Details of the Target

General Information of Target

Target ID LDTP05985
Target Name Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)
Gene Name SPTAN1
Gene ID 6709
Synonyms
NEAS; SPTA2; Spectrin alpha chain, non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWI
QEKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI
RTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQD
LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRL
KGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGL
ERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDS
YRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSA
DESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVD
NWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA
MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEA
YKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW
KKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH
ALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL
ADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRI
KAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN
EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQV
APTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAY
VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELG
EKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDL
KANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVH
TVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDN
YGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQA
WSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLER
HQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMM
LDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEK
IAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV
DEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERG
ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEAL
LASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRD
TINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ
NLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAA
ARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT
VHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQ
FNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALK
DQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKA
SAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSF
RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQW
IQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDN
KYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKS
GRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRET
ENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAF
DYVEFTRSLFVN
Target Bioclass
Other
Family
Spectrin family
Subcellular location
Cytoplasm, cytoskeleton
Function Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Uniprot ID
Q13813
Ensemble ID
ENST00000358161.9
HGNC ID
HGNC:11273

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
CY4
 Probe Info  		100.00  LDD0244  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
TH216
 Probe Info  		Y2423(20.00)  LDD0259  [2]
YN-4
 Probe Info  		100.00  LDD0445  [3]
ONAyne
 Probe Info  		K296(0.00); K2251(0.00); K1274(0.00)  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K1193(0.43); K2000(0.55); K1838(0.73); K1432(0.77)  LDD3494  [5]
Probe 1
 Probe Info  		Y44(261.77); Y361(112.19); Y539(9.40); Y1792(11.60)  LDD3495  [6]
DBIA
 Probe Info  		C1935(0.87); C956(1.43); C1444(1.14)  LDD3310  [7]
JZ128-DTB
 Probe Info  		C1622(0.00); C2441(0.00)  LDD0462  [8]
BTD
 Probe Info  		C1622(3.29); C956(2.56)  LDD1700  [9]
HHS-482
 Probe Info  		Y1020(0.86); Y2423(0.82)  LDD0285  [10]
HHS-475
 Probe Info  		Y1261(0.71); Y976(0.83); Y1020(0.87); Y2423(0.89)  LDD0264  [11]
5E-2FA
 Probe Info  		H1408(0.00); H574(0.00); H2444(0.00); H413(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K637(0.00); K1784(0.00); K613(0.00); K719(0.00)  LDD0199  [13]
m-APA
 Probe Info  		H1408(0.00); H574(0.00); H413(0.00); H730(0.00)  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C315(0.00); C2120(0.00); C1314(0.00); C1454(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C956(0.00); C2120(0.00); C1930(0.00); C1314(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		C2441(0.00); C1622(0.00); C1314(0.00); C315(0.00)  LDD0030  [16]
IPIAA_L
 Probe Info  		C2441(0.00); C1930(0.00); C1622(0.00); C956(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C315(0.00); C2120(0.00); C1314(0.00); C1454(0.00)  LDD0037  [14]
TFBX
 Probe Info  		C2441(0.00); C1622(0.00)  LDD0027  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [18]
1d-yne
 Probe Info  		K1110(0.00); K2099(0.00); K1246(0.00); K909(0.00)  LDD0356  [19]
Compound 10
 Probe Info  		N.A.  LDD2216  [20]
Compound 11
 Probe Info  		N.A.  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [18]
IPM
 Probe Info  		C315(0.00); C1314(0.00)  LDD0005  [18]
NHS
 Probe Info  		K718(0.00); K2088(0.00); K1963(0.00); K2421(0.00)  LDD0010  [18]
NPM
 Probe Info  		N.A.  LDD0016  [18]
SF
 Probe Info  		K825(0.00); Y361(0.00); K2426(0.00); Y2423(0.00)  LDD0028  [21]
STPyne
 Probe Info  		K1659(0.00); K1588(0.00); K637(0.00)  LDD0009  [18]
VSF
 Probe Info  		C1314(0.00); C956(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C1444(0.00); C956(0.00); C1622(0.00)  LDD0018  [22]
Ox-W18
 Probe Info  		W1248(0.00); W1779(0.00); W799(0.00); W2220(0.00)  LDD2175  [23]
1c-yne
 Probe Info  		K637(0.00); K770(0.00); K1546(0.00); K909(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H1710(0.00); C2441(0.00); H432(0.00); C315(0.00)  LDD0217  [24]
Crotonaldehyde
 Probe Info  		C1622(0.00); H1303(0.00); H559(0.00); H2133(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C2441(0.00); C1622(0.00); C1930(0.00); C956(0.00)  LDD0218  [24]
W1
 Probe Info  		C1930(0.00); C1622(0.00); C315(0.00); C956(0.00)  LDD0236  [25]
NAIA_5
 Probe Info  		C2120(0.00); C1622(0.00); C956(0.00); C1444(0.00)  LDD2223  [26]
TPP-AC
 Probe Info  		N.A.  LDD0427  [27]
HHS-465
 Probe Info  		K1022(0.00); K2426(0.00); Y1020(0.00); Y2423(0.00)  LDD2240  [28]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C391
 Probe Info  		12.55  LDD2050  [29]
FFF probe11
 Probe Info  		8.83  LDD0471  [30]
FFF probe13
 Probe Info  		14.24  LDD0475  [30]
FFF probe14
 Probe Info  		20.00  LDD0477  [30]
FFF probe2
 Probe Info  		9.64  LDD0463  [30]
FFF probe3
 Probe Info  		5.34  LDD0464  [30]
FFF probe4
 Probe Info  		6.87  LDD0466  [30]
STS-1
 Probe Info  		N.A.  LDD0136  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
Photonaproxen
 Probe Info  		N.A.  LDD0157  [32]
DA-2
 Probe Info  		N.A.  LDD0071  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C315(0.46); C1622(0.40); C956(0.35)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C315(0.80); C1622(0.71); C956(0.60); C1314(0.89)  LDD2112  [9]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C315(0.48); C1622(0.40)  LDD2095  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C315(1.25); C1622(1.07); C1930(1.24); C1314(1.31)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C315(2.03); C1622(1.96); C956(1.80)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1622(0.96)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1622(0.49)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1622(0.98)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C956(20.00)  LDD0371  [34]
 LDCM0026  4SU-RNA+native RNA HEK-293T C956(5.21)  LDD0372  [34]
 LDCM0214  AC1 HEK-293T C956(0.98); C1622(1.04); C2120(0.96); C1930(1.03)  LDD1507  [35]
 LDCM0215  AC10 HEK-293T C956(0.99); C1622(0.99); C1454(1.01); C2120(0.99)  LDD1508  [35]
 LDCM0226  AC11 HEK-293T C956(1.00); C1622(1.01); C1454(0.95); C2120(0.96)  LDD1509  [35]
 LDCM0237  AC12 HEK-293T C956(0.99); C1622(1.00); C1454(0.96); C2120(0.90)  LDD1510  [35]
 LDCM0259  AC14 HEK-293T C956(0.99); C1622(0.97); C2120(0.99); C1930(1.00)  LDD1512  [35]
 LDCM0270  AC15 HEK-293T C956(1.03); C1622(0.94); C2120(1.01); C1930(0.96)  LDD1513  [35]
 LDCM0276  AC17 HEK-293T C956(0.95); C1622(1.04); C2120(0.93); C1930(0.92)  LDD1515  [35]
 LDCM0277  AC18 HEK-293T C956(0.98); C1622(1.00); C1454(1.00); C2120(0.96)  LDD1516  [35]
 LDCM0278  AC19 HEK-293T C956(0.83); C1622(0.88); C1454(0.99); C2120(0.89)  LDD1517  [35]
 LDCM0279  AC2 HEK-293T C956(1.06); C1622(0.96); C1454(0.96); C2120(0.93)  LDD1518  [35]
 LDCM0280  AC20 HEK-293T C956(0.96); C1622(1.06); C1454(0.95); C2120(0.98)  LDD1519  [35]
 LDCM0281  AC21 HEK-293T C956(1.03); C1622(0.92); C1454(0.94); C2120(1.04)  LDD1520  [35]
 LDCM0282  AC22 HEK-293T C956(0.99); C1622(1.02); C2120(0.97); C1930(0.91)  LDD1521  [35]
 LDCM0283  AC23 HEK-293T C956(1.00); C1622(1.07); C2120(0.95); C1930(0.94)  LDD1522  [35]
 LDCM0284  AC24 HEK-293T C956(0.95); C1622(0.99); C1454(0.92); C2120(0.96)  LDD1523  [35]
 LDCM0285  AC25 HEK-293T C956(0.98); C1622(1.15); C2120(0.99); C1930(0.93)  LDD1524  [35]
 LDCM0286  AC26 HEK-293T C956(1.01); C1622(0.94); C1454(0.93); C2120(1.01)  LDD1525  [35]
 LDCM0287  AC27 HEK-293T C956(1.01); C1622(0.99); C1454(1.10); C2120(0.98)  LDD1526  [35]
 LDCM0288  AC28 HEK-293T C956(1.00); C1622(1.01); C1454(1.01); C2120(0.98)  LDD1527  [35]
 LDCM0289  AC29 HEK-293T C956(0.99); C1622(1.02); C1454(0.91); C2120(1.15)  LDD1528  [35]
 LDCM0290  AC3 HEK-293T C956(0.96); C1622(0.98); C1454(0.89); C2120(0.91)  LDD1529  [35]
 LDCM0291  AC30 HEK-293T C956(1.00); C1622(1.07); C2120(0.98); C1930(1.00)  LDD1530  [35]
 LDCM0292  AC31 HEK-293T C956(1.02); C1622(1.11); C2120(1.04); C1930(1.01)  LDD1531  [35]
 LDCM0293  AC32 HEK-293T C956(0.95); C1622(0.98); C1454(1.19); C2120(0.96)  LDD1532  [35]
 LDCM0294  AC33 HEK-293T C956(0.92); C1622(1.03); C2120(0.85); C1930(0.95)  LDD1533  [35]
 LDCM0295  AC34 HEK-293T C956(0.99); C1622(0.95); C1454(1.05); C2120(0.91)  LDD1534  [35]
 LDCM0296  AC35 HEK-293T C956(0.97); C1622(1.03); C1454(0.90); C2120(0.92)  LDD1535  [35]
 LDCM0297  AC36 HEK-293T C956(0.95); C1622(1.00); C1454(0.99); C2120(0.86)  LDD1536  [35]
 LDCM0298  AC37 HEK-293T C956(1.07); C1622(0.99); C1454(0.99); C2120(0.96)  LDD1537  [35]
 LDCM0299  AC38 HEK-293T C956(0.96); C1622(0.96); C2120(1.00); C1930(1.00)  LDD1538  [35]
 LDCM0300  AC39 HEK-293T C956(0.96); C1622(0.94); C2120(0.97); C1930(0.96)  LDD1539  [35]
 LDCM0301  AC4 HEK-293T C956(1.06); C1622(1.01); C1454(1.00); C2120(0.95)  LDD1540  [35]
 LDCM0302  AC40 HEK-293T C956(0.92); C1622(0.87); C1454(1.08); C2120(1.01)  LDD1541  [35]
 LDCM0303  AC41 HEK-293T C956(0.98); C1622(0.89); C2120(0.87); C1930(0.96)  LDD1542  [35]
 LDCM0304  AC42 HEK-293T C956(1.02); C1622(0.90); C1454(1.06); C2120(0.95)  LDD1543  [35]
 LDCM0305  AC43 HEK-293T C956(0.99); C1622(0.98); C1454(0.88); C2120(0.93)  LDD1544  [35]
 LDCM0306  AC44 HEK-293T C956(0.99); C1622(0.98); C1454(0.92); C2120(0.90)  LDD1545  [35]
 LDCM0307  AC45 HEK-293T C956(1.03); C1622(0.98); C1454(0.99); C2120(1.07)  LDD1546  [35]
 LDCM0308  AC46 HEK-293T C956(1.03); C1622(0.96); C2120(0.99); C1930(0.94)  LDD1547  [35]
 LDCM0309  AC47 HEK-293T C956(1.02); C1622(0.93); C2120(0.95); C1930(0.95)  LDD1548  [35]
 LDCM0310  AC48 HEK-293T C956(0.93); C1622(1.21); C1454(1.22); C2120(1.01)  LDD1549  [35]
 LDCM0311  AC49 HEK-293T C956(0.95); C1622(0.96); C2120(0.95); C1930(0.97)  LDD1550  [35]
 LDCM0312  AC5 HEK-293T C956(1.05); C1622(0.97); C1454(0.87); C2120(0.94)  LDD1551  [35]
 LDCM0313  AC50 HEK-293T C956(0.94); C1622(0.99); C1454(0.83); C2120(0.92)  LDD1552  [35]
 LDCM0314  AC51 HEK-293T C956(0.99); C1622(0.94); C1454(0.96); C2120(0.95)  LDD1553  [35]
 LDCM0315  AC52 HEK-293T C956(1.03); C1622(0.98); C1454(1.06); C2120(0.94)  LDD1554  [35]
 LDCM0316  AC53 HEK-293T C956(1.01); C1622(0.95); C1454(1.00); C2120(1.04)  LDD1555  [35]
 LDCM0317  AC54 HEK-293T C956(0.96); C1622(0.93); C2120(1.00); C1930(1.00)  LDD1556  [35]
 LDCM0318  AC55 HEK-293T C956(0.96); C1622(0.87); C2120(0.94); C1930(0.97)  LDD1557  [35]
 LDCM0319  AC56 HEK-293T C956(0.96); C1622(0.71); C1454(1.22); C2120(1.06)  LDD1558  [35]
 LDCM0320  AC57 HEK-293T C956(0.95); C1622(0.93); C2120(0.83); C1930(0.98)  LDD1559  [35]
 LDCM0321  AC58 HEK-293T C956(1.01); C1622(0.97); C1454(0.99); C2120(0.92)  LDD1560  [35]
 LDCM0322  AC59 HEK-293T C956(0.96); C1622(1.05); C1454(0.84); C2120(0.89)  LDD1561  [35]
 LDCM0323  AC6 HEK-293T C956(1.04); C1622(0.92); C2120(0.95); C1930(1.00)  LDD1562  [35]
 LDCM0324  AC60 HEK-293T C956(0.98); C1622(0.99); C1454(1.03); C2120(0.90)  LDD1563  [35]
 LDCM0325  AC61 HEK-293T C956(1.02); C1622(0.92); C1454(0.98); C2120(0.95)  LDD1564  [35]
 LDCM0326  AC62 HEK-293T C956(0.92); C1622(0.90); C2120(0.97); C1930(0.99)  LDD1565  [35]
 LDCM0327  AC63 HEK-293T C956(0.95); C1622(0.98); C2120(0.89); C1930(0.97)  LDD1566  [35]
 LDCM0328  AC64 HEK-293T C956(0.95); C1622(0.92); C1454(0.96); C2120(1.00)  LDD1567  [35]
 LDCM0334  AC7 HEK-293T C956(0.96); C1622(0.86); C2120(1.00); C1930(1.03)  LDD1568  [35]
 LDCM0345  AC8 HEK-293T C956(0.99); C1622(0.80); C1454(1.13); C2120(1.01)  LDD1569  [35]
 LDCM0545  Acetamide MDA-MB-231 C1622(0.41); C956(0.39)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C315(0.75); C1622(0.68); C956(0.92); C1930(0.71)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C956(1.01); C1622(0.99); C1454(1.04); C2120(1.05)  LDD1511  [35]
 LDCM0356  AKOS034007680 HEK-293T C956(0.96); C1622(1.05); C2120(0.93); C1930(0.97)  LDD1570  [35]
 LDCM0275  AKOS034007705 HEK-293T C956(0.95); C1622(0.97); C1454(1.22); C2120(1.06)  LDD1514  [35]
 LDCM0498  BS-3668 MDA-MB-231 C1622(0.58); C956(0.42)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa H1516(0.00); C315(0.00); C2441(0.00); H1710(0.00)  LDD0222  [24]
 LDCM0367  CL1 HEK-293T C956(0.90); C1622(0.87); C1454(0.65); C2120(0.84)  LDD1571  [35]
 LDCM0368  CL10 HEK-293T C956(0.80); C1622(0.76); C2120(0.89); C1930(0.70)  LDD1572  [35]
 LDCM0369  CL100 HEK-293T C956(1.01); C1622(0.79); C2120(0.94); C1930(0.93)  LDD1573  [35]
 LDCM0370  CL101 HEK-293T C956(0.93); C1622(0.95); C1454(0.97); C2120(0.95)  LDD1574  [35]
 LDCM0371  CL102 HEK-293T C956(0.97); C1622(0.83); C1930(0.90); C1314(1.00)  LDD1575  [35]
 LDCM0372  CL103 HEK-293T C956(0.96); C1622(1.03); C1454(0.78); C2120(0.94)  LDD1576  [35]
 LDCM0373  CL104 HEK-293T C956(0.99); C1622(0.98); C2120(0.98); C1930(0.92)  LDD1577  [35]
 LDCM0374  CL105 HEK-293T C956(0.89); C1622(0.96); C1454(0.81); C2120(0.94)  LDD1578  [35]
 LDCM0375  CL106 HEK-293T C956(1.00); C1622(0.92); C1930(0.90); C1314(1.04)  LDD1579  [35]
 LDCM0376  CL107 HEK-293T C956(0.97); C1622(0.96); C1454(0.86); C2120(0.95)  LDD1580  [35]
 LDCM0377  CL108 HEK-293T C956(0.98); C1622(0.96); C2120(1.03); C1930(1.03)  LDD1581  [35]
 LDCM0378  CL109 HEK-293T C956(0.95); C1622(0.96); C1454(0.78); C2120(1.01)  LDD1582  [35]
 LDCM0379  CL11 HEK-293T C956(0.96); C1622(0.95); C2120(0.98); C1930(0.84)  LDD1583  [35]
 LDCM0380  CL110 HEK-293T C956(0.88); C1622(0.85); C1930(0.82); C1314(0.94)  LDD1584  [35]
 LDCM0381  CL111 HEK-293T C956(0.96); C1622(1.08); C1454(0.88); C2120(1.01)  LDD1585  [35]
 LDCM0382  CL112 HEK-293T C956(1.03); C1622(0.84); C2120(0.93); C1930(0.39)  LDD1586  [35]
 LDCM0383  CL113 HEK-293T C956(0.90); C1622(0.95); C1454(1.09); C2120(0.95)  LDD1587  [35]
 LDCM0384  CL114 HEK-293T C956(0.97); C1622(0.80); C1930(0.83); C1314(0.95)  LDD1588  [35]
 LDCM0385  CL115 HEK-293T C956(0.98); C1622(1.01); C1454(0.80); C2120(0.89)  LDD1589  [35]
 LDCM0386  CL116 HEK-293T C956(1.07); C1622(0.85); C2120(0.89); C1930(0.92)  LDD1590  [35]
 LDCM0387  CL117 HEK-293T C956(0.93); C1622(0.93); C1454(0.83); C2120(0.95)  LDD1591  [35]
 LDCM0388  CL118 HEK-293T C956(1.01); C1622(0.91); C1930(0.95); C1314(0.98)  LDD1592  [35]
 LDCM0389  CL119 HEK-293T C956(0.93); C1622(1.04); C1454(0.94); C2120(0.96)  LDD1593  [35]
 LDCM0390  CL12 HEK-293T C956(0.94); C1622(1.00); C1454(1.49); C2120(1.02)  LDD1594  [35]
 LDCM0391  CL120 HEK-293T C956(0.96); C1622(0.91); C2120(0.89); C1930(1.07)  LDD1595  [35]
 LDCM0392  CL121 HEK-293T C956(0.91); C1622(0.94); C1454(0.83); C2120(0.96)  LDD1596  [35]
 LDCM0393  CL122 HEK-293T C956(0.95); C1622(0.86); C1930(0.98); C1314(1.07)  LDD1597  [35]
 LDCM0394  CL123 HEK-293T C956(0.83); C1622(0.87); C1454(0.67); C2120(0.91)  LDD1598  [35]
 LDCM0395  CL124 HEK-293T C956(0.92); C1622(0.90); C2120(0.86); C1930(0.97)  LDD1599  [35]
 LDCM0396  CL125 HEK-293T C956(0.90); C1622(0.92); C1454(1.13); C2120(0.92)  LDD1600  [35]
 LDCM0397  CL126 HEK-293T C956(1.01); C1622(0.93); C1930(0.99); C1314(1.03)  LDD1601  [35]
 LDCM0398  CL127 HEK-293T C956(0.99); C1622(0.93); C1454(0.90); C2120(0.91)  LDD1602  [35]
 LDCM0399  CL128 HEK-293T C956(0.98); C1622(0.82); C2120(0.85); C1930(1.02)  LDD1603  [35]
 LDCM0400  CL13 HEK-293T C956(0.91); C1622(0.85); C1454(0.87); C2120(0.88)  LDD1604  [35]
 LDCM0401  CL14 HEK-293T C956(0.93); C1622(0.97); C1930(0.92); C1314(1.16)  LDD1605  [35]
 LDCM0402  CL15 HEK-293T C956(0.86); C1622(0.85); C1454(0.90); C2120(0.92)  LDD1606  [35]
 LDCM0403  CL16 HEK-293T C956(0.97); C1622(0.94); C2120(0.88); C1930(0.97)  LDD1607  [35]
 LDCM0404  CL17 HEK-293T C956(0.83); C1622(0.91); C2120(1.05); C1930(0.87)  LDD1608  [35]
 LDCM0405  CL18 HEK-293T C956(0.99); C1622(1.00); C1454(0.84); C2120(0.91)  LDD1609  [35]
 LDCM0406  CL19 HEK-293T C956(0.95); C1622(0.99); C1454(1.19); C2120(0.99)  LDD1610  [35]
 LDCM0407  CL2 HEK-293T C956(1.00); C1622(0.94); C1930(0.99); C1314(1.00)  LDD1611  [35]
 LDCM0408  CL20 HEK-293T C956(1.01); C1622(0.96); C1454(1.05); C2120(0.96)  LDD1612  [35]
 LDCM0409  CL21 HEK-293T C956(0.93); C1622(0.91); C1454(1.00); C2120(0.96)  LDD1613  [35]
 LDCM0410  CL22 HEK-293T C956(0.94); C1622(0.96); C2120(1.05); C1930(0.83)  LDD1614  [35]
 LDCM0411  CL23 HEK-293T C956(1.06); C1622(1.08); C2120(1.06); C1930(0.86)  LDD1615  [35]
 LDCM0412  CL24 HEK-293T C956(0.97); C1622(0.90); C1454(1.50); C2120(1.11)  LDD1616  [35]
 LDCM0413  CL25 HEK-293T C956(0.94); C1622(0.99); C1454(0.87); C2120(0.94)  LDD1617  [35]
 LDCM0414  CL26 HEK-293T C956(1.05); C1622(1.10); C1930(0.96); C1314(1.06)  LDD1618  [35]
 LDCM0415  CL27 HEK-293T C956(1.04); C1622(1.12); C1454(0.67); C2120(0.91)  LDD1619  [35]
 LDCM0416  CL28 HEK-293T C956(1.04); C1622(1.02); C2120(0.91); C1930(0.96)  LDD1620  [35]
 LDCM0417  CL29 HEK-293T C956(1.01); C1622(1.06); C2120(0.93); C1930(0.98)  LDD1621  [35]
 LDCM0418  CL3 HEK-293T C956(0.96); C1622(1.03); C1454(0.93); C2120(0.95)  LDD1622  [35]
 LDCM0419  CL30 HEK-293T C956(1.01); C1622(1.02); C1454(0.86); C2120(0.99)  LDD1623  [35]
 LDCM0420  CL31 HEK-293T C956(1.04); C1622(1.01); C1454(1.02); C2120(1.01)  LDD1624  [35]
 LDCM0421  CL32 HEK-293T C956(0.96); C1622(1.01); C1454(1.04); C2120(0.95)  LDD1625  [35]
 LDCM0422  CL33 HEK-293T C956(0.83); C1622(0.84); C1454(0.78); C2120(1.10)  LDD1626  [35]
 LDCM0423  CL34 HEK-293T C956(1.01); C1622(0.92); C2120(1.08); C1930(0.79)  LDD1627  [35]
 LDCM0424  CL35 HEK-293T C956(1.06); C1622(1.06); C2120(1.02); C1930(0.85)  LDD1628  [35]
 LDCM0425  CL36 HEK-293T C956(1.03); C1622(1.22); C1454(1.67); C2120(1.04)  LDD1629  [35]
 LDCM0426  CL37 HEK-293T C956(0.94); C1622(1.03); C1454(1.00); C2120(0.92)  LDD1630  [35]
 LDCM0428  CL39 HEK-293T C956(0.96); C1622(1.00); C1454(1.00); C2120(0.95)  LDD1632  [35]
 LDCM0429  CL4 HEK-293T C956(0.99); C1622(0.84); C2120(0.90); C1930(1.03)  LDD1633  [35]
 LDCM0430  CL40 HEK-293T C956(0.97); C1622(0.93); C2120(1.02); C1930(0.96)  LDD1634  [35]
 LDCM0431  CL41 HEK-293T C956(0.93); C1622(1.19); C2120(0.91); C1930(0.92)  LDD1635  [35]
 LDCM0432  CL42 HEK-293T C956(1.10); C1622(0.98); C1454(0.88); C2120(0.99)  LDD1636  [35]
 LDCM0433  CL43 HEK-293T C956(1.02); C1622(1.12); C1454(1.11); C2120(0.97)  LDD1637  [35]
 LDCM0434  CL44 HEK-293T C956(0.96); C1622(1.02); C1454(1.12); C2120(1.01)  LDD1638  [35]
 LDCM0435  CL45 HEK-293T C956(0.97); C1622(0.95); C1454(1.05); C2120(1.04)  LDD1639  [35]
 LDCM0436  CL46 HEK-293T C956(1.01); C1622(1.03); C2120(1.06); C1930(0.80)  LDD1640  [35]
 LDCM0437  CL47 HEK-293T C956(1.08); C1622(1.04); C2120(1.05); C1930(0.83)  LDD1641  [35]
 LDCM0438  CL48 HEK-293T C956(1.01); C1622(1.31); C1454(1.55); C2120(1.00)  LDD1642  [35]
 LDCM0439  CL49 HEK-293T C956(0.93); C1622(1.01); C1454(1.05); C2120(0.94)  LDD1643  [35]
 LDCM0440  CL5 HEK-293T C956(0.97); C1622(0.87); C2120(1.05); C1930(1.02)  LDD1644  [35]
 LDCM0441  CL50 HEK-293T C956(1.04); C1622(0.92); C1930(1.03); C1314(1.02)  LDD1645  [35]
 LDCM0443  CL52 HEK-293T C956(1.08); C1622(0.91); C2120(0.93); C1930(0.99)  LDD1646  [35]
 LDCM0444  CL53 HEK-293T C956(0.95); C1622(0.96); C2120(0.96); C1930(0.88)  LDD1647  [35]
 LDCM0445  CL54 HEK-293T C956(0.88); C1622(0.89); C1454(0.96); C2120(0.93)  LDD1648  [35]
 LDCM0446  CL55 HEK-293T C956(1.03); C1622(1.07); C1454(1.09); C2120(0.96)  LDD1649  [35]
 LDCM0447  CL56 HEK-293T C956(1.05); C1622(1.00); C1454(1.19); C2120(0.92)  LDD1650  [35]
 LDCM0448  CL57 HEK-293T C956(0.97); C1622(0.84); C1454(0.92); C2120(1.03)  LDD1651  [35]
 LDCM0449  CL58 HEK-293T C956(0.97); C1622(0.87); C2120(0.99); C1930(0.84)  LDD1652  [35]
 LDCM0450  CL59 HEK-293T C956(1.04); C1622(1.01); C2120(0.99); C1930(0.84)  LDD1653  [35]
 LDCM0451  CL6 HEK-293T C956(0.91); C1622(0.90); C1454(0.78); C2120(0.95)  LDD1654  [35]
 LDCM0452  CL60 HEK-293T C956(1.00); C1622(0.98); C1454(1.64); C2120(0.98)  LDD1655  [35]
 LDCM0453  CL61 HEK-293T C956(1.01); C1622(1.06); C1454(1.07); C2120(0.92)  LDD1656  [35]
 LDCM0454  CL62 HEK-293T C956(1.06); C1622(1.01); C1930(1.03); C1314(1.09)  LDD1657  [35]
 LDCM0455  CL63 HEK-293T C956(1.04); C1622(1.12); C1454(0.85); C2120(0.92)  LDD1658  [35]
 LDCM0456  CL64 HEK-293T C956(0.99); C1622(0.82); C2120(0.90); C1930(0.91)  LDD1659  [35]
 LDCM0457  CL65 HEK-293T C956(0.98); C1622(0.88); C2120(0.91); C1930(0.99)  LDD1660  [35]
 LDCM0458  CL66 HEK-293T C956(0.98); C1622(1.07); C1454(0.89); C2120(0.94)  LDD1661  [35]
 LDCM0459  CL67 HEK-293T C956(1.04); C1622(1.02); C1454(1.12); C2120(0.99)  LDD1662  [35]
 LDCM0460  CL68 HEK-293T C956(1.00); C1622(1.09); C1454(1.12); C2120(0.98)  LDD1663  [35]
 LDCM0461  CL69 HEK-293T C956(1.02); C1622(0.95); C1454(1.08); C2120(1.09)  LDD1664  [35]
 LDCM0462  CL7 HEK-293T C956(0.91); C1622(0.96); C1454(1.17); C2120(0.99)  LDD1665  [35]
 LDCM0463  CL70 HEK-293T C956(0.99); C1622(0.93); C2120(1.00); C1930(0.87)  LDD1666  [35]
 LDCM0464  CL71 HEK-293T C956(1.03); C1622(1.01); C2120(1.02); C1930(0.84)  LDD1667  [35]
 LDCM0465  CL72 HEK-293T C956(1.01); C1622(1.04); C1454(1.48); C2120(0.99)  LDD1668  [35]
 LDCM0466  CL73 HEK-293T C956(0.94); C1622(0.93); C1454(0.76); C2120(0.96)  LDD1669  [35]
 LDCM0467  CL74 HEK-293T C956(1.01); C1622(0.96); C1930(1.01); C1314(1.05)  LDD1670  [35]
 LDCM0469  CL76 HEK-293T C956(1.00); C1622(0.88); C2120(0.94); C1930(1.02)  LDD1672  [35]
 LDCM0470  CL77 HEK-293T C956(0.89); C1622(0.85); C2120(0.96); C1930(0.86)  LDD1673  [35]
 LDCM0471  CL78 HEK-293T C956(1.01); C1622(0.96); C1454(0.96); C2120(0.95)  LDD1674  [35]
 LDCM0472  CL79 HEK-293T C956(0.98); C1622(1.04); C1454(0.95); C2120(0.96)  LDD1675  [35]
 LDCM0473  CL8 HEK-293T C956(0.72); C1622(0.73); C1454(0.78); C2120(0.75)  LDD1676  [35]
 LDCM0474  CL80 HEK-293T C956(1.04); C1622(1.07); C1454(1.02); C2120(1.03)  LDD1677  [35]
 LDCM0475  CL81 HEK-293T C956(1.01); C1622(0.95); C1454(0.98); C2120(1.01)  LDD1678  [35]
 LDCM0476  CL82 HEK-293T C956(0.98); C1622(0.90); C2120(1.08); C1930(0.93)  LDD1679  [35]
 LDCM0477  CL83 HEK-293T C956(0.97); C1622(0.93); C2120(0.96); C1930(0.84)  LDD1680  [35]
 LDCM0478  CL84 HEK-293T C956(0.90); C1622(0.89); C1454(1.17); C2120(1.08)  LDD1681  [35]
 LDCM0479  CL85 HEK-293T C956(0.97); C1622(0.97); C1454(0.76); C2120(0.85)  LDD1682  [35]
 LDCM0480  CL86 HEK-293T C956(1.10); C1622(0.95); C1930(1.20); C1314(1.00)  LDD1683  [35]
 LDCM0481  CL87 HEK-293T C956(0.98); C1622(0.99); C1454(1.08); C2120(0.87)  LDD1684  [35]
 LDCM0482  CL88 HEK-293T C956(1.07); C1622(0.92); C2120(0.94); C1930(1.14)  LDD1685  [35]
 LDCM0483  CL89 HEK-293T C956(1.03); C1622(0.89); C2120(0.88); C1930(1.05)  LDD1686  [35]
 LDCM0484  CL9 HEK-293T C956(1.03); C1622(0.92); C1454(1.33); C2120(1.02)  LDD1687  [35]
 LDCM0485  CL90 HEK-293T C956(0.84); C1622(0.82); C1454(0.85); C2120(0.84)  LDD1688  [35]
 LDCM0486  CL91 HEK-293T C956(1.02); C1622(1.06); C1454(1.06); C2120(0.96)  LDD1689  [35]
 LDCM0487  CL92 HEK-293T C956(1.00); C1622(0.97); C1454(1.25); C2120(0.86)  LDD1690  [35]
 LDCM0488  CL93 HEK-293T C956(0.99); C1622(0.95); C1454(0.92); C2120(1.02)  LDD1691  [35]
 LDCM0489  CL94 HEK-293T C956(1.00); C1622(0.94); C2120(0.99); C1930(0.89)  LDD1692  [35]
 LDCM0490  CL95 HEK-293T C956(0.90); C1622(0.86); C2120(0.96); C1930(0.72)  LDD1693  [35]
 LDCM0491  CL96 HEK-293T C956(0.93); C1622(0.91); C1454(1.24); C2120(0.94)  LDD1694  [35]
 LDCM0492  CL97 HEK-293T C956(0.93); C1622(0.88); C1454(0.67); C2120(0.87)  LDD1695  [35]
 LDCM0493  CL98 HEK-293T C956(1.08); C1622(0.88); C1930(0.95); C1314(0.94)  LDD1696  [35]
 LDCM0494  CL99 HEK-293T C956(0.98); C1622(0.98); C1454(0.89); C2120(0.95)  LDD1697  [35]
 LDCM0495  E2913 HEK-293T C956(1.01); C1622(0.92); C1454(0.95); C2120(0.88)  LDD1698  [35]
 LDCM0625  F8 Ramos C1622(1.94)  LDD2187  [36]
 LDCM0572  Fragment10 Ramos C1622(0.72)  LDD2189  [36]
 LDCM0573  Fragment11 Ramos C1622(7.72)  LDD2190  [36]
 LDCM0574  Fragment12 Ramos C1622(0.58)  LDD2191  [36]
 LDCM0575  Fragment13 Ramos C1622(1.11)  LDD2192  [36]
 LDCM0576  Fragment14 Ramos C1622(1.15)  LDD2193  [36]
 LDCM0579  Fragment20 Ramos C1622(0.53)  LDD2194  [36]
 LDCM0580  Fragment21 Ramos C1622(1.10)  LDD2195  [36]
 LDCM0582  Fragment23 Ramos C1622(0.84)  LDD2196  [36]
 LDCM0578  Fragment27 Ramos C1622(0.95)  LDD2197  [36]
 LDCM0588  Fragment30 Ramos C1622(1.13)  LDD2199  [36]
 LDCM0589  Fragment31 Ramos C1622(0.87)  LDD2200  [36]
 LDCM0590  Fragment32 Ramos C1622(0.69)  LDD2201  [36]
 LDCM0468  Fragment33 HEK-293T C956(0.97); C1622(0.97); C1454(0.81); C2120(0.94)  LDD1671  [35]
 LDCM0566  Fragment4 Ramos C1622(0.46)  LDD2184  [36]
 LDCM0427  Fragment51 HEK-293T C956(1.16); C1622(1.01); C1930(1.02); C1314(1.06)  LDD1631  [35]
 LDCM0610  Fragment52 Ramos C1622(1.42)  LDD2204  [36]
 LDCM0614  Fragment56 Ramos C1622(1.36)  LDD2205  [36]
 LDCM0569  Fragment7 Ramos C1622(1.12)  LDD2186  [36]
 LDCM0571  Fragment9 Ramos C1622(0.63)  LDD2188  [36]
 LDCM0116  HHS-0101 DM93 Y1261(0.71); Y976(0.83); Y1020(0.87); Y2423(0.89)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y1261(0.61); Y976(0.66); Y1020(0.79); Y2423(0.81)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y695(0.44); Y1261(0.61); Y2423(0.76); Y1020(0.82)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y976(0.45); Y1261(0.71); Y2423(0.82); Y1020(0.86)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y1261(0.73); Y2423(0.83); Y1020(0.88); Y601(1.41)  LDD0268  [11]
 LDCM0107  IAA HeLa H1710(0.00); H1263(0.00); H432(0.00); H730(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y1020(0.86); Y2423(0.82)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y1020(1.37); Y2423(0.84)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y1020(1.25); Y2423(0.70)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y1020(3.61); Y2423(2.69)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y1020(2.06); Y2423(1.71)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y1020(0.15); Y2423(0.81)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y1020(1.08); Y2423(0.68)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y1020(1.95); Y2423(0.84)  LDD0292  [10]
 LDCM0179  JZ128 PC-3 C1622(0.00); C2441(0.00)  LDD0462  [8]
 LDCM0022  KB02 HEK-293T C956(0.96); C1622(0.99); C2441(1.06); C1930(1.00)  LDD1492  [35]
 LDCM0023  KB03 HEK-293T C956(0.94); C1622(1.02); C2441(0.94); C1930(0.98)  LDD1497  [35]
 LDCM0024  KB05 COLO792 C1935(0.87); C956(1.43); C1444(1.14)  LDD3310  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1622(1.01); C956(1.04)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C315(0.99); C1622(0.56)  LDD2121  [9]
 LDCM0109  NEM HeLa H432(0.00); H730(0.00); H1710(0.00); H2306(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C956(0.58)  LDD2089  [9]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1622(1.04); C956(1.02)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1622(0.84); C1314(1.03)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1622(0.93); C956(0.86)  LDD2093  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1930(0.80); C1314(0.84)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C315(1.14); C1622(0.69); C956(0.66)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1622(1.15); C1314(0.93)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C315(1.96); C1622(0.83); C956(1.08)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C315(0.69); C1622(0.59); C956(0.46)  LDD2100  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C315(0.93); C1622(0.69); C956(1.16); C1930(1.04)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C315(0.49); C1622(0.39); C956(0.46); C1314(0.58)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1622(1.38); C956(1.60)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C956(0.37); C1314(0.39)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C315(1.25); C956(1.10); C1930(0.94); C1314(1.39)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C315(0.67); C1622(0.50); C956(0.32)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C956(0.50)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C956(0.64)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C315(1.94); C1622(1.40); C956(1.11)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1622(0.57); C956(0.79); C1314(0.50)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C315(0.77); C1622(0.46); C956(0.54)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C1314(0.83)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C956(0.60); C1930(0.38)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C315(2.73); C956(2.77)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1622(0.85); C956(1.03)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C956(0.45)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C315(1.19); C956(0.96); C1314(1.36)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1622(0.68); C956(0.45); C1930(0.77)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C315(1.10); C956(0.83); C1314(1.20)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C956(0.38)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C315(1.57); C1622(1.05); C956(1.02)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1622(1.55); C956(1.05); C1930(0.42)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1622(1.30); C956(1.03)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C315(0.48); C1622(0.41); C956(0.46)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C315(0.65); C1622(0.35); C956(0.46)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1622(1.16); C956(1.06)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C315(2.04); C1622(1.34); C956(1.29); C1930(1.96)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C315(1.44); C1622(1.33); C956(1.06)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1622(3.29); C956(2.56)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1622(1.02); C956(0.71); C1930(1.40)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C315(0.57); C1622(0.94); C956(0.46); C1314(0.98)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C956(1.20)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C315(4.02); C1622(4.57); C956(4.21); C1930(3.51)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C956(0.18)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C315(1.54); C1622(1.15); C956(0.83)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C315(0.83); C1622(0.41); C956(0.35); C1930(0.57)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C956(0.53); C2441(0.21)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C315(0.64); C956(0.33)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C956(0.68); C2441(0.20)  LDD2151  [9]
 LDCM0131  RA190 MM1.R C2233(1.09)  LDD0304  [37]
 LDCM0113  W17 Hep-G2 E2081(1.18)  LDD0240  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) Spectrin family Q01082
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Ena/VASP-like protein (EVL) Ena/VASP family Q9UI08
Disrupted in schizophrenia 1 protein (DISC1) . Q9NRI5
Fanconi anemia group G protein (FANCG) . O15287

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
28 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
32 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
33 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
34 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
35 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
36 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.