Details of the Target

General Information of Target

Target ID LDTP05971
Target Name Mannosyl-oligosaccharide glucosidase (MOGS)
Gene Name MOGS
Gene ID 7841
Synonyms
GCS1; Mannosyl-oligosaccharide glucosidase; EC 3.2.1.106; Processing A-glucosidase I
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARGERRRRAVPAEGVRTAERAARGGPGRRDGRGGGPRSTAGGVALAVVVLSLALGMSGR
WVLAWYRARRAVTLHSAPPVLPADSSSPAVAPDLFWGTYRPHVYFGMKTRSPKPLLTGLM
WAQQGTTPGTPKLRHTCEQGDGVGPYGWEFHDGLSFGRQHIQDGALRLTTEFVKRPGGQH
GGDWSWRVTVEPQDSGTSALPLVSLFFYVVTDGKEVLLPEVGAKGQLKFISGHTSELGDF
RFTLLPPTSPGDTAPKYGSYNVFWTSNPGLPLLTEMVKSRLNSWFQHRPPGAPPERYLGL
PGSLKWEDRGPSGQGQGQFLIQQVTLKIPISIEFVFESGSAQAGGNQALPRLAGSLLTQA
LESHAEGFRERFEKTFQLKEKGLSSGEQVLGQAALSGLLGGIGYFYGQGLVLPDIGVEGS
EQKVDPALFPPVPLFTAVPSRSFFPRGFLWDEGFHQLVVQRWDPSLTREALGHWLGLLNA
DGWIGREQILGDEARARVPPEFLVQRAVHANPPTLLLPVAHMLEVGDPDDLAFLRKALPR
LHAWFSWLHQSQAGPLPLSYRWRGRDPALPTLLNPKTLPSGLDDYPRASHPSVTERHLDL
RCWVALGARVLTRLAEHLGEAEVAAELGPLAASLEAAESLDELHWAPELGVFADFGNHTK
AVQLKPRPPQGLVRVVGRPQPQLQYVDALGYVSLFPLLLRLLDPTSSRLGPLLDILADSR
HLWSPFGLRSLAASSSFYGQRNSEHDPPYWRGAVWLNVNYLALGALHHYGHLEGPHQARA
AKLHGELRANVVGNVWRQYQATGFLWEQYSDRDGRGMGCRPFHGWTSLVLLAMAEDY
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 63 family
Subcellular location
Endoplasmic reticulum membrane
Function In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
Uniprot ID
Q13724
Ensemble ID
ENST00000448666.7
HGNC ID
HGNC:24862
ChEMBL ID
CHEMBL4684

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.M1? A-DA    Probe Info 
CALU6 Insertion: p.L205IfsTer10 DBIA    Probe Info 
G361 SNV: p.K256R .
HCT116 SNV: p.P557S DBIA    Probe Info 
JURKAT SNV: p.A343V; p.R563W .
MOLT4 SNV: p.R158H; p.V173F IA-alkyne    Probe Info 
NB4 SNV: p.G178D .
NCIH1048 SNV: p.A510G .
NCIH2286 SNV: p.G142R DBIA    Probe Info 
NCIH82 SNV: p.A13S .
OVK18 SNV: p.Q359H .
RKN Substitution: p.P293F DBIA    Probe Info 
SNU1 SNV: p.L766R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.93  LDD0402  [1]
TH211
 Probe Info  		Y738(9.38)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K665(1.96); K782(5.56)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
DBIA
 Probe Info  		C602(1.31)  LDD0532  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C602(0.00); C137(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C137(0.00); C602(0.00); C819(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C602(0.00); C137(0.00)  LDD0037  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
W1
 Probe Info  		C137(0.00); E362(0.00); E366(0.00); Q359(0.00)  LDD0236  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C041
 Probe Info  		7.94  LDD1741  [11]
C183
 Probe Info  		5.94  LDD1861  [11]
C367
 Probe Info  		5.17  LDD2028  [11]
FFF probe11
 Probe Info  		8.02  LDD0471  [12]
FFF probe13
 Probe Info  		15.35  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]
FFF probe3
 Probe Info  		20.00  LDD0464  [12]
FFF probe9
 Probe Info  		12.90  LDD0470  [12]
A-DA
 Probe Info  		2.52  LDD0145  [13]
DA-2
 Probe Info  		N.A.  LDD0071  [14]
OEA-DA
 Probe Info  		10.33  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C602(1.14)  LDD1507  [16]
 LDCM0215  AC10 HCT 116 C602(1.31)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C602(1.39)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C602(0.99)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C602(0.64)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C602(0.84)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C602(0.88)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C602(0.94)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C602(1.18)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C602(0.70)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C602(0.98)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C602(0.70)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C602(0.86)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C602(0.61)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C602(0.67)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C602(0.85)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C602(1.14)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C602(1.15)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C602(1.10)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C602(1.05)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C602(1.09)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C602(1.06)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C602(1.13)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C602(0.81)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C602(1.15)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C602(0.88)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C602(1.06)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C602(0.86)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C602(1.09)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C602(1.23)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C602(1.05)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C602(1.00)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C602(0.81)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C602(0.93)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C602(1.36)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C602(0.77)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C602(1.07)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C602(0.96)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C602(0.97)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C602(1.15)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C602(1.11)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C602(0.92)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C602(0.79)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C602(1.03)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C602(1.05)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C602(1.06)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C602(1.02)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C602(1.13)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C602(1.15)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C602(1.02)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C602(1.10)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C602(1.10)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C602(0.97)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C602(0.49)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C602(1.35)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C602(0.99)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C602(1.51)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C602(0.92)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C602(0.94)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C602(0.38)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C602(1.31)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C602(0.95)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C602(2.07)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C602(1.20)  LDD2161  [6]
 LDCM0276  AC17 HEK-293T C602(1.07)  LDD1515  [16]
 LDCM0277  AC18 HEK-293T C602(0.85); C137(1.04)  LDD1516  [16]
 LDCM0278  AC19 HEK-293T C602(0.93); C137(0.98)  LDD1517  [16]
 LDCM0279  AC2 HEK-293T C602(0.81); C137(1.02)  LDD1518  [16]
 LDCM0280  AC20 HEK-293T C602(1.03); C137(1.01)  LDD1519  [16]
 LDCM0281  AC21 HEK-293T C602(1.24); C137(0.97)  LDD1520  [16]
 LDCM0282  AC22 HEK-293T C602(1.05); C137(0.94)  LDD1521  [16]
 LDCM0283  AC23 HEK-293T C602(0.96); C137(1.01)  LDD1522  [16]
 LDCM0284  AC24 HEK-293T C602(1.02); C137(1.06)  LDD1523  [16]
 LDCM0285  AC25 HCT 116 C602(0.75)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C602(0.85)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C602(0.90)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C602(0.97)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C602(0.78)  LDD0606  [6]
 LDCM0290  AC3 HEK-293T C602(0.80); C137(0.98)  LDD1529  [16]
 LDCM0291  AC30 HCT 116 C602(0.91)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C602(0.94)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C602(0.84)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C602(0.99)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C602(0.70)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C602(1.12)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C602(1.06)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C602(1.18)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C602(1.42)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C602(1.24)  LDD0617  [6]
 LDCM0301  AC4 HEK-293T C602(1.07); C137(0.89)  LDD1540  [16]
 LDCM0302  AC40 HCT 116 C602(1.28)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C602(0.95)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C602(1.04)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C602(1.26)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C602(1.30)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C602(1.06)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C602(1.10); C137(0.95)  LDD1547  [16]
 LDCM0309  AC47 HEK-293T C602(0.97); C137(1.07)  LDD1548  [16]
 LDCM0310  AC48 HEK-293T C602(1.14); C137(0.92)  LDD1549  [16]
 LDCM0311  AC49 HEK-293T C602(1.17)  LDD1550  [16]
 LDCM0312  AC5 HEK-293T C602(0.90); C137(1.03)  LDD1551  [16]
 LDCM0313  AC50 HEK-293T C602(0.80); C137(0.96)  LDD1552  [16]
 LDCM0314  AC51 HEK-293T C602(0.91); C137(1.00)  LDD1553  [16]
 LDCM0315  AC52 HEK-293T C602(1.24); C137(0.97)  LDD1554  [16]
 LDCM0316  AC53 HEK-293T C602(0.90); C137(1.05)  LDD1555  [16]
 LDCM0317  AC54 HEK-293T C602(1.10); C137(1.08)  LDD1556  [16]
 LDCM0318  AC55 HEK-293T C602(1.00); C137(0.98)  LDD1557  [16]
 LDCM0319  AC56 HEK-293T C602(1.08); C137(1.04)  LDD1558  [16]
 LDCM0320  AC57 HEK-293T C602(1.01)  LDD1559  [16]
 LDCM0321  AC58 HEK-293T C602(0.91); C137(1.13)  LDD1560  [16]
 LDCM0322  AC59 HEK-293T C602(0.88); C137(0.91)  LDD1561  [16]
 LDCM0323  AC6 HCT 116 C602(1.21)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C602(0.92); C137(1.00)  LDD1563  [16]
 LDCM0325  AC61 HEK-293T C602(1.00); C137(0.98)  LDD1564  [16]
 LDCM0326  AC62 HEK-293T C602(1.03); C137(0.93)  LDD1565  [16]
 LDCM0327  AC63 HEK-293T C602(0.82); C137(1.12)  LDD1566  [16]
 LDCM0328  AC64 HEK-293T C602(1.17); C137(1.11)  LDD1567  [16]
 LDCM0332  AC68 HCT 116 C602(0.88)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C602(0.75)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C602(1.22)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C602(0.82)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C602(0.82)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C602(0.90)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C602(0.94)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C602(0.81)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C602(0.92)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C602(0.97)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C602(0.89)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C602(0.85)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C602(0.88)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C602(1.05)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C602(0.90)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C602(0.77)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C602(0.80)  LDD0665  [6]
 LDCM0365  AC98 HCT 116 C602(0.73)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C602(0.92)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C602(1.38)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C602(1.24)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C602(0.99)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C602(1.22)  LDD2171  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C602(1.13)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C602(0.98)  LDD0685  [6]
 LDCM0369  CL100 HEK-293T C602(1.07); C137(0.98)  LDD1573  [16]
 LDCM0370  CL101 HCT 116 C602(1.15)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C602(0.88)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C602(1.11)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C602(1.03)  LDD0690  [6]
 LDCM0374  CL105 HEK-293T C602(1.28); C137(0.94)  LDD1578  [16]
 LDCM0375  CL106 HEK-293T C602(0.79); C137(1.19)  LDD1579  [16]
 LDCM0376  CL107 HEK-293T C602(0.91); C137(0.94)  LDD1580  [16]
 LDCM0377  CL108 HEK-293T C602(0.97); C137(0.96)  LDD1581  [16]
 LDCM0378  CL109 HEK-293T C602(1.04); C137(1.03)  LDD1582  [16]
 LDCM0379  CL11 HCT 116 C602(0.93)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C602(1.22); C137(0.87)  LDD1584  [16]
 LDCM0381  CL111 HEK-293T C602(1.02); C137(0.92)  LDD1585  [16]
 LDCM0382  CL112 HCT 116 C602(0.79)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C602(0.77)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C602(0.43)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C602(0.89)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C602(0.88)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C602(1.27)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C602(1.20)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C602(1.04)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C602(1.00)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C602(1.00)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C602(1.11); C137(0.90)  LDD1596  [16]
 LDCM0393  CL122 HEK-293T C602(1.19); C137(0.88)  LDD1597  [16]
 LDCM0394  CL123 HEK-293T C602(1.26); C137(0.99)  LDD1598  [16]
 LDCM0395  CL124 HEK-293T C602(1.11); C137(1.01)  LDD1599  [16]
 LDCM0396  CL125 HEK-293T C602(1.03); C137(0.94)  LDD1600  [16]
 LDCM0397  CL126 HEK-293T C602(1.01); C137(0.92)  LDD1601  [16]
 LDCM0398  CL127 HEK-293T C602(1.01); C137(0.99)  LDD1602  [16]
 LDCM0399  CL128 HEK-293T C602(1.07); C137(1.06)  LDD1603  [16]
 LDCM0400  CL13 HCT 116 C602(1.08)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C602(1.38)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C602(1.15)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C602(0.76)  LDD0720  [6]
 LDCM0404  CL17 HEK-293T C602(1.79)  LDD1608  [16]
 LDCM0405  CL18 HEK-293T C602(0.86); C137(1.03)  LDD1609  [16]
 LDCM0406  CL19 HEK-293T C602(1.20); C137(0.91)  LDD1610  [16]
 LDCM0407  CL2 HCT 116 C602(0.98)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C602(1.22); C137(1.05)  LDD1612  [16]
 LDCM0409  CL21 HEK-293T C602(1.38); C137(1.02)  LDD1613  [16]
 LDCM0410  CL22 HEK-293T C602(1.14); C137(0.94)  LDD1614  [16]
 LDCM0411  CL23 HEK-293T C602(1.04); C137(1.23)  LDD1615  [16]
 LDCM0412  CL24 HEK-293T C602(1.34); C137(0.80)  LDD1616  [16]
 LDCM0413  CL25 HEK-293T C602(1.39); C137(0.89)  LDD1617  [16]
 LDCM0414  CL26 HEK-293T C602(0.96); C137(0.84)  LDD1618  [16]
 LDCM0415  CL27 HEK-293T C602(0.98); C137(1.03)  LDD1619  [16]
 LDCM0416  CL28 HEK-293T C602(1.04); C137(0.99)  LDD1620  [16]
 LDCM0417  CL29 HEK-293T C602(1.12)  LDD1621  [16]
 LDCM0418  CL3 HCT 116 C602(1.11)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C602(1.08); C137(0.92)  LDD1623  [16]
 LDCM0420  CL31 HCT 116 C602(1.25)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C602(0.92)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C602(1.00)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C602(0.94)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C602(1.16)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C602(1.01)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C602(0.92)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C602(0.89)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C602(1.06)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C602(1.12)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C602(1.16)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C602(0.67)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C602(0.94)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C602(1.06)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C602(1.17)  LDD0752  [6]
 LDCM0436  CL46 HEK-293T C602(1.07); C137(0.99)  LDD1640  [16]
 LDCM0437  CL47 HEK-293T C602(1.04); C137(0.96)  LDD1641  [16]
 LDCM0438  CL48 HEK-293T C602(0.93); C137(0.89)  LDD1642  [16]
 LDCM0439  CL49 HEK-293T C602(1.14); C137(0.97)  LDD1643  [16]
 LDCM0440  CL5 HCT 116 C602(0.97)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C602(0.92); C137(1.16)  LDD1645  [16]
 LDCM0443  CL52 HEK-293T C602(1.07); C137(1.03)  LDD1646  [16]
 LDCM0444  CL53 HEK-293T C602(1.56)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C602(1.57); C137(1.05)  LDD1648  [16]
 LDCM0446  CL55 HEK-293T C602(1.07); C137(1.08)  LDD1649  [16]
 LDCM0447  CL56 HEK-293T C602(0.98); C137(0.94)  LDD1650  [16]
 LDCM0448  CL57 HEK-293T C602(1.36); C137(1.04)  LDD1651  [16]
 LDCM0449  CL58 HEK-293T C602(1.24); C137(0.95)  LDD1652  [16]
 LDCM0450  CL59 HEK-293T C602(1.09); C137(1.11)  LDD1653  [16]
 LDCM0451  CL6 HCT 116 C602(1.14)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C602(1.28); C137(0.73)  LDD1655  [16]
 LDCM0453  CL61 HEK-293T C602(1.11); C137(0.79)  LDD1656  [16]
 LDCM0454  CL62 HEK-293T C602(0.97); C137(0.91)  LDD1657  [16]
 LDCM0455  CL63 HEK-293T C602(1.04); C137(1.07)  LDD1658  [16]
 LDCM0456  CL64 HEK-293T C602(1.13); C137(0.93)  LDD1659  [16]
 LDCM0457  CL65 HEK-293T C602(1.13)  LDD1660  [16]
 LDCM0458  CL66 HEK-293T C602(0.77); C137(1.03)  LDD1661  [16]
 LDCM0459  CL67 HEK-293T C602(0.87); C137(1.02)  LDD1662  [16]
 LDCM0460  CL68 HEK-293T C602(1.30); C137(1.03)  LDD1663  [16]
 LDCM0461  CL69 HEK-293T C602(1.26); C137(1.06)  LDD1664  [16]
 LDCM0462  CL7 HCT 116 C602(1.10)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C602(1.08); C137(0.96)  LDD1666  [16]
 LDCM0464  CL71 HEK-293T C602(0.96); C137(1.20)  LDD1667  [16]
 LDCM0465  CL72 HEK-293T C602(1.21); C137(0.84)  LDD1668  [16]
 LDCM0466  CL73 HEK-293T C602(1.00); C137(1.13)  LDD1669  [16]
 LDCM0467  CL74 HEK-293T C602(0.82); C137(0.90)  LDD1670  [16]
 LDCM0469  CL76 HCT 116 C602(1.15)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C602(0.89)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C602(1.04)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C602(1.22)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C602(0.86)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C602(1.27)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C602(1.14)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C602(1.11)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C602(1.10)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C602(0.88)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C602(1.22)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C602(1.23)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C602(1.23)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C602(0.98)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C602(0.61)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C602(1.10)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C602(1.03)  LDD0802  [6]
 LDCM0486  CL91 HEK-293T C602(0.96); C137(1.01)  LDD1689  [16]
 LDCM0487  CL92 HEK-293T C602(1.13); C137(0.98)  LDD1690  [16]
 LDCM0488  CL93 HEK-293T C602(1.26); C137(1.08)  LDD1691  [16]
 LDCM0489  CL94 HEK-293T C602(1.08); C137(1.14)  LDD1692  [16]
 LDCM0490  CL95 HEK-293T C602(1.32); C137(1.06)  LDD1693  [16]
 LDCM0491  CL96 HEK-293T C602(1.13); C137(0.89)  LDD1694  [16]
 LDCM0492  CL97 HEK-293T C602(1.32); C137(0.96)  LDD1695  [16]
 LDCM0493  CL98 HEK-293T C602(1.22); C137(0.99)  LDD1696  [16]
 LDCM0494  CL99 HEK-293T C602(1.01); C137(0.90)  LDD1697  [16]
 LDCM0495  E2913 HEK-293T C602(1.00); C137(0.97)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C602(0.91)  LDD1702  [17]
 LDCM0468  Fragment33 HEK-293T C602(0.95); C137(1.03)  LDD1671  [16]
 LDCM0427  Fragment51 HCT 116 C602(0.88)  LDD0744  [6]
 LDCM0022  KB02 HEK-293T C137(0.94)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C137(1.00)  LDD1497  [16]
 LDCM0024  KB05 HMCB C602(3.62)  LDD3312  [18]
 LDCM0109  NEM HeLa N.A.  LDD0227  [9]
 LDCM0084  Ro 48-8071 A-549 2.52  LDD0145  [13]
 LDCM0021  THZ1 HCT 116 C602(1.22)  LDD2173  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840