Details of the Target

General Information of Target

Target ID LDTP03664
Target Name Kinesin-1 heavy chain (KIF5B)
Gene Name KIF5B
Gene ID 3799
Synonyms
KNS; KNS1; Kinesin-1 heavy chain; Conventional kinesin heavy chain; Ubiquitous kinesin heavy chain; UKHC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQ
VYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIY
SMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSK
TGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRK
CEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAE
NDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQL
EESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQ
DLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLE
QLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVD
RIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVRGGGG
KQV
Target Bioclass
Transporter and channel
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation. Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells.
Uniprot ID
P33176
Ensemble ID
ENST00000302418.5
HGNC ID
HGNC:6324
ChEMBL ID
CHEMBL5864

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 40 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.44  LDD0402  [1]
A-EBA
 Probe Info  		7.25  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y274(16.00); Y228(13.38)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
STPyne
 Probe Info  		K28(1.64); K44(0.84); K450(9.00); K539(5.61)  LDD0277  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
Probe 1
 Probe Info  		Y516(37.54)  LDD3495  [7]
BTD
 Probe Info  		C421(3.15); C858(1.51); C632(1.50)  LDD1700  [8]
AHL-Pu-1
 Probe Info  		C174(2.08)  LDD0168  [9]
HHS-475
 Probe Info  		Y307(0.23); Y164(0.69); Y274(0.85); Y649(0.91)  LDD0264  [10]
HHS-465
 Probe Info  		Y164(10.00); Y649(10.00)  LDD2237  [11]
DBIA
 Probe Info  		C421(0.99)  LDD0078  [12]
5E-2FA
 Probe Info  		H100(0.00); H191(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K159(0.00); K685(0.00); K539(0.00); K541(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C174(0.00); C294(0.00); C421(0.00); C65(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C301(0.00); C294(0.00); C174(0.00); C65(0.00)  LDD0032  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C858(0.00); C174(0.00); C294(0.00); C65(0.00)  LDD0037  [15]
JW-RF-010
 Probe Info  		C7(0.00); C65(0.00)  LDD0026  [18]
TFBX
 Probe Info  		C7(0.00); C65(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C65(0.00); C294(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C294(0.00); C65(0.00)  LDD0022  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C7(0.00); C858(0.00); C294(0.00)  LDD0147  [18]
NHS
 Probe Info  		K240(0.00); K642(0.00)  LDD0010  [19]
VSF
 Probe Info  		N.A.  LDD0007  [19]
1c-yne
 Probe Info  		K514(0.00); K402(0.00); K526(0.00); K256(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C65(0.00); C174(0.00); C301(0.00); H191(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [22]
Methacrolein
 Probe Info  		C65(0.00); C301(0.00); C632(0.00); C421(0.00)  LDD0218  [22]
W1
 Probe Info  		C174(0.00); C294(0.00); C632(0.00); C421(0.00)  LDD0236  [23]
AOyne
 Probe Info  		5.40  LDD0443  [24]
NAIA_5
 Probe Info  		C421(0.00); C608(0.00); C174(0.00); C632(0.00)  LDD2223  [25]
HHS-482
 Probe Info  		Y502(1.13)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [26]
FFF probe13
 Probe Info  		12.76  LDD0475  [26]
FFF probe3
 Probe Info  		6.94  LDD0465  [26]
JN0003
 Probe Info  		12.19  LDD0469  [26]
STS-1
 Probe Info  		N.A.  LDD0136  [27]
STS-2
 Probe Info  		N.A.  LDD0138  [27]
EN
 Probe Info  		1.55  LDD0418  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C858(0.52)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C632(0.89)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C858(0.73)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C421(0.73)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C858(0.99); C421(1.33)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C858(1.46); C421(1.52)  LDD2152  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C858(0.61); C421(0.59); C632(0.72)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C858(0.82)  LDD2131  [8]
 LDCM0025  4SU-RNA HEK-293T C174(2.08)  LDD0168  [9]
 LDCM0214  AC1 HCT 116 C174(1.02); C294(0.78); C301(0.84); C302(0.80)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C174(0.83); C294(0.90); C301(0.67); C302(0.67)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C174(0.72); C294(0.69); C301(0.57); C302(0.56)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C174(0.80); C294(0.53); C301(0.57); C302(0.52)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C174(0.74); C294(0.57); C301(0.54); C302(0.57)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C174(0.68); C294(0.45); C301(0.37); C302(0.38)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C174(0.66); C294(0.51); C301(0.43); C302(0.42)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C174(0.80); C294(0.44); C301(0.45); C302(0.46)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C174(0.73); C294(0.50); C301(0.48); C302(0.46)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C174(0.92); C294(0.52); C301(0.42); C302(0.46)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C174(0.84); C294(0.64); C301(0.78); C302(0.88)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C174(0.97); C294(0.68); C301(0.67); C302(0.80)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C174(1.01); C294(0.86); C301(0.61); C302(0.60)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C174(0.89); C294(0.61); C301(0.60); C302(0.76)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C174(0.77); C294(0.55); C301(0.56); C302(0.67)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C174(0.95); C294(0.40); C301(0.39); C302(0.49)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C174(0.82); C294(0.93); C301(0.93); C302(0.94)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C174(0.87); C294(0.77); C301(0.78); C302(0.76)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C174(0.95); C294(0.60); C301(0.62); C302(0.62)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C174(0.97); C294(0.65); C301(0.69); C302(0.68)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C174(0.88); C294(0.79); C301(0.93); C302(0.92)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C174(0.96); C294(0.95); C301(1.03); C302(1.05)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C174(0.96); C294(0.78); C301(0.73); C302(0.72)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C174(0.94); C294(1.45); C301(0.95); C302(0.96)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C174(0.89); C294(0.74); C301(0.70); C302(0.71)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C174(1.20); C294(1.09); C301(1.25); C302(1.27)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C174(0.78); C294(0.87); C301(0.85); C302(0.88)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C174(0.70); C294(1.11); C301(1.10); C302(1.11)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C174(0.99); C294(1.15); C301(1.29); C302(1.30)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C174(1.08); C294(0.92); C301(1.19); C302(1.22)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C174(0.89); C294(0.72); C301(0.71); C302(0.74)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C174(1.06); C294(0.83); C301(0.69); C302(0.70)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C174(1.01); C294(0.74); C301(0.88); C302(0.80)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C174(0.98); C294(1.28); C301(1.56); C302(1.50)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C174(1.02); C294(0.79); C301(0.83); C302(0.79)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C174(1.06); C294(1.07); C301(1.25); C302(1.20)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C174(1.00); C294(1.11); C301(1.34); C302(1.34)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C174(0.95); C294(0.72); C301(0.91); C302(0.82)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C174(0.98); C294(0.71); C301(0.87); C302(0.73)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C174(0.97); C294(0.75); C301(0.78); C302(0.71)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C174(0.89); C294(0.76); C301(0.83); C302(0.74)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C174(0.92); C294(0.80); C301(1.00); C302(0.92)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C174(0.77); C294(0.75); C301(0.78); C302(0.73)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C174(0.99); C294(0.62); C301(0.88); C302(0.73)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C174(0.85); C294(0.85); C301(0.67); C302(0.67)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C174(0.91); C294(0.64); C301(0.82); C302(0.71)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C174(0.88); C294(0.78); C301(0.84); C302(0.74)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C174(0.95); C294(1.17); C301(1.53); C302(1.52)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C294(0.84); C632(0.95); C174(1.00); C301(1.01)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C294(0.46); C301(0.63); C302(0.74); C174(0.78)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C294(0.73); C174(0.95); C301(0.96); C421(0.97)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C294(0.48); C301(0.63); C65(0.83); C302(0.83)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C294(0.54); C301(0.61); C174(0.74); C302(0.76)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C294(0.48); C301(0.65); C174(0.79); C65(0.83)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C294(0.41); C301(0.48); C302(0.55); C65(0.56)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C301(0.63); C302(0.64); C65(0.73); C174(0.81)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C632(0.78); C294(0.80); C301(0.87); C174(0.90)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C301(0.83); C302(0.93); C65(0.94); C294(0.95)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C294(0.44); C301(0.57); C174(0.65); C302(0.77)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C294(0.37); C301(0.62); C174(0.85); C302(0.85)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C174(0.86); C294(0.52); C301(0.73); C302(1.04)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C174(0.88); C294(0.48); C301(0.76); C302(1.08)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C174(1.03); C294(0.94); C301(1.21); C302(1.40)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C174(1.03); C294(0.94); C301(1.26); C302(1.65)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C65(0.89); C632(0.89); C294(0.94); C302(0.96)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C302(0.44); C301(0.57); C65(0.57); C294(0.59)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C302(0.74); C301(0.76); C65(0.78); C294(0.85)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C302(0.77); C294(0.78); C65(0.82); C301(0.88)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C421(0.83); C302(0.88); C65(0.95); C632(0.95)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C65(0.81); C301(0.82); C302(0.83); C632(0.86)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C632(1.03); C421(1.05); C174(1.08); C302(1.11)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C632(0.74); C421(0.87); C302(0.94); C301(0.95)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C632(0.65); C421(0.86); C174(0.99); C65(1.05)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C302(0.79); C301(0.79); C632(0.81); C294(0.82)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C65(0.59); C301(0.66); C302(0.66); C294(0.73)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C301(0.53); C65(0.54); C302(0.55); C294(0.69)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C65(0.56); C301(0.60); C302(0.60); C632(0.69)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C301(0.48); C302(0.49); C65(0.53); C294(0.66)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C294(0.90); C302(0.94); C301(1.00); C174(1.03)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C65(0.45); C301(0.46); C302(0.47); C294(0.52)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C65(0.60); C301(0.64); C302(0.64); C632(0.78)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C301(0.36); C302(0.36); C65(0.38); C294(0.48)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C301(0.40); C65(0.42); C302(0.42); C294(0.51)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C301(0.32); C302(0.33); C65(0.38); C294(0.56)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C421(0.93); C174(1.11); C632(1.21); C302(1.41)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C421(0.95); C174(1.00); C65(1.26); C632(1.27)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C421(1.07); C174(1.11); C65(1.29); C302(1.29)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C174(0.92); C421(0.98); C65(1.05); C302(1.08)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C421(0.92); C302(0.94); C301(0.98); C174(1.02)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C294(0.77); C302(0.88); C632(0.89); C301(0.93)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C302(0.81); C65(0.82); C301(0.83); C174(0.88)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C421(0.91); C174(0.93); C302(0.95); C301(0.99)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C421(0.77); C174(0.84); C301(0.85); C302(0.87)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C302(0.84); C301(0.89); C174(0.92); C65(0.93)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C421(0.74); C302(0.88); C301(0.90); C174(0.97)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C421(0.76); C301(0.79); C302(0.81); C174(0.81)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C302(0.89); C301(0.89); C65(0.91); C174(0.93)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C65(0.79); C302(0.82); C301(0.83); C294(0.85)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C301(0.88); C302(0.90); C174(0.99); C421(1.03)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C301(0.64); C302(0.64); C65(0.65); C294(0.72)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C294(0.70); C302(0.78); C301(0.84); C632(0.89)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C301(0.67); C302(0.68); C65(0.69); C294(0.72)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C421(0.87); C174(1.12); C302(1.33); C632(1.34)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C301(0.87); C65(0.87); C302(0.89); C174(0.90)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C65(0.64); C301(0.71); C302(0.72); C294(0.74)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C65(0.70); C294(0.80); C174(0.81); C632(0.82)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C301(0.74); C302(0.74); C632(0.78); C65(0.78)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C301(0.77); C302(0.78); C294(0.79); C65(0.81)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C632(0.47); C301(0.50); C302(0.51); C65(0.55)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C632(0.39); C302(0.43); C301(0.43); C65(0.57)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C632(0.35); C302(0.45); C301(0.45); C65(0.50)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C302(0.55); C301(0.56); C65(0.62); C294(0.69)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C302(0.46); C301(0.46); C632(0.47); C65(0.47)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C65(0.54); C302(0.54); C301(0.54); C632(0.58)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C632(0.31); C301(0.48); C302(0.48); C65(0.52)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C632(0.40); C302(0.54); C301(0.54); C65(0.67)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C632(0.38); C65(0.52); C301(0.54); C302(0.55)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C302(0.39); C301(0.40); C65(0.44); C632(0.45)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C302(0.44); C301(0.44); C632(0.50); C65(0.51)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C632(0.30); C302(0.40); C301(0.40); C65(0.41)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C65(0.69); C301(0.75); C294(0.76); C421(0.78)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C632(0.62); C421(0.73); C65(0.74); C301(0.76)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C301(0.68); C302(0.68); C65(0.77); C174(0.81)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C632(0.52); C65(0.61); C301(0.62); C302(0.64)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C421(0.92); C301(0.95); C174(0.97); C632(0.99)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C632(0.68); C302(0.69); C301(0.69); C65(0.70)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C632(0.44); C65(0.66); C301(0.72); C302(0.73)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C632(0.54); C65(0.84); C301(0.84); C302(0.85)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C632(0.50); C65(0.72); C301(0.81); C294(0.83)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C632(0.56); C301(0.74); C302(0.75); C174(0.80)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C632(0.60); C301(0.65); C65(0.69); C302(0.69)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C65(0.88); C301(0.88); C302(0.94); C174(0.95)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C65(0.74); C301(0.78); C294(0.80); C302(0.82)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C301(0.60); C302(0.62); C65(0.71); C294(0.82)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C632(0.52); C301(0.78); C302(0.80); C174(0.82)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C174(0.79); C301(1.02); C294(1.09); C302(1.12)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C632(0.56); C65(0.77); C301(0.87); C294(0.87)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C632(0.38); C301(0.40); C302(0.41); C65(0.43)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C632(0.37); C301(0.37); C302(0.41); C65(0.43)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C302(0.50); C301(0.50); C632(0.53); C294(0.54)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C302(0.53); C65(0.55); C294(0.56); C301(0.57)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C302(0.77); C301(0.78); C174(0.82); C632(0.93)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C632(0.62); C302(0.68); C294(0.69); C301(0.69)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C65(0.41); C302(0.43); C301(0.44); C632(0.46)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C174(0.92); C301(1.19); C421(1.23); C302(1.37)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C632(0.31); C65(0.43); C302(0.43); C301(0.45)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C632(0.34); C301(0.41); C302(0.42); C65(0.46)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C632(0.50); C301(0.55); C302(0.57); C294(0.63)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C632(0.74); C302(0.78); C301(0.80); C65(0.87)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C302(0.55); C301(0.61); C65(0.68); C294(0.70)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C632(0.40); C302(0.63); C65(0.63); C301(0.68)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C302(0.36); C301(0.37); C65(0.38); C632(0.38)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C65(0.31); C294(0.33); C302(0.33); C301(0.35)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C65(0.58); C302(0.66); C174(0.68); C301(0.74)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C858(0.66); C421(0.45)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C421(0.62)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C174(0.95); C294(1.20); C301(0.85); C302(0.87)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C301(0.67); C302(0.70); C65(0.78); C174(0.85)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C301(0.46); C302(0.46); C65(0.57); C294(0.68)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C421(0.99)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C421(0.56); C294(0.89)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C174(0.00); C65(0.00); H681(0.00); C294(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C858(20.00); C608(20.00); C174(1.40); C7(1.37)  LDD2227  [25]
 LDCM0367  CL1 HCT 116 C174(0.93); C421(1.02); C632(1.03); C65(1.23)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C632(0.62); C294(0.63); C301(0.64); C302(0.64)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C294(0.73); C302(0.77); C301(0.81); C632(0.84)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C301(0.61); C65(0.61); C302(0.62); C294(0.72)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C301(0.78); C174(0.80); C302(0.82); C65(0.90)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C421(0.88); C301(0.90); C302(0.91); C174(1.01)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C301(0.77); C302(0.81); C65(0.88); C421(0.90)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C302(0.58); C301(0.65); C65(0.70); C632(0.77)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C302(0.47); C301(0.54); C632(0.71); C65(0.75)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C302(0.41); C301(0.53); C65(0.61); C294(0.64)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C302(0.49); C65(0.57); C301(0.57); C294(0.63)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C302(0.58); C65(0.58); C301(0.65); C294(0.68)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C632(0.55); C294(0.73); C301(0.75); C302(0.75)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C632(0.64); C294(0.65); C65(0.67); C301(0.67)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C302(0.58); C65(0.61); C301(0.63); C294(0.67)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C294(0.78); C421(0.86); C301(0.93); C65(0.94)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C301(0.39); C302(0.40); C65(0.42); C294(0.47)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C65(0.51); C301(0.60); C294(0.61); C302(0.62)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C301(0.49); C65(0.50); C302(0.51); C294(0.64)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C65(0.56); C301(0.56); C302(0.57); C294(0.74)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C632(0.86); C302(0.87); C421(0.89); C301(0.91)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C301(0.88); C65(0.89); C174(0.93); C302(0.96)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C294(0.84); C302(0.88); C65(0.90); C301(0.92)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C632(0.52); C294(0.67); C301(0.69); C302(0.69)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C421(0.95); C174(0.98); C302(1.01); C301(1.06)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C65(0.58); C294(0.81); C174(1.04); C632(1.09)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C302(0.70); C65(0.71); C301(0.72); C294(0.76)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C65(0.61); C294(0.69); C302(0.70); C301(0.71)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C65(0.60); C302(0.63); C301(0.63); C294(0.71)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C294(0.80); C632(0.82); C65(0.86); C301(0.88)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C301(0.62); C302(0.64); C294(0.69); C65(0.69)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C301(0.57); C302(0.58); C294(0.65); C65(0.66)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C632(0.38); C65(0.48); C301(0.54); C302(0.55)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C301(0.68); C302(0.68); C632(0.69); C294(0.71)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C632(0.80); C301(0.86); C302(0.86); C294(0.86)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C632(0.80); C301(0.80); C302(0.80); C294(0.85)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C294(0.63); C65(0.64); C632(0.79); C302(0.79)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C302(0.76); C294(0.77); C65(0.79); C301(0.82)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C301(0.63); C302(0.63); C65(0.65); C294(0.66)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C65(0.62); C632(0.65); C302(0.67); C301(0.70)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C632(0.83); C174(0.99); C421(1.09); C294(1.26)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C65(0.48); C632(0.48); C302(0.51); C301(0.54)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C632(0.47); C301(0.55); C302(0.57); C65(0.58)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C632(0.46); C65(0.58); C301(0.59); C302(0.63)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C65(0.53); C302(0.55); C294(0.59); C301(0.61)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C65(0.51); C301(0.52); C302(0.54); C632(0.54)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C174(1.05); C294(0.59); C301(0.53); C302(0.57)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C174(0.90); C294(0.65); C301(0.57); C302(0.57)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C174(1.18); C294(0.73); C301(0.69); C302(0.71)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C174(1.15); C294(0.51); C301(0.54); C302(0.54)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C174(1.34); C294(0.52); C301(0.56); C302(0.55)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C174(0.92); C294(1.02); C301(1.13); C302(1.13)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C174(1.25); C294(0.80); C301(0.78); C302(0.81)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C174(0.89); C294(0.78); C301(0.63); C302(0.64)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C174(0.80); C294(0.59); C301(0.50); C302(0.50)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C174(0.83); C294(0.54); C301(0.51); C302(0.51)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C174(0.86); C294(0.42); C301(0.44); C302(0.44)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C174(0.86); C294(0.49); C301(0.48); C302(0.48)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C174(0.78); C294(0.43); C301(0.47); C302(0.47)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C174(0.89); C294(0.51); C301(0.53); C302(0.53)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C174(0.77); C294(0.51); C301(0.47); C302(0.47)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C174(0.98); C294(0.95); C301(0.99); C302(0.99)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C174(0.83); C294(0.51); C301(0.54); C302(0.54)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C174(0.84); C294(0.51); C301(0.55); C302(0.55)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C174(0.98); C294(0.53); C301(0.54); C302(0.54)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C174(0.87); C294(0.50); C301(0.47); C302(0.47)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C174(0.80); C294(0.58); C301(0.55); C302(0.55)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C174(0.74); C294(0.52); C301(0.49); C302(0.49)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C174(1.23); C294(2.05); C301(2.50); C302(2.50)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C174(1.03); C294(2.00); C301(1.99); C302(1.99)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C174(1.02); C294(2.32); C301(2.18); C302(2.18)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C174(1.26); C294(1.25); C301(1.36); C302(1.36)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C174(0.97); C294(1.01); C301(0.98); C302(0.98)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C174(0.91); C294(1.75); C301(1.83); C302(1.83)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C174(1.05); C294(1.57); C301(1.90); C302(1.90)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C174(1.19); C294(1.44); C301(1.88); C302(1.88)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C174(0.94); C294(1.61); C301(2.10); C302(2.10)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C174(0.99); C294(1.66); C301(2.52); C302(2.52)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C174(1.06); C294(1.81); C301(2.07); C302(2.07)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C174(0.92); C294(1.26); C301(1.31); C302(1.31)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C174(0.98); C294(1.64); C301(2.00); C302(2.00)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C174(1.07); C294(2.02); C301(2.10); C302(2.10)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C174(1.00); C294(1.37); C301(1.32); C302(1.32)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C174(0.96); C294(0.79); C301(0.73); C302(0.73)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C174(1.15); C294(1.25); C301(1.26); C302(1.26)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C174(1.03); C294(0.94); C301(0.97); C302(0.97)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C174(1.18); C294(0.87); C301(0.75); C302(0.75)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C174(0.94); C294(0.73); C301(0.56); C302(0.56)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C174(1.08); C294(0.68); C301(0.65); C302(0.65)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C174(1.13); C294(0.88); C301(0.74); C302(0.74)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C174(1.14); C294(0.68); C301(0.61); C302(0.61)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C174(0.95); C294(0.77); C301(0.57); C302(0.57)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C174(1.10); C294(0.77); C301(0.85); C302(0.85)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C174(0.96); C294(0.61); C301(0.56); C302(0.56)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C174(0.94); C294(0.76); C301(0.76); C302(0.76)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C174(0.91); C294(0.72); C301(0.72); C302(0.72)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C174(1.06); C294(0.69); C301(0.67); C302(0.67)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C174(1.01); C294(0.89); C301(0.87); C302(0.87)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C174(0.89); C294(0.71); C301(0.69); C302(0.69)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C174(0.90); C294(0.66); C301(0.53); C302(0.53)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C294(0.74); C301(0.92); C302(0.76); C421(0.92)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C294(0.97); C301(0.85); C302(0.77); C421(0.88)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C294(0.73); C301(0.75); C302(0.72); C421(0.85)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C294(0.63); C301(0.70); C302(0.59); C421(0.87)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C174(0.93); C294(0.65); C301(0.60); C302(0.60)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C294(0.78); C301(0.84); C302(0.82); C421(0.92)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C294(0.85); C301(0.96); C302(0.85); C421(0.92)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C294(0.80); C301(0.84); C302(0.74); C421(0.94)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C294(0.80); C301(0.75); C302(0.67); C421(1.02)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C294(0.61); C301(0.64); C302(0.60); C421(1.01)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C294(0.64); C301(0.64); C302(0.64); C421(0.95)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C294(0.96); C301(0.97); C302(0.79); C421(0.86)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C294(0.87); C301(0.97); C302(0.87); C421(0.89)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C294(0.85); C301(0.77); C302(0.74); C421(0.85)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C294(0.66); C301(0.69); C302(0.61); C421(0.83)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C174(0.92); C294(0.75); C301(0.69); C302(0.69)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C294(1.57); C301(1.31); C302(1.06); C421(0.76)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C174(0.93); C294(0.83); C301(0.93); C302(0.89)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C174(0.90); C294(0.83); C301(0.92); C302(0.86)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C174(0.96); C294(1.01); C301(1.04); C302(1.00)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C174(1.05); C294(0.78); C301(0.97); C302(0.85)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C174(0.96); C294(0.69); C301(0.82); C302(0.71)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C174(1.14); C294(0.73); C301(0.90); C302(0.82)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C174(1.05); C294(0.60); C301(0.69); C302(0.69)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C174(0.84); C294(0.60); C301(0.64); C302(0.61)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C174(1.12); C294(0.67); C301(0.84); C302(0.79)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C65(0.66)  LDD2228  [25]
 LDCM0495  E2913 HEK-293T C421(1.18); C65(0.90); C174(1.04); C330(0.93)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C294(0.79)  LDD1702  [8]
 LDCM0163  Entinostat Hep-G2 1.55  LDD0418  [28]
 LDCM0625  F8 Ramos C65(0.73)  LDD2187  [30]
 LDCM0572  Fragment10 Ramos C65(1.29)  LDD2189  [30]
 LDCM0573  Fragment11 Ramos C65(2.10)  LDD2190  [30]
 LDCM0574  Fragment12 Ramos C65(0.93)  LDD2191  [30]
 LDCM0575  Fragment13 Ramos C65(0.88)  LDD2192  [30]
 LDCM0576  Fragment14 Ramos C65(0.77)  LDD2193  [30]
 LDCM0579  Fragment20 Ramos C65(0.76)  LDD2194  [30]
 LDCM0580  Fragment21 Ramos C65(0.91)  LDD2195  [30]
 LDCM0582  Fragment23 Ramos C65(0.48)  LDD2196  [30]
 LDCM0578  Fragment27 Ramos C65(0.95)  LDD2197  [30]
 LDCM0586  Fragment28 Ramos C65(0.65)  LDD2198  [30]
 LDCM0588  Fragment30 Ramos C65(1.17)  LDD2199  [30]
 LDCM0589  Fragment31 Ramos C65(1.22)  LDD2200  [30]
 LDCM0590  Fragment32 Ramos C65(0.93)  LDD2201  [30]
 LDCM0468  Fragment33 HCT 116 C174(1.06); C294(0.86); C301(0.92); C302(0.92)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C65(1.16)  LDD2203  [30]
 LDCM0566  Fragment4 Ramos C65(1.01)  LDD2184  [30]
 LDCM0427  Fragment51 HCT 116 C174(0.79); C294(0.50); C301(0.55); C302(0.55)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C65(1.27)  LDD2204  [30]
 LDCM0614  Fragment56 Ramos C65(1.31)  LDD2205  [30]
 LDCM0569  Fragment7 Ramos C65(0.98)  LDD2186  [30]
 LDCM0571  Fragment9 Ramos C65(1.02)  LDD2188  [30]
 LDCM0116  HHS-0101 DM93 Y307(0.23); Y164(0.69); Y274(0.85); Y649(0.91)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y307(0.15); Y649(0.69); Y274(0.74); Y164(0.77)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y307(0.14); Y502(0.53); Y649(0.73); Y274(0.88)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y307(0.23); Y274(0.52); Y164(0.54); Y649(0.76)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y307(0.35); Y649(0.65); Y274(0.86); Y502(0.93)  LDD0268  [10]
 LDCM0107  IAA HeLa C174(0.00); H200(0.00); C294(0.00); H100(0.00)  LDD0221  [22]
 LDCM0022  KB02 HCT 116 C421(1.42)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C421(1.35)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C421(1.54)  LDD0082  [12]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C858(0.65); C421(0.89); C632(3.09)  LDD2121  [8]
 LDCM0109  NEM HeLa H200(0.00); H191(0.00); H100(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C858(0.73); C632(1.56); C65(0.63)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C632(1.20)  LDD2090  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C858(0.95); C421(0.73)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C421(1.50)  LDD2094  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C858(0.65); C421(0.88)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C858(0.93); C421(1.21)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C858(0.51)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C858(0.74); C421(0.84)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C858(0.68)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C858(1.44)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C632(0.47)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C858(0.79); C421(1.41)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C858(0.41)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C858(0.68); C421(0.65)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C858(0.60); C632(0.30)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C858(1.26); C421(0.96)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C858(0.39); C421(0.47)  LDD2115  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C858(0.97); C632(0.44)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C421(1.53)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C421(0.90)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C858(0.68)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C858(0.80); C421(0.82); C294(1.01)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C632(0.53)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C858(0.72); C421(0.69); C65(0.86)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C858(1.00); C421(1.25)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C421(0.80)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C858(1.07); C421(0.80)  LDD2129  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C858(0.41); C421(0.44)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C858(1.14); C421(1.02); C632(0.94)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C858(0.95); C421(1.35); C294(0.83)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C858(0.56); C421(0.94); C632(0.79); C294(0.90)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C421(3.15); C858(1.51); C632(1.50)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C858(0.72); C421(0.83); C65(0.62)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C632(0.61)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C858(1.02); C421(1.27)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C858(2.09); C421(1.75); C294(1.29)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C858(1.37); C632(0.19)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C858(0.94); C421(0.74); C632(0.52); C294(0.98)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C858(3.14); C421(5.08)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C421(0.47)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C858(0.78); C421(0.92); C632(1.85)  LDD2150  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C632(4.21)  LDD2153  [8]
 LDCM0021  THZ1 HCT 116 C421(1.06); C294(0.96)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Kinesin-1 heavy chain (KIF5B) Kinesin family P33176
FYVE and coiled-coil domain-containing protein 1 (FYCO1) . Q9BQS8
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Transcription factor LBX1 (LBX1) . P52954
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) CAMP-dependent kinase regulatory chain family P31323
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Four and a half LIM domains protein 2 (FHL2) . Q14192
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
24 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
25 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
28 Expanding the "minimalist" small molecule tagging approach to different bioactive compounds. Org Biomol Chem. 2019 Mar 13;17(11):3010-3017. doi: 10.1039/c8ob03175d.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578