Details of the Target

General Information of Target

Target ID LDTP05870
Target Name Splicing factor 3B subunit 2 (SF3B2)
Gene Name SF3B2
Gene ID 10992
Synonyms
SAP145; Splicing factor 3B subunit 2; Pre-mRNA-splicing factor SF3b 145 kDa subunit; SF3b145; Spliceosome-associated protein 145; SAP 145
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATEHPEPPKAELQLPPPPPPGHYGAWAAQELQAKLAEIGAPIQGNREELVERLQSYTRQ
TGIVLNRPVLRGEDGDKAAPPPMSAQLPGIPMPPPPLGLPPLQPPPPPPPPPPGLGLGFP
MAHPPNLGPPPPLRVGEPVALSEEERLKLAQQQAALLMQQEERAKQQGDHSLKEHELLEQ
QKRAAVLLEQERQQEIAKMGTPVPRPPQDMGQIGVRTPLGPRVAAPVGPVGPTPTVLPMG
APVPRPRGPPPPPGDENREMDDPSVGPKIPQALEKILQLKESRQEEMNSQQEEEEMETDA
RSSLGQSASETEEDTVSVSKKEKNRKRRNRKKKKKPQRVRGVSSESSGDREKDSTRSRGS
DSPAADVEIEYVTEEPEIYEPNFIFFKRIFEAFKLTDDVKKEKEKEPEKLDKLENSAAPK
KKGFEEEHKDSDDDSSDDEQEKKPEAPKLSKKKLRRMNRFTVAELKQLVARPDVVEMHDV
TAQDPKLLVHLKATRNSVPVPRHWCFKRKYLQGKRGIEKPPFELPDFIKRTGIQEMREAL
QEKEEQKTMKSKMREKVRPKMGKIDIDYQKLHDAFFKWQTKPKLTIHGDLYYEGKEFETR
LKEKKPGDLSDELRISLGMPVGPNAHKVPPPWLIAMQRYGPPPSYPNLKIPGLNSPIPES
CSFGYHAGGWGKPPVDETGKPLYGDVFGTNAAEFQTKTEEEEIDRTPWGELEPSDEESSE
EEEEEESDEDKPDETGFITPADSGLITPGGFSSVPAGMETPELIELRKKKIEEAMDGSET
PQLFTVLPEKRTATVGGAMMGSTHIYDMSTVMSRKGPAPELQGVEVALAPEELELDPMAM
TQKYEEHVREQQAQVEKEDFSDMVAEHAAKQKQKKRKAQPQDSRGGSKKYKEFKF
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs.
Uniprot ID
Q13435
Ensemble ID
ENST00000322535.11
HGNC ID
HGNC:10769
ChEMBL ID
CHEMBL1229011

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY-1
 Probe Info  		100.00  LDD0243  [1]
C-Sul
 Probe Info  		3.70  LDD0066  [2]
TH211
 Probe Info  		Y592(20.00); Y568(9.49)  LDD0257  [3]
TH216
 Probe Info  		Y568(17.32)  LDD0259  [3]
STPyne
 Probe Info  		K275(8.55); K280(9.38); K394(4.42); K466(9.09)  LDD0277  [4]
AZ-9
 Probe Info  		E191(1.02)  LDD2208  [5]
Probe 1
 Probe Info  		Y57(32.28); Y844(20.78)  LDD3495  [6]
HHS-475
 Probe Info  		Y806(0.73); Y639(0.76); Y844(1.44)  LDD0264  [7]
HHS-465
 Probe Info  		Y568(4.36); Y639(8.65)  LDD2237  [8]
DBIA
 Probe Info  		C661(0.98)  LDD1492  [9]
5E-2FA
 Probe Info  		H23(0.00); H626(0.00); H175(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K570(0.00); K280(0.00); K870(0.00); K872(0.00)  LDD0199  [11]
m-APA
 Probe Info  		H23(0.00); H478(0.00)  LDD2231  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
ATP probe
 Probe Info  		K529(0.00); K275(0.00)  LDD0035  [14]
IPM
 Probe Info  		N.A.  LDD2156  [15]
NHS
 Probe Info  		K790(0.00); K182(0.00)  LDD0010  [16]
SF
 Probe Info  		Y639(0.00); Y844(0.00); K280(0.00)  LDD0028  [17]
Ox-W18
 Probe Info  		W578(0.00); W632(0.00)  LDD2175  [18]
1c-yne
 Probe Info  		K148(0.00); K770(0.00); K790(0.00); K570(0.00)  LDD0228  [19]
1d-yne
 Probe Info  		K198(0.00); K492(0.00)  LDD0357  [19]
Acrolein
 Probe Info  		H867(0.00); H175(0.00); H572(0.00); H587(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		5.27  LDD0473  [21]
FFF probe13
 Probe Info  		16.68  LDD0475  [21]
FFF probe2
 Probe Info  		7.85  LDD0463  [21]
FFF probe3
 Probe Info  		13.39  LDD0464  [21]
FFF probe9
 Probe Info  		12.32  LDD0470  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C661(1.07)  LDD1507  [9]
 LDCM0226  AC11 HEK-293T C661(0.90)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C661(1.06)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C661(1.09)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C661(0.92)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C661(0.92)  LDD1515  [9]
 LDCM0278  AC19 HEK-293T C661(0.80)  LDD1517  [9]
 LDCM0280  AC20 HEK-293T C661(1.21)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C661(1.18)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C661(1.17)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C661(1.00)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C661(1.12)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C661(0.85)  LDD1524  [9]
 LDCM0287  AC27 HEK-293T C661(0.88)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C661(1.03)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C661(1.13)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C661(0.95)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C661(1.12)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C661(1.12)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C661(1.12)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C661(1.00)  LDD1533  [9]
 LDCM0296  AC35 HEK-293T C661(0.94)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C661(1.29)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C661(1.09)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C661(1.07)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C661(1.15)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C661(1.20)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C661(1.19)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C661(0.96)  LDD1542  [9]
 LDCM0305  AC43 HEK-293T C661(1.01)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C661(0.95)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C661(1.13)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C661(1.10)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C661(1.05)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C661(1.03)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C661(0.95)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C661(1.01)  LDD1551  [9]
 LDCM0314  AC51 HEK-293T C661(0.96)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C661(1.01)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C661(1.09)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C661(0.99)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C661(0.89)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C661(0.89)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C661(0.89)  LDD1559  [9]
 LDCM0322  AC59 HEK-293T C661(0.96)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C661(1.08)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C661(1.02)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C661(0.98)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C661(0.99)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C661(1.06)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C661(1.00)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C661(1.02)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C661(1.24)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C661(1.07)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C661(1.14)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C661(1.09)  LDD1514  [9]
 LDCM0108  Chloroacetamide HeLa H175(0.00); H572(0.00); H867(0.00); H587(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C661(0.94)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C661(1.28)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C661(0.80)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C661(0.88)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C661(0.86)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C661(1.02)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C661(0.88)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C661(1.00)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C661(0.91)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C661(1.02)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C661(0.87)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C661(0.92)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C661(0.95)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C661(0.93)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C661(0.96)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C661(0.94)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C661(1.08)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C661(0.87)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C661(1.03)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C661(0.92)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C661(0.95)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C661(0.88)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C661(1.07)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C661(1.33)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C661(1.00)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C661(0.84)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C661(0.83)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C661(0.88)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C661(0.69)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C661(0.78)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C661(0.80)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C661(0.89)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C661(0.81)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C661(0.79)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C661(0.97)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C661(0.84)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C661(1.02)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C661(0.96)  LDD1608  [9]
 LDCM0406  CL19 HEK-293T C661(1.18)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C661(0.89)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C661(0.79)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C661(1.21)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C661(1.31)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C661(1.00)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C661(1.20)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C661(0.77)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C661(0.91)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C661(1.00)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C661(0.88)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C661(1.14)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C661(0.95)  LDD1622  [9]
 LDCM0420  CL31 HEK-293T C661(1.07)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C661(0.77)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C661(1.08)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C661(1.18)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C661(1.00)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C661(1.35)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C661(0.98)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C661(1.03)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C661(0.78)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C661(0.90)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C661(0.96)  LDD1635  [9]
 LDCM0433  CL43 HEK-293T C661(1.25)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C661(0.92)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C661(1.17)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C661(1.33)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C661(1.02)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C661(1.48)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C661(0.85)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C661(0.87)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C661(0.93)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C661(0.89)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C661(0.90)  LDD1647  [9]
 LDCM0446  CL55 HEK-293T C661(1.32)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C661(0.82)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C661(1.19)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C661(1.27)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C661(0.99)  LDD1653  [9]
 LDCM0452  CL60 HEK-293T C661(1.37)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C661(0.87)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C661(0.97)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C661(1.14)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C661(0.93)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C661(0.92)  LDD1660  [9]
 LDCM0459  CL67 HEK-293T C661(1.17)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C661(0.84)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C661(1.31)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C661(1.13)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C661(1.29)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C661(0.87)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C661(1.39)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C661(0.89)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C661(0.88)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C661(0.99)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C661(0.92)  LDD1673  [9]
 LDCM0472  CL79 HEK-293T C661(1.17)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C661(0.63)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C661(0.96)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C661(1.26)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C661(1.37)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C661(0.85)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C661(1.28)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C661(0.71)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C661(0.71)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C661(0.88)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C661(0.92)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C661(0.80)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C661(1.29)  LDD1687  [9]
 LDCM0486  CL91 HEK-293T C661(1.11)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C661(0.84)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C661(1.10)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C661(1.19)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C661(0.87)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C661(0.84)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C661(0.91)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C661(0.93)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C661(1.01)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C661(1.02)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C661(0.98)  LDD1671  [9]
 LDCM0427  Fragment51 HEK-293T C661(0.85)  LDD1631  [9]
 LDCM0116  HHS-0101 DM93 Y806(0.73); Y639(0.76); Y844(1.44)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y844(0.58); Y639(0.58)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y806(0.57); Y639(0.58); Y844(0.71)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y844(0.71); Y806(0.96); Y639(1.01)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y639(0.60); Y844(0.73); Y806(1.82)  LDD0268  [7]
 LDCM0107  IAA HeLa H867(0.00); H587(0.00); H175(0.00); H572(0.00)  LDD0221  [20]
 LDCM0022  KB02 HEK-293T C661(0.98)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C661(0.91)  LDD1497  [9]
 LDCM0024  KB05 HEK-293T C661(1.03)  LDD1502  [9]
 LDCM0109  NEM HeLa H867(0.00); H587(0.00); H572(0.00); H175(0.00)  LDD0223  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein arginine N-methyltransferase 9 (PRMT9) Protein arginine N-methyltransferase family Q6P2P2
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) DEAD box helicase family O60231
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
E3 ubiquitin-protein ligase RNF113A (RNF113A) . O15541
Protein FRA10AC1 (FRA10AC1) . Q70Z53
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor SYF1 (XAB2) Crooked-neck family Q9HCS7
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
Pre-mRNA-processing-splicing factor 8 (PRPF8) . Q6P2Q9
RNA-binding protein 7 (RBM7) . Q9Y580
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395
Zinc finger protein 830 (ZNF830) . Q96NB3

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.