Details of the Target

General Information of Target

Target ID LDTP02944
Target Name Large ribosomal subunit protein uL30 (RPL7)
Gene Name RPL7
Gene ID 6129
Synonyms
Large ribosomal subunit protein uL30; 60S ribosomal protein L7
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEGVEEKKKEVPAVPETLKKKRRNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKE
YRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNG
TFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLG
KYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQI
NRLIRRMN
Target Bioclass
Other
Family
Universal ribosomal protein uL30 family
Subcellular location
Cytoplasm
Function
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Uniprot ID
P18124
Ensemble ID
ENST00000352983.7
HGNC ID
HGNC:10363

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		6.42  LDD0402  [1]
A-EBA
 Probe Info  		3.42  LDD0215  [2]
CHEMBL5175495
 Probe Info  		6.95  LDD0196  [3]
TH211
 Probe Info  		Y144(20.00); Y155(20.00); Y51(20.00); Y82(14.58)  LDD0260  [4]
C-Sul
 Probe Info  		3.18  LDD0066  [5]
TH216
 Probe Info  		Y139(19.81); Y144(19.05); Y155(10.14)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
STPyne
 Probe Info  		K107(6.48); K156(2.49); K161(8.33); K19(10.00)  LDD0277  [7]
AZ-9
 Probe Info  		E5(1.02)  LDD2208  [8]
ONAyne
 Probe Info  		K77(0.00); K29(0.00)  LDD0273  [7]
AF-1
 Probe Info  		1.58  LDD0421  [9]
THZ1-DTB
 Probe Info  		C186(1.08)  LDD0460  [10]
HHS-482
 Probe Info  		Y195(0.77)  LDD0285  [11]
DBIA
 Probe Info  		C186(0.97)  LDD0078  [12]
W1
 Probe Info  		K107(0.54); K156(0.56); R157(0.56); K29(0.67)  LDD0237  [13]
AMP probe
 Probe Info  		K19(0.00); K20(0.00)  LDD0200  [14]
ATP probe
 Probe Info  		K19(0.00); K20(0.00); K29(0.00); K8(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [15]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [16]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [17]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
IPM
 Probe Info  		N.A.  LDD0025  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
1d-yne
 Probe Info  		K181(0.00); K77(0.00)  LDD0356  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
NHS
 Probe Info  		K19(0.00); K77(0.00); K9(0.00)  LDD0010  [23]
OSF
 Probe Info  		N.A.  LDD0029  [24]
SF
 Probe Info  		Y144(0.00); K88(0.00); Y82(0.00); K19(0.00)  LDD0028  [24]
TFBX
 Probe Info  		N.A.  LDD0148  [19]
Ox-W18
 Probe Info  		W209(0.00); W142(0.00)  LDD2175  [25]
1c-yne
 Probe Info  		K88(0.00); K202(0.00); K212(0.00); K223(0.00)  LDD0228  [21]
Acrolein
 Probe Info  		N.A.  LDD0217  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
NAIA_5
 Probe Info  		N.A.  LDD2223  [20]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
TPP-AC
 Probe Info  		N.A.  LDD0427  [27]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		14.04  LDD0464  [28]
STS-1
 Probe Info  		N.A.  LDD0137  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C186(0.40)  LDD1093  [12]
 LDCM0215  AC10 HEK-293T C186(1.07)  LDD1508  [30]
 LDCM0216  AC100 PaTu 8988t C186(0.93)  LDD1095  [12]
 LDCM0217  AC101 PaTu 8988t C186(1.20)  LDD1096  [12]
 LDCM0218  AC102 PaTu 8988t C186(1.21)  LDD1097  [12]
 LDCM0219  AC103 PaTu 8988t C186(1.00)  LDD1098  [12]
 LDCM0220  AC104 PaTu 8988t C186(0.88)  LDD1099  [12]
 LDCM0221  AC105 PaTu 8988t C186(1.03)  LDD1100  [12]
 LDCM0222  AC106 PaTu 8988t C186(0.54)  LDD1101  [12]
 LDCM0223  AC107 PaTu 8988t C186(0.86)  LDD1102  [12]
 LDCM0224  AC108 PaTu 8988t C186(0.80)  LDD1103  [12]
 LDCM0225  AC109 PaTu 8988t C186(1.05)  LDD1104  [12]
 LDCM0226  AC11 HEK-293T C186(0.99)  LDD1509  [30]
 LDCM0227  AC110 PaTu 8988t C186(1.53)  LDD1106  [12]
 LDCM0228  AC111 PaTu 8988t C186(0.44)  LDD1107  [12]
 LDCM0229  AC112 PaTu 8988t C186(1.02)  LDD1108  [12]
 LDCM0230  AC113 HEK-293T C186(3.14)  LDD0828  [12]
 LDCM0231  AC114 HEK-293T C186(2.83)  LDD0829  [12]
 LDCM0232  AC115 HEK-293T C186(1.71)  LDD0830  [12]
 LDCM0233  AC116 HEK-293T C186(1.57)  LDD0831  [12]
 LDCM0234  AC117 HEK-293T C186(1.39)  LDD0832  [12]
 LDCM0235  AC118 HEK-293T C186(1.37)  LDD0833  [12]
 LDCM0236  AC119 HEK-293T C186(2.02)  LDD0834  [12]
 LDCM0237  AC12 HEK-293T C186(1.03)  LDD1510  [30]
 LDCM0238  AC120 HEK-293T C186(3.27)  LDD0836  [12]
 LDCM0239  AC121 HEK-293T C186(1.91)  LDD0837  [12]
 LDCM0240  AC122 HEK-293T C186(3.32)  LDD0838  [12]
 LDCM0241  AC123 HEK-293T C186(4.09)  LDD0839  [12]
 LDCM0242  AC124 HEK-293T C186(2.12)  LDD0840  [12]
 LDCM0243  AC125 HEK-293T C186(1.94)  LDD0841  [12]
 LDCM0244  AC126 HEK-293T C186(3.64)  LDD0842  [12]
 LDCM0245  AC127 HEK-293T C186(3.76)  LDD0843  [12]
 LDCM0246  AC128 HCT 116 C186(0.60)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C186(1.64)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C186(0.68)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C186(2.84)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C186(1.76)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C186(0.66)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C186(0.57)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C186(0.68)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C186(0.81)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C186(1.19)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C186(0.66)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C186(0.81)  LDD0575  [12]
 LDCM0259  AC14 HEK-293T C186(0.95)  LDD1512  [30]
 LDCM0260  AC140 HCT 116 C186(0.62)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C186(0.86)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C186(2.19)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C186(0.86)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C186(0.39)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C186(0.54)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C186(0.67)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C186(0.45)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C186(0.32)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C186(0.32)  LDD0586  [12]
 LDCM0270  AC15 HEK-293T C186(1.00)  LDD1513  [30]
 LDCM0271  AC150 HCT 116 C186(0.74)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C186(0.66)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C186(0.37)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C186(0.38)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C186(0.61)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C186(0.43)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C186(0.84)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C186(0.85)  LDD2161  [12]
 LDCM0276  AC17 HEK-293T C186(1.11)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C186(1.03)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C186(1.00)  LDD1517  [30]
 LDCM0279  AC2 PaTu 8988t C186(0.85)  LDD1158  [12]
 LDCM0280  AC20 HEK-293T C186(1.03)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C186(1.01)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C186(0.98)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C186(0.96)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C186(1.00)  LDD1523  [30]
 LDCM0285  AC25 HCT 116 C186(1.34)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C186(1.64)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C186(1.31)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C186(1.40)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C186(1.28)  LDD0606  [12]
 LDCM0290  AC3 PaTu 8988t C186(0.46)  LDD1169  [12]
 LDCM0291  AC30 HCT 116 C186(1.19)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C186(1.37)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C186(0.86)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C186(1.17)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C186(1.08)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C186(1.24)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C186(1.49)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C186(1.59)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C186(1.44)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C186(1.01)  LDD0617  [12]
 LDCM0301  AC4 PaTu 8988t C186(0.67)  LDD1180  [12]
 LDCM0302  AC40 HCT 116 C186(0.82)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C186(1.10)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C186(1.23)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C186(1.51)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C186(0.93)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C186(1.03)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C186(1.43)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C186(0.59)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C186(1.82)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C186(0.82)  LDD0628  [12]
 LDCM0312  AC5 PaTu 8988t C186(0.51)  LDD1191  [12]
 LDCM0313  AC50 HCT 116 C186(0.63)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C186(1.46)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C186(0.70)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C186(0.66)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C186(0.64)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C186(0.63)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C186(0.85)  LDD0636  [12]
 LDCM0320  AC57 HEK-293T C186(0.89)  LDD0918  [12]
 LDCM0321  AC58 HEK-293T C186(0.86)  LDD0919  [12]
 LDCM0322  AC59 HEK-293T C186(0.93)  LDD0920  [12]
 LDCM0323  AC6 HEK-293T C186(1.01)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C186(0.91)  LDD0922  [12]
 LDCM0325  AC61 HEK-293T C186(1.47)  LDD0923  [12]
 LDCM0326  AC62 HEK-293T C186(1.53)  LDD0924  [12]
 LDCM0327  AC63 HEK-293T C186(1.19)  LDD0925  [12]
 LDCM0328  AC64 HEK-293T C186(1.86)  LDD0926  [12]
 LDCM0329  AC65 HEK-293T C186(1.75)  LDD0927  [12]
 LDCM0330  AC66 HEK-293T C186(1.20)  LDD0928  [12]
 LDCM0331  AC67 HEK-293T C186(1.48)  LDD0929  [12]
 LDCM0332  AC68 HEK-293T C186(1.00)  LDD0930  [12]
 LDCM0333  AC69 HEK-293T C186(0.95)  LDD0931  [12]
 LDCM0334  AC7 HEK-293T C186(0.99)  LDD1568  [30]
 LDCM0335  AC70 HEK-293T C186(0.84)  LDD0933  [12]
 LDCM0336  AC71 HEK-293T C186(1.01)  LDD0934  [12]
 LDCM0337  AC72 HEK-293T C186(1.12)  LDD0935  [12]
 LDCM0338  AC73 HEK-293T C186(1.01)  LDD0936  [12]
 LDCM0339  AC74 HEK-293T C186(0.82)  LDD0937  [12]
 LDCM0340  AC75 HEK-293T C186(0.92)  LDD0938  [12]
 LDCM0341  AC76 HEK-293T C186(0.97)  LDD0939  [12]
 LDCM0342  AC77 HEK-293T C186(1.05)  LDD0940  [12]
 LDCM0343  AC78 HEK-293T C186(1.24)  LDD0941  [12]
 LDCM0344  AC79 HEK-293T C186(1.14)  LDD0942  [12]
 LDCM0345  AC8 HEK-293T C186(1.02)  LDD1569  [30]
 LDCM0346  AC80 HEK-293T C186(0.90)  LDD0944  [12]
 LDCM0347  AC81 HEK-293T C186(0.94)  LDD0945  [12]
 LDCM0348  AC82 HEK-293T C186(1.14)  LDD0946  [12]
 LDCM0349  AC83 HCT 116 C186(0.28)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C186(0.30)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C186(0.97)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C186(0.61)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C186(1.48)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C186(0.88)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C186(0.37)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C186(1.49)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C186(0.29)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C186(0.27)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C186(0.54)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C186(1.17)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C186(1.85)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C186(0.57)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C186(0.36)  LDD0681  [12]
 LDCM0365  AC98 PaTu 8988t C186(2.10)  LDD1244  [12]
 LDCM0366  AC99 PaTu 8988t C186(0.94)  LDD1245  [12]
 LDCM0166  Afatinib A431 1.58  LDD0421  [9]
 LDCM0248  AKOS034007472 HEK-293T C186(0.95)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C186(1.02)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C186(1.00)  LDD1514  [30]
 LDCM0020  ARS-1620 HCC44 C186(0.97)  LDD0078  [12]
 LDCM0630  CCW28-3 231MFP C186(1.61)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C186(0.73)  LDD2227  [20]
 LDCM0367  CL1 HEK-293T C186(1.88)  LDD0965  [12]
 LDCM0368  CL10 HEK-293T C186(2.44)  LDD0966  [12]
 LDCM0369  CL100 PaTu 8988t C186(0.84)  LDD1248  [12]
 LDCM0370  CL101 HEK-293T C186(1.01)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C186(0.94)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C186(1.00)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C186(0.97)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C186(1.01)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C186(1.02)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C186(1.04)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C186(1.09)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C186(0.98)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C186(1.87)  LDD0977  [12]
 LDCM0380  CL110 HEK-293T C186(0.91)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C186(0.97)  LDD1585  [30]
 LDCM0382  CL112 HCT 116 C186(1.33)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C186(1.06)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C186(1.62)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C186(1.37)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C186(1.23)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C186(0.93)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C186(0.72)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C186(1.05)  LDD0706  [12]
 LDCM0390  CL12 HEK-293T C186(1.12)  LDD0988  [12]
 LDCM0391  CL120 HCT 116 C186(0.93)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C186(0.67)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C186(0.98)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C186(0.83)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C186(0.72)  LDD0712  [12]
 LDCM0396  CL125 HEK-293T C186(0.84)  LDD0994  [12]
 LDCM0397  CL126 HEK-293T C186(1.27)  LDD0995  [12]
 LDCM0398  CL127 HEK-293T C186(1.03)  LDD0996  [12]
 LDCM0399  CL128 HEK-293T C186(0.67)  LDD0997  [12]
 LDCM0400  CL13 HEK-293T C186(1.23)  LDD0998  [12]
 LDCM0401  CL14 HEK-293T C186(1.86)  LDD0999  [12]
 LDCM0402  CL15 HEK-293T C186(1.49)  LDD1000  [12]
 LDCM0403  CL16 HEK-293T C186(1.02)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C186(0.96)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C186(0.97)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C186(0.93)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C186(1.73)  LDD1005  [12]
 LDCM0408  CL20 HEK-293T C186(0.90)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C186(0.82)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C186(0.86)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C186(0.73)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C186(0.93)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C186(0.98)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C186(1.05)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C186(1.03)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C186(1.09)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C186(1.02)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C186(3.24)  LDD1016  [12]
 LDCM0419  CL30 HEK-293T C186(0.94)  LDD1623  [30]
 LDCM0420  CL31 HCT 116 C186(1.01)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C186(0.88)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C186(0.69)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C186(0.82)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C186(2.73)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C186(0.72)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C186(0.83)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C186(0.76)  LDD0745  [12]
 LDCM0429  CL4 HEK-293T C186(2.58)  LDD1027  [12]
 LDCM0430  CL40 HCT 116 C186(0.67)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C186(1.25)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C186(0.98)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C186(1.05)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C186(1.29)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C186(1.06)  LDD0752  [12]
 LDCM0436  CL46 HEK-293T C186(0.86)  LDD1034  [12]
 LDCM0437  CL47 HEK-293T C186(0.93)  LDD1035  [12]
 LDCM0438  CL48 HEK-293T C186(0.71)  LDD1036  [12]
 LDCM0439  CL49 HEK-293T C186(1.20)  LDD1037  [12]
 LDCM0440  CL5 HEK-293T C186(3.01)  LDD1038  [12]
 LDCM0441  CL50 HEK-293T C186(1.15)  LDD1039  [12]
 LDCM0442  CL51 HEK-293T C186(1.48)  LDD1040  [12]
 LDCM0443  CL52 HEK-293T C186(0.56)  LDD1041  [12]
 LDCM0444  CL53 HEK-293T C186(0.58)  LDD1042  [12]
 LDCM0445  CL54 HEK-293T C186(1.22)  LDD1043  [12]
 LDCM0446  CL55 HEK-293T C186(1.16)  LDD1044  [12]
 LDCM0447  CL56 HEK-293T C186(0.85)  LDD1045  [12]
 LDCM0448  CL57 HEK-293T C186(1.08)  LDD1046  [12]
 LDCM0449  CL58 HEK-293T C186(0.94)  LDD1047  [12]
 LDCM0450  CL59 HEK-293T C186(1.24)  LDD1048  [12]
 LDCM0451  CL6 HEK-293T C186(1.57)  LDD1049  [12]
 LDCM0452  CL60 HEK-293T C186(1.52)  LDD1050  [12]
 LDCM0453  CL61 HEK-293T C186(0.93)  LDD1051  [12]
 LDCM0454  CL62 HEK-293T C186(1.27)  LDD1052  [12]
 LDCM0455  CL63 HEK-293T C186(0.97)  LDD1053  [12]
 LDCM0456  CL64 HEK-293T C186(0.96)  LDD1054  [12]
 LDCM0457  CL65 HEK-293T C186(0.99)  LDD1055  [12]
 LDCM0458  CL66 HEK-293T C186(1.06)  LDD1056  [12]
 LDCM0459  CL67 HEK-293T C186(1.14)  LDD1057  [12]
 LDCM0460  CL68 HEK-293T C186(1.74)  LDD1058  [12]
 LDCM0461  CL69 HEK-293T C186(1.16)  LDD1059  [12]
 LDCM0462  CL7 HEK-293T C186(2.70)  LDD1060  [12]
 LDCM0463  CL70 HEK-293T C186(1.17)  LDD1061  [12]
 LDCM0464  CL71 HEK-293T C186(1.15)  LDD1062  [12]
 LDCM0465  CL72 HEK-293T C186(1.00)  LDD1063  [12]
 LDCM0466  CL73 HEK-293T C186(1.17)  LDD1064  [12]
 LDCM0467  CL74 HEK-293T C186(2.02)  LDD1065  [12]
 LDCM0469  CL76 HEK-293T C186(1.05)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C186(1.10)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C186(1.00)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C186(1.01)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C186(0.84)  LDD1071  [12]
 LDCM0474  CL80 HEK-293T C186(0.99)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C186(0.93)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C186(0.90)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C186(0.85)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C186(0.86)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C186(1.01)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C186(1.02)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C186(1.04)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C186(0.99)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C186(1.00)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C186(1.25)  LDD1082  [12]
 LDCM0485  CL90 HEK-293T C186(1.24)  LDD1688  [30]
 LDCM0486  CL91 PaTu 8988t C186(0.96)  LDD1365  [12]
 LDCM0487  CL92 PaTu 8988t C186(1.38)  LDD1366  [12]
 LDCM0488  CL93 PaTu 8988t C186(0.93)  LDD1367  [12]
 LDCM0489  CL94 PaTu 8988t C186(1.29)  LDD1368  [12]
 LDCM0490  CL95 PaTu 8988t C186(0.90)  LDD1369  [12]
 LDCM0491  CL96 PaTu 8988t C186(0.90)  LDD1370  [12]
 LDCM0492  CL97 PaTu 8988t C186(0.97)  LDD1371  [12]
 LDCM0493  CL98 PaTu 8988t C186(1.11)  LDD1372  [12]
 LDCM0494  CL99 PaTu 8988t C186(0.78)  LDD1373  [12]
 LDCM0495  E2913 HEK-293T C186(1.26)  LDD1698  [30]
 LDCM0573  Fragment11 Ramos C186(0.03)  LDD2190  [32]
 LDCM0576  Fragment14 Ramos C186(0.54)  LDD2193  [32]
 LDCM0586  Fragment28 Ramos C186(1.66)  LDD2198  [32]
 LDCM0468  Fragment33 HEK-293T C186(1.51)  LDD1066  [12]
 LDCM0566  Fragment4 Ramos C186(0.58)  LDD2184  [32]
 LDCM0427  Fragment51 HCT 116 C186(0.94)  LDD0744  [12]
 LDCM0569  Fragment7 Ramos C186(0.29)  LDD2186  [32]
 LDCM0107  IAA HeLa N.A.  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y195(0.77)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y195(0.45)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y195(0.53)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y195(4.07)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y195(0.85)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y195(0.89)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y195(0.32)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y195(0.86)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C186(0.97)  LDD1492  [30]
 LDCM0023  KB03 Jurkat C186(5.33)  LDD0209  [33]
 LDCM0024  KB05 COLO792 C186(1.31)  LDD3310  [34]
 LDCM0109  NEM HeLa N.A.  LDD0223  [26]
 LDCM0627  NUDT7-COV-1 HEK-293T C186(0.96)  LDD2206  [35]
 LDCM0628  OTUB2-COV-1 HEK-293T C186(2.27); C186(1.04)  LDD2207  [35]
 LDCM0021  THZ1 HeLa S3 C186(1.08)  LDD0460  [10]
 LDCM0110  W12 Hep-G2 K107(0.54); K156(0.56); R157(0.56); K29(0.67)  LDD0237  [13]
 LDCM0111  W14 Hep-G2 K40(0.69)  LDD0238  [13]
 LDCM0112  W16 Hep-G2 Q39(1.11)  LDD0239  [13]
 LDCM0113  W17 Hep-G2 K107(0.58); K40(0.61); Q39(0.61)  LDD0240  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin-5 (IPO5) Importin beta family O00410
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NEDD8 (NEDD8) Ubiquitin family Q15843

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
9 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
10 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
22 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
32 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
33 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
34 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
35 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.