Details of the Target

General Information of Target

Target ID LDTP04943
Target Name Large ribosomal subunit protein eL37 (RPL37)
Gene Name RPL37
Gene ID 6167
Synonyms
Large ribosomal subunit protein eL37; 60S ribosomal protein L37; G1.16
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTG
TGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eL37 family
Subcellular location
Cytoplasm
Function Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P61927
Ensemble ID
ENST00000274242.10
HGNC ID
HGNC:10347

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y27(20.00)  LDD0260  [1]
C-Sul
 Probe Info  		4.09  LDD0066  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K10(0.37); K14(4.02); K31(10.00)  LDD0277  [4]
ONAyne
 Probe Info  		K3(0.00); K14(0.00); K10(0.00)  LDD0273  [4]
Probe 1
 Probe Info  		Y27(3.61); Y47(35.01)  LDD3495  [5]
DBIA
 Probe Info  		C19(2.75)  LDD3318  [6]
BTD
 Probe Info  		C19(1.31)  LDD1700  [7]
HHS-482
 Probe Info  		Y27(0.94)  LDD0285  [8]
HHS-465
 Probe Info  		Y27(10.00)  LDD2237  [9]
ATP probe
 Probe Info  		K3(0.00); K25(0.00); K52(0.00); K36(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C37(0.00); C19(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		K31(0.00); K52(0.00); K10(0.00)  LDD0035  [14]
TFBX
 Probe Info  		C19(0.00); C37(0.00); C22(0.00)  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
IPM
 Probe Info  		C37(0.00); C19(0.00)  LDD0005  [16]
SF
 Probe Info  		Y27(0.00); K3(0.00)  LDD0028  [17]
Phosphinate-6
 Probe Info  		C22(0.00); C19(0.00); C37(0.00); C34(0.00)  LDD0018  [18]
Ox-W18
 Probe Info  		N.A.  LDD2175  [19]
Acrolein
 Probe Info  		C19(0.00); H28(0.00); C37(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		H16(0.00); C19(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
NAIA_5
 Probe Info  		C22(0.00); C37(0.00); C19(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IMP2070
 Probe Info  		1.65  LDD0370  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C19(0.83)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C19(1.19)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C19(0.43); C37(0.47)  LDD2132  [7]
 LDCM0545  Acetamide MDA-MB-231 C37(0.65)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C19(1.16)  LDD2113  [7]
 LDCM0498  BS-3668 MDA-MB-231 C19(0.91)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa C19(0.00); H28(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C37(2.83); C19(1.47)  LDD2227  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C37(0.81); C19(0.67)  LDD1702  [7]
 LDCM0625  F8 Ramos C37(2.46); C19(6.83)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C37(0.38); C19(0.25)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C37(0.02); C19(0.11)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C37(0.50); C19(0.33)  LDD2191  [23]
 LDCM0575  Fragment13 Ramos C37(1.12); C19(0.51)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos C37(0.43); C19(0.45)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C37(0.57); C19(0.36)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C37(1.68); C19(0.50)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C37(1.39); C19(0.97)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C37(1.40); C19(1.62)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C37(0.93); C19(0.88)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C37(1.05); C19(0.38)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos C37(0.66); C19(0.92)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos C37(0.42); C19(0.39)  LDD2201  [23]
 LDCM0468  Fragment33 Ramos C37(0.89); C19(0.60)  LDD2202  [23]
 LDCM0596  Fragment38 Ramos C37(0.70); C19(0.72)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C37(0.87); C19(0.72)  LDD2184  [23]
 LDCM0610  Fragment52 Ramos C37(1.47); C19(0.70)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C37(1.11); C19(0.31)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C37(0.44); C19(0.40)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C37(0.42); C19(0.13)  LDD2188  [23]
 LDCM0107  IAA HeLa H16(0.00); C19(0.00); H28(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y27(0.94)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y27(0.82)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y27(1.20)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y27(4.30)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y27(2.25)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y27(1.45)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y27(0.48)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y27(1.13)  LDD0292  [8]
 LDCM0022  KB02 Ramos C37(0.43); C19(0.33)  LDD2182  [23]
 LDCM0023  KB03 MDA-MB-231 C19(0.56)  LDD1701  [7]
 LDCM0024  KB05 MELHO C19(2.75)  LDD3318  [6]
 LDCM0145  MCC950 THP-1 1.65  LDD0370  [22]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C19(0.99)  LDD2121  [7]
 LDCM0109  NEM HeLa H28(0.00); H16(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C19(0.82)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C19(1.28)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C19(0.80)  LDD2097  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C19(0.95); C37(1.20)  LDD2099  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C19(0.95); C37(0.97)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C19(0.79)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C19(1.02)  LDD2111  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C19(0.82)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C19(2.69)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C19(0.61); C37(0.34)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C19(0.65); C37(1.43)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C19(0.76)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C19(0.86)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C19(0.52)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C19(1.36)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C19(0.75)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C19(0.57)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C19(1.57)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C19(0.93)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C19(0.94); C37(0.97)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C19(1.31)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C19(0.78)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C19(0.60)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C19(2.91)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C19(0.93)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C19(1.34)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C19(0.71)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C19(0.70)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C19(1.06)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C19(0.68)  LDD2207  [24]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-3-phenyllactic Acid . DB02494
Anisomycin . DB07374
Puromycin . DB08437
Puromycin Aminonucleoside-5'-monophosphate . DB04602
Virginiamycin S1 . DB04805

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target. ACS Chem Biol. 2021 Jun 18;16(6):982-990. doi: 10.1021/acschembio.1c00218. Epub 2021 May 18.
Mass spectrometry data entry: PXD024915 , PXD024913
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.