Details of the Target

General Information of Target

Target ID LDTP09769
Target Name Zinc transporter SLC39A7 (SLC39A7)
Gene Name SLC39A7
Gene ID 7922
Synonyms
HKE4; RING5; Zinc transporter SLC39A7; Histidine-rich membrane protein Ke4; Really interesting new gene 5 protein; Solute carrier family 39 member 7; Zrt-, Irt-like protein 7; ZIP7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCK
LDVDAPRLLKKIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPEN
EDWTCFEQSASLDIKSFFGFESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPR
WSPPSITTSSETSSSSSKKQAASMAVVIPEAALKEGLSGDALSSPSAPEPVVGTPDDKLD
ADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILRFLRARDFNIDKAREIMCQ
SLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGE
EALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEV
VEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDK
EIIPDFLSGECMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILI
QIVDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQ
LGRDYSMVESPLICKEGESVQGSHVTRWPGFYILQWKFHSMPACAASSLPRVDDVLASLQ
VSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAATTSSSQSHSSSMISR
Target Bioclass
Transporter and channel
Family
ZIP transporter (TC 2.A.5) family, KE4/Catsup subfamily
Subcellular location
Endoplasmic reticulum membrane
Function
Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. Has a protective role against ER stress in different biological contexts. Mediates Zn(2+)-induced ferroptosis.
Uniprot ID
Q92504
Ensemble ID
ENST00000374675.7
HGNC ID
HGNC:4927

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
TH211
 Probe Info  		Y320(15.35)  LDD0260  [2]
C-Sul
 Probe Info  		7.06  LDD0066  [3]
YN-4
 Probe Info  		100.00  LDD0445  [4]
STPyne
 Probe Info  		K310(0.13)  LDD0277  [5]
ONAyne
 Probe Info  		K310(6.03)  LDD0275  [5]
HPAP
 Probe Info  		3.83  LDD0063  [6]
DBIA
 Probe Info  		C375(1.01)  LDD1507  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		6.02  LDD1761  [11]
C376
 Probe Info  		6.92  LDD2036  [11]
C378
 Probe Info  		6.28  LDD2037  [11]
C382
 Probe Info  		12.73  LDD2041  [11]
A-DA
 Probe Info  		2.32  LDD0142  [12]
LD-F
 Probe Info  		D326(0.00); F331(0.00); A328(0.00); A324(0.00)  LDD0015  [13]
OEA-DA
 Probe Info  		13.34  LDD0046  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C375(1.01)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C375(0.89)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C375(0.99)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C375(1.04)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C375(1.02)  LDD1512  [7]
 LDCM0276  AC17 HEK-293T C375(1.06)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C375(0.91)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C375(0.99)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C375(1.03)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C375(0.96)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C375(0.97)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C375(1.04)  LDD1521  [7]
 LDCM0285  AC25 HEK-293T C375(1.18)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C375(0.94)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C375(0.91)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C375(0.97)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C375(1.02)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C375(0.86)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C375(0.95)  LDD1530  [7]
 LDCM0294  AC33 HEK-293T C375(1.07)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C375(1.02)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C375(0.98)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C375(1.04)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C375(0.99)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C375(0.96)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C375(1.04)  LDD1540  [7]
 LDCM0303  AC41 HEK-293T C375(1.12)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C375(0.98)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C375(0.97)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C375(0.92)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C375(1.15)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C375(0.96)  LDD1547  [7]
 LDCM0311  AC49 HEK-293T C375(1.13)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C375(1.07)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C375(0.92)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C375(0.90)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C375(0.96)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C375(1.02)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C375(0.94)  LDD1556  [7]
 LDCM0320  AC57 HEK-293T C375(1.10)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C375(1.00)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C375(0.99)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C375(1.03)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C375(1.12)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C375(1.03)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C375(1.05)  LDD1565  [7]
 LDCM0248  AKOS034007472 HEK-293T C375(1.10)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C375(1.00)  LDD1570  [7]
 LDCM0367  CL1 HEK-293T C375(1.20)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C375(1.14)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C375(0.95)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C375(0.92)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C375(1.07)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C375(0.95)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C375(1.17)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C375(0.97)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C375(0.95)  LDD1582  [7]
 LDCM0380  CL110 HEK-293T C375(1.31)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C375(1.07)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C375(0.93)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C375(1.08)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C375(1.11)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C375(0.95)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C375(1.07)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C375(1.00)  LDD1593  [7]
 LDCM0392  CL121 HEK-293T C375(0.92)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C375(0.83)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C375(1.03)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C375(1.32)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C375(1.20)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C375(1.00)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C375(1.13)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C375(0.86)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C375(1.19)  LDD1606  [7]
 LDCM0404  CL17 HEK-293T C375(1.26)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C375(1.07)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C375(1.10)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C375(1.19)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C375(1.10)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C375(1.08)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C375(1.10)  LDD1614  [7]
 LDCM0413  CL25 HEK-293T C375(1.22)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C375(1.00)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C375(0.93)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C375(1.00)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C375(1.18)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C375(0.93)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C375(1.12)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C375(1.15)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C375(1.09)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C375(1.18)  LDD1627  [7]
 LDCM0426  CL37 HEK-293T C375(0.97)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C375(1.04)  LDD1632  [7]
 LDCM0431  CL41 HEK-293T C375(0.68)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C375(0.89)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C375(1.08)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C375(0.96)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C375(1.12)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C375(0.99)  LDD1640  [7]
 LDCM0439  CL49 HEK-293T C375(1.06)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C375(0.99)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C375(1.31)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C375(1.05)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C375(1.15)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C375(1.06)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C375(1.11)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C375(1.21)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C375(1.16)  LDD1652  [7]
 LDCM0451  CL6 HEK-293T C375(0.99)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C375(1.04)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C375(0.98)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C375(0.96)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C375(1.00)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C375(0.89)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C375(1.00)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C375(1.15)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C375(1.08)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C375(1.21)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C375(1.10)  LDD1666  [7]
 LDCM0466  CL73 HEK-293T C375(1.08)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C375(1.17)  LDD1670  [7]
 LDCM0470  CL77 HEK-293T C375(1.11)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C375(0.97)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C375(1.07)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C375(1.82)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C375(1.01)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C375(0.99)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C375(1.08)  LDD1679  [7]
 LDCM0479  CL85 HEK-293T C375(1.52)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C375(1.01)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C375(1.12)  LDD1684  [7]
 LDCM0483  CL89 HEK-293T C375(1.09)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C375(1.14)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C375(0.87)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C375(1.03)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C375(1.13)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C375(1.16)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C375(1.03)  LDD1692  [7]
 LDCM0492  CL97 HEK-293T C375(1.06)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C375(0.82)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C375(1.04)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C375(1.16)  LDD1698  [7]
 LDCM0082  FK866 A-549 2.32  LDD0142  [12]
 LDCM0468  Fragment33 HEK-293T C375(1.02)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C375(1.29)  LDD1631  [7]
 LDCM0014  Panhematin K562 3.83  LDD0063  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Potassium voltage-gated channel subfamily F member 1 (KCNF1) Potassium channel family Q9H3M0
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Late cornified envelope-like proline-rich protein 1 (LELP1) Cornifin (SPRR) family Q5T871
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 5-7 (KRTAP5-7) KRTAP type 5 family Q6L8G8
Keratin-associated protein 9-2 (KRTAP9-2) KRTAP type 9 family Q9BYQ4
Late cornified envelope protein 1A (LCE1A) LCE family Q5T7P2
Late cornified envelope protein 1C (LCE1C) LCE family Q5T751
Late cornified envelope protein 1F (LCE1F) LCE family Q5T754
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81
Late cornified envelope protein 2D (LCE2D) LCE family Q5TA82
Late cornified envelope protein 4A (LCE4A) LCE family Q5TA78
Late cornified envelope protein 5A (LCE5A) LCE family Q5TCM9
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Protein sprouty homolog 3 (SPRY3) Sprouty family O43610
Bcl-2-interacting killer (BIK) . Q13323
Cysteine-rich C-terminal protein 1 (CRCT1) . Q9UGL9
Regulator of G-protein signaling 17 (RGS17) . Q9UGC6
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901
WAP four-disulfide core domain protein 12 (WFDC12) . Q8WWY7

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
13 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
14 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570