Details of the Target

General Information of Target

Target ID LDTP00664
Target Name ATP-dependent RNA helicase DDX3Y (DDX3Y)
Gene Name DDX3Y
Gene ID 8653
Synonyms
DBY; ATP-dependent RNA helicase DDX3Y; EC 3.6.4.13; DEAD box protein 3, Y-chromosomal
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHVVVKNDPELDQQLANLDLNSEKQSGGASTASKGRYIPPHLRNREASKGFHDKDSSGW
SCSKDKDAYSSFGSRDSRGKPGYFSERGSGSRGRFDDRGRSDYDGIGNRERPGFGRFERS
GHSRWCDKSVEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGSNCPPHIENF
SDIDMGEIIMGNIELTRYTRPTPVQKHAIPIIKGKRDLMACAQTGSGKTAAFLLPILSQI
YTDGPGEALKAVKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG
GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIR
RIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWV
EDLDKRSFLLDILGATGSDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREE
ALHQFRSGKSPILVATAVAARGLDISNVRHVINFDLPSDIEEYVHRIGRTGRVGNLGLAT
SFFNEKNMNITKDLLDLLVEAKQEVPSWLENMAYEHHYKGGSRGRSKSNRFSGGFGARDY
RQSSGSSSSGFGASRGSSSRSGGGGYGNSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
Target Bioclass
Enzyme
Family
DEAD box helicase family, DDX3/DED1 subfamily
Subcellular location
Cytoplasm
Function Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway.
Uniprot ID
O15523
Ensemble ID
ENST00000336079.8
HGNC ID
HGNC:2699

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
G401 SNV: p.C221F DBIA    Probe Info 
HCT15 SNV: p.P201L DBIA    Probe Info 
MEC1 SNV: p.C221F DBIA    Probe Info 
MSTO211H SNV: p.Q223P DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
YN-4
 Probe Info  		100.00  LDD0445  [1]
AZ-9
 Probe Info  		E330(1.09)  LDD2208  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C315(2.36); C221(1.14)  LDD1700  [4]
DBIA
 Probe Info  		C296(8.41)  LDD0209  [5]
HHS-475
 Probe Info  		Y69(0.72); Y264(1.13); Y578(1.28)  LDD0264  [6]
HHS-465
 Probe Info  		Y264(7.46); Y574(4.07); Y69(10.00)  LDD2237  [7]
IA-alkyne
 Probe Info  		C339(0.00); C296(0.00); C62(0.00); C221(0.00)  LDD0167  [8]
NAIA_4
 Probe Info  		C221(0.00); C296(0.00)  LDD2226  [9]
WYneN
 Probe Info  		C221(0.00); C315(0.00); C296(0.00); C62(0.00)  LDD0021  [10]
Compound 10
 Probe Info  		C221(0.00); C296(0.00); C315(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C296(0.00); C315(0.00)  LDD2213  [11]
PF-06672131
 Probe Info  		N.A.  LDD0152  [12]
Acrolein
 Probe Info  		C466(0.00); C315(0.00); C296(0.00); H207(0.00)  LDD0217  [13]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [13]
Crotonaldehyde
 Probe Info  		C339(0.00); H483(0.00)  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		C315(0.00); C339(0.00); C221(0.00); C62(0.00)  LDD0236  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0071  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C315(0.49)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C296(0.92); C315(0.64)  LDD2112  [4]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C221(0.84); C296(0.48)  LDD2095  [4]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C296(0.65); C339(0.99); C315(0.68)  LDD2130  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C221(1.03); C296(0.82); C339(1.15); C315(1.02)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C221(1.35); C296(1.33); C339(0.99); C315(1.48)  LDD2152  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C221(0.91); C296(0.57); C339(0.67); C315(0.50)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C221(0.93); C296(0.78); C315(0.45)  LDD2131  [4]
 LDCM0214  AC1 HCT 116 C221(0.75); C296(0.61); C339(0.69)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C221(0.67); C296(0.58); C315(0.59); C339(0.62)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C221(0.45); C296(0.53); C315(0.64); C339(0.44)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C221(0.44); C296(0.56); C315(0.76); C339(0.42)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C221(0.37); C296(0.47); C315(0.48); C339(0.40)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C221(0.30); C296(0.36); C315(0.44); C339(0.25)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C221(0.35); C296(0.40); C315(0.77); C339(0.27)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C221(0.32); C296(0.37); C315(0.78); C339(0.27)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C221(0.45); C296(0.39); C315(0.58); C339(0.29)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C221(0.83); C296(0.45); C315(0.34); C339(0.34)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C221(0.68); C296(0.64); C315(0.83); C339(0.66)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C221(0.70); C296(0.54); C315(1.04); C339(0.57)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C221(0.82); C296(0.64); C315(0.65); C339(0.65)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C221(0.79); C296(0.50); C315(0.84); C339(0.59)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C221(0.74); C296(0.57); C315(0.84); C339(0.60)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C221(0.73); C296(0.49); C315(0.63); C339(0.46)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C221(0.99); C315(0.92); C339(1.00)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C221(0.66); C315(0.60); C339(0.68)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C221(0.52); C315(0.51); C339(0.51)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C221(0.60); C315(0.57); C339(0.50)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C221(0.82); C315(0.72); C339(0.69)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C221(0.89); C315(0.71); C339(0.76)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C221(0.71); C315(0.63); C339(0.70)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C221(1.16); C296(0.83); C315(0.76); C339(0.86)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C221(0.69); C315(0.65); C339(0.68)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C221(0.89); C315(0.86); C339(0.86)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C221(0.80); C315(0.69); C339(0.78)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C221(0.86); C315(0.81); C339(0.90)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C221(0.99); C315(0.69); C339(0.84)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C221(1.01); C315(0.66); C339(0.75)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C221(0.69); C315(0.58); C339(0.56)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C221(0.67); C315(0.56); C339(0.59)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C221(0.82); C296(1.09); C315(0.83); C339(0.80)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C221(1.14); C296(2.12); C315(1.43); C339(1.36)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C221(0.85); C296(0.94); C315(0.77); C339(0.83)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C221(1.11); C296(1.27); C315(1.26); C339(1.17)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C221(1.12); C296(1.64); C315(1.27); C339(1.32)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C221(0.85); C296(0.96); C315(0.93); C339(0.87)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C221(0.85); C296(1.02); C315(0.74); C339(0.80)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C221(0.87); C296(0.99); C315(0.78); C339(0.83)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C221(0.97); C296(1.35); C315(1.00); C339(0.93)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C221(0.99); C296(1.70); C315(1.05); C339(1.19)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C221(0.90); C296(1.00); C315(0.86); C339(0.97)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C221(1.00); C296(1.26); C315(0.88); C339(0.95)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C221(0.67); C296(0.68); C315(0.68); C339(0.62)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C221(0.84); C296(0.97); C315(0.84); C339(0.85)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C221(0.95); C296(1.25); C315(1.00); C339(0.94)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C221(1.33); C296(1.60); C315(1.29); C339(1.29)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C221(0.86); C296(0.73); C339(0.78); C62(1.07)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C339(0.40); C296(0.41); C221(0.42); C62(1.51)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C221(0.61); C339(0.62); C296(0.84); C62(1.12)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C339(0.47); C221(0.54); C296(0.67); C62(1.32)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C339(0.35); C221(0.43); C296(0.51); C62(1.44)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C339(0.41); C221(0.52); C296(0.54); C62(1.59)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C339(0.37); C221(0.45); C296(0.55); C62(1.39)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C339(0.65); C296(0.65); C315(0.67); C221(0.83)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C339(0.65); C221(0.69); C296(1.04); C62(1.16)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C339(0.65); C221(0.83); C296(0.97); C62(1.29)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C339(0.37); C221(0.39); C296(0.47); C62(1.41)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C339(0.45); C221(0.50); C296(0.57); C62(1.99)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C221(0.46); C296(0.60); C339(0.41); C62(1.70)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C221(0.48); C296(0.63); C339(0.42); C62(1.52)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C221(0.81); C296(1.19); C339(0.85); C62(1.79)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C221(0.81); C296(1.99); C339(0.78); C62(1.75)  LDD2161  [15]
 LDCM0276  AC17 HCT 116 C221(0.84); C339(0.87); C296(0.89); C315(0.96)  LDD0593  [15]
 LDCM0277  AC18 HCT 116 C339(0.59); C221(0.59); C315(0.64); C296(0.64)  LDD0594  [15]
 LDCM0278  AC19 HCT 116 C339(0.70); C221(0.78); C296(0.83); C315(0.87)  LDD0595  [15]
 LDCM0279  AC2 HCT 116 C296(0.75); C339(0.76); C221(0.84)  LDD0596  [15]
 LDCM0280  AC20 HCT 116 C339(0.79); C221(0.82); C315(0.85); C296(0.85)  LDD0597  [15]
 LDCM0281  AC21 HCT 116 C339(0.72); C296(0.83); C315(0.83); C221(0.93)  LDD0598  [15]
 LDCM0282  AC22 HCT 116 C315(0.93); C221(0.94); C296(1.00); C339(1.06)  LDD0599  [15]
 LDCM0283  AC23 HCT 116 C221(0.78); C315(0.82); C296(0.85); C339(0.85)  LDD0600  [15]
 LDCM0284  AC24 HCT 116 C339(0.92); C221(0.93); C296(0.99); C315(1.13)  LDD0601  [15]
 LDCM0285  AC25 HCT 116 C296(0.73); C339(0.75); C221(0.86); C315(1.01)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C339(0.61); C296(0.74); C221(0.78); C315(0.85)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C339(0.51); C221(0.66); C296(0.70); C315(0.74)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C339(0.54); C221(0.71); C296(0.73); C315(0.77)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C315(0.56); C339(0.59); C296(0.65); C221(0.73)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C296(0.73); C339(0.79); C221(0.92)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C339(0.53); C296(0.63); C315(0.64); C221(0.68)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C339(0.49); C296(0.60); C221(0.67); C315(1.15)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C339(0.40); C315(0.52); C296(0.61); C221(0.63)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C339(0.45); C315(0.55); C221(0.61); C296(0.66)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C339(0.38); C296(0.51); C221(0.56); C315(0.75)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C296(1.22); C221(1.36); C339(1.38)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C221(1.02); C296(1.24); C339(1.33)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C296(1.08); C339(1.14); C221(1.26)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C296(1.07); C339(1.14); C221(1.16)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C221(0.95); C296(1.03); C339(1.05)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C296(0.63); C339(0.65); C221(0.76)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C296(0.82); C339(0.86); C221(1.26)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C221(1.07); C296(1.09); C339(1.12)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C221(0.92); C339(0.94); C296(0.98)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C296(1.01); C221(1.06); C339(1.07)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C221(0.92); C339(0.94); C296(0.99)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C221(0.87); C339(0.88); C296(0.89)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C315(1.02); C339(1.02); C221(1.11); C296(1.13)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C339(0.98); C315(1.00); C221(1.03); C296(1.03)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C296(1.08); C315(1.13); C339(1.19); C221(1.23)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C339(0.83); C296(0.97); C221(0.99); C315(1.11)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C296(0.61); C339(0.64); C221(0.76)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C339(0.77); C315(0.82); C221(0.99); C296(1.02)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C315(1.21); C296(1.22); C339(1.58); C221(1.65)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C339(0.96); C296(0.98); C315(1.08); C221(1.09)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C315(0.72); C339(0.76); C221(0.87); C296(0.96)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C315(0.72); C339(0.75); C296(0.87); C221(0.87)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C315(0.80); C339(0.81); C221(1.00); C296(1.05)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C315(0.98); C339(1.00); C296(1.17); C221(1.21)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C339(0.45); C221(0.47); C315(0.54); C296(0.60)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C339(0.46); C315(0.52); C221(0.52); C296(0.58)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C339(0.43); C315(0.50); C221(0.51); C296(0.54)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C296(0.58); C221(0.61); C339(0.62); C315(0.73)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C339(0.47); C221(0.52); C315(0.54); C296(0.66)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C221(0.53); C339(0.53); C296(0.55); C315(0.58)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C339(0.45); C221(0.47); C315(0.50); C296(0.62)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C339(0.45); C315(0.52); C221(0.57); C296(0.61)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C339(0.44); C221(0.49); C315(0.50); C296(0.58)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C339(0.50); C221(0.55); C315(0.57); C296(0.62)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C339(0.52); C221(0.53); C315(0.56); C296(0.77)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C339(0.51); C221(0.55); C315(0.57); C296(0.63)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C339(0.79); C62(0.80); C315(0.81); C296(0.83)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C339(0.77); C315(0.79); C221(0.82); C296(0.86)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C296(0.71); C315(0.76); C339(0.84); C221(0.86)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C339(0.64); C296(0.75); C62(0.85); C221(0.89)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C62(0.85); C339(0.98); C315(0.98); C296(1.00)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C339(0.69); C315(0.71); C296(0.82); C221(0.97)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C339(0.82); C315(0.85); C296(0.92); C221(0.93)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C339(0.82); C315(0.88); C296(0.92); C221(0.98)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C339(0.91); C315(0.99); C296(1.00); C221(1.19)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C339(0.68); C315(0.71); C296(0.77); C221(0.83)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C315(0.67); C339(0.69); C296(0.73); C221(0.88)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C315(0.88); C339(0.92); C296(1.11); C221(1.17)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C315(0.80); C339(0.85); C296(1.09); C221(1.10)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C315(0.64); C339(0.73); C296(0.75); C221(0.87)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C339(0.67); C315(0.67); C296(0.74); C221(0.80)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C296(1.10); C339(1.14); C315(1.22); C221(1.30)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C315(1.00); C339(1.06); C296(1.14); C221(1.51)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C315(0.51); C339(0.52); C296(0.57); C221(0.61)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C315(0.48); C339(0.55); C296(0.55); C221(0.57)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C296(0.65); C315(0.69); C221(0.69); C339(0.71)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C296(0.64); C339(0.64); C315(0.66); C221(0.68)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C315(0.76); C339(0.84); C296(0.85); C221(0.88)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C315(0.68); C339(0.69); C296(0.77); C221(0.78)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C339(0.48); C296(0.51); C221(0.52); C315(0.52)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C62(0.95); C296(1.04); C221(1.10); C315(1.19)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C339(0.49); C315(0.50); C296(0.53); C221(0.60)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C315(0.47); C339(0.49); C221(0.51); C296(0.52)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C315(0.62); C221(0.66); C296(0.68); C339(0.73)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C339(0.68); C315(0.70); C221(0.70); C296(0.77)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C315(0.58); C339(0.62); C296(0.64); C221(0.70)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C339(0.55); C315(0.56); C221(0.60); C296(0.62)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C315(0.49); C339(0.50); C221(0.52); C296(0.56)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C339(0.31); C221(0.36); C296(0.41); C315(0.55)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C62(0.50); C339(0.55); C296(0.66); C221(0.73)  LDD0683  [15]
 LDCM0545  Acetamide MDA-MB-231 C221(0.42); C339(0.85)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C296(0.77); C315(0.83)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C221(0.86); C296(0.83); C315(0.78); C339(0.87)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C296(0.64); C339(0.71); C221(0.72); C315(0.94)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C296(0.44); C339(0.45); C221(0.46); C315(0.56)  LDD0592  [15]
 LDCM0498  BS-3668 MDA-MB-231 C296(0.40); C339(1.11); C315(0.54)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C466(0.00); H525(0.00); C296(0.00); C315(0.00)  LDD0222  [13]
 LDCM0367  CL1 HCT 116 C221(1.08); C315(1.26); C339(1.33); C296(1.33)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C296(0.60); C221(0.61); C339(0.72); C315(0.77)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C296(0.66); C339(0.71); C221(0.79)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C221(0.57); C339(0.58); C315(0.59); C296(0.63)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C296(0.76); C339(0.82); C221(0.87); C315(0.88)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C296(0.76); C339(0.86); C221(0.91); C315(1.01)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C296(0.75); C339(0.79); C221(0.85); C315(0.91)  LDD0690  [15]
 LDCM0374  CL105 HCT 116 C339(0.58); C221(0.62); C296(0.67); C315(0.72)  LDD0691  [15]
 LDCM0375  CL106 HCT 116 C339(0.49); C221(0.50); C315(0.53); C296(0.57)  LDD0692  [15]
 LDCM0376  CL107 HCT 116 C339(0.50); C221(0.53); C315(0.56); C296(0.59)  LDD0693  [15]
 LDCM0377  CL108 HCT 116 C339(0.44); C221(0.52); C296(0.52); C315(0.75)  LDD0694  [15]
 LDCM0378  CL109 HCT 116 C339(0.62); C296(0.66); C221(0.69); C315(0.72)  LDD0695  [15]
 LDCM0379  CL11 HCT 116 C221(0.59); C296(0.59); C339(0.75); C315(0.80)  LDD0696  [15]
 LDCM0380  CL110 HCT 116 C339(0.52); C221(0.57); C296(0.57); C315(0.64)  LDD0697  [15]
 LDCM0381  CL111 HCT 116 C339(0.71); C221(0.75); C296(0.78); C315(0.80)  LDD0698  [15]
 LDCM0382  CL112 HCT 116 C315(0.66); C296(0.76); C339(0.84); C221(0.88)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C339(0.47); C315(0.61); C221(0.67); C296(0.73)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C339(0.69); C296(0.85); C221(0.89); C315(1.53)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C339(0.59); C296(0.68); C221(0.71); C315(0.93)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C339(0.58); C296(0.73); C221(0.76); C315(0.78)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C296(0.99); C339(1.01); C221(1.16)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C221(0.95); C339(0.98); C296(1.01)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C339(0.90); C221(0.93); C296(0.95)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C221(0.54); C339(0.58); C296(0.59); C315(0.74)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C296(1.10); C339(1.18); C221(1.56)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C221(0.74); C315(0.85); C339(0.86); C296(1.10)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C339(0.91); C315(0.95); C221(1.06); C296(1.26)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C339(0.74); C315(0.80); C221(0.86); C296(1.02)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C339(0.74); C221(0.87); C315(0.90); C296(0.90)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C221(0.81); C339(0.94); C296(1.06); C315(1.09)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C221(0.64); C339(0.74); C315(0.76); C296(0.77)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C296(0.74); C339(0.75); C315(0.78); C221(0.79)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C339(0.42); C221(0.44); C315(0.51); C296(0.57)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C296(0.64); C221(0.68); C339(0.70); C315(0.89)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C296(0.67); C221(0.80); C339(0.88); C315(1.01)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C296(0.66); C221(0.72); C339(0.81); C315(1.00)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C296(0.82); C221(0.88); C339(0.92); C315(1.01)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C296(0.66); C221(0.69); C315(0.78); C339(0.84)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C315(0.49); C296(0.51); C221(0.62); C339(0.66)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C315(0.55); C296(0.60); C339(0.63); C221(0.64)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C296(0.99); C221(1.10); C315(1.16); C339(1.35)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C296(0.45); C315(0.47); C339(0.51); C221(0.53)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C315(0.45); C296(0.45); C339(0.49); C221(0.51)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C315(0.53); C296(0.59); C221(0.66); C339(0.66)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C315(0.53); C296(0.60); C221(0.61); C339(0.67)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C315(0.42); C296(0.46); C339(0.55); C221(0.59)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C221(0.56); C296(0.53); C315(0.44); C339(0.56)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C221(0.67); C296(0.59); C315(0.55); C339(0.74)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C221(0.66); C296(0.59); C315(0.55); C339(0.61)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C221(0.59); C296(0.53); C315(0.49); C339(0.57)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C221(0.56); C296(0.50); C315(0.47); C339(0.63)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C221(0.80); C296(0.97); C315(1.08); C339(1.09)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C221(0.84); C296(0.74); C315(0.76); C339(0.85)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C221(0.83); C296(0.78); C339(0.72)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C221(0.68); C296(0.62); C339(0.62)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C221(0.43); C296(0.60); C339(0.63)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C221(0.46); C296(0.54); C339(0.44)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C221(0.54); C296(0.49); C339(0.43)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C221(0.49); C296(0.54); C339(0.48)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C221(0.51); C296(0.49); C339(0.41)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C221(0.40); C296(0.48); C339(0.44)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C221(0.74); C296(0.90); C315(1.00); C339(0.91)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C221(0.44); C296(0.51); C339(0.50)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C221(0.66); C296(0.58); C339(0.48)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C221(0.56); C296(0.63); C339(0.60)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C221(0.59); C296(0.49); C339(0.48)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C221(0.54); C296(0.59); C339(0.52)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C221(0.46); C296(0.54); C339(0.52)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C221(1.21); C296(1.44)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C221(1.15); C296(1.31)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C221(1.21); C296(1.28)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C221(0.91); C296(0.93)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C221(0.66); C296(0.88); C315(1.25); C339(0.87)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C221(1.08); C296(1.20)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C221(1.15); C296(1.17)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C221(1.04); C296(1.13)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C221(1.09); C296(1.22)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C221(1.13); C296(1.33)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C221(1.09); C296(1.43)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C221(0.99); C296(0.96)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C221(1.06); C296(1.12)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C221(1.08); C296(1.31)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C221(1.07); C296(1.15)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C221(0.69); C296(0.84); C315(1.01); C339(0.83)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C221(1.05); C296(1.16)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C221(1.03); C296(1.06); C315(0.78); C339(0.89)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C221(0.95); C296(0.98); C315(0.93); C339(0.98)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C221(0.79); C296(0.90); C315(0.72); C339(0.80)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C221(0.70); C296(0.76); C315(0.53); C339(0.58)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C221(0.89); C296(0.96); C315(0.81); C339(0.82)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C221(0.62); C296(0.67); C315(0.48); C339(0.55)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C221(0.71); C296(0.74); C315(0.54); C339(0.56)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C221(0.74); C296(0.79); C315(0.56); C339(0.64)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C221(0.82); C296(0.84); C315(0.64); C339(0.75)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C221(0.65); C296(0.70); C315(0.90); C339(0.67)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C221(0.85); C296(0.93); C315(0.65); C339(0.77)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C221(0.81); C296(0.93); C315(0.64); C339(0.79)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C221(1.04); C296(1.08); C315(0.83); C339(0.97)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C221(0.78); C296(0.93); C315(0.59); C339(0.67)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C221(0.79); C296(0.86); C315(0.64); C339(0.65)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C221(0.87); C296(0.77); C315(0.66); C339(0.77)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C221(0.87); C296(1.21); C315(0.72); C339(0.93)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C221(1.10); C296(0.82); C315(0.70); C339(0.79)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C221(0.64); C296(0.65); C315(0.51); C339(0.53)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C221(0.51); C296(0.62); C315(0.78); C339(0.58)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C221(0.71); C296(0.86); C315(0.68); C339(0.76)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C221(0.75); C296(0.83); C315(0.64); C339(0.72)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C221(0.66); C296(0.69); C315(0.47); C339(0.56)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C221(0.77); C296(0.73); C315(0.50); C339(0.58)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C221(0.72); C296(0.79); C315(0.54); C339(0.65)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C221(1.17); C296(0.84); C315(0.60); C339(0.76)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C221(0.99); C296(1.13); C315(0.81); C339(1.00)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C221(0.66); C296(0.86); C315(0.62); C339(0.66)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C221(0.60); C296(0.64); C315(0.48); C339(0.56)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C221(0.90); C296(0.97); C315(0.68); C339(0.77)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C221(0.68); C296(0.73); C315(0.93); C339(0.76)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C221(0.95); C296(1.68); C315(1.35); C339(1.47)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C221(0.91); C296(0.79); C339(0.83)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C221(0.92); C296(0.84); C339(0.92)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C221(0.86); C296(0.73); C339(0.91)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C221(0.77); C296(0.60); C339(0.62)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C221(0.77); C296(0.62); C339(0.65)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C221(0.82); C296(0.66); C339(0.74)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C221(0.77); C296(0.62); C339(0.68)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C221(0.77); C296(0.64); C339(0.64)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C221(0.72); C296(0.61); C339(0.67)  LDD0811  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C296(2.88); C221(1.87); C315(1.84); C339(1.61)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C221(0.81); C296(0.86); C315(0.66); C339(0.68)  LDD0785  [15]
 LDCM0427  Fragment51 HCT 116 C221(0.50); C296(0.61); C339(0.49)  LDD0744  [15]
 LDCM0116  HHS-0101 DM93 Y69(0.72); Y264(1.13); Y578(1.28)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y69(0.74); Y578(1.92); Y264(2.09)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y69(0.52); Y578(1.92)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y69(0.62); Y578(2.68); Y264(6.52)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y578(1.03); Y69(1.07)  LDD0268  [6]
 LDCM0107  IAA HeLa H525(0.00); H483(0.00); H207(0.00); C339(0.00)  LDD0221  [13]
 LDCM0022  KB02 22RV1 C331(2.14); C317(2.27); C298(2.41)  LDD2243  [16]
 LDCM0023  KB03 Jurkat C296(8.41)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C317(3.33); C298(3.22)  LDD3310  [16]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C221(0.76); C296(0.77); C339(0.91); C315(0.61)  LDD2121  [4]
 LDCM0109  NEM HeLa H525(0.00); H483(0.00); H207(0.00); H316(0.00)  LDD0223  [13]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C296(0.58); C339(0.80)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C339(1.04); C315(1.13)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C315(0.40)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C296(0.67); C315(0.89)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C221(0.97); C296(0.88); C339(1.14); C315(1.25)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C315(0.48)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C221(0.83); C296(0.66); C315(0.82)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C296(0.82); C315(0.51)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C315(1.06)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C296(0.62); C315(0.51)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C221(0.99); C296(0.95); C339(1.17); C315(1.01)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C296(0.55); C315(0.65)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C221(0.81); C296(0.68); C339(1.23); C315(0.66)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C296(1.13)  LDD2110  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C296(0.80); C315(0.51)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C315(0.59)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C296(0.70); C315(0.90)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C296(0.81); C315(0.91)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C221(2.27); C296(2.40); C315(1.81)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C221(1.00); C296(0.83); C315(0.73)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C296(0.54)  LDD2122  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C296(0.60); C315(0.75)  LDD2124  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C315(0.87)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C221(0.89); C296(0.91); C315(1.05)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C221(1.39); C315(0.79)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C221(1.15); C296(1.06); C339(1.31); C315(1.20)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C221(0.59); C315(0.67)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C221(1.29); C296(0.46); C315(0.50)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C221(1.16); C296(1.21); C315(1.56)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C221(1.08); C296(1.04); C339(1.43); C315(1.17)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C221(0.98); C296(0.87); C339(1.00); C315(1.03)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C315(2.36); C221(1.14)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C221(0.71); C296(0.60); C339(0.77); C315(0.81)  LDD2140  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C296(0.92); C315(0.64)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C339(1.74); C315(1.67)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C296(5.13)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C221(1.11); C296(0.83); C339(1.00); C315(1.03)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C221(1.58); C296(2.47)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C296(0.49); C315(0.53)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C296(0.90); C315(0.90)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C296(0.43); C339(0.50); C315(0.53)  LDD2150  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C221(0.81); C315(0.68)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C221(1.77); C315(0.48)  LDD2207  [17]
 LDCM0112  W16 Hep-G2 C62(0.61)  LDD0239  [3]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.