Details of the Target

General Information of Target

Target ID LDTP09615
Target Name Sec1 family domain-containing protein 1 (SCFD1)
Gene Name SCFD1
Gene ID 23256
Synonyms
C14orf163; KIAA0917; STXBP1L2; Sec1 family domain-containing protein 1; SLY1 homolog; Sly1p; Syntaxin-binding protein 1-like 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAATAAAAASIRERQTVALKRMLNFNVPHIKNSTGEPVWKVLIYDRFGQDIISPLL
SVKELRDMGITLHLLLHSDRDPIPDVPAVYFVMPTEENIDRMCQDLRNQLYESYYLNFIS
AISRSKLEDIANAALAASAVTQVAKVFDQYLNFITLEDDMFVLCNQNKELVSYRAINRPD
ITDTEMETVMDTIVDSLFCFFVTLGAVPIIRCSRGTAAEMVAVKLDKKLRENLRDARNSL
FTGDTLGAGQFSFQRPLLVLVDRNIDLATPLHHTWTYQALVHDVLDFHLNRVNLEESSGV
ENSPAGARPKRKNKKSYDLTPVDKFWQKHKGSPFPEVAESVQQELESYRAQEDEVKRLKS
IMGLEGEDEGAISMLSDNTAKLTSAVSSLPELLEKKRLIDLHTNVATAVLEHIKARKLDV
YFEYEEKIMSKTTLDKSLLDIISDPDAGTPEDKMRLFLIYYISTQQAPSEADLEQYKKAL
TDAGCNLNPLQYIKQWKAFTKMASAPASYGSTTTKPMGLLSRVMNTGSQFVMEGVKNLVL
KQQNLPVTRILDNLMEMKSNPETDDYRYFDPKMLRGNDSSVPRNKNPFQEAIVFVVGGGN
YIEYQNLVDYIKGKQGKHILYGCSELFNATQFIKQLSQLGQK
Target Bioclass
Other
Family
STXBP/unc-18/SEC1 family
Subcellular location
Cytoplasm
Function Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi.
Uniprot ID
Q8WVM8
Ensemble ID
ENST00000396629.6
HGNC ID
HGNC:20726

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 Deletion: p.K381TfsTer6 .
CORL88 SNV: p.I413V DBIA    Probe Info 
HCT116 SNV: p.A479T .
HCT15 SNV: p.R522Ter .
HT115 SNV: p.S437Y .
MCC26 SNV: p.Q109Ter DBIA    Probe Info 
MINO SNV: p.N560H .
RKO Deletion: p.R397DfsTer14 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.05  LDD0402  [1]
C-Sul
 Probe Info  		15.57  LDD0066  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
YN-4
 Probe Info  		100.00  LDD0445  [3]
STPyne
 Probe Info  		K126(7.14); K228(3.95); K24(10.00); K395(8.93)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
OPA-S-S-alkyne
 Probe Info  		K572(2.58)  LDD3494  [6]
Probe 1
 Probe Info  		Y48(54.15); Y424(8.70)  LDD3495  [7]
BTD
 Probe Info  		C103(0.79)  LDD2108  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
DBIA
 Probe Info  		C623(0.91)  LDD0078  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C485(0.00); C623(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C485(0.00); C623(0.00); C164(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C485(0.00); C623(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
NHS
 Probe Info  		K395(0.00); K436(0.00)  LDD0010  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
1c-yne
 Probe Info  		K541(0.00); K501(0.00)  LDD0228  [16]
W1
 Probe Info  		C485(0.00); C623(0.00)  LDD0236  [5]
NAIA_5
 Probe Info  		C485(0.00); C623(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		17.75  LDD1793  [17]
FFF probe13
 Probe Info  		13.15  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe2
 Probe Info  		15.27  LDD0463  [18]
FFF probe3
 Probe Info  		9.66  LDD0465  [18]
JN0003
 Probe Info  		16.60  LDD0469  [18]
STS-2
 Probe Info  		1.00  LDD0139  [19]
OEA-DA
 Probe Info  		3.22  LDD0046  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C103(0.55)  LDD2142  [8]
 LDCM0214  AC1 HCT 116 C623(0.99)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C485(0.57)  LDD0532  [10]
 LDCM0216  AC100 PaTu 8988t C623(0.58); C485(0.88)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C623(0.64); C485(0.90)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C623(0.36); C485(1.24)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C623(0.63); C485(0.85)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C623(0.44); C485(1.13)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C623(0.50); C485(1.20)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C623(0.56); C485(0.96)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C623(0.67); C485(0.86)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C623(0.52); C485(0.91)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C623(0.35); C485(0.95)  LDD1104  [10]
 LDCM0226  AC11 HCT 116 C485(0.55)  LDD0543  [10]
 LDCM0227  AC110 PaTu 8988t C623(0.40); C485(0.72)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C623(0.39); C485(0.84)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C623(0.52); C485(0.99)  LDD1108  [10]
 LDCM0230  AC113 HCT 116 C485(1.08); C623(0.87)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C485(0.80); C623(0.86)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C485(0.70); C623(0.84)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C485(0.69); C623(0.74)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C485(0.75); C623(0.80)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C485(0.90); C623(0.93)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C485(0.93); C623(0.74)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C485(0.72)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C485(0.89); C623(1.09)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C485(1.02); C623(1.36)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C485(0.85); C623(0.81)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C485(0.88); C623(1.32)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C485(0.84); C623(1.01)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C485(0.80); C623(1.07)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C485(0.60); C623(1.09)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C485(0.71); C623(0.99)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C623(1.38)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C623(1.22)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C623(1.03)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C623(1.38)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C623(1.11)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C623(1.24)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C623(1.31)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C623(1.09)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C623(1.19)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C623(1.32)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C623(1.47)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C623(1.02)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C485(0.55)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C623(1.15)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C623(1.43)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C623(1.18)  LDD0579  [10]
 LDCM0263  AC143 PaTu 8988t C623(0.70); C485(0.60)  LDD1142  [10]
 LDCM0264  AC144 PaTu 8988t C623(0.66); C485(0.74)  LDD1143  [10]
 LDCM0265  AC145 PaTu 8988t C623(0.66); C485(0.68)  LDD1144  [10]
 LDCM0266  AC146 PaTu 8988t C623(0.82); C485(0.74)  LDD1145  [10]
 LDCM0267  AC147 PaTu 8988t C623(0.67); C485(0.64)  LDD1146  [10]
 LDCM0268  AC148 PaTu 8988t C623(0.62); C485(0.61)  LDD1147  [10]
 LDCM0269  AC149 PaTu 8988t C623(0.62); C485(0.62)  LDD1148  [10]
 LDCM0270  AC15 HCT 116 C485(0.53)  LDD0587  [10]
 LDCM0271  AC150 PaTu 8988t C623(0.71); C485(0.82)  LDD1150  [10]
 LDCM0272  AC151 PaTu 8988t C623(0.63); C485(0.62)  LDD1151  [10]
 LDCM0273  AC152 PaTu 8988t C623(0.56); C485(0.67)  LDD1152  [10]
 LDCM0274  AC153 PaTu 8988t C623(0.64); C485(0.62)  LDD1153  [10]
 LDCM0621  AC154 PaTu 8988t C623(0.60); C485(0.71)  LDD2166  [10]
 LDCM0622  AC155 PaTu 8988t C623(0.60); C485(0.76)  LDD2167  [10]
 LDCM0623  AC156 PaTu 8988t C623(0.53); C485(0.72)  LDD2168  [10]
 LDCM0624  AC157 PaTu 8988t C623(0.73); C485(0.96)  LDD2169  [10]
 LDCM0276  AC17 HCT 116 C623(0.70); C485(0.94)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C485(0.62); C623(0.81)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C623(0.70); C485(0.76)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C623(0.96)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C485(0.90); C623(0.96)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C485(0.73); C623(0.77)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C623(0.85); C485(1.00)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C623(0.65); C485(0.81)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C623(0.77); C485(1.00)  LDD0601  [10]
 LDCM0285  AC25 HEK-293T C623(1.32)  LDD0883  [10]
 LDCM0286  AC26 HEK-293T C623(1.49)  LDD0884  [10]
 LDCM0287  AC27 HEK-293T C623(1.45)  LDD0885  [10]
 LDCM0288  AC28 HEK-293T C623(1.24)  LDD0886  [10]
 LDCM0289  AC29 HEK-293T C623(1.48)  LDD0887  [10]
 LDCM0290  AC3 HCT 116 C623(0.97)  LDD0607  [10]
 LDCM0291  AC30 HEK-293T C623(1.68)  LDD0889  [10]
 LDCM0292  AC31 HEK-293T C623(2.36)  LDD0890  [10]
 LDCM0293  AC32 HEK-293T C623(1.68)  LDD0891  [10]
 LDCM0294  AC33 HEK-293T C623(1.86)  LDD0892  [10]
 LDCM0295  AC34 HEK-293T C623(1.88)  LDD0893  [10]
 LDCM0296  AC35 PaTu 8988t C485(0.69)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C485(0.53)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C485(0.54)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C485(0.48)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C485(0.49)  LDD1179  [10]
 LDCM0301  AC4 HCT 116 C623(1.18)  LDD0618  [10]
 LDCM0302  AC40 PaTu 8988t C485(0.39)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C485(0.66)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C485(0.55)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C485(0.64)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C485(0.44)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C485(0.52)  LDD1186  [10]
 LDCM0308  AC46 HCT 116 C623(0.80)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C623(0.74)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C623(0.82)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C623(0.95)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C623(1.05)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C623(0.85)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C623(0.88)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C623(0.80)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C623(0.90)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C623(1.01)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C623(1.01)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C623(0.88)  LDD0636  [10]
 LDCM0320  AC57 PaTu 8988t C485(0.91)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C485(1.21)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C485(1.18)  LDD1201  [10]
 LDCM0323  AC6 HCT 116 C485(0.56)  LDD0640  [10]
 LDCM0324  AC60 PaTu 8988t C485(1.17)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C485(1.22)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C485(1.03)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C485(0.98)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C485(0.95)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C485(1.34)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C485(1.24)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C485(1.09)  LDD1210  [10]
 LDCM0332  AC68 HCT 116 C623(0.67)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C623(0.77)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C485(0.70)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C623(0.64)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C623(0.86)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C623(0.75)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C623(0.82)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C623(0.81)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C623(0.89)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C623(0.73)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C623(0.61)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C623(0.86)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C623(0.97)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C485(0.66)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C623(0.87)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C623(0.96)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C623(0.76)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C623(0.81)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C623(0.78)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C623(0.66)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C623(0.90)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C623(1.03)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C623(1.05)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C623(0.78)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C623(0.80)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C623(0.76)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C623(0.81)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C623(0.77)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C623(0.66)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C623(0.88)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C623(0.68)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C623(0.60)  LDD0681  [10]
 LDCM0365  AC98 PaTu 8988t C623(0.34); C485(0.92)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C623(0.54); C485(1.16)  LDD1245  [10]
 LDCM0248  AKOS034007472 HCT 116 C485(0.86)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C485(0.67)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C485(0.39)  LDD0592  [10]
 LDCM0020  ARS-1620 HCC44 C623(0.91)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C485(2.48)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C485(1.10)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C485(0.54)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C623(0.85)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C485(0.53)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C485(0.75)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C485(0.82)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C485(0.77)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C623(0.64); C485(0.65)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C485(0.50); C623(0.54)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C485(0.57); C623(0.69)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C485(0.58); C623(0.70)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C623(0.63); C485(0.65)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C485(0.52)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C623(0.54); C485(0.57)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C623(0.53); C485(0.71)  LDD0698  [10]
 LDCM0382  CL112 HEK-293T C623(1.52)  LDD0980  [10]
 LDCM0383  CL113 HEK-293T C623(1.65)  LDD0981  [10]
 LDCM0384  CL114 HEK-293T C623(1.74)  LDD0982  [10]
 LDCM0385  CL115 HEK-293T C623(1.39)  LDD0983  [10]
 LDCM0386  CL116 HEK-293T C623(1.59)  LDD0984  [10]
 LDCM0387  CL117 PaTu 8988t C485(0.67)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C485(0.70)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C485(0.56)  LDD1268  [10]
 LDCM0390  CL12 HCT 116 C485(0.48)  LDD0707  [10]
 LDCM0391  CL120 PaTu 8988t C485(0.61)  LDD1270  [10]
 LDCM0392  CL121 HCT 116 C623(0.95)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C623(1.01)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C623(0.87)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C623(0.92)  LDD0712  [10]
 LDCM0396  CL125 PaTu 8988t C485(1.19)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C485(1.20)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C485(1.25)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C485(1.03)  LDD1278  [10]
 LDCM0400  CL13 HCT 116 C485(0.52)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C485(0.71)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C485(0.52)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C485(0.77)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C485(0.59)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C485(0.50)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C485(0.54)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C485(0.94)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C485(0.54)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C485(0.44)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C485(0.54)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C485(0.55)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C485(0.52)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C485(0.50)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C485(0.58)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C485(0.62)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C485(0.52)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C485(0.53)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C485(0.65)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C485(0.66)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C485(0.87); C623(0.83)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C485(0.67); C623(0.57)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C485(0.57); C623(0.58)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C485(0.59); C623(0.66)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C485(0.53); C623(0.69)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C485(0.68); C623(0.69)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C485(0.52); C623(0.65)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C485(0.58); C623(0.68)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C485(0.74)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C485(0.59); C623(0.61)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C485(0.64); C623(0.71)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C485(0.58); C623(0.84)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C485(0.61); C623(0.67)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C485(0.65); C623(0.69)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C485(0.65); C623(0.65)  LDD0752  [10]
 LDCM0436  CL46 PaTu 8988t C623(0.72); C485(0.83)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C623(0.54); C485(0.76)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C623(0.52); C485(0.64)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C623(0.67); C485(0.66)  LDD1318  [10]
 LDCM0440  CL5 HCT 116 C485(0.67)  LDD0757  [10]
 LDCM0441  CL50 PaTu 8988t C623(0.34); C485(0.56)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C623(0.46); C485(0.70)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C623(0.49); C485(0.64)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C623(0.36); C485(0.48)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C623(0.36); C485(0.68)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C623(0.37); C485(0.58)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C623(0.11); C485(0.47)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C623(0.40); C485(0.57)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C623(0.39); C485(0.56)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C623(0.35); C485(0.53)  LDD1329  [10]
 LDCM0451  CL6 HCT 116 C485(0.58)  LDD0768  [10]
 LDCM0452  CL60 PaTu 8988t C623(0.30); C485(0.55)  LDD1331  [10]
 LDCM0453  CL61 PaTu 8988t C485(0.84)  LDD1332  [10]
 LDCM0454  CL62 PaTu 8988t C485(0.83)  LDD1333  [10]
 LDCM0455  CL63 PaTu 8988t C485(0.82)  LDD1334  [10]
 LDCM0456  CL64 PaTu 8988t C485(0.74)  LDD1335  [10]
 LDCM0457  CL65 PaTu 8988t C485(0.83)  LDD1336  [10]
 LDCM0458  CL66 PaTu 8988t C485(0.74)  LDD1337  [10]
 LDCM0459  CL67 PaTu 8988t C485(0.64)  LDD1338  [10]
 LDCM0460  CL68 PaTu 8988t C485(0.62)  LDD1339  [10]
 LDCM0461  CL69 PaTu 8988t C485(0.53)  LDD1340  [10]
 LDCM0462  CL7 HCT 116 C485(0.57)  LDD0779  [10]
 LDCM0463  CL70 PaTu 8988t C485(0.66)  LDD1342  [10]
 LDCM0464  CL71 PaTu 8988t C485(0.96)  LDD1343  [10]
 LDCM0465  CL72 PaTu 8988t C485(1.13)  LDD1344  [10]
 LDCM0466  CL73 PaTu 8988t C485(0.59)  LDD1345  [10]
 LDCM0467  CL74 PaTu 8988t C485(0.73)  LDD1346  [10]
 LDCM0469  CL76 HCT 116 C623(0.62)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C623(1.18)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C623(0.82)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C623(0.70)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C485(0.52)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C623(0.93)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C623(0.74)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C623(0.60)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C623(0.79)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C623(0.69)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C623(0.70)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C623(0.92)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C623(0.75)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C623(0.72)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C623(0.84)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C485(0.72)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C623(1.25)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C623(0.95)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C623(0.91)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C623(0.94)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C623(1.00)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C623(0.90)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C623(0.98)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C623(1.04)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C623(0.86)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C623(0.88)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C623(1.06); C485(0.93); C164(1.13)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C485(1.53)  LDD1702  [8]
 LDCM0468  Fragment33 PaTu 8988t C485(0.67)  LDD1347  [10]
 LDCM0427  Fragment51 HCT 116 C485(0.53); C623(0.69)  LDD0744  [10]
 LDCM0022  KB02 HEK-293T C623(1.00); C485(1.04); C164(1.08)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C623(1.05); C485(1.08); C164(1.13)  LDD1497  [21]
 LDCM0024  KB05 HMCB C485(8.35); C623(4.08)  LDD3312  [22]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C103(0.79)  LDD2108  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C103(0.48)  LDD2114  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840