Details of the Target

General Information of Target

Target ID LDTP12141
Target Name Guanine nucleotide-binding protein subunit beta-4 (GNB4)
Gene Name GNB4
Gene ID 59345
Synonyms
Guanine nucleotide-binding protein subunit beta-4; Transducin beta chain 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAQCCCRQAPGAEAAPVRPPPEPPPALDVASASSAQLFRLRHLQLGLELRPEARELAGC
LVLELCALRPAPRALVLDAHPALRLHSAAFRRAPAAAAETPCAFAFSAPGPGPAPPPPLP
AFPEAPGSEPACCPLAFRVDPFTDYGSSLTVTLPPELQAHQPFQVILRYTSTDAPAIWWL
DPELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVVKAPSGVQVLMSATRSAYM
EEEGVFHFHMEHPVPAYLVALVAGDLKPADIGPRSRVWAEPCLLPTATSKLSGAVEQWLS
AAERLYGPYMWGRYDIVFLPPSFPIVAMENPCLTFIISSILESDEFLVIDVIHEVAHSWF
GNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLETAFRLDALHRQMKLLGEDSPV
SKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDFLRAYVEKYKFTSVVA
QDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLTRPVEALFQLW
TAEPLDQAAASASAIDISKWRTFQTALFLDRLLDGSPLPQEVVMSLSKCYSSLLDSMNAE
IRIRWLQIVVRNDYYPDLHRVRRFLESQMSRMYTIPLYEDLCTGALKSFALEVFYQTQGR
LHPNLRRAIQQILSQGLGSSTEPASEPSTELGKAEADTDSDAQALLLGDEAPSSAISLRD
VNVSA
Target Bioclass
Other
Family
WD repeat G protein beta family
Function
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot ID
Q9HAV0
Ensemble ID
ENST00000232564.8
HGNC ID
HGNC:20731

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.97  LDD0402  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
BTD
 Probe Info  		C204(2.10)  LDD1700  [3]
DBIA
 Probe Info  		C148(6.77); C149(6.77); C204(2.38)  LDD0080  [4]
IA-alkyne
 Probe Info  		C148(0.00); C294(0.00); C204(0.00); C271(0.00)  LDD0032  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		C25(0.00); C294(0.00)  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		C204(0.00); C148(0.00)  LDD0147  [6]
YN-1
 Probe Info  		N.A.  LDD0447  [2]
Acrolein
 Probe Info  		C25(0.00); C204(0.00); C317(0.00)  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		8.00  LDD0443  [9]
MPP-AC
 Probe Info  		N.A.  LDD0428  [10]
TER-AC
 Probe Info  		N.A.  LDD0426  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C204(1.43)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C148(0.78); C149(0.78)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C148(0.66); C149(0.66)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C148(0.61); C149(0.61)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C148(0.81); C149(0.81)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C148(1.02); C149(1.02)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C148(0.92); C149(0.92)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C148(0.95); C149(0.95)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C148(0.83); C149(0.83)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C148(0.65); C149(0.65)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C148(0.84); C149(0.84)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C148(0.61); C149(0.61)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C148(0.86); C149(0.86)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C148(0.58); C149(0.58)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C148(0.75); C149(0.75)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C148(0.56); C149(0.56)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C148(0.70); C149(0.70)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C148(1.06); C149(1.06)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C148(0.97); C149(0.98)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C148(1.01); C149(1.00)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C148(1.04); C149(1.11)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C148(1.20); C149(0.93)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C148(1.09); C149(1.03)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C148(0.92); C149(1.13)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C148(1.08); C149(1.08)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C148(0.90); C149(1.01)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C148(1.01); C149(1.10)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C148(0.88); C149(1.29)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C148(1.04); C149(0.89)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C148(1.00); C149(0.95)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C148(0.93); C149(1.25)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C148(1.03); C149(1.17)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C148(1.06); C149(1.08)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C148(0.90); C149(0.90)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C148(0.91); C149(0.91)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C148(0.83); C149(0.83)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C148(1.09); C149(1.09)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C148(0.77); C149(0.77)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C148(1.04); C149(1.04)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C148(0.88); C149(0.88)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C148(0.78); C149(0.78)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C148(0.80); C149(0.80)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C148(0.89); C149(0.89)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C148(0.71); C149(0.71)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C148(0.67); C149(0.67)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C148(0.85); C149(0.85)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C148(0.73); C149(0.73)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C148(0.60); C149(0.60)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C148(0.86); C149(0.86)  LDD0579  [4]
 LDCM0263  AC143 HEK-293T C148(1.09); C149(1.09)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C148(1.11); C149(1.07)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C148(1.10); C149(0.97)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C148(1.27); C149(1.15)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C148(1.29); C149(1.10)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C148(1.26); C149(1.20)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C148(1.07); C149(0.96)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C148(0.86); C149(0.86)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C148(1.03); C149(1.00)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C148(1.05); C149(1.03)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C148(0.98); C149(0.99)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C148(1.05); C149(1.00)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C148(1.08); C149(1.21)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C148(1.21); C149(1.39)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C148(1.32); C149(1.18)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C148(1.37); C149(1.12)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C148(0.92); C149(0.98)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C148(1.04); C149(1.02)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C148(0.81); C149(0.87)  LDD0876  [4]
 LDCM0279  AC2 HCT 116 C148(0.83); C149(0.83)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C148(0.82); C149(0.91)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C148(0.85); C149(0.81)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C148(0.73); C149(0.84)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C148(0.81); C149(0.86)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C148(0.83); C149(0.95)  LDD0882  [4]
 LDCM0285  AC25 HCT 116 C148(0.95); C149(0.95)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C148(0.85); C149(0.85)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C148(1.10); C149(1.10)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C148(0.86); C149(0.86)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C148(0.96); C149(0.96)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C148(0.88); C149(0.88)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C148(0.90); C149(0.90)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C148(0.85); C149(0.85)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C148(0.80); C149(0.80)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C148(1.10); C149(1.10)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C148(1.57); C149(1.57)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C148(1.28); C149(1.28)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C148(1.10); C149(1.10)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C148(1.14); C149(1.14)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C148(0.96); C149(0.96)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C148(0.98); C149(0.98)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C148(0.75); C149(0.75)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C148(1.04); C149(1.04)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C148(0.77); C149(0.77)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C148(0.83); C149(0.83)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C148(0.50); C149(0.50)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C148(0.95); C149(0.95)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C148(0.90); C149(0.90)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C148(0.76); C149(0.76)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C148(0.57); C149(0.57)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C148(0.68); C149(0.68)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C148(0.68); C149(0.68)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C148(0.74); C149(0.74)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C148(0.52); C149(0.52)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C148(0.72); C149(0.72)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C148(0.62); C149(0.62)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C148(0.53); C149(0.53)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C148(0.65); C149(0.65)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C148(0.71); C149(0.71)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C148(0.58); C149(0.58)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C148(0.91); C149(0.91)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C148(0.98); C149(0.98)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C148(0.83); C149(0.83)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C148(0.94); C149(0.94)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C148(0.97); C149(0.97)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C148(0.84); C149(0.84)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C148(0.80); C149(0.80)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C148(0.92); C149(0.92)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C148(0.84); C149(0.84)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C148(0.89); C149(0.89)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C148(0.72); C149(0.72)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C148(0.97); C149(0.97)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C148(1.66); C149(1.66)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C148(1.49); C149(1.49)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C148(1.00); C149(1.00)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C148(1.29); C149(1.29)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C148(1.30); C149(1.30)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C148(1.23); C149(1.23)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C148(1.29); C149(1.29)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C148(1.58); C149(1.58)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C148(1.10); C149(1.10)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C148(1.55); C149(1.55)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C148(1.17); C149(1.17)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C148(1.35); C149(1.35)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C148(1.26); C149(1.26)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C148(0.86); C149(0.86)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C148(1.48); C149(1.48)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C148(2.08); C149(2.08)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C148(1.77); C149(1.77)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C148(1.10); C149(1.10)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C148(1.27); C149(1.27)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C148(1.08); C149(1.08)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C148(1.05); C149(1.05)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C148(1.04); C149(1.04)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C148(1.06); C149(1.06)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C148(1.11); C149(1.11)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C148(0.84); C149(0.84)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C148(1.09); C149(1.09)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C148(0.97); C149(0.97)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C148(1.27); C149(1.27)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C148(0.97); C149(0.97)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C148(0.97); C149(0.97)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C148(1.09); C149(1.09)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C148(0.96); C149(0.96)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C148(0.64); C149(0.64)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C148(0.71); C149(0.71)  LDD0683  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C204(0.79)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C148(0.70); C149(0.70)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C148(0.73); C149(0.73)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C148(0.79); C149(0.79)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 10.27  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C25(0.00); C204(0.00); C317(0.00); H91(0.00)  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C148(1.09); C149(1.09)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C148(1.03); C149(1.03)  LDD0966  [4]
 LDCM0369  CL100 HCT 116 C148(0.63); C149(0.63)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C148(0.90); C149(0.90)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C148(1.20); C149(1.20)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C148(0.65); C149(0.65)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C148(0.85); C149(0.85)  LDD0690  [4]
 LDCM0374  CL105 HEK-293T C148(0.80); C149(0.90)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C148(0.79); C149(0.87)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C148(0.92); C149(0.94)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C148(0.98); C149(1.11)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C148(0.82); C149(0.91)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C148(1.21); C149(1.21)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C148(1.19); C149(1.23)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C148(0.95); C149(0.98)  LDD0979  [4]
 LDCM0382  CL112 HCT 116 C148(1.03); C149(1.03)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C148(0.88); C149(0.88)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C148(1.19); C149(1.19)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C148(1.12); C149(1.12)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C148(1.22); C149(1.22)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C148(0.86); C149(0.86)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C148(0.86); C149(0.86)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C148(0.59); C149(0.59)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C148(1.10); C149(1.10)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C148(0.64); C149(0.64)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C148(0.81); C149(0.81)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C148(1.01); C149(1.01)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C148(1.27); C149(1.27)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C148(0.68); C149(0.68)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C148(0.76); C149(0.76)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C148(0.88); C149(0.88)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C148(0.84); C149(0.84)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C148(0.87); C149(0.87)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C148(1.10); C149(1.10)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C148(1.03); C149(1.03)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C148(1.16); C149(1.16)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C148(1.02); C149(1.04)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C148(1.18); C149(0.88)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C148(1.14); C149(0.91)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C148(1.01); C149(0.97)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C148(1.21); C149(1.21)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C148(1.09); C149(0.81)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C148(1.48); C149(1.17)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C148(1.25); C149(0.97)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C148(1.44); C149(1.10)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C148(1.04); C149(0.99)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C148(1.22); C149(0.85)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C148(1.23); C149(1.02)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C148(1.05); C149(0.93)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C148(1.20); C149(1.07)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C148(1.19); C149(1.00)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C148(0.77); C149(0.77)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C148(1.38); C149(1.10)  LDD1017  [4]
 LDCM0420  CL31 HCT 116 C148(1.17); C149(1.17)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C148(0.95); C149(0.95)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C148(0.79); C149(0.79)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C148(0.82); C149(0.82)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C148(1.19); C149(1.19)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C148(1.07); C149(1.07)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C148(1.31); C149(1.31)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C148(0.91); C149(0.91)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C148(0.88); C149(0.88)  LDD1027  [4]
 LDCM0430  CL40 HCT 116 C148(1.35); C149(1.35)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C148(0.83); C149(0.83)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C148(0.77); C149(0.77)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C148(0.73); C149(0.73)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C148(0.93); C149(0.93)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C148(0.97); C149(0.97)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C148(0.92); C149(0.92)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C148(0.94); C149(0.94)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C148(0.87); C149(0.87)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C148(0.89); C149(0.89)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C148(1.00); C149(1.00)  LDD1038  [4]
 LDCM0441  CL50 HCT 116 C148(0.83); C149(0.83)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C148(0.93); C149(0.93)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C148(1.09); C149(1.09)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C148(0.84); C149(0.84)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C148(0.90); C149(0.90)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C148(0.94); C149(0.94)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C148(0.91); C149(0.91)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C148(0.92); C149(0.92)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C148(0.91); C149(0.91)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C148(0.97); C149(0.97)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C148(0.97); C149(0.97)  LDD1049  [4]
 LDCM0452  CL60 HCT 116 C148(0.97); C149(0.97)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C148(0.93); C149(1.24)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C148(0.86); C149(1.22)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C148(0.97); C149(1.23)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C148(0.87); C149(1.30)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C148(1.15); C149(1.31)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C148(0.77); C149(1.00)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C148(1.32); C149(1.17)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C148(1.46); C149(1.19)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C148(1.02); C149(1.03)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C148(0.73); C149(0.73)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C148(1.41); C149(1.32)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C148(1.03); C149(1.04)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C148(0.89); C149(0.93)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C148(1.26); C149(1.13)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C148(1.14); C149(1.09)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C148(1.45); C149(1.45)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C148(0.79); C149(0.79)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C148(1.09); C149(1.09)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C148(1.17); C149(1.17)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C148(0.88); C149(2.27)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C148(1.13); C149(1.13)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C148(1.35); C149(1.35)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C148(1.20); C149(1.20)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C148(1.30); C149(1.30)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C148(1.32); C149(1.32)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C148(1.48); C149(1.48)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C148(1.27); C149(1.27)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C148(1.27); C149(1.27)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C148(0.99); C149(0.99)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C148(1.12); C149(1.12)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C148(0.99); C149(1.07)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C148(0.89); C149(0.89)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C148(0.74); C149(0.74)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C148(0.92); C149(0.92)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C148(0.80); C149(0.80)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C148(0.81); C149(0.81)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C148(0.90); C149(0.90)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C148(0.86); C149(0.86)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C148(0.89); C149(0.89)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C148(0.66); C149(0.66)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C148(0.58); C149(0.58)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C204(0.90); C271(0.94); C294(0.94); C25(1.13)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C204(1.84)  LDD1702  [3]
 LDCM0625  F8 Ramos C204(0.92); C25(0.87); C218(0.86)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C204(1.03); C25(0.66); C218(1.51)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C204(0.26); C25(0.56); C218(0.97)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C204(1.44); C25(1.07); C218(1.12)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C204(1.08); C25(0.99); C218(0.75)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C204(1.42); C25(0.85); C218(0.53)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C204(1.00); C25(0.81); C218(1.11)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C204(1.09); C25(1.03); C218(0.83)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C204(1.06); C25(1.33); C218(0.87)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C204(0.89); C25(1.19); C218(0.83)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C204(0.87); C25(1.53); C218(0.86)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C204(1.26); C25(1.09); C218(0.85)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C204(0.94); C25(1.13); C218(0.72)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C204(1.03); C25(0.88); C218(1.00)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C148(1.01); C149(1.05)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C204(1.34); C25(1.10); C218(0.65)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C204(1.46); C25(0.93); C218(1.48)  LDD2184  [14]
 LDCM0427  Fragment51 HCT 116 C148(1.42); C149(1.42)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C204(1.42); C25(0.93); C218(0.73)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C204(1.24); C25(0.95); C218(0.54)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C204(1.06); C25(0.80); C218(2.05)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C204(1.05); C25(0.65); C218(1.19)  LDD2188  [14]
 LDCM0107  IAA HeLa C25(0.00); C204(0.00)  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C148(6.77); C149(6.77); C204(2.38)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C148(8.76); C149(8.76); C204(1.99)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C148(5.59); C149(5.59); C204(2.57)  LDD0082  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C148(0.98)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C204(1.23)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C25(0.33)  LDD2096  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C204(1.53)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C25(0.64)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C204(1.16)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C25(0.45)  LDD2104  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C149(2.18)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C204(1.31)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C204(0.90)  LDD2109  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C149(0.85); C148(1.36)  LDD2110  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C204(1.08)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C204(0.74)  LDD2115  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C148(0.29)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C25(0.69)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C204(2.64)  LDD2119  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C25(0.40)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C204(1.21)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C25(0.40)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C204(0.99)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C25(0.58)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C204(1.53)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C148(0.78)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C204(1.42)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C204(1.13)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C25(1.53)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C204(1.33)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C204(1.33)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C204(1.35)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C204(2.10)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C204(0.98)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C204(2.24); C25(0.96)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C204(0.76)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C204(0.99)  LDD2146  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C25(0.48)  LDD2149  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C25(0.36)  LDD2151  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578