); C408(0.57); C427(1.88); C485(0.70)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C255(0.72); C408(0.60); C427(1.71); C485(0.66)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C255(0.83); C408(0.83); C427(1.39); C485(1.01)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C255(0.72); C408(0.56); C427(2.42); C485(0.64)  LDD0887  [11]
 LDCM0290  AC3 HCT 116 C485(0.98)  LDD0607  [11]
 LDCM0291  AC30 HEK-293T C255(0.72); C408(0.58); C427(2.00); C485(0.65)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C255(0.91); C408(0.91); C427(2.49); C485(1.01)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C255(0.92); C408(0.70); C427(2.56); C485(0.82)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C255(0.88); C408(0.59); C427(2.32); C485(0.81)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C255(0.68); C408(0.57); C427(2.23); C485(0.86)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C193(0.90); C427(0.84)  LDD0894  [11]
 LDCM0297  AC36 HEK-293T C193(0.75); C427(1.09)  LDD0895  [11]
 LDCM0298  AC37 HEK-293T C193(0.80); C427(1.14)  LDD0896  [11]
 LDCM0299  AC38 HEK-293T C193(0.63); C427(1.09)  LDD0897  [11]
 LDCM0300  AC39 HEK-293T C193(1.04); C427(1.38)  LDD0898  [11]
 LDCM0301  AC4 HCT 116 C485(1.07)  LDD0618  [11]
 LDCM0302  AC40 HEK-293T C193(0.65); C427(1.14)  LDD0900  [11]
 LDCM0303  AC41 HEK-293T C193(1.04); C427(0.93)  LDD0901  [11]
 LDCM0304  AC42 HEK-293T C193(0.60); C427(0.91)  LDD0902  [11]
 LDCM0305  AC43 HEK-293T C193(0.84); C427(1.07)  LDD0903  [11]
 LDCM0306  AC44 HEK-293T C193(0.82); C427(1.25)  LDD0904  [11]
 LDCM0307  AC45 HEK-293T C193(2.00); C427(0.91)  LDD0905  [11]
 LDCM0308  AC46 HCT 116 C485(0.93); C193(1.09)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C485(0.78); C193(1.03)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C485(0.87); C193(0.88)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C485(0.47); C193(0.51)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C485(1.03)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C485(0.53); C193(0.53)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C485(1.13); C193(1.51)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C485(0.98); C193(1.04)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C485(0.67); C193(0.69)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C193(0.74); C485(0.80)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C193(0.44); C485(0.46)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C193(0.30); C485(0.33)  LDD0636  [11]
 LDCM0320  AC57 HEK-293T C255(0.85); C427(0.86)  LDD0918  [11]
 LDCM0321  AC58 HEK-293T C255(1.08); C427(0.90)  LDD0919  [11]
 LDCM0322  AC59 HEK-293T C255(0.65); C427(0.88)  LDD0920  [11]
 LDCM0323  AC6 HEK-293T C255(0.95); C408(0.95); C427(1.22); C485(1.06)  LDD0921  [11]
 LDCM0324  AC60 HEK-293T C255(0.55); C427(0.90)  LDD0922  [11]
 LDCM0325  AC61 HEK-293T C255(1.02); C427(1.02)  LDD0923  [11]
 LDCM0326  AC62 HEK-293T C255(0.98); C427(0.79)  LDD0924  [11]
 LDCM0327  AC63 HEK-293T C255(0.88); C427(1.03)  LDD0925  [11]
 LDCM0328  AC64 HEK-293T C255(0.71); C427(0.89)  LDD0926  [11]
 LDCM0329  AC65 HEK-293T C255(0.93); C427(0.99)  LDD0927  [11]
 LDCM0330  AC66 HEK-293T C255(0.98); C427(0.87)  LDD0928  [11]
 LDCM0331  AC67 HEK-293T C255(0.99); C427(1.19)  LDD0929  [11]
 LDCM0332  AC68 HCT 116 C193(0.45); C485(0.72)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C193(0.44); C485(0.61)  LDD0650  [11]
 LDCM0334  AC7 HEK-293T C255(0.80); C408(0.80); C427(1.17); C485(1.00)  LDD0932  [11]
 LDCM0335  AC70 HCT 116 C193(0.25); C485(0.29)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C485(0.74); C193(0.80)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C193(0.38); C485(0.52)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C193(0.18); C485(0.27)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C193(0.17); C485(0.25)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C193(0.16); C485(0.26)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C193(0.34); C485(0.51)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C193(0.29); C485(0.53)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C193(0.63); C485(0.73)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C193(0.54); C485(0.62)  LDD0661  [11]
 LDCM0345  AC8 HEK-293T C255(0.80); C408(0.80); C427(2.01); C485(0.73)  LDD0943  [11]
 LDCM0346  AC80 HCT 116 C193(0.44); C485(0.76)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C193(0.57); C485(0.70)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C193(0.13); C485(0.19)  LDD0665  [11]
 LDCM0349  AC83 HEK-293T C193(0.83); C255(0.88); C408(0.79); C427(0.82)  LDD0947  [11]
 LDCM0350  AC84 HEK-293T C193(0.61); C255(0.73); C408(0.66); C427(1.17)  LDD0948  [11]
 LDCM0351  AC85 HEK-293T C193(0.68); C255(0.75); C408(0.75); C427(0.97)  LDD0949  [11]
 LDCM0352  AC86 HEK-293T C193(0.79); C255(0.86); C408(0.85); C427(0.70)  LDD0950  [11]
 LDCM0353  AC87 HEK-293T C193(0.73); C255(0.76); C408(0.79); C427(0.80)  LDD0951  [11]
 LDCM0354  AC88 HEK-293T C193(0.62); C255(0.68); C408(0.66); C427(0.99)  LDD0952  [11]
 LDCM0355  AC89 HEK-293T C193(1.67); C255(0.75); C408(0.74); C427(1.04)  LDD0953  [11]
 LDCM0357  AC90 HEK-293T C193(0.55); C255(0.65); C408(0.67); C427(2.27)  LDD0955  [11]
 LDCM0358  AC91 HEK-293T C193(0.66); C255(0.70); C408(0.68); C427(0.87)  LDD0956  [11]
 LDCM0359  AC92 HEK-293T C193(0.67); C255(0.65); C408(0.66); C427(1.08)  LDD0957  [11]
 LDCM0360  AC93 HEK-293T C193(0.72); C255(0.71); C408(0.70); C427(1.06)  LDD0958  [11]
 LDCM0361  AC94 HEK-293T C193(0.56); C255(0.72); C408(0.67); C427(0.80)  LDD0959  [11]
 LDCM0362  AC95 HEK-293T C193(0.63); C255(0.69); C408(0.65); C427(1.12)  LDD0960  [11]
 LDCM0363  AC96 HEK-293T C193(0.51); C255(0.62); C408(0.59); C427(1.24)  LDD0961  [11]
 LDCM0364  AC97 HEK-293T C193(0.46); C255(0.67); C408(0.53); C427(1.95)  LDD0962  [11]
 LDCM0365  AC98 HCT 116 C485(0.09); C193(0.09)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C485(0.60); C193(0.72)  LDD0683  [11]
 LDCM0520  AKOS000195272 MDA-MB-231 C485(0.87)  LDD2113  [7]
 LDCM0248  AKOS034007472 HEK-293T C255(1.31); C408(1.31); C427(1.22); C485(1.21)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C255(0.89); C408(0.89); C427(1.35); C485(0.75)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C255(0.81); C408(0.81); C427(1.80); C485(0.77)  LDD0873  [11]
 LDCM0156  Aniline NCI-H1299 11.82  LDD0403  [6]
 LDCM0498  BS-3668 MDA-MB-231 C485(0.76)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C193(0.00); C485(0.00); H150(0.00); C255(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C193(20.00); C255(0.57)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C193(0.61); C255(0.62); C408(0.62); C427(2.08)  LDD0965  [11]
 LDCM0368  CL10 HEK-293T C193(0.48); C255(0.46); C408(0.46); C427(3.38)  LDD0966  [11]
 LDCM0369  CL100 HCT 116 C485(0.79)  LDD0686  [11]
 LDCM0370  CL101 HEK-293T C255(0.80); C408(0.80); C427(1.67); C485(0.75)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C255(0.77); C408(0.77); C427(1.81); C485(0.74)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C255(0.78); C408(0.78); C427(1.74); C485(0.74)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C255(0.84); C408(0.84); C427(1.82); C485(0.71)  LDD0971  [11]
 LDCM0374  CL105 HCT 116 C193(0.91)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C193(0.58)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C193(0.75)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C193(0.63)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C193(0.99)  LDD0695  [11]
 LDCM0379  CL11 HEK-293T C193(0.50); C255(0.49); C408(0.49); C427(1.65)  LDD0977  [11]
 LDCM0380  CL110 HCT 116 C193(0.77)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C193(0.92)  LDD0698  [11]
 LDCM0382  CL112 HEK-293T C255(0.76); C408(0.54); C427(1.61); C485(0.65)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C255(0.70); C408(0.70); C427(1.96); C485(0.87)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C255(0.68); C408(0.46); C427(3.13); C485(0.57)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C255(0.90); C408(0.46); C427(2.55); C485(0.72)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C255(0.85); C408(0.43); C427(3.30); C485(0.64)  LDD0984  [11]
 LDCM0387  CL117 HEK-293T C193(1.02); C427(0.97)  LDD0985  [11]
 LDCM0388  CL118 HEK-293T C193(1.09); C427(0.86)  LDD0986  [11]
 LDCM0389  CL119 HEK-293T C193(0.80); C427(1.72)  LDD0987  [11]
 LDCM0390  CL12 HEK-293T C193(0.71); C255(0.60); C408(0.60); C427(1.45)  LDD0988  [11]
 LDCM0391  CL120 HEK-293T C193(0.69); C427(0.91)  LDD0989  [11]
 LDCM0392  CL121 HCT 116 C193(0.68); C485(0.71)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C485(0.72); C193(0.79)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C485(0.58); C193(0.59)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C193(0.51); C485(0.56)  LDD0712  [11]
 LDCM0396  CL125 HEK-293T C255(0.84); C427(0.87)  LDD0994  [11]
 LDCM0397  CL126 HEK-293T C255(0.71); C427(0.84)  LDD0995  [11]
 LDCM0398  CL127 HEK-293T C255(0.79); C427(0.77)  LDD0996  [11]
 LDCM0399  CL128 HEK-293T C255(0.87); C427(0.85)  LDD0997  [11]
 LDCM0400  CL13 HEK-293T C193(0.69); C255(0.63); C408(0.63); C427(1.02)  LDD0998  [11]
 LDCM0401  CL14 HEK-293T C193(0.65); C255(0.67); C408(0.67); C427(1.30)  LDD0999  [11]
 LDCM0402  CL15 HEK-293T C193(0.49); C255(0.58); C408(0.58); C427(1.20)  LDD1000  [11]
 LDCM0403  CL16 HCT 116 C485(0.92)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C485(1.06)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C485(1.49)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C485(1.10)  LDD0723  [11]
 LDCM0407  CL2 HEK-293T C193(0.70); C255(0.65); C408(0.65); C427(1.46)  LDD1005  [11]
 LDCM0408  CL20 HCT 116 C485(1.43)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C485(1.46)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C485(1.13)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C485(1.14)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C485(1.38)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C485(1.18)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C485(1.06)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C485(1.38)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C485(1.24)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C485(1.53)  LDD0734  [11]
 LDCM0418  CL3 HEK-293T C193(0.64); C255(0.66); C408(0.66); C427(2.62)  LDD1016  [11]
 LDCM0419  CL30 HCT 116 C485(1.40)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C485(0.97)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C485(0.79)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C485(0.67)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C485(0.54)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C485(0.66)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C485(0.84)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C485(0.57)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C485(0.67)  LDD0745  [11]
 LDCM0429  CL4 HEK-293T C193(0.59); C255(0.67); C408(0.67); C427(1.19)  LDD1027  [11]
 LDCM0430  CL40 HCT 116 C485(0.81)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C485(0.80)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C485(0.38)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C485(0.55)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C485(0.73)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C485(0.56)  LDD0752  [11]
 LDCM0436  CL46 HEK-293T C255(0.74); C408(0.64); C427(2.46); C485(0.74)  LDD1034  [11]
 LDCM0437  CL47 HEK-293T C255(0.81); C408(0.76); C427(1.30); C485(0.81)  LDD1035  [11]
 LDCM0438  CL48 HEK-293T C255(0.86); C408(0.76); C427(1.43); C485(0.86)  LDD1036  [11]
 LDCM0439  CL49 HEK-293T C255(0.81); C408(0.72); C427(1.26); C485(0.81)  LDD1037  [11]
 LDCM0440  CL5 HEK-293T C193(0.65); C255(0.52); C408(0.52); C427(1.74)  LDD1038  [11]
 LDCM0441  CL50 HEK-293T C255(0.76); C408(0.65); C427(1.36); C485(0.76)  LDD1039  [11]
 LDCM0442  CL51 HEK-293T C255(0.80); C408(0.71); C427(0.94); C485(0.80)  LDD1040  [11]
 LDCM0443  CL52 HEK-293T C255(0.99); C408(0.98); C427(0.96); C485(0.99)  LDD1041  [11]
 LDCM0444  CL53 HEK-293T C255(1.11); C408(0.90); C427(0.99); C485(1.11)  LDD1042  [11]
 LDCM0445  CL54 HEK-293T C255(0.82); C408(0.82); C427(0.92); C485(0.82)  LDD1043  [11]
 LDCM0446  CL55 HEK-293T C255(0.77); C408(0.68); C427(1.24); C485(0.77)  LDD1044  [11]
 LDCM0447  CL56 HEK-293T C255(0.94); C408(0.90); C427(0.95); C485(0.94)  LDD1045  [11]
 LDCM0448  CL57 HEK-293T C255(0.93); C408(0.80); C427(1.07); C485(0.93)  LDD1046  [11]
 LDCM0449  CL58 HEK-293T C255(1.07); C408(0.99); C427(0.75); C485(1.07)  LDD1047  [11]
 LDCM0450  CL59 HEK-293T C255(0.71); C408(0.65); C427(1.31); C485(0.71)  LDD1048  [11]
 LDCM0451  CL6 HEK-293T C193(0.70); C255(0.56); C408(0.56); C427(1.51)  LDD1049  [11]
 LDCM0452  CL60 HEK-293T C255(0.86); C408(0.67); C427(1.40); C485(0.86)  LDD1050  [11]
 LDCM0453  CL61 HCT 116 C193(0.96); C485(1.10)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C193(1.12); C485(1.50)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C193(0.92); C485(0.81)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C193(1.07); C485(1.07)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C193(1.17); C485(0.97)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C193(0.65); C485(0.57)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C193(1.18); C485(0.91)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C193(1.04); C485(1.26)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C193(0.91); C485(0.99)  LDD0778  [11]
 LDCM0462  CL7 HEK-293T C193(0.51); C255(0.54); C408(0.54); C427(2.07)  LDD1060  [11]
 LDCM0463  CL70 HCT 116 C193(0.91); C485(1.15)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C193(0.97); C485(0.74)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C193(1.07); C485(0.90)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C193(0.97); C485(0.83)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C193(1.04); C485(0.71)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C193(0.84); C485(0.91)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C193(0.63); C485(0.89)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C193(1.00); C485(0.95)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C193(0.56); C485(0.81)  LDD0789  [11]
 LDCM0473  CL8 HEK-293T C193(0.36); C408(1.22); C485(1.44)  LDD1071  [11]
 LDCM0474  CL80 HCT 116 C193(0.89); C485(1.18)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C193(0.86); C485(1.08)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C193(0.41); C485(0.61)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C193(0.45); C485(0.51)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C193(0.28); C485(0.40)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C193(0.81); C485(0.79)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C193(1.13); C485(0.82)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C193(0.69); C485(0.74)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C193(0.49); C485(0.54)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C193(0.26); C485(0.38)  LDD0800  [11]
 LDCM0484  CL9 HEK-293T C193(0.64); C408(1.56); C485(1.25)  LDD1082  [11]
 LDCM0485  CL90 HCT 116 C193(0.98); C485(0.80)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C485(1.05)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C485(1.00)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C485(1.00)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C485(0.86)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C485(1.22)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C485(0.96)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C485(0.91)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C485(0.79)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C485(0.94)  LDD0811  [11]
 LDCM0033  Curcusone1d MCF-7 4.05  LDD0188  [8]
 LDCM0495  E2913 HEK-293T C193(1.08); C255(1.03); C485(1.13); C122(1.08)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C485(1.22)  LDD1702  [7]
 LDCM0625  F8 Ramos C19(1.40)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C19(0.23)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C19(0.60); C485(0.59)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C19(0.13)  LDD2191  [27]
 LDCM0576  Fragment14 Ramos C19(0.95); C485(0.37)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C19(0.11)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C19(0.27)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C19(0.31)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C19(0.36)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C19(1.03)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C19(0.46)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C19(0.32)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C19(0.24)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C193(1.08); C485(0.77)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C19(0.54)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C19(1.17)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C485(0.49)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C19(0.21)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C19(0.37)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C19(0.59); C485(0.57)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C19(0.17)  LDD2188  [27]
 LDCM0107  IAA HeLa H267(0.00); H150(0.00); H361(0.00); C193(0.00)  LDD0221  [22]
 LDCM0125  JWB146 DM93 Y475(2.70)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y475(5.06)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y475(4.22)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y475(2.77)  LDD0290  [10]
 LDCM0130  JWB211 DM93 Y475(1.87)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C485(0.98)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C485(0.90)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C485(0.94)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C485(1.04)  LDD2121  [7]
 LDCM0109  NEM HeLa H267(0.00); H150(0.00); H80(0.00); C255(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C485(0.84)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C485(0.84)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C485(0.90)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C255(1.17); C485(1.10)  LDD2093  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C255(0.92)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C485(1.05)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C485(0.99)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C255(0.93); C485(1.13)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C485(0.41)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C485(0.92)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C485(1.12)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C485(0.28)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C255(1.07); C485(1.02)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C485(0.52)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C255(0.52); C485(0.89)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C485(0.54)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C255(0.85); C485(1.27)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C485(0.39)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C485(0.45)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C255(0.89)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C485(1.63)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C255(0.93)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C255(0.98); C485(0.35)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C255(1.01); C485(0.99); C193(1.21)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C255(1.10)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C485(1.02); C193(1.86)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C255(0.57); C485(0.94)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C255(1.05); C485(1.26)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C255(1.02); C485(0.64)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C255(1.60); C485(1.18)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C485(0.55)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C255(0.75); C485(0.49)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C485(1.12)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C255(1.93); C485(1.34); C193(2.55)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C255(0.96)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C255(2.26)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C255(0.88); C485(1.06)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C485(0.75)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C255(1.19); C485(0.70)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C255(1.25); C485(2.04)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C255(0.86); C485(0.95)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C485(1.31)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C485(0.47)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C255(0.95)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C485(0.49)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C255(0.70); C485(0.78)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C255(1.13); C485(1.69)  LDD2153  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein archease (ZBTB8OS) Archease family Q8IWT0
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA transcription, translation and transport factor protein (RTRAF) RTRAF family Q9Y224
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sucrose Small molecular drug DB02772

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578