Details of the Target

General Information of Target

Target ID LDTP06959
Target Name Uromodulin-like 1 (UMODL1)
Gene Name UMODL1
Gene ID 89766
Synonyms
Uromodulin-like 1; Olfactorin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRTSGLALLALVSAVGPSQASGFTEKGLSLLGYQLCSHRVTHTVQKVEAVQTSYTSYVS
CGGWIPWRRCPKMVYRTQYLVVEVPESRNVTDCCEGYEQLGLYCVLPLNQSGQFTSRPGA
CPAEGPEPSTSPCSLDIDCPGLEKCCPWSGGRYCMAPAPQAPERDPVGSWYNVTILVKMD
FKELQQVDPRLLNHMRLLHSLVTSALQPMASTVHHLHSAPGNASTTVSRLLLGLPRPLPV
ADVSTLLGDIAKRVYEVISVQVQDVNECFYEELNACSGRELCANLEGSYWCVCHQEAPAT
SPRKLNLEWEDCPPVSDYVVLNVTSDSFQVSWRLNSTQNHTFHVRVYRGMELLRSARTQS
QALAVAGLEAGVLYRVKTSYQGCGADVSTTLTIKTNAQVFEVTIKIVNHNLTEKLLNRSS
VEYQDFSRQLLHEVESSFPPVVSDLYRSGKLRMQIVSLQAGSVVVRLKLTVQDPGFPMGI
STLAPILQPLLASTVFQIDRQGTRVQDWDECVDSAEHDCSPAAWCINLEGSYTCQCRTTR
DATPSRAGRACEGDLVSPMGGGLSAATGVTVPGLGTGTAALGLENFTLSPSPGYPQGTPA
AGQAWTPEPSPRRGGSNVVGYDRNNTGKGVEQELQGNSIMEPPSWPSPTEDPTGHFLWHA
TRSTRETLLNPTWLRNEDSGPSGSVDLPLTSTLTALKTPACVPVSIGRIMVSNVTSTGFH
LAWEADLAMDSTFQLTLTSMWSPAVVLETWNTSVTLSGLEPGVLHLVEIMAKACGKEGAR
AHLKVRTAARKLIGKVRIKNVRYSESFRNASSQEYRDFLELFFRMVRGSLPATMCQHMDA
GGVRMEVVSVTNGSIVVEFHLLIIADVDVQEVSAAFLTAFQTVPLLEVIRGDTFIQDYDE
CERKEDDCVPGTSCRNTLGSFTCSCEGGAPDFPVEYSERPCEGDSPGNETWATSPERPLT
TAGTKAAFVQGTSPTPQGLPQRLNLTGAVRVLCEIEKVVVAIQKRFLQQESIPESSLYLS
HPSCNVSHSNGTHVLLEAGWSECGTLMQSNMTNTVVRTTLRNDLSQEGIIHHLKILSPIY
CAFQNDLLTSSGFTLEWGVYTIIEDLHGAGNFVTEMQLFIGDSPIPQNYSVSASDDVRIE
VGLYRQKSNLKVVLTECWATPSSNARDPITFSFINNSCPVPNTYTNVIENGNSNKAQFKL
RIFSFINDSIVYLHCKLRVCMESPGATCKINCNNFRLLQNSETSATHQMSWGPLIRSEGE
PPHAEAGLGAGYVVLIVVAIFVLVAGTATLLIVRYQRMNGRYNFKIQSNNFSYQVFYE
Target Bioclass
Other
Subcellular location
Cytoplasm; Cell membrane
Uniprot ID
Q5DID0
Ensemble ID
ENST00000400424.6
HGNC ID
HGNC:12560

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S5P .
COLO678 SNV: p.D1063E .
COLO679 SNV: p.G1068D .
COLO800 SNV: p.A840T .
DEL SNV: p.L737P .
HCT116 SNV: p.P477H .
HCT15 SNV: p.L1007R .
IGROV1 Deletion: p.P1161RfsTer27 .
JURKAT Deletion: p.A120PfsTer58
SNV: p.G119R;p.Q596H;p.N1303K		 .
KYSE150 SNV: p.Y898Ter .
MCC13 Deletion: p.G636KfsTer14
Insertion: p.N637IfsTer34		 .
MOLT4 SNV: p.V1000I .
NCIH2291 SNV: p.N1231Y .
NCIH446 Deletion: p.V16WfsTer26 .
OV56 SNV: p.I995F .
PANC0403 SNV: p.V442M .
PF382 SNV: p.E83D .
SNU1079 Deletion: p.F1235SfsTer6 .
SUPT1 Deletion: p.A120PfsTer58;p.Q977KfsTer7
SNV: p.G119R		 .
TCCSUP SNV: p.S169F .
TF1 SNV: p.S277F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
YN-4
 Probe Info  		100.00  LDD0445  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.