Details of the Target

General Information of Target

Target ID LDTP12256
Target Name UPF0606 protein KIAA1549 (KIAA1549)
Gene Name KIAA1549
Gene ID 57670
Synonyms
UPF0606 protein KIAA1549
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAMPWNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGFNHLVVDERT
GHIYLGAVNRIYKLSSDLKVLVTHETGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLI
DYKENRLIACGSLYQGICKLLRLEDLFKLGEPYHKKEHYLSGVNESGSVFGVIVSYSNLD
DKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDF
DIYYVYGFSSGNFVYFLTLQPEMVSPPGSTTKEQVYTSKLVRLCKEDTAFNSYVEVPIGC
ERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFIL
KQINDRIKERLQSCYRGEGTLDLAWLKVKDIPCSSALLTIDDNFCGLDMNAPLGVSDMVR
GIPVFTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVDGPRGNALQYETVQVVDPGP
VLRDMAFSKDHEQLYIMSERQLTRVPVESCGQYQSCGECLGSGDPHCGWCVLHNTCTRKE
RCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLVLETYNVPELSAGVNCTFEDLSE
MDGLVVGNQIQCYSPAAKEVPRIITENGDHHVVQLQLKSKETGMTFASTSFVFYNCSVHN
SCLSCVESPYRCHWCKYRHVCTHDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPI
TLKAKNLPQPQSGQRGYECILNIQGSEQRVPALRFNSSSVQCQNTSYSYEGMEINNLPVE
LTVVWNGHFNIDNPAQNKVHLYKCGAMRESCGLCLKADPDFACGWCQGPGQCTLRQHCPA
QESQWLELSGAKSKCTNPRITEIIPVTGPREGGTKVTIRGENLGLEFRDIASHVKVAGVE
CSPLVDGYIPAEQIVCEMGEAKPSQHAGFVEICVAVCRPEFMARSSQLYYFMTLTLSDLK
PSRGPMSGGTQVTITGTNLNAGSNVVVMFGKQPCLFHRRSPSYIVCNTTSSDEVLEMKVS
VQVDRAKIHQDLVFQYVEDPTIVRIEPEWSIVSGNTPIAVWGTHLDLIQNPQIRAKHGGK
EHINICEVLNATEMTCQAPALALGPDHQSDLTERPEEFGFILDNVQSLLILNKTNFTYYP
NPVFEAFGPSGILELKPGTPIILKGKNLIPPVAGGNVKLNYTVLVGEKPCTVTVSDVQLL
CESPNLIGRHKVMARVGGMEYSPGMVYIAPDSPLSLPAIVSIAVAGGLLIIFIVAVLIAY
KRKSRESDLTLKRLQMQMDNLESRVALECKEAFAELQTDIHELTSDLDGAGIPFLDYRTY
TMRVLFPGIEDHPVLRDLEVPGYRQERVEKGLKLFAQLINNKVFLLSFIRTLESQRSFSM
RDRGNVASLIMTVLQSKLEYATDVLKQLLADLIDKNLESKNHPKLLLRRTESVAEKMLTN
WFTFLLYKFLKECAGEPLFSLFCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTL
VLSCVSPDNANSPEVPVKILNCDTITQVKEKILDAIFKNVPCSHRPKAADMDLEWRQGSG
ARMILQDEDITTKIENDWKRLNTLAHYQVPDGSVVALVSKQVTAYNAVNNSTVSRTSASK
YENMIRYTGSPDSLRSRTPMITPDLESGVKMWHLVKNHEHGDQKEGDRGSKMVSEIYLTR
LLATKGTLQKFVDDLFETIFSTAHRGSALPLAIKYMFDFLDEQADKHGIHDPHVRHTWKS
NCLPLRFWVNMIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLY
AKDIPSYKNWVERYYSDIGKMPAISDQDMNAYLAEQSRMHMNEFNTMSALSEIFSYVGKY
SEEILGPLDHDDQCGKQKLAYKLEQVITLMSLDS
Target Bioclass
Other
Family
UPF0606 family
Subcellular location
Membrane
Function May play a role in photoreceptor function.
Uniprot ID
Q9HCM3
Ensemble ID
ENST00000422774.2
HGNC ID
HGNC:22219

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A101D SNV: p.K615E .
BT549 SNV: p.P1147L .
CHL1 SNV: p.T940N .
COLO320 SNV: p.V1482G .
COLO679 SNV: p.P254S .
EFO27 Deletion: p.L283Ter .
ETK1 SNV: p.H1460L .
HCT116 Insertion: p.E1477GfsTer3
SNV: p.A423V;p.R1194H		 .
HCT15 SNV: p.P916H .
HEC1 SNV: p.A319T; p.L581F; p.P1906T .
HEC1B SNV: p.A319T; p.L581F .
HT Deletion: p.L283Ter .
HT115 SNV: p.R1325H .
HT3 SNV: p.E206Ter .
JURKAT Deletion: p.G1633AfsTer78
SNV: p.E1373K		 .
KASUMI2 SNV: p.R1566H .
LNCaP clone FGC SNV: p.Y1565H .
LS123 SNV: p.T940N .
LS180 Deletion: p.P1759RfsTer66
SNV: p.V1508M		 .
MELHO SNV: p.T940N; p.P1724S .
MFE319 Insertion: p.G773RfsTer3 .
NCIH1703 SNV: p.P596L .
NCIH2286 SNV: p.V1116F .
NCIH23 SNV: p.A538S .
NCIH716 SNV: p.T885I; p.T940N .
OVCAR5 SNV: p.V1607G .
PF382 SNV: p.L281P .
RL Deletion: p.H1900TfsTer75 .
SKMEL2 SNV: p.P478S .
SKMEL24 SNV: p.I1528L .
SNGM SNV: p.E1249Ter .
SNU1 SNV: p.G1921V .
SSP25 SNV: p.H1460L .
SUPT1 SNV: p.P1764S .
SW1116 SNV: p.T940N .
TOV21G Deletion: p.L283Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K1262(0.81); K1195(2.77)  LDD3494  [1]
DBIA
 Probe Info  		C1748(1.13)  LDD0078  [2]
AOyne
 Probe Info  		10.20  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		15.89  LDD1850  [4]
C171
 Probe Info  		7.26  LDD1851  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1748(0.61)  LDD1093  [2]
 LDCM0263  AC143 PaTu 8988t C1748(2.33)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C1748(1.53)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C1748(1.64)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C1748(1.59)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C1748(1.40)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C1748(1.70)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C1748(2.46)  LDD1148  [2]
 LDCM0271  AC150 PaTu 8988t C1748(2.13)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C1748(3.09)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C1748(2.57)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C1748(2.90)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C1748(3.16)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C1748(2.98)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C1748(2.95)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C1748(3.07)  LDD2169  [2]
 LDCM0279  AC2 PaTu 8988t C1748(0.47)  LDD1158  [2]
 LDCM0285  AC25 PaTu 8988t C1748(0.80)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C1748(0.81)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C1748(1.09)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C1748(1.40)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C1748(0.79)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C1748(0.52)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C1748(0.68)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C1748(1.06)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C1748(1.02)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C1748(1.46)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C1748(1.05)  LDD1174  [2]
 LDCM0301  AC4 PaTu 8988t C1748(0.60)  LDD1180  [2]
 LDCM0312  AC5 PaTu 8988t C1748(0.61)  LDD1191  [2]
 LDCM0320  AC57 PaTu 8988t C1748(1.56)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C1748(1.47)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C1748(1.42)  LDD1201  [2]
 LDCM0324  AC60 PaTu 8988t C1748(1.67)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C1748(0.97)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C1748(1.00)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C1748(1.09)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C1748(0.93)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C1748(0.76)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C1748(0.87)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C1748(0.86)  LDD1210  [2]
 LDCM0020  ARS-1620 HCC44 C1748(1.13)  LDD0078  [2]
 LDCM0369  CL100 PaTu 8988t C1748(0.50)  LDD1248  [2]
 LDCM0382  CL112 PaTu 8988t C1748(1.01)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C1748(1.03)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C1748(1.02)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C1748(1.10)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C1748(1.18)  LDD1265  [2]
 LDCM0396  CL125 PaTu 8988t C1748(1.79)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C1748(1.06)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C1748(0.97)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C1748(1.18)  LDD1278  [2]
 LDCM0420  CL31 PaTu 8988t C1748(1.25)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C1748(1.03)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C1748(1.28)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C1748(1.21)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C1748(1.38)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C1748(1.17)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C1748(1.61)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C1748(1.51)  LDD1307  [2]
 LDCM0430  CL40 PaTu 8988t C1748(1.14)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C1748(1.00)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C1748(1.61)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C1748(1.37)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C1748(2.03)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C1748(2.03)  LDD1314  [2]
 LDCM0436  CL46 PaTu 8988t C1748(1.60)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C1748(1.05)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C1748(1.73)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C1748(1.52)  LDD1318  [2]
 LDCM0441  CL50 PaTu 8988t C1748(1.23)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C1748(1.30)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C1748(1.53)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C1748(1.59)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C1748(1.04)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C1748(1.30)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C1748(1.17)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C1748(1.42)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C1748(1.62)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C1748(1.39)  LDD1329  [2]
 LDCM0452  CL60 PaTu 8988t C1748(1.10)  LDD1331  [2]
 LDCM0486  CL91 PaTu 8988t C1748(0.42)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C1748(0.44)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C1748(0.45)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C1748(0.39)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C1748(0.46)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C1748(0.44)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C1748(0.44)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C1748(0.47)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C1748(0.54)  LDD1373  [2]
 LDCM0427  Fragment51 PaTu 8988t C1748(1.71)  LDD1306  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587