Details of the Target

General Information of Target

Target ID LDTP02553
Target Name Glycogen phosphorylase, muscle form (PYGM)
Gene Name PYGM
Gene ID 5837
Synonyms
Glycogen phosphorylase, muscle form; EC 2.4.1.1; Myophosphorylase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKISGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGHVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRILVDLERM
DWDKAWDVTVRTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEVIAERIGEDFISDLDQLRKLLSFVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDIQVKRIHEYKRQLLNCLHVITLYNRIKREPNKFFV
PRTVMIGGKAAPGYHMAKMIIRLVTAIGDVVNHDPAVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
KLDQRGYNAQEYYDRIPELRQVIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYED
YIKCQEKVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
AI
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Glycogen phosphorylase family
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
TTD ID
T98062
Uniprot ID
P11217
DrugMap ID
TT31JXP
Ensemble ID
ENST00000164139.4
HGNC ID
HGNC:9726
ChEMBL ID
CHEMBL3526

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.H615N DBIA    Probe Info 
HCT116 SNV: p.Y375H .
HT SNV: p.Y156H .
KMCH1 SNV: p.K364Ter .
LS123 SNV: p.E77D; p.G318A DBIA    Probe Info 
LS180 SNV: p.R520H DBIA    Probe Info 
PF382 SNV: p.S789G .
RL952 SNV: p.R70H .
SW1783 SNV: p.V323M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-4
 Probe Info  		100.00  LDD0445  [1]
DBIA
 Probe Info  		C373(1.55)  LDD3310  [2]
AHL-Pu-1
 Probe Info  		C319(2.74); C143(3.49)  LDD0170  [3]
HHS-475
 Probe Info  		Y614(0.83); Y298(0.99); Y186(1.51)  LDD0264  [4]
HHS-465
 Probe Info  		Y186(10.00); Y281(10.00); Y574(10.00); Y614(9.33)  LDD2237  [5]
NAIA_4
 Probe Info  		C109(0.00); C373(0.00)  LDD2226  [6]
YN-1
 Probe Info  		N.A.  LDD0447  [1]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [7]
STS-2
 Probe Info  		N.A.  LDD0139  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C319(2.74); C143(3.49)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C319(4.24)  LDD0171  [3]
 LDCM0116  HHS-0101 DM93 Y614(0.83); Y298(0.99); Y186(1.51)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y186(0.80); Y614(0.80); Y298(0.88)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y614(0.70); Y298(0.72); Y186(1.13)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y614(0.78); Y298(0.82); Y186(0.87)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y614(0.46); Y298(0.55); Y186(0.68)  LDD0268  [4]
 LDCM0022  KB02 42-MG-BA C373(1.58)  LDD2244  [2]
 LDCM0023  KB03 769-P C373(1.54)  LDD2663  [2]
 LDCM0024  KB05 COLO792 C373(1.55)  LDD3310  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Glycogen phosphorylase, brain form (PYGB) Glycogen phosphorylase family P11216
Glycogen phosphorylase, liver form (PYGL) Glycogen phosphorylase family P06737
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyridoxal Phosphate Small molecular drug DB00114
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ursolic Acid Small molecular drug D07LUJ
Investigative
Click To Hide/Show 82 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-d-glucopyranosyl Cytosine Small molecular drug D02AFI
1-d-glucopyranosyl Uracil Small molecular drug D0P1XH
1-deoxy-1-methoxycarbamido-beta-d-glucopyranose Small molecular drug D0J6KJ
1-deoxy-1-methoxycarbamido-beta-d-glucopyranose Small molecular drug DB03657
1-n-acetyl-beta-d-glucosamine Small molecular drug D0I9PG
2-deoxy-glucose-6-phosphate Small molecular drug D0U8RR
2-hydroxyiminoolean-12-en-28-oic Acid Small molecular drug D0J3YD
2-hydroxyiminours-12-en-28-oic Acid Small molecular drug D0G9FQ
2-isooleanolic Acid Small molecular drug D08ZIA
2-isoursolic Acid Small molecular drug D05LDI
2-oxoolean-12-en-28-oic Acid Small molecular drug D07ZJM
23-hydroxybetulinic Acid Small molecular drug D06YDW
2alpha-hydroxyolean-12-en-28-oic Acid Small molecular drug D0X5YM
2alpha-hydroxyurs-12-en-28-oic Acid Small molecular drug D0KS6A
2beta,3alpha-dihydroxyolean-12-en-28-oic Acid Small molecular drug D0N2SM
2beta,3alpha-dihydroxyurs-12-en-28-oic Acid Small molecular drug D0BU6J
3alpha-hydroxyurs-12-en-28-oic Acid Small molecular drug D07MTU
4-{2-[(3-nitrobenzoyl)Amino]Phenoxy}Phthalic Acid Small molecular drug D0E4SM
Acurea Small molecular drug D0Q7SP
Alpha-d-glucopyranosyl-2-carboxylic Acid Amide Small molecular drug D03WQK
Alpha-d-glucopyranosyl-2-carboxylic Acid Amide Small molecular drug DB02720
Alpha-d-glucose 6-phosphate Small molecular drug DB02007
Alpha-d-glucose-1-phosphate Small molecular drug D0S5WE
Alpha-d-glucose-1-phosphate Small molecular drug DB02843
Alpha-d-glucose-6-phosphate Small molecular drug D01AWD
Alvocidib Small molecular drug DB03496
Asiatic Acid Small molecular drug D0LC7K
Benzyl 2-hydroxyiminoolean-12-en-28-oate Small molecular drug D09NIM
Beta-d-glucopyranose Spirohydantoin Small molecular drug D05WSU
Beta-d-glucose Small molecular drug D07ONX
Betulin Small molecular drug D05KJY
C-(1-hydrogyl-beta-d-glucopyranosyl) Formamide Small molecular drug D03DUN
C-(1-hydrogyl-beta-d-glucopyranosyl) Formamide Small molecular drug DB02719
Cp-320626 Small molecular drug DB03383
Dexfosfoserine Small molecular drug DB04522
Ethyl 2beta-hydroxyolean-12-en-28-oate Small molecular drug D08VUO
Fluoro-phosphite Ion Small molecular drug D05DGE
Heptulose-2-phosphate Small molecular drug D0T9CW
Indirubin-5-sulfonate Small molecular drug D0G2CT
Inosinic Acid Small molecular drug D0H2YT
L-serine-o-phosphate Small molecular drug D07PZQ
Monofluorophosphate Ion Small molecular drug DB02348
N'-pyridoxyl-lysine-5'-monophosphate Small molecular drug D0I5PZ
N-(Benzoylcarbamoyl)-beta-d-glucopyranosylamine Small molecular drug DB04295
N-acetyl-n'-beta-d-glucopyranosyl Urea Small molecular drug D03EDR
N-acetyl-n'-beta-d-glucopyranosyl Urea Small molecular drug DB03218
N-benzoyl-n'-beta-d-glucopyranosyl Urea Small molecular drug D0X7IZ
N-beta-d-glucopyranosylacetamide Small molecular drug DB02320
N-butyl 2beta-hydroxyolean-12-en-28-oate Small molecular drug D00ASL
Nojirimycine Tetrazole Small molecular drug D0E2BH
Oleanolic_acid Small molecular drug D0SJ2Q
Oleanonic Acid Small molecular drug D02KKU
(2s)-n-[(3s)-1-(2-amino-2-oxoethyl)-2-oxo-1234-tetrahydroquinolin-3-yl]-2-chloro-2h-thieno[23-b]Pyrrole-5-carboxamide . DB07793
(345-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-phosphoramidic Acid Dimethyl Ester . DB03392
(3r4r5r)-5-(Hydroxymethyl)-1-(3-phenylpropyl)Piperidine-34-diol . DB07807
(3s5r7r8s9s10r)-7-(Hydroxymethyl)-3-(2-naphthyl)-16-dioxa-2-azaspiro[4.5]Decane-8910-triol . DB08500
(3s5r7r8s9s10r)-7-(Hydroxymethyl)-3-(4-methylphenyl)-16-dioxa-2-azaspiro[4.5]Decane-8910-triol . DB08503
(5r7r8s9s10r)-7-(Hydroxymethyl)-3-phenyl-16-dioxa-2-azaspiro[4.5]Dec-2-ene-8910-triol . DB08151
(5s7r8s9s10r)-3-amino-8910-trihydroxy-7-(Hydroxymethyl)-6-oxa-13-diazaspiro[4.5]Decane-24-dione . DB01843
(S)-2-chloro-n-(1-(2-(2-hydroxyethylamino)-2-oxoethyl)-2-oxo-1234-tetrahydroquinolin-3-yl)-6h-thieno[23-b]Pyrrole-5-carboxamide . DB07792
({[(3e)-2'-oxo-2'7'-dihydro-23'-biindol-3(7h)-ylidene]Amino}Oxy)Acetic Acid . DB07949
1-deoxy-1-acetylamino-beta-d-gluco-2-heptulopyranosonamide . DB04544
1-deoxy-1-methoxycarbamido-beta-d-gluco-2-heptulopyranosonamide . DB04013
2-(Beta-d-glucopyranosyl)-5-methyl-123-benzimidazole . DB03133
2-(Beta-d-glucopyranosyl)-5-methyl-134-benzothiazole . DB03250
2-(Beta-d-glucopyranosyl)-5-methyl-134-oxadiazole . DB03354
2-chloro-n-[(1r2r)-1-hydroxy-23-dihydro-1h-inden-2-yl]-6h-thieno[23-b]Pyrrole-5-carboxamide . DB06986
2-chloro-n-[(3r)-2-oxo-1234-tetrahydroquinolin-3-yl]-6h-thieno[23-b]Pyrrole-5-carboxamide . DB07066
2-deoxy-34-bis-o-[3-(4-hydroxyphenyl)Propanoyl]-l-threo-pentaric Acid . DB08322
23-dicarboxy-4-(2-chloro-phenyl)-1-ethyl-5-isopropoxycarbonyl-6-methyl-pyridinium . DB04055
38910-tetrahydroxy-7-hydroxymethyl-6-oxa-13-diaza-spiro[4.5]Decane-24-dione . DB02447
4-{24-bis[(3-nitrobenzoyl)Amino]Phenoxy}Phthalic Acid . DB03067
4-{3-chloro-4-[3-(24-dichloro-benzoyl)-ureido]-phenoxy}-butyric Acid . DB04643
4-{4-[3-(24-dichloro-benzoyl)-ureido]-23-dimethyl-phenoxy}-butyric Acid . DB04644
5-{3-[3-(24-dichloro-benzoyl)-ureido]-2-methyl-phenoxy}-pentanoic Acid . DB04645
7-{26-dichloro-4-[3-(2-chloro-benzoyl)-ureido]-phenoxy}-heptanoic Acid . DB04642
8910-trihydroxy-7-hydroxymethyl-2-thioxo-6-oxa-13-diaza-spiro[4.5]Decan-4-one . DB02964
8910-trihydroxy-7-hydroxymethyl-3-methyl-6-oxa-13-diaza-spiro[4.5]Decane-24-dione . DB03479
C-(1-azido-alpha-d-glucopyranosyl) Formamide . D0W8RS
Indirubin-5-sulphonate . DB02519
N(6)-(Pyridoxal Phosphate)-l-lysine . DB04083
N-[(5s7r8s9s10r)-8910-trihydroxy-7-(Hydroxymethyl)-24-dioxo-6-oxa-13-diazaspiro[4.5]Dec-3-yl]Acetamide . DB03835
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Jtt-651 . D09HAL

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.