Details of the Target

General Information of Target

Target ID LDTP12884
Target Name Molybdenum cofactor biosynthesis protein 1 (MOCS1)
Gene Name MOCS1
Gene ID 4337
Synonyms
Molybdenum cofactor biosynthesis protein 1; Cell migration-inducing gene 11 protein; Molybdenum cofactor synthesis-step 1 protein A-B) [Includes: GTP 3',8-cyclase; EC 4.1.99.22; Molybdenum cofactor biosynthesis protein A; Cyclic pyranopterin monophosphate synthase; EC 4.6.1.17; Molybdenum cofactor biosynthesis protein C)]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGG
FYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQ
QIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFH
GLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALL
GNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLD
AIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHV
PPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSN
IPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKI
GWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNH
MDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAAL
LYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVE
ALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLR
YMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMA
LFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQ
SVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGE
TVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGS
RRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPY
AASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESA
LNNDSKTCNTNPHLNALSTDSACRREAALEAAVLNKEE
Target Type
Clinical trial
Target Bioclass
Other
Family
MoaC family; Radical SAM superfamily, MoaA family
Function
Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP.
TTD ID
T98196
Uniprot ID
Q9NZB8
DrugMap ID
TTH13AB
Ensemble ID
ENST00000340692.10
HGNC ID
HGNC:7190

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC15 SNV: p.M221I .
HCT15 SNV: p.K205N .
HEC1 SNV: p.L342M .
HEC1B SNV: p.L342M .
HT115 SNV: p.S16F .
JURKAT SNV: p.H310Y Compound 10    Probe Info 
MOLT4 SNV: p.A55T .
NCIH1793 SNV: p.E266D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C84(0.91); C87(0.91)  LDD0813  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C461(0.00); C329(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C608(0.00); C461(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C608(0.00); C461(0.00); C218(0.00)  LDD0037  [3]
Compound 10
 Probe Info  		C329(0.00); C461(0.00)  LDD2216  [4]
Compound 11
 Probe Info  		C329(0.00); C461(0.00)  LDD2213  [4]
NAIA_5
 Probe Info  		C608(0.00); C554(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		13.64  LDD1760  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C218(0.79); C461(1.04)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C84(0.91); C87(0.91)  LDD0813  [1]
 LDCM0226  AC11 HEK-293T C84(1.05); C87(1.05)  LDD0824  [1]
 LDCM0230  AC113 HEK-293T C84(1.07); C87(1.07)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C84(0.90); C87(0.90)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C84(1.09); C87(1.09)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C84(0.87); C87(0.87)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C84(0.99); C87(0.99)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C84(1.14); C87(1.14)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C84(1.16); C87(1.16)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C84(1.25); C87(1.25)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C84(0.77); C87(0.77)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C84(1.12); C87(1.12)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C84(0.94); C87(0.94)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C84(0.87); C87(0.87)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C84(0.94); C87(0.94)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C84(0.95); C87(0.95)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C84(1.14); C87(1.14)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C84(1.12); C87(1.12)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C84(1.22); C87(1.22)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C84(1.11); C87(1.11)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C84(1.00); C87(1.00)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C84(1.23); C87(1.23)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C84(1.31); C87(1.31)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C84(0.96); C87(0.96)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C84(1.04); C87(1.04)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C84(1.20); C87(1.20)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C84(0.91); C87(0.91)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C84(1.23); C87(1.23)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C84(1.19); C87(1.19)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C84(1.18); C87(1.18)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C84(1.44); C87(1.44)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C84(1.22); C87(1.22)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C84(1.18); C87(1.18)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C84(1.22); C87(1.22)  LDD0860  [1]
 LDCM0270  AC15 HEK-293T C84(1.01); C87(1.01)  LDD0868  [1]
 LDCM0276  AC17 HEK-293T C84(1.56); C87(1.56)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C84(1.68); C87(1.68)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C84(1.48); C87(1.48)  LDD0876  [1]
 LDCM0279  AC2 HEK-293T C218(1.02)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C84(1.42); C87(1.42)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C84(1.37); C87(1.37)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C84(1.56); C87(1.56)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C84(1.62); C87(1.62)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C84(1.34); C87(1.34)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C84(0.53); C87(0.53)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C84(0.67); C87(0.67)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C84(0.61); C87(0.61)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C84(0.67); C87(0.67)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C84(0.63); C87(0.63)  LDD0887  [1]
 LDCM0290  AC3 HEK-293T C218(0.92); C461(0.88)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C84(0.67); C87(0.67)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C84(0.46); C87(0.46)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C84(0.64); C87(0.64)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C84(0.62); C87(0.62)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C84(0.60); C87(0.60)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C84(1.07); C87(1.07)  LDD0894  [1]
 LDCM0297  AC36 HEK-293T C84(0.72); C87(0.72)  LDD0895  [1]
 LDCM0298  AC37 HEK-293T C84(0.92); C87(0.92)  LDD0896  [1]
 LDCM0299  AC38 HEK-293T C84(1.28); C87(1.28)  LDD0897  [1]
 LDCM0300  AC39 HEK-293T C84(1.68); C87(1.68)  LDD0898  [1]
 LDCM0301  AC4 HEK-293T C218(1.12)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C84(1.11); C87(1.11)  LDD0900  [1]
 LDCM0303  AC41 HEK-293T C84(0.90); C87(0.90)  LDD0901  [1]
 LDCM0304  AC42 HEK-293T C84(1.00); C87(1.00)  LDD0902  [1]
 LDCM0305  AC43 HEK-293T C84(1.04); C87(1.04)  LDD0903  [1]
 LDCM0306  AC44 HEK-293T C84(0.97); C87(0.97)  LDD0904  [1]
 LDCM0307  AC45 HEK-293T C84(0.98); C87(0.98)  LDD0905  [1]
 LDCM0308  AC46 HEK-293T C218(1.05)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C218(1.07); C461(1.22)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C218(1.04); C461(1.05)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C218(0.93); C461(1.04)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C218(0.78)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C218(1.19)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C218(1.01); C461(1.05)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C218(1.01)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C218(0.89)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C218(0.92)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C218(0.94); C461(1.02)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C218(0.99); C461(1.02)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C218(1.04); C461(0.98)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C218(1.09)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C218(1.04); C461(1.02)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C84(0.94); C87(0.94)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C218(1.03)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C218(1.01)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C218(0.93)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C218(1.04); C461(1.30)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C218(0.98); C461(1.84)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C84(0.78); C87(0.78)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C84(0.96); C87(0.96)  LDD0943  [1]
 LDCM0248  AKOS034007472 HEK-293T C84(0.99); C87(0.99)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C84(0.99); C87(0.99)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C84(1.33); C87(1.33)  LDD0873  [1]
 LDCM0367  CL1 HEK-293T C218(1.14); C461(0.98)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C218(1.02)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C218(0.97)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C84(0.93); C87(0.93)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C84(1.22); C87(1.22)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C84(0.92); C87(0.92)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C84(0.82); C87(0.82)  LDD0971  [1]
 LDCM0374  CL105 HEK-293T C84(1.51); C87(1.51)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C84(1.56); C87(1.56)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C84(1.40); C87(1.40)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C84(1.34); C87(1.34)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C84(1.49); C87(1.49)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C218(1.00); C461(1.05)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C84(1.93); C87(1.93)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C84(1.53); C87(1.53)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C84(0.71); C87(0.71)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C84(0.90); C87(0.90)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C84(0.83); C87(0.83)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C84(0.65); C87(0.65)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C84(0.53); C87(0.53)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C84(1.17); C87(1.17)  LDD0985  [1]
 LDCM0388  CL118 HEK-293T C84(0.90); C87(0.90)  LDD0986  [1]
 LDCM0389  CL119 HEK-293T C84(0.80); C87(0.80)  LDD0987  [1]
 LDCM0390  CL12 HEK-293T C218(0.95); C461(1.07)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C84(1.04); C87(1.04)  LDD0989  [1]
 LDCM0392  CL121 HEK-293T C218(1.06); C461(1.09)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C218(0.91); C461(1.01)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C218(1.07); C461(1.29)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C218(1.05)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C218(1.16); C461(0.97)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C218(1.07); C461(1.02)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C218(1.05); C461(1.06)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C218(1.05)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C218(0.99); C461(1.17)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C218(0.83); C461(0.96)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C218(0.98); C461(1.33)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C218(0.98)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C218(0.82); C461(0.98)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C218(1.01)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C218(0.88); C461(0.94)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C218(0.91); C461(0.84)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C218(0.98)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C218(0.92)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C218(0.92)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C218(1.00); C461(1.16)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C218(0.86); C461(0.91)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C218(1.03); C461(0.89)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C218(0.95); C461(0.96)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C218(1.00); C461(1.25)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C218(0.96)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C218(1.12); C461(1.17)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C218(0.99); C461(1.22)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C218(1.23)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C218(0.99); C461(1.06)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C218(1.02)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C218(0.88)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C218(0.90)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C218(1.02); C461(1.44)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C218(0.94); C461(1.07)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C218(1.13); C461(1.03)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C218(1.05); C461(1.15)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C218(1.01)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C218(1.01)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C218(0.99); C461(1.26)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C218(1.04)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C218(1.02); C461(1.01)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C218(1.04)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C218(0.77)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C218(0.99)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C218(1.01); C461(1.21)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C218(0.87); C461(1.06)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C218(1.10); C461(1.10)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C218(1.00); C461(0.91)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C218(0.96); C461(0.98)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C218(0.96)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C218(1.02); C461(1.13)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C218(1.07)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C218(1.07); C461(1.17)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C218(1.16)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C218(0.84)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C218(0.97)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C218(1.16); C461(1.05)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C218(1.03)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C218(0.97); C461(1.05)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C218(1.14); C461(1.07)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C218(1.03); C461(0.92)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C218(1.21); C461(1.17)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C218(1.13)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C218(1.06); C461(1.06)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C218(1.08)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C218(0.97); C461(0.86)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C218(1.01)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C218(0.92)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C218(0.96); C461(0.95)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C218(1.04)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C218(0.96); C461(1.11)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C218(0.92); C461(0.96)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C218(1.08); C461(1.13)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C218(1.01); C461(1.02)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C218(1.02)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C218(0.96); C461(1.25)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C218(0.96)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C218(1.04); C461(0.87)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C218(1.30)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C218(0.99)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C218(0.89)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C218(0.92)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C218(1.15); C461(0.94)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C218(1.01); C461(0.87)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C218(0.92); C461(1.04)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C218(0.99); C461(1.01)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C218(1.04); C461(1.12)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C218(1.10)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C218(1.10); C461(0.97)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C218(0.99)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C218(1.28)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C218(1.07); C461(1.00)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C218(1.07)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C218(0.72)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C218(0.96)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C218(1.23); C461(1.20)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C218(1.07); C461(1.29)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C218(1.05); C461(0.91)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C218(0.98); C461(1.06)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C218(1.11); C461(1.17)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C218(1.12); C461(1.07)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C218(0.99); C461(1.18)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C218(0.97); C461(0.95)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C218(0.99); C461(0.88)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C218(1.08); C461(0.89)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C218(0.97); C461(0.57)  LDD1502  [7]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alxn1101 . D01AKK

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402