Details of the Target
General Information of Target
| Target ID | LDTP06116 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glycerol kinase 2 (GK2) | |||||
| Gene Name | GK2 | |||||
| Gene ID | 2712 | |||||
| Synonyms |
GKP2; GKTA; Glycerol kinase 2; GK 2; Glycerokinase 2; EC 2.7.1.30; ATP:glycerol 3-phosphotransferase 2; Glycerol kinase, testis specific 2 |
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| 3D Structure | ||||||
| Sequence |
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEI
LQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQ TTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDS WLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIY GLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGL LTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYF VPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLR HLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALS VLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSM VMLIGARYISGVP |
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| Target Bioclass |
Enzyme
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| Family |
FGGY kinase family
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| Subcellular location |
Mitochondrion outer membrane
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| Function |
Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation. Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis. Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
YN-4 Probe Info |
 |
100.00 | LDD0445 | [1] | |
|
IPM Probe Info |
 |
C293(1.14) | LDD1701 | [2] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0032 | [3] | |
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SF Probe Info |
 |
N.A. | LDD0028 | [4] | |
Competitor(s) Related to This Target
References