Details of the Target

General Information of Target

Target ID LDTP04617
Target Name Tyrosine--tRNA ligase, cytoplasmic (YARS1)
Gene Name YARS1
Gene ID 8565
Synonyms
YARS; Tyrosine--tRNA ligase, cytoplasmic; EC 6.1.1.1; Tyrosyl-tRNA synthetase; TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIA
DFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKG
TDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVD
AQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKED
VKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFA
AEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEP
EEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLV
VVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEE
LKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS
Target Bioclass
Enzyme
Family
Class-I aminoacyl-tRNA synthetase family
Subcellular location
Cytoplasm
Function
Tyrosine--tRNA ligase that catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (Probable). Also acts as a positive regulator of poly-ADP-ribosylation in the nucleus, independently of its tyrosine--tRNA ligase activity. Activity is switched upon resveratrol-binding: resveratrol strongly inhibits the tyrosine--tRNA ligase activity and promotes relocalization to the nucleus, where YARS1 specifically stimulates the poly-ADP-ribosyltransferase activity of PARP1.
Uniprot ID
P54577
Ensemble ID
ENST00000373477.9
HGNC ID
HGNC:12840
ChEMBL ID
CHEMBL3179

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 46 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.35  LDD0215  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
C-Sul
 Probe Info  		4.44  LDD0066  [3]
TH211
 Probe Info  		Y341(20.00); Y472(20.00); Y123(17.81); Y388(12.01)  LDD0257  [4]
TH216
 Probe Info  		Y134(20.00)  LDD0259  [4]
YN-4
 Probe Info  		100.00  LDD0445  [5]
BTD
 Probe Info  		C501(1.58); C519(4.73)  LDD1699  [6]
AZ-9
 Probe Info  		E128(0.95)  LDD2208  [7]
ONAyne
 Probe Info  		K147(0.92)  LDD0275  [8]
Probe 1
 Probe Info  		Y123(30.44); Y129(34.57); Y134(21.79); Y198(8.97)  LDD3495  [9]
AHL-Pu-1
 Probe Info  		C250(2.78)  LDD0169  [10]
DBIA
 Probe Info  		C519(6.16); C501(12.47)  LDD0209  [11]
HHS-482
 Probe Info  		Y134(0.92); Y198(0.89)  LDD0285  [12]
HHS-475
 Probe Info  		Y341(2.52)  LDD0268  [13]
HHS-465
 Probe Info  		Y134(10.00); Y166(2.87); Y198(10.00); Y52(10.00)  LDD2237  [14]
5E-2FA
 Probe Info  		H305(0.00); H381(0.00)  LDD2235  [15]
AMP probe
 Probe Info  		N.A.  LDD0200  [16]
ATP probe
 Probe Info  		K247(0.00); K147(0.00); K190(0.00); K282(0.00)  LDD0199  [16]
m-APA
 Probe Info  		H305(0.00); H381(0.00)  LDD2231  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C250(0.00); C67(0.00); C442(0.00); C501(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C250(0.00); C519(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		C250(0.00); C501(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C250(0.00); C67(0.00); C442(0.00); C501(0.00)  LDD0037  [17]
JW-RF-010
 Probe Info  		C250(0.00); C442(0.00)  LDD0026  [20]
TFBX
 Probe Info  		C519(0.00); C442(0.00); C501(0.00); C250(0.00)  LDD0027  [20]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
WYneO
 Probe Info  		C519(0.00); C501(0.00)  LDD0022  [21]
1d-yne
 Probe Info  		N.A.  LDD0356  [22]
Compound 10
 Probe Info  		C250(0.00); C424(0.00); C501(0.00); C519(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		C250(0.00); C501(0.00)  LDD0005  [21]
NHS
 Probe Info  		K335(0.00); K490(0.00); K356(0.00); K474(0.00)  LDD0010  [21]
PF-06672131
 Probe Info  		C250(0.00); C501(0.00); C519(0.00)  LDD0017  [24]
SF
 Probe Info  		Y134(0.00); K334(0.00); Y204(0.00); K147(0.00)  LDD0028  [25]
STPyne
 Probe Info  		K335(0.00); K147(0.00)  LDD0009  [21]
Ox-W18
 Probe Info  		W87(0.00); W283(0.00)  LDD2175  [26]
1c-yne
 Probe Info  		K474(0.00); K356(0.00); K380(0.00); K470(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C250(0.00); H143(0.00); C501(0.00); C424(0.00)  LDD0217  [27]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [27]
Methacrolein
 Probe Info  		C501(0.00); C250(0.00); C519(0.00); H143(0.00)  LDD0218  [27]
W1
 Probe Info  		C424(0.00); C501(0.00); C250(0.00)  LDD0236  [28]
AOyne
 Probe Info  		4.40  LDD0443  [29]
NAIA_5
 Probe Info  		C250(0.00); C424(0.00); C442(0.00); C501(0.00)  LDD2223  [30]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		6.12  LDD0473  [31]
FFF probe13
 Probe Info  		5.51  LDD0475  [31]
FFF probe4
 Probe Info  		5.03  LDD0466  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
DA-2
 Probe Info  		N.A.  LDD0072  [33]
STS-1
 Probe Info  		N.A.  LDD0068  [34]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C519(0.59)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C519(0.80)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C519(0.93); C501(0.92)  LDD2117  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C519(0.64)  LDD2132  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C250(2.78)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C250(1.13)  LDD0531  [35]
 LDCM0215  AC10 HCT 116 C250(0.89); C424(0.66); C519(0.60)  LDD0532  [35]
 LDCM0216  AC100 HCT 116 C501(0.57); C250(0.84)  LDD0533  [35]
 LDCM0217  AC101 HCT 116 C501(0.46); C250(0.84)  LDD0534  [35]
 LDCM0218  AC102 HCT 116 C501(0.33); C250(0.88)  LDD0535  [35]
 LDCM0219  AC103 HCT 116 C501(0.13); C250(0.56)  LDD0536  [35]
 LDCM0220  AC104 HCT 116 C501(0.17); C250(0.59)  LDD0537  [35]
 LDCM0221  AC105 HCT 116 C501(0.15); C250(0.61)  LDD0538  [35]
 LDCM0222  AC106 HCT 116 C501(0.17); C250(0.56)  LDD0539  [35]
 LDCM0223  AC107 HCT 116 C501(0.15); C250(0.54)  LDD0540  [35]
 LDCM0224  AC108 HCT 116 C501(0.63); C250(0.78)  LDD0541  [35]
 LDCM0225  AC109 HCT 116 C501(0.74); C250(0.84)  LDD0542  [35]
 LDCM0226  AC11 HCT 116 C250(0.88); C424(0.56); C519(0.79)  LDD0543  [35]
 LDCM0227  AC110 HCT 116 C501(0.47); C250(0.82)  LDD0544  [35]
 LDCM0228  AC111 HCT 116 C501(0.49); C250(0.81)  LDD0545  [35]
 LDCM0229  AC112 HCT 116 C501(0.23); C250(0.76)  LDD0546  [35]
 LDCM0230  AC113 HCT 116 C501(1.15); C250(1.11)  LDD0547  [35]
 LDCM0231  AC114 HCT 116 C501(0.80); C250(1.03)  LDD0548  [35]
 LDCM0232  AC115 HCT 116 C501(0.30); C250(0.98)  LDD0549  [35]
 LDCM0233  AC116 HCT 116 C501(0.27); C250(1.02)  LDD0550  [35]
 LDCM0234  AC117 HCT 116 C501(0.49); C250(0.94)  LDD0551  [35]
 LDCM0235  AC118 HCT 116 C501(0.87); C250(0.80)  LDD0552  [35]
 LDCM0236  AC119 HCT 116 C501(0.78); C250(1.03)  LDD0553  [35]
 LDCM0237  AC12 HCT 116 C250(1.06); C424(0.97); C519(1.14)  LDD0554  [35]
 LDCM0238  AC120 HCT 116 C501(0.70); C250(1.05)  LDD0555  [35]
 LDCM0239  AC121 HCT 116 C501(0.98); C250(0.89)  LDD0556  [35]
 LDCM0240  AC122 HCT 116 C501(0.90); C250(1.00)  LDD0557  [35]
 LDCM0241  AC123 HCT 116 C501(2.73); C250(0.80)  LDD0558  [35]
 LDCM0242  AC124 HCT 116 C501(2.38); C250(1.00)  LDD0559  [35]
 LDCM0243  AC125 HCT 116 C501(0.65); C250(0.89)  LDD0560  [35]
 LDCM0244  AC126 HCT 116 C501(0.33); C250(0.84)  LDD0561  [35]
 LDCM0245  AC127 HCT 116 C501(0.35); C250(0.89)  LDD0562  [35]
 LDCM0246  AC128 HCT 116 C501(0.54); C424(0.60)  LDD0563  [35]
 LDCM0247  AC129 HCT 116 C501(2.28); C424(1.48)  LDD0564  [35]
 LDCM0249  AC130 HCT 116 C501(0.75); C424(0.70)  LDD0566  [35]
 LDCM0250  AC131 HCT 116 C501(1.40); C424(1.41)  LDD0567  [35]
 LDCM0251  AC132 HCT 116 C501(2.03); C424(1.69)  LDD0568  [35]
 LDCM0252  AC133 HCT 116 C501(0.82); C424(0.83)  LDD0569  [35]
 LDCM0253  AC134 HCT 116 C501(0.71); C424(0.69)  LDD0570  [35]
 LDCM0254  AC135 HCT 116 C501(0.81); C424(0.69)  LDD0571  [35]
 LDCM0255  AC136 HCT 116 C501(0.97); C424(0.79)  LDD0572  [35]
 LDCM0256  AC137 HCT 116 C501(1.40); C424(1.27)  LDD0573  [35]
 LDCM0257  AC138 HCT 116 C501(1.06); C424(0.73)  LDD0574  [35]
 LDCM0258  AC139 HCT 116 C501(0.86); C424(0.91)  LDD0575  [35]
 LDCM0259  AC14 HCT 116 C250(1.09); C424(0.95); C519(0.77)  LDD0576  [35]
 LDCM0260  AC140 HCT 116 C501(0.72); C424(0.73)  LDD0577  [35]
 LDCM0261  AC141 HCT 116 C501(1.16); C424(0.89)  LDD0578  [35]
 LDCM0262  AC142 HCT 116 C501(5.65); C424(1.90)  LDD0579  [35]
 LDCM0263  AC143 HCT 116 C424(0.85); C519(0.98); C250(1.08)  LDD0580  [35]
 LDCM0264  AC144 HCT 116 C424(0.16); C519(0.62); C250(0.77)  LDD0581  [35]
 LDCM0265  AC145 HCT 116 C424(0.59); C519(0.87); C250(1.04)  LDD0582  [35]
 LDCM0266  AC146 HCT 116 C424(0.33); C519(0.83); C250(0.95)  LDD0583  [35]
 LDCM0267  AC147 HCT 116 C424(0.16); C519(0.59); C250(0.75)  LDD0584  [35]
 LDCM0268  AC148 HCT 116 C424(0.12); C519(0.54); C250(0.96)  LDD0585  [35]
 LDCM0269  AC149 HCT 116 C424(0.14); C519(0.60); C250(0.96)  LDD0586  [35]
 LDCM0270  AC15 HCT 116 C424(0.58); C519(0.64); C250(0.88)  LDD0587  [35]
 LDCM0271  AC150 HCT 116 C424(0.83); C519(0.89); C250(1.03)  LDD0588  [35]
 LDCM0272  AC151 HCT 116 C250(1.08); C424(1.19); C519(1.56)  LDD0589  [35]
 LDCM0273  AC152 HCT 116 C424(0.11); C519(0.67); C250(0.69)  LDD0590  [35]
 LDCM0274  AC153 HCT 116 C424(0.13); C519(0.58); C250(1.04)  LDD0591  [35]
 LDCM0621  AC154 HCT 116 C250(0.77); C424(0.17); C519(0.74)  LDD2158  [35]
 LDCM0622  AC155 HCT 116 C250(0.90); C424(0.18); C519(0.71)  LDD2159  [35]
 LDCM0623  AC156 HCT 116 C250(1.04); C424(0.82); C519(0.89)  LDD2160  [35]
 LDCM0624  AC157 HCT 116 C250(1.01); C424(0.80); C519(0.79)  LDD2161  [35]
 LDCM0276  AC17 HCT 116 C424(0.74); C250(1.02); C519(1.15)  LDD0593  [35]
 LDCM0277  AC18 HCT 116 C519(0.35); C424(0.46); C250(0.72)  LDD0594  [35]
 LDCM0278  AC19 HCT 116 C424(0.59); C250(0.95); C519(1.04)  LDD0595  [35]
 LDCM0279  AC2 HCT 116 C250(1.16)  LDD0596  [35]
 LDCM0280  AC20 HCT 116 C424(0.82); C250(1.04); C519(1.08)  LDD0597  [35]
 LDCM0281  AC21 HCT 116 C424(0.65); C250(0.93); C519(0.96)  LDD0598  [35]
 LDCM0282  AC22 HCT 116 C424(0.91); C250(0.97); C519(1.11)  LDD0599  [35]
 LDCM0283  AC23 HCT 116 C424(0.75); C250(0.88); C519(1.15)  LDD0600  [35]
 LDCM0284  AC24 HCT 116 C424(0.81); C250(1.09); C519(1.45)  LDD0601  [35]
 LDCM0285  AC25 HCT 116 C250(1.14)  LDD0602  [35]
 LDCM0286  AC26 HCT 116 C250(0.91)  LDD0603  [35]
 LDCM0287  AC27 HCT 116 C250(1.09)  LDD0604  [35]
 LDCM0288  AC28 HCT 116 C250(1.00)  LDD0605  [35]
 LDCM0289  AC29 HCT 116 C250(1.09)  LDD0606  [35]
 LDCM0290  AC3 HCT 116 C250(1.07)  LDD0607  [35]
 LDCM0291  AC30 HCT 116 C250(1.13)  LDD0608  [35]
 LDCM0292  AC31 HCT 116 C250(1.06)  LDD0609  [35]
 LDCM0293  AC32 HCT 116 C250(0.84)  LDD0610  [35]
 LDCM0294  AC33 HCT 116 C250(0.77)  LDD0611  [35]
 LDCM0295  AC34 HCT 116 C250(0.74)  LDD0612  [35]
 LDCM0296  AC35 PaTu 8988t C250(0.93)  LDD1175  [35]
 LDCM0297  AC36 PaTu 8988t C250(0.86)  LDD1176  [35]
 LDCM0298  AC37 PaTu 8988t C250(0.70)  LDD1177  [35]
 LDCM0299  AC38 PaTu 8988t C250(0.64)  LDD1178  [35]
 LDCM0300  AC39 PaTu 8988t C250(0.95)  LDD1179  [35]
 LDCM0301  AC4 HCT 116 C250(1.08)  LDD0618  [35]
 LDCM0302  AC40 PaTu 8988t C250(0.39)  LDD1181  [35]
 LDCM0303  AC41 PaTu 8988t C250(0.82)  LDD1182  [35]
 LDCM0304  AC42 PaTu 8988t C250(1.08)  LDD1183  [35]
 LDCM0305  AC43 PaTu 8988t C250(1.00)  LDD1184  [35]
 LDCM0306  AC44 PaTu 8988t C250(0.39)  LDD1185  [35]
 LDCM0307  AC45 PaTu 8988t C250(1.03)  LDD1186  [35]
 LDCM0308  AC46 HCT 116 C442(1.27); C424(1.39); C250(1.53)  LDD0625  [35]
 LDCM0309  AC47 HCT 116 C424(0.86); C442(0.99); C250(1.11)  LDD0626  [35]
 LDCM0310  AC48 HCT 116 C442(1.78); C250(2.01); C424(3.43)  LDD0627  [35]
 LDCM0311  AC49 HCT 116 C250(0.49); C442(0.54); C424(0.64)  LDD0628  [35]
 LDCM0312  AC5 HCT 116 C250(1.12)  LDD0629  [35]
 LDCM0313  AC50 HCT 116 C250(0.50); C442(0.59); C424(0.60)  LDD0630  [35]
 LDCM0314  AC51 HCT 116 C250(1.34); C442(2.46); C424(3.07)  LDD0631  [35]
 LDCM0315  AC52 HCT 116 C424(0.96); C442(1.05); C250(1.22)  LDD0632  [35]
 LDCM0316  AC53 HCT 116 C424(0.63); C442(0.65); C250(0.68)  LDD0633  [35]
 LDCM0317  AC54 HCT 116 C442(0.64); C424(0.71); C250(0.75)  LDD0634  [35]
 LDCM0318  AC55 HCT 116 C250(0.52); C424(0.63); C442(0.66)  LDD0635  [35]
 LDCM0319  AC56 HCT 116 C250(0.54); C442(0.59); C424(0.75)  LDD0636  [35]
 LDCM0320  AC57 HCT 116 C424(0.46); C442(0.50); C250(0.70)  LDD0637  [35]
 LDCM0321  AC58 HCT 116 C424(0.54); C442(0.63); C250(0.71)  LDD0638  [35]
 LDCM0322  AC59 HCT 116 C442(0.37); C424(0.43); C250(0.64)  LDD0639  [35]
 LDCM0323  AC6 HCT 116 C424(0.63); C519(0.69); C250(0.90)  LDD0640  [35]
 LDCM0324  AC60 HCT 116 C424(0.68); C442(0.88); C250(0.92)  LDD0641  [35]
 LDCM0325  AC61 HCT 116 C250(1.18); C424(1.34); C442(1.38)  LDD0642  [35]
 LDCM0326  AC62 HCT 116 C442(0.39); C424(0.46); C250(0.60)  LDD0643  [35]
 LDCM0327  AC63 HCT 116 C424(0.56); C442(0.69); C250(0.79)  LDD0644  [35]
 LDCM0328  AC64 HCT 116 C442(0.39); C424(0.44); C250(0.59)  LDD0645  [35]
 LDCM0329  AC65 HCT 116 C442(0.35); C424(0.44); C250(0.66)  LDD0646  [35]
 LDCM0330  AC66 HCT 116 C442(0.51); C424(0.53); C250(0.84)  LDD0647  [35]
 LDCM0331  AC67 HCT 116 C442(0.23); C424(0.37); C250(0.54)  LDD0648  [35]
 LDCM0332  AC68 HCT 116 C424(0.60); C442(0.79); C250(0.90)  LDD0649  [35]
 LDCM0333  AC69 HCT 116 C424(0.47); C442(0.73); C250(0.74)  LDD0650  [35]
 LDCM0334  AC7 HCT 116 C424(0.84); C250(0.89); C519(0.90)  LDD0651  [35]
 LDCM0335  AC70 HCT 116 C250(0.30); C424(0.30); C442(0.44)  LDD0652  [35]
 LDCM0336  AC71 HCT 116 C424(1.13); C442(1.27); C250(1.37)  LDD0653  [35]
 LDCM0337  AC72 HCT 116 C424(0.41); C250(0.58); C442(0.73)  LDD0654  [35]
 LDCM0338  AC73 HCT 116 C250(0.30); C424(0.36); C442(0.59)  LDD0655  [35]
 LDCM0339  AC74 HCT 116 C250(0.35); C424(0.39); C442(0.60)  LDD0656  [35]
 LDCM0340  AC75 HCT 116 C250(0.32); C424(0.44); C442(0.61)  LDD0657  [35]
 LDCM0341  AC76 HCT 116 C424(0.34); C250(0.42); C442(0.62)  LDD0658  [35]
 LDCM0342  AC77 HCT 116 C424(0.32); C250(0.36); C442(0.68)  LDD0659  [35]
 LDCM0343  AC78 HCT 116 C250(1.19); C424(1.45); C442(1.87)  LDD0660  [35]
 LDCM0344  AC79 HCT 116 C424(0.53); C250(0.84); C442(0.92)  LDD0661  [35]
 LDCM0345  AC8 HCT 116 C424(0.66); C519(0.74); C250(0.93)  LDD0662  [35]
 LDCM0346  AC80 HCT 116 C424(0.39); C250(0.43); C442(0.61)  LDD0663  [35]
 LDCM0347  AC81 HCT 116 C424(0.97); C250(1.08); C442(1.34)  LDD0664  [35]
 LDCM0348  AC82 HCT 116 C250(0.42); C424(0.45); C442(0.52)  LDD0665  [35]
 LDCM0349  AC83 HCT 116 C501(0.14); C442(0.25)  LDD0666  [35]
 LDCM0350  AC84 HCT 116 C501(0.15); C442(0.26)  LDD0667  [35]
 LDCM0351  AC85 HCT 116 C501(0.60); C442(0.69)  LDD0668  [35]
 LDCM0352  AC86 HCT 116 C501(0.36); C442(0.61)  LDD0669  [35]
 LDCM0353  AC87 HCT 116 C501(1.25); C442(1.71)  LDD0670  [35]
 LDCM0354  AC88 HCT 116 C501(0.48); C442(0.70)  LDD0671  [35]
 LDCM0355  AC89 HCT 116 C501(0.19); C442(0.41)  LDD0672  [35]
 LDCM0357  AC90 HCT 116 C442(1.29); C501(1.59)  LDD0674  [35]
 LDCM0358  AC91 HCT 116 C501(0.14); C442(0.24)  LDD0675  [35]
 LDCM0359  AC92 HCT 116 C501(0.14); C442(0.25)  LDD0676  [35]
 LDCM0360  AC93 HCT 116 C501(0.36); C442(0.66)  LDD0677  [35]
 LDCM0361  AC94 HCT 116 C501(0.95); C442(1.14)  LDD0678  [35]
 LDCM0362  AC95 HCT 116 C442(1.32); C501(1.58)  LDD0679  [35]
 LDCM0363  AC96 HCT 116 C501(0.33); C442(0.53)  LDD0680  [35]
 LDCM0364  AC97 HCT 116 C501(0.16); C442(0.31)  LDD0681  [35]
 LDCM0365  AC98 HCT 116 C501(0.11); C250(0.46)  LDD0682  [35]
 LDCM0366  AC99 HCT 116 C501(0.65); C250(0.92)  LDD0683  [35]
 LDCM0545  Acetamide MDA-MB-231 C519(0.46)  LDD2138  [6]
 LDCM0248  AKOS034007472 HCT 116 C250(0.94); C424(1.17); C519(1.00)  LDD0565  [35]
 LDCM0356  AKOS034007680 HCT 116 C250(0.86); C424(0.88); C519(1.03)  LDD0673  [35]
 LDCM0275  AKOS034007705 HCT 116 C424(0.20); C519(0.22); C250(0.51)  LDD0592  [35]
 LDCM0498  BS-3668 MDA-MB-231 C501(1.21)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa H143(0.00); C501(0.00); C442(0.00); C424(0.00)  LDD0222  [27]
 LDCM0632  CL-Sc Hep-G2 C250(2.50)  LDD2227  [30]
 LDCM0367  CL1 HCT 116 C250(0.96); C501(1.27)  LDD0684  [35]
 LDCM0368  CL10 HCT 116 C501(0.49); C250(0.72)  LDD0685  [35]
 LDCM0369  CL100 HCT 116 C250(1.05)  LDD0686  [35]
 LDCM0370  CL101 HCT 116 C424(0.45); C519(0.55); C250(0.86)  LDD0687  [35]
 LDCM0371  CL102 HCT 116 C424(0.90); C250(0.96); C519(1.10)  LDD0688  [35]
 LDCM0372  CL103 HCT 116 C424(0.88); C250(0.90); C519(0.92)  LDD0689  [35]
 LDCM0373  CL104 HCT 116 C424(0.84); C519(0.85); C250(0.96)  LDD0690  [35]
 LDCM0374  CL105 HCT 116 C424(0.51); C519(0.65); C250(0.94)  LDD0691  [35]
 LDCM0375  CL106 HCT 116 C424(0.29); C519(0.49); C250(0.73)  LDD0692  [35]
 LDCM0376  CL107 HCT 116 C424(0.25); C519(0.37); C250(0.73)  LDD0693  [35]
 LDCM0377  CL108 HCT 116 C424(0.20); C519(0.28); C250(0.72)  LDD0694  [35]
 LDCM0378  CL109 HCT 116 C424(0.43); C519(0.66); C250(0.89)  LDD0695  [35]
 LDCM0379  CL11 HCT 116 C250(0.50); C501(0.51)  LDD0696  [35]
 LDCM0380  CL110 HCT 116 C424(0.31); C519(0.45); C250(0.71)  LDD0697  [35]
 LDCM0381  CL111 HCT 116 C424(0.63); C519(0.81); C250(0.92)  LDD0698  [35]
 LDCM0382  CL112 HCT 116 C250(0.99)  LDD0699  [35]
 LDCM0383  CL113 HCT 116 C250(0.95)  LDD0700  [35]
 LDCM0384  CL114 HCT 116 C250(0.99)  LDD0701  [35]
 LDCM0385  CL115 HCT 116 C250(0.96)  LDD0702  [35]
 LDCM0386  CL116 HCT 116 C250(1.01)  LDD0703  [35]
 LDCM0387  CL117 PaTu 8988t C250(0.92)  LDD1266  [35]
 LDCM0388  CL118 PaTu 8988t C250(0.50)  LDD1267  [35]
 LDCM0389  CL119 PaTu 8988t C250(0.67)  LDD1268  [35]
 LDCM0390  CL12 HCT 116 C501(0.44); C250(0.56)  LDD0707  [35]
 LDCM0391  CL120 PaTu 8988t C250(0.98)  LDD1270  [35]
 LDCM0392  CL121 HCT 116 C424(0.77); C442(0.96); C250(1.31)  LDD0709  [35]
 LDCM0393  CL122 HCT 116 C250(1.06); C442(1.08); C424(1.26)  LDD0710  [35]
 LDCM0394  CL123 HCT 116 C250(0.55); C424(0.60); C442(0.69)  LDD0711  [35]
 LDCM0395  CL124 HCT 116 C250(0.46); C442(0.60); C424(0.60)  LDD0712  [35]
 LDCM0396  CL125 HCT 116 C424(0.77); C250(0.95); C442(1.04)  LDD0713  [35]
 LDCM0397  CL126 HCT 116 C424(0.68); C442(0.78); C250(0.93)  LDD0714  [35]
 LDCM0398  CL127 HCT 116 C424(0.76); C442(1.02); C250(1.10)  LDD0715  [35]
 LDCM0399  CL128 HCT 116 C424(0.36); C250(0.57); C442(0.66)  LDD0716  [35]
 LDCM0400  CL13 HCT 116 C501(0.61); C250(0.89)  LDD0717  [35]
 LDCM0401  CL14 HCT 116 C250(0.94); C501(1.06)  LDD0718  [35]
 LDCM0402  CL15 HCT 116 C250(0.81); C501(0.89)  LDD0719  [35]
 LDCM0403  CL16 HCT 116 C442(0.55); C424(0.68); C250(0.68)  LDD0720  [35]
 LDCM0404  CL17 HCT 116 C442(0.68); C424(0.88); C250(0.94)  LDD0721  [35]
 LDCM0405  CL18 HCT 116 C442(1.00); C250(1.13); C424(1.52)  LDD0722  [35]
 LDCM0406  CL19 HCT 116 C442(0.88); C424(0.89); C250(0.94)  LDD0723  [35]
 LDCM0407  CL2 HCT 116 C250(0.87); C501(2.54)  LDD0724  [35]
 LDCM0408  CL20 HCT 116 C424(0.36); C250(0.41); C442(0.51)  LDD0725  [35]
 LDCM0409  CL21 HCT 116 C250(0.35); C424(0.35); C442(0.41)  LDD0726  [35]
 LDCM0410  CL22 HCT 116 C250(0.31); C424(0.34); C442(0.43)  LDD0727  [35]
 LDCM0411  CL23 HCT 116 C424(0.37); C250(0.54); C442(0.58)  LDD0728  [35]
 LDCM0412  CL24 HCT 116 C250(0.33); C424(0.36); C442(0.50)  LDD0729  [35]
 LDCM0413  CL25 HCT 116 C250(0.33); C424(0.33); C442(0.47)  LDD0730  [35]
 LDCM0414  CL26 HCT 116 C250(0.64); C424(0.45); C442(0.51)  LDD0731  [35]
 LDCM0415  CL27 HCT 116 C250(0.68); C424(0.45); C442(0.78)  LDD0732  [35]
 LDCM0416  CL28 HCT 116 C250(0.58); C424(0.46); C442(0.60)  LDD0733  [35]
 LDCM0417  CL29 HCT 116 C250(0.47); C424(0.43); C442(0.56)  LDD0734  [35]
 LDCM0418  CL3 HCT 116 C501(0.80); C250(0.98)  LDD0735  [35]
 LDCM0419  CL30 HCT 116 C250(0.67); C424(0.76); C442(0.69)  LDD0736  [35]
 LDCM0420  CL31 HCT 116 C250(0.57); C519(0.50)  LDD0737  [35]
 LDCM0421  CL32 HCT 116 C250(0.72); C519(0.52)  LDD0738  [35]
 LDCM0422  CL33 HCT 116 C250(0.58); C519(0.46)  LDD0739  [35]
 LDCM0423  CL34 HCT 116 C250(0.31); C519(0.38)  LDD0740  [35]
 LDCM0424  CL35 HCT 116 C250(0.27); C519(0.38)  LDD0741  [35]
 LDCM0425  CL36 HCT 116 C250(0.30); C519(0.44)  LDD0742  [35]
 LDCM0426  CL37 HCT 116 C250(0.19); C519(0.37)  LDD0743  [35]
 LDCM0428  CL39 HCT 116 C250(0.25); C519(0.39)  LDD0745  [35]
 LDCM0429  CL4 HCT 116 C501(0.84); C250(0.84)  LDD0746  [35]
 LDCM0430  CL40 HCT 116 C250(0.35); C519(0.40)  LDD0747  [35]
 LDCM0431  CL41 HCT 116 C250(0.35); C519(0.40)  LDD0748  [35]
 LDCM0432  CL42 HCT 116 C250(0.23); C519(0.31)  LDD0749  [35]
 LDCM0433  CL43 HCT 116 C250(0.23); C519(0.39)  LDD0750  [35]
 LDCM0434  CL44 HCT 116 C250(0.57); C519(0.40)  LDD0751  [35]
 LDCM0435  CL45 HCT 116 C250(0.27); C519(0.39)  LDD0752  [35]
 LDCM0436  CL46 HCT 116 C250(1.09)  LDD0753  [35]
 LDCM0437  CL47 HCT 116 C250(1.25)  LDD0754  [35]
 LDCM0438  CL48 HCT 116 C250(1.04)  LDD0755  [35]
 LDCM0439  CL49 HCT 116 C250(0.94)  LDD0756  [35]
 LDCM0440  CL5 HCT 116 C501(0.87); C250(0.85)  LDD0757  [35]
 LDCM0441  CL50 HCT 116 C250(0.94)  LDD0758  [35]
 LDCM0442  CL51 HCT 116 C250(1.01)  LDD0759  [35]
 LDCM0443  CL52 HCT 116 C250(1.03)  LDD0760  [35]
 LDCM0444  CL53 HCT 116 C250(1.01)  LDD0761  [35]
 LDCM0445  CL54 HCT 116 C250(1.01)  LDD0762  [35]
 LDCM0446  CL55 HCT 116 C250(1.11)  LDD0763  [35]
 LDCM0447  CL56 HCT 116 C250(1.05)  LDD0764  [35]
 LDCM0448  CL57 HCT 116 C250(1.09)  LDD0765  [35]
 LDCM0449  CL58 HCT 116 C250(1.06)  LDD0766  [35]
 LDCM0450  CL59 HCT 116 C250(0.95)  LDD0767  [35]
 LDCM0451  CL6 HCT 116 C501(1.21); C250(0.80)  LDD0768  [35]
 LDCM0452  CL60 HCT 116 C250(0.93)  LDD0769  [35]
 LDCM0453  CL61 HCT 116 C250(1.08)  LDD0770  [35]
 LDCM0454  CL62 HCT 116 C250(0.89)  LDD0771  [35]
 LDCM0455  CL63 HCT 116 C250(0.97)  LDD0772  [35]
 LDCM0456  CL64 HCT 116 C250(0.96)  LDD0773  [35]
 LDCM0457  CL65 HCT 116 C250(0.90)  LDD0774  [35]
 LDCM0458  CL66 HCT 116 C250(1.04)  LDD0775  [35]
 LDCM0459  CL67 HCT 116 C250(0.96)  LDD0776  [35]
 LDCM0460  CL68 HCT 116 C250(1.25)  LDD0777  [35]
 LDCM0461  CL69 HCT 116 C250(0.99)  LDD0778  [35]
 LDCM0462  CL7 HCT 116 C501(0.42); C250(0.60)  LDD0779  [35]
 LDCM0463  CL70 HCT 116 C250(0.89)  LDD0780  [35]
 LDCM0464  CL71 HCT 116 C250(1.01)  LDD0781  [35]
 LDCM0465  CL72 HCT 116 C250(1.11)  LDD0782  [35]
 LDCM0466  CL73 HCT 116 C250(0.93)  LDD0783  [35]
 LDCM0467  CL74 HCT 116 C250(1.10)  LDD0784  [35]
 LDCM0469  CL76 HCT 116 C250(1.04); C424(0.88)  LDD0786  [35]
 LDCM0470  CL77 HCT 116 C250(0.77); C424(0.63)  LDD0787  [35]
 LDCM0471  CL78 HCT 116 C250(0.60); C424(0.31)  LDD0788  [35]
 LDCM0472  CL79 HCT 116 C250(0.34); C424(0.14)  LDD0789  [35]
 LDCM0473  CL8 HCT 116 C501(0.34); C250(0.43)  LDD0790  [35]
 LDCM0474  CL80 HCT 116 C250(0.97); C424(1.59)  LDD0791  [35]
 LDCM0475  CL81 HCT 116 C250(0.55); C424(0.23)  LDD0792  [35]
 LDCM0476  CL82 HCT 116 C250(0.22); C424(0.13)  LDD0793  [35]
 LDCM0477  CL83 HCT 116 C250(0.26); C424(0.15)  LDD0794  [35]
 LDCM0478  CL84 HCT 116 C250(0.19); C424(0.14)  LDD0795  [35]
 LDCM0479  CL85 HCT 116 C250(0.56); C424(0.29)  LDD0796  [35]
 LDCM0480  CL86 HCT 116 C250(0.91); C424(0.68)  LDD0797  [35]
 LDCM0481  CL87 HCT 116 C250(0.67); C424(0.25)  LDD0798  [35]
 LDCM0482  CL88 HCT 116 C250(0.25); C424(0.15)  LDD0799  [35]
 LDCM0483  CL89 HCT 116 C250(0.24); C424(0.18)  LDD0800  [35]
 LDCM0484  CL9 HCT 116 C501(0.63); C250(0.78)  LDD0801  [35]
 LDCM0485  CL90 HCT 116 C250(0.69); C424(0.91)  LDD0802  [35]
 LDCM0486  CL91 HCT 116 C250(1.03)  LDD0803  [35]
 LDCM0487  CL92 HCT 116 C250(1.01)  LDD0804  [35]
 LDCM0488  CL93 HCT 116 C250(0.98)  LDD0805  [35]
 LDCM0489  CL94 HCT 116 C250(1.02)  LDD0806  [35]
 LDCM0490  CL95 HCT 116 C250(0.90)  LDD0807  [35]
 LDCM0491  CL96 HCT 116 C250(1.09)  LDD0808  [35]
 LDCM0492  CL97 HCT 116 C250(1.13)  LDD0809  [35]
 LDCM0493  CL98 HCT 116 C250(1.01)  LDD0810  [35]
 LDCM0494  CL99 HCT 116 C250(1.05)  LDD0811  [35]
 LDCM0495  E2913 HEK-293T C519(1.27); C442(1.17); C250(0.99); C424(1.01)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C519(5.17); C501(1.51)  LDD1702  [6]
 LDCM0625  F8 Ramos C519(0.70); C501(0.99); C424(0.87); C250(0.96)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C519(0.64); C501(1.22); C424(0.29); C250(0.84)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C519(0.06); C501(0.13); C424(0.39); C250(0.95)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C519(0.54); C501(1.31); C424(0.34); C250(1.15)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C519(0.87); C501(0.90); C424(0.72); C250(1.15)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C519(0.46); C501(0.54); C424(0.65); C250(1.14)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C519(0.55); C501(0.97); C424(0.24); C250(0.96)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C519(0.82); C501(0.95); C424(0.79); C250(0.73)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C519(0.17); C501(0.76); C424(0.14); C250(1.14)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C519(0.91); C501(0.88); C424(1.25); C250(0.97)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C519(0.61); C501(0.69); C424(1.00); C250(0.74)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C519(1.35); C501(1.16); C424(0.63); C250(1.07)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C519(0.71); C501(0.84); C424(0.60); C250(0.80)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C519(0.41); C501(1.04); C424(0.27); C250(0.88)  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C250(0.95)  LDD0785  [35]
 LDCM0596  Fragment38 Ramos C519(0.95); C501(1.97); C424(0.87); C250(1.02)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C519(0.71); C501(1.98); C424(0.79); C250(0.80)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C250(0.20); C519(0.35)  LDD0744  [35]
 LDCM0610  Fragment52 Ramos C519(0.83); C501(0.87); C424(0.68); C250(1.03)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C519(0.81); C501(0.85); C424(0.57); C250(1.04)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C519(0.34); C501(1.09); C424(0.46); C250(0.71)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C519(0.54); C501(1.33); C424(0.25); C250(0.75)  LDD2188  [37]
 LDCM0120  HHS-0701 DM93 Y341(2.52)  LDD0268  [13]
 LDCM0107  IAA HeLa C501(0.00); H143(0.00); H266(0.00); H305(0.00)  LDD0221  [27]
 LDCM0123  JWB131 DM93 Y134(0.92); Y198(0.89)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y134(1.70); Y198(1.23)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y134(0.67); Y198(0.89)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y134(2.20); Y198(4.29)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y134(1.34); Y198(1.89)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y198(0.25)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y134(0.67); Y198(0.89)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y134(0.77); Y198(1.06)  LDD0292  [12]
 LDCM0022  KB02 HEK-293T C519(0.98); C501(0.92); C442(0.95); C424(1.07)  LDD1492  [36]
 LDCM0023  KB03 Jurkat C519(6.16); C501(12.47)  LDD0209  [11]
 LDCM0024  KB05 G361 C250(2.92); C442(1.32); C501(1.70)  LDD3311  [38]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C519(1.13)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C519(0.67)  LDD2121  [6]
 LDCM0109  NEM HeLa H143(0.00); H209(0.00); H381(0.00); H266(0.00)  LDD0223  [27]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C519(0.44)  LDD2089  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C519(0.99)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C519(1.46); C424(1.09)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C519(0.13)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C519(0.44)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C519(0.90)  LDD2099  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C519(1.19); C424(1.43)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C501(1.70)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C519(1.10); C501(0.93); C424(0.50)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C519(0.35)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C519(1.12)  LDD2111  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C519(0.30)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C519(2.43)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C519(1.02)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C519(0.80); C501(1.18); C424(0.85)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C519(0.74); C501(1.00)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C519(0.87)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C519(1.31)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C519(1.13)  LDD2129  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C519(0.64)  LDD2134  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C519(1.19); C501(1.25)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C519(0.87); C501(1.03)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C519(1.08)  LDD1700  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C519(0.46)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C519(1.06); C424(0.81)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C519(0.89)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C519(3.08); C424(1.67)  LDD2147  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C519(0.23)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C519(0.44)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C519(1.24)  LDD2153  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C250(0.48)  LDD2207  [39]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly [ADP-ribose] polymerase 1 (PARP1) ARTD/PARP family P09874
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
E3 SUMO-protein ligase PIAS1 (PIAS1) PIAS family O75925
Ribonuclease SLFN12 (SLFN12) Schlafen family Q8IYM2
Atlastin-1 (ATL1) GB1/RHD3 GTPase family Q8WXF7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth hormone-inducible transmembrane protein (GHITM) BI1 family Q9H3K2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 20 (ZNF20) Krueppel C2H2-type zinc-finger protein family P17024
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hippocalcin-like protein 1 (HPCAL1) Recoverin family P37235
Transcription elongation factor A protein-like 8 (TCEAL8) TFS-II family Q8IYN2
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
Melanoma-associated antigen C2 (MAGEC2) . Q9UBF1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tyrosine Small molecular drug DB00135
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-(2-naphthyl)-alanine Small molecular drug DB01766
P-benzoyl-l-phenylalanine Small molecular drug DB08371
Resveratrol Small molecular drug DB02709
4-(222-trifluoroethyl)-l-phenylalanine . DB08617
N6-isopentenyl-adenosine-5'-monophosphate . DB07205
Tyrosinal . DB03978

References

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Mass spectrometry data entry: PXD037665
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
25 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
26 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
27 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
28 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
29 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
34 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
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36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840
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