Details of the Target

General Information of Target

Target ID LDTP02001
Target Name Catalase (CAT)
Gene Name CAT
Gene ID 847
Synonyms
Catalase; EC 1.11.1.6
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Catalase family
Subcellular location
Peroxisome
Function
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
TTD ID
T01597
Uniprot ID
P04040
DrugMap ID
TTPS279
Ensemble ID
ENST00000241052.5
HGNC ID
HGNC:1516
ChEMBL ID
CHEMBL3627594

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		20.00  LDD0391  [1]
P3
 Probe Info  		7.19  LDD0450  [2]
P8
 Probe Info  		4.38  LDD0451  [2]
A-EBA
 Probe Info  		3.67  LDD0215  [3]
TH211
 Probe Info  		Y84(18.36)  LDD0260  [4]
C-Sul
 Probe Info  		2.68  LDD0066  [5]
STPyne
 Probe Info  		K237(4.65)  LDD2218  [6]
AZ-9
 Probe Info  		D249(10.00); E248(10.00); E228(10.00)  LDD2209  [7]
AHL-Pu-1
 Probe Info  		C377(5.43)  LDD0171  [8]
HHS-482
 Probe Info  		Y358(1.09)  LDD0285  [9]
HHS-475
 Probe Info  		Y358(8.41)  LDD0264  [10]
DBIA
 Probe Info  		C377(0.98)  LDD0078  [11]
5E-2FA
 Probe Info  		H14(0.00); H89(0.00); H372(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
m-APA
 Probe Info  		H14(0.00); H372(0.00)  LDD2231  [12]
1d-yne
 Probe Info  		N.A.  LDD0358  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C460(0.00); C377(0.00); C232(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C460(0.00); C377(0.00); C232(0.00)  LDD0036  [15]
Lodoacetamide azide
 Probe Info  		C460(0.00); C377(0.00)  LDD0037  [15]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
BTD
 Probe Info  		C460(0.00); C232(0.00)  LDD0004  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
WYneC
 Probe Info  		C460(0.00); C232(0.00)  LDD0014  [17]
WYneN
 Probe Info  		C460(0.00); C232(0.00)  LDD0021  [17]
WYneO
 Probe Info  		C460(0.00); C232(0.00)  LDD0022  [17]
Compound 10
 Probe Info  		N.A.  LDD2216  [19]
Compound 11
 Probe Info  		N.A.  LDD2213  [19]
ENE
 Probe Info  		C232(0.00); C460(0.00)  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0005  [17]
NHS
 Probe Info  		K476(0.00); K243(0.00)  LDD0010  [17]
PPMS
 Probe Info  		N.A.  LDD0008  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
VSF
 Probe Info  		N.A.  LDD0007  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Acrolein
 Probe Info  		C232(0.00); C460(0.00)  LDD0217  [21]
Crotonaldehyde
 Probe Info  		C460(0.00); C232(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		C377(0.00); C460(0.00)  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
MPP-AC
 Probe Info  		N.A.  LDD0428  [23]
NAIA_5
 Probe Info  		C460(0.00); C377(0.00)  LDD2223  [24]
TER-AC
 Probe Info  		N.A.  LDD0426  [23]
TPP-AC
 Probe Info  		N.A.  LDD0427  [23]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.43  LDD0476  [25]
FFF probe2
 Probe Info  		20.00  LDD0463  [25]
FFF probe3
 Probe Info  		7.46  LDD0465  [25]
FFF probe6
 Probe Info  		20.00  LDD0468  [25]
FFF probe9
 Probe Info  		20.00  LDD0470  [25]
STS-1
 Probe Info  		3.55  LDD0136  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]
DA-2
 Probe Info  		N.A.  LDD0072  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C232(0.25); C460(0.31)  LDD2142  [29]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C232(0.47); C460(0.54)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C232(0.94); C460(0.42)  LDD2095  [29]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C232(1.36); C460(0.78)  LDD2130  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C232(1.02); C460(0.95)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C460(1.26)  LDD2152  [29]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C232(1.90); C460(1.06)  LDD2103  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C232(0.59); C460(0.40)  LDD2132  [29]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C232(1.31); C460(0.49)  LDD2131  [29]
 LDCM0026  4SU-RNA+native RNA DM93 C377(5.43)  LDD0171  [8]
 LDCM0214  AC1 HEK-293T C460(1.14); C377(1.01)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C460(0.99); C377(0.84)  LDD1508  [30]
 LDCM0216  AC100 HCT 116 C377(1.05)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C377(1.12)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C377(1.06)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C377(1.12)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C377(0.97)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C377(1.05)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C377(1.10)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C377(1.11)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C377(1.06)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C377(0.95)  LDD0542  [11]
 LDCM0226  AC11 HEK-293T C460(0.85); C377(1.18)  LDD1509  [30]
 LDCM0227  AC110 HCT 116 C377(1.18)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C377(1.07)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C377(1.18)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C377(1.02)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C377(1.02)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C377(1.27)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C377(1.17)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C377(0.88)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C377(1.10)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C377(0.99)  LDD0553  [11]
 LDCM0237  AC12 HEK-293T C460(1.22); C377(0.94)  LDD1510  [30]
 LDCM0238  AC120 HCT 116 C377(1.41)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C377(0.84)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C377(1.16)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C377(0.86)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C377(1.04)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C377(1.14)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C377(1.15)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C377(1.21)  LDD0562  [11]
 LDCM0259  AC14 HEK-293T C460(1.02); C377(0.98)  LDD1512  [30]
 LDCM0263  AC143 HCT 116 C377(0.97)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C377(0.88)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C377(0.87)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C377(1.16)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C377(1.01)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C377(0.90)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C377(1.04)  LDD0586  [11]
 LDCM0270  AC15 HEK-293T C460(1.04); C377(1.04)  LDD1513  [30]
 LDCM0271  AC150 HCT 116 C377(1.10)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C377(1.27)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C377(0.98)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C377(1.18)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C377(1.02)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C377(1.03)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C377(1.04)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C377(0.93)  LDD2161  [11]
 LDCM0276  AC17 HEK-293T C460(1.38); C377(1.14)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C460(1.25); C377(0.98)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C460(1.50); C377(0.91)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C460(1.04); C377(1.08)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C460(0.89); C377(0.99)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C460(1.07); C377(1.03)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C460(0.85); C377(0.97)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C460(0.97); C377(1.15)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C377(1.07)  LDD1523  [30]
 LDCM0285  AC25 HCT 116 C377(0.86)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C377(0.98)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C377(1.07)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C377(1.04)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C377(1.20)  LDD0606  [11]
 LDCM0290  AC3 HEK-293T C460(1.07); C377(1.04)  LDD1529  [30]
 LDCM0291  AC30 HCT 116 C377(1.13)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C377(0.88)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C377(1.08)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C377(1.14)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C377(1.46)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C377(0.78)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C377(0.76)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C377(0.83)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C377(0.91)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C377(0.93)  LDD0617  [11]
 LDCM0301  AC4 HEK-293T C460(0.94); C377(1.01)  LDD1540  [30]
 LDCM0302  AC40 HCT 116 C377(1.08)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C377(1.20)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C377(1.08)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C377(1.04)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C377(1.16)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C377(1.36)  LDD0624  [11]
 LDCM0308  AC46 HEK-293T C460(1.00); C377(0.98)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C460(1.02); C377(1.11)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C377(1.18)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C460(1.31); C377(1.08)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C460(0.99); C377(1.00)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C460(1.16); C377(0.95)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C460(1.17); C377(1.02)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C460(0.99); C377(1.20)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C460(0.94); C377(1.16)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C460(0.95); C377(1.14)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C460(0.98); C377(1.07)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C377(1.12)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C460(1.24); C377(0.97)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C460(1.14); C377(0.85)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C460(1.02); C377(1.10)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C460(0.95); C377(0.99)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C460(1.07); C377(1.03)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C460(1.15); C377(0.91)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C460(0.92); C377(1.03)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C460(1.03); C377(1.13)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C377(1.03)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C460(1.00); C377(1.07)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C377(0.98)  LDD1569  [30]
 LDCM0349  AC83 HCT 116 C377(0.93)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C377(0.79)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C377(0.86)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C377(0.86)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C377(1.04)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C377(0.98)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C377(1.04)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C377(1.28)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C377(0.83)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C377(0.79)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C377(0.96)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C377(0.78)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C377(1.12)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C377(0.74)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C377(1.07)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C377(1.18)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C377(1.08)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C232(1.01); C460(0.67)  LDD2138  [29]
 LDCM0520  AKOS000195272 MDA-MB-231 C232(0.85); C460(0.60)  LDD2113  [29]
 LDCM0248  AKOS034007472 HEK-293T C460(1.04); C377(0.99)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C460(1.11); C377(0.98)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C377(1.06)  LDD1514  [30]
 LDCM0020  ARS-1620 HCC44 C377(0.98)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C232(1.52); C460(0.80)  LDD2091  [29]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C377(1.23)  LDD2227  [24]
 LDCM0367  CL1 HCT 116 C377(1.34)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C377(1.07)  LDD0685  [11]
 LDCM0369  CL100 HEK-293T C460(1.09); C377(0.98)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C460(1.24)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C460(1.18); C377(0.89)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C460(0.87); C377(1.13)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C460(1.03); C377(0.94)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C460(1.07)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C460(0.98); C377(0.97)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C460(0.95); C377(1.20)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C460(1.06); C377(0.96)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C460(1.48)  LDD1582  [30]
 LDCM0379  CL11 HCT 116 C377(1.19)  LDD0696  [11]
 LDCM0380  CL110 HEK-293T C460(1.05); C377(0.86)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C460(1.17); C377(1.05)  LDD1585  [30]
 LDCM0382  CL112 HCT 116 C377(0.85)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C377(0.92)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C377(0.98)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C377(1.18)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C377(1.15)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C377(1.11)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C377(0.91)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C377(0.93)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C377(1.00)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C377(1.01)  LDD0708  [11]
 LDCM0392  CL121 HEK-293T C460(1.06)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C460(1.04); C377(1.02)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C460(1.09); C377(0.96)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C460(1.11); C377(0.94)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C460(0.94)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C460(1.14); C377(1.05)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C460(1.12); C377(0.98)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C460(0.96); C377(0.96)  LDD1603  [30]
 LDCM0400  CL13 HCT 116 C377(1.05)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C377(1.01)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C377(1.02)  LDD0719  [11]
 LDCM0403  CL16 HEK-293T C460(1.12); C377(1.00)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C460(1.45); C377(1.00)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C460(1.10); C377(0.94)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C460(0.92); C377(1.22)  LDD1610  [30]
 LDCM0407  CL2 HCT 116 C377(1.17)  LDD0724  [11]
 LDCM0408  CL20 HEK-293T C460(1.18); C377(1.13)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C460(1.05); C377(0.87)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C460(0.86); C377(1.05)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C460(1.21); C377(1.15)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C377(0.97)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C460(1.00)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C460(1.34); C377(1.30)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C460(0.80); C377(1.08)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C460(1.07); C377(0.99)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C460(1.36); C377(0.96)  LDD1621  [30]
 LDCM0418  CL3 HCT 116 C377(1.29)  LDD0735  [11]
 LDCM0419  CL30 HEK-293T C460(1.07); C377(1.17)  LDD1623  [30]
 LDCM0420  CL31 HCT 116 C377(1.24)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C377(1.20)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C377(1.31)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C377(1.19)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C377(1.00)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C377(1.16)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C377(1.04)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C377(1.00)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C377(1.38)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C377(1.06)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C377(0.99)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C377(1.00)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C377(1.10)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C377(1.23)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C377(0.91)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C377(1.04)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C377(0.92)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C377(1.09)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C377(0.80)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C377(1.09)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C377(1.02)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C377(0.89)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C377(1.00)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C377(0.96)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C377(1.01)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C377(0.93)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C377(0.95)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C377(0.80)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C377(0.98)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C377(0.74)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C377(1.00)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C377(1.00)  LDD0769  [11]
 LDCM0453  CL61 HEK-293T C460(0.98)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C460(0.96); C377(1.12)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C460(0.83); C377(1.49)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C460(0.95); C377(0.99)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C460(1.30); C377(1.06)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C460(1.05); C377(0.97)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C460(1.44); C377(1.04)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C460(1.34); C377(1.03)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C460(1.19); C377(0.99)  LDD1664  [30]
 LDCM0462  CL7 HCT 116 C377(1.05)  LDD0779  [11]
 LDCM0463  CL70 HEK-293T C460(0.80); C377(0.94)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C460(1.11); C377(1.00)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C377(1.62)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C460(0.94)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C460(1.05); C377(1.03)  LDD1670  [30]
 LDCM0469  CL76 HCT 116 C377(1.02)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C377(1.18)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C377(0.99)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C377(1.04)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C377(1.16)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C377(0.83)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C377(1.04)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C377(1.08)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C377(0.96)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C377(1.08)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C377(1.23)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C377(1.14)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C377(1.04)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C377(1.12)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C377(0.84)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C377(1.20)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C377(0.90)  LDD0802  [11]
 LDCM0486  CL91 HEK-293T C460(1.12); C377(1.12)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C460(1.03); C377(1.15)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C460(1.05); C377(0.86)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C460(0.95); C377(1.00)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C460(1.08); C377(0.84)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C377(0.92)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C460(0.94)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C460(0.99); C377(0.96)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C460(1.16); C377(1.03)  LDD1697  [30]
 LDCM0495  E2913 HEK-293T C460(1.07); C377(1.46)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C460(3.08); C377(0.98); C232(0.75)  LDD1702  [29]
 LDCM0625  F8 Ramos C377(0.94)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C377(0.69)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C377(0.77)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C377(0.76)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C377(1.02)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C377(1.72)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C377(0.72)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C377(1.10)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C377(1.23)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C377(0.95)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C377(1.65)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C377(1.02)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C377(1.07)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C377(0.73)  LDD2201  [31]
 LDCM0468  Fragment33 HEK-293T C460(1.14); C377(1.03)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C377(0.82)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C377(1.15)  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C377(0.85)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C377(0.91)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C377(0.91)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C377(0.72)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C377(0.61)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y358(8.41)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y358(10.14)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y358(5.16)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y358(3.99)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y358(6.79)  LDD0268  [10]
 LDCM0123  JWB131 DM93 Y358(1.09)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y358(0.75)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y358(1.62)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y358(1.50)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y358(0.98)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y358(1.69)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y358(1.27)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y358(1.34)  LDD0292  [9]
 LDCM0022  KB02 HEK-293T C377(1.10)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C377(0.88)  LDD1497  [30]
 LDCM0024  KB05 COLO792 C377(1.08)  LDD3310  [32]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C232(3.32); C460(1.23)  LDD2102  [29]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C232(1.34); C460(0.85)  LDD2121  [29]
 LDCM0109  NEM HeLa C232(0.00); H518(0.00); C460(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C232(1.04); C460(0.88)  LDD2089  [29]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C232(0.92)  LDD2090  [29]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C232(2.29); C460(1.47)  LDD2092  [29]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C460(1.35)  LDD2093  [29]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C232(3.21); C460(1.52); C377(0.99)  LDD2094  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C460(0.65)  LDD2096  [29]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C232(1.00); C460(0.78)  LDD2097  [29]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C460(0.95)  LDD2098  [29]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C232(2.03); C460(1.01)  LDD2099  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C232(0.31); C460(0.36)  LDD2100  [29]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C232(1.05); C460(0.74)  LDD2101  [29]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C232(0.29); C460(0.33)  LDD2104  [29]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C232(1.93); C460(1.32)  LDD2105  [29]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C460(0.36)  LDD2106  [29]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C232(1.39); C460(0.82)  LDD2107  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C232(0.29); C460(0.42)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C232(0.77); C460(0.75)  LDD2109  [29]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C232(0.36); C460(0.38)  LDD2110  [29]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C232(1.31)  LDD2111  [29]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C232(0.49); C460(0.44)  LDD2114  [29]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C232(0.49); C460(0.47)  LDD2115  [29]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C232(0.17); C460(0.95)  LDD2116  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C232(0.13); C460(0.68)  LDD2118  [29]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C460(1.47)  LDD2119  [29]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C232(0.65); C460(0.73)  LDD2120  [29]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C232(0.08); C460(1.00)  LDD2122  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C232(0.97); C460(1.01)  LDD2123  [29]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C460(0.70)  LDD2124  [29]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C232(1.18); C460(1.05)  LDD2125  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C232(0.05); C460(0.91)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C232(1.12); C460(0.99)  LDD2127  [29]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C232(0.63); C460(0.91)  LDD2128  [29]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C460(1.20)  LDD2129  [29]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C232(0.59); C460(0.57)  LDD2133  [29]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C232(0.49); C460(0.47)  LDD2134  [29]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C460(1.38)  LDD2135  [29]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C232(1.53); C460(1.06)  LDD2136  [29]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C232(1.12); C460(1.03)  LDD2137  [29]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C460(1.24)  LDD1700  [29]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C232(1.27); C460(0.93)  LDD2140  [29]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C460(0.59)  LDD2141  [29]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C232(0.54); C460(0.72)  LDD2143  [29]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C460(1.01)  LDD2144  [29]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C460(0.21)  LDD2145  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C232(1.19); C460(0.97)  LDD2146  [29]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C232(1.21); C460(1.56)  LDD2147  [29]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C232(0.49); C460(0.48)  LDD2148  [29]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C232(0.09)  LDD2149  [29]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C232(0.85); C460(0.64)  LDD2150  [29]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C232(0.12)  LDD2151  [29]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C232(3.59); C460(3.00)  LDD2153  [29]
 LDCM0021  THZ1 HCT 116 C377(1.12)  LDD2173  [11]
 LDCM0110  W12 Hep-G2 C377(1.06)  LDD0237  [22]
 LDCM0113  W17 Hep-G2 C377(1.17)  LDD0240  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catalase (CAT) Catalase family P04040

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Carbimide Small molecular drug DB09116
Cannabidiol Small molecular drug DB09061
Fomepizole Small molecular drug DB01213
Benzoyl Peroxide . DB09096
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Euk-189 Small molecular drug D06VAQ
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nabiximols Small molecular drug DB14011
Medical Cannabis . DB14009

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
6 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
24 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840