Details of the Target

General Information of Target

Target ID LDTP04761
Target Name Claudin-6 (CLDN6)
Gene Name CLDN6
Gene ID 9074
Synonyms
Claudin-6; Skullin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTG
QMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLT
SGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGL
LCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
Target Type
Clinical trial
Target Bioclass
Other
Family
Claudin family
Subcellular location
Cell junction, tight junction
Function Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
TTD ID
T63166
Uniprot ID
P56747
DrugMap ID
TTKSV48
Ensemble ID
ENST00000328796.5
HGNC ID
HGNC:2048

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
YN-4
 Probe Info  		100.00  LDD0445  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Membrane-spanning 4-domains subfamily A member 3 (MS4A3) MS4A family Q96HJ5
Peripheral myelin protein 22 (PMP22) PMP-22/EMP/MP20 family Q01453
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.