Details of the Target

General Information of Target

Target ID LDTP06315
Target Name Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3)
Gene Name PAFAH1B3
Gene ID 5050
Synonyms
PAFAHG; Platelet-activating factor acetylhydrolase IB subunit alpha1; EC 3.1.1.47; PAF acetylhydrolase 29 kDa subunit; PAF-AH 29 kDa subunit; PAF-AH subunit gamma; PAFAH subunit gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRE
LFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAI
VQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVH
SDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP
Target Bioclass
Enzyme
Family
'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
Subcellular location
Cytoplasm
Function
Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain.
Uniprot ID
Q15102
Ensemble ID
ENST00000262890.8
HGNC ID
HGNC:8576
ChEMBL ID
CHEMBL5108

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.87  LDD0402  [1]
A-EBA
 Probe Info  		4.55  LDD0215  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K118(2.73); K37(20.00)  LDD2217  [4]
BTD
 Probe Info  		C205(1.95)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C55(9.57)  LDD0170  [6]
DBIA
 Probe Info  		C205(4.05)  LDD0209  [7]
5E-2FA
 Probe Info  		H66(0.00); H144(0.00); H91(0.00)  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C55(0.00); C205(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C55(0.00); C205(0.00)  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD0025  [12]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
PF-06672131
 Probe Info  		N.A.  LDD0152  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
NAIA_5
 Probe Info  		C55(0.00); C205(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C348
 Probe Info  		12.64  LDD2009  [18]
C349
 Probe Info  		11.39  LDD2010  [18]
C350
 Probe Info  		24.42  LDD2011  [18]
C353
 Probe Info  		7.84  LDD2014  [18]
C354
 Probe Info  		8.22  LDD2015  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C205(0.79)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C205(0.98)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C205(1.53)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C205(0.73)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C205(1.21)  LDD2131  [5]
 LDCM0025  4SU-RNA DM93 C55(9.57)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C205(0.63); C55(0.56)  LDD0531  [19]
 LDCM0215  AC10 HCT 116 C205(0.79); C55(0.61)  LDD0532  [19]
 LDCM0216  AC100 HCT 116 C205(2.75)  LDD0533  [19]
 LDCM0217  AC101 HCT 116 C205(0.67)  LDD0534  [19]
 LDCM0218  AC102 HCT 116 C205(0.71)  LDD0535  [19]
 LDCM0219  AC103 HCT 116 C205(0.53)  LDD0536  [19]
 LDCM0220  AC104 HCT 116 C205(0.68)  LDD0537  [19]
 LDCM0221  AC105 HCT 116 C205(0.62)  LDD0538  [19]
 LDCM0222  AC106 HCT 116 C205(0.59)  LDD0539  [19]
 LDCM0223  AC107 HCT 116 C205(0.48)  LDD0540  [19]
 LDCM0224  AC108 HCT 116 C205(0.78)  LDD0541  [19]
 LDCM0225  AC109 HCT 116 C205(0.87)  LDD0542  [19]
 LDCM0226  AC11 HCT 116 C205(0.79); C55(0.48)  LDD0543  [19]
 LDCM0227  AC110 HCT 116 C205(0.76)  LDD0544  [19]
 LDCM0228  AC111 HCT 116 C205(0.79)  LDD0545  [19]
 LDCM0229  AC112 HCT 116 C205(0.53)  LDD0546  [19]
 LDCM0230  AC113 HCT 116 C205(1.26); C55(1.00)  LDD0547  [19]
 LDCM0231  AC114 HCT 116 C205(0.76); C55(0.85)  LDD0548  [19]
 LDCM0232  AC115 HCT 116 C205(0.62); C55(0.63)  LDD0549  [19]
 LDCM0233  AC116 HCT 116 C205(0.64); C55(0.55)  LDD0550  [19]
 LDCM0234  AC117 HCT 116 C205(0.99); C55(0.76)  LDD0551  [19]
 LDCM0235  AC118 HCT 116 C205(0.97); C55(0.61)  LDD0552  [19]
 LDCM0236  AC119 HCT 116 C205(0.88); C55(0.58)  LDD0553  [19]
 LDCM0237  AC12 HCT 116 C205(1.07); C55(0.65)  LDD0554  [19]
 LDCM0238  AC120 HCT 116 C205(0.81); C55(0.59)  LDD0555  [19]
 LDCM0239  AC121 HCT 116 C205(1.10); C55(0.87)  LDD0556  [19]
 LDCM0240  AC122 HCT 116 C205(0.81); C55(0.73)  LDD0557  [19]
 LDCM0241  AC123 HCT 116 C205(0.94); C55(0.84)  LDD0558  [19]
 LDCM0242  AC124 HCT 116 C205(1.12); C55(0.90)  LDD0559  [19]
 LDCM0243  AC125 HCT 116 C205(0.86); C55(0.73)  LDD0560  [19]
 LDCM0244  AC126 HCT 116 C205(0.72); C55(0.67)  LDD0561  [19]
 LDCM0245  AC127 HCT 116 C205(0.80); C55(0.61)  LDD0562  [19]
 LDCM0246  AC128 HCT 116 C205(0.90); C55(0.61)  LDD0563  [19]
 LDCM0247  AC129 HCT 116 C205(1.32); C55(3.20)  LDD0564  [19]
 LDCM0249  AC130 HCT 116 C205(0.87); C55(0.89)  LDD0566  [19]
 LDCM0250  AC131 HCT 116 C205(1.50); C55(2.43)  LDD0567  [19]
 LDCM0251  AC132 HCT 116 C205(1.29); C55(1.33)  LDD0568  [19]
 LDCM0252  AC133 HCT 116 C205(0.87); C55(0.66)  LDD0569  [19]
 LDCM0253  AC134 HCT 116 C205(0.79); C55(1.13)  LDD0570  [19]
 LDCM0254  AC135 HCT 116 C205(0.72); C55(0.94)  LDD0571  [19]
 LDCM0255  AC136 HCT 116 C205(0.89); C55(0.83)  LDD0572  [19]
 LDCM0256  AC137 HCT 116 C205(1.02); C55(1.18)  LDD0573  [19]
 LDCM0257  AC138 HCT 116 C205(0.77); C55(1.02)  LDD0574  [19]
 LDCM0258  AC139 HCT 116 C205(0.88); C55(0.99)  LDD0575  [19]
 LDCM0259  AC14 HCT 116 C205(0.69); C55(0.43)  LDD0576  [19]
 LDCM0260  AC140 HCT 116 C205(0.76); C55(1.08)  LDD0577  [19]
 LDCM0261  AC141 HCT 116 C205(0.89); C55(1.07)  LDD0578  [19]
 LDCM0262  AC142 HCT 116 C205(1.16); C55(1.24)  LDD0579  [19]
 LDCM0263  AC143 HCT 116 C205(0.65)  LDD0580  [19]
 LDCM0264  AC144 HCT 116 C205(0.44)  LDD0581  [19]
 LDCM0265  AC145 HCT 116 C205(0.59)  LDD0582  [19]
 LDCM0266  AC146 HCT 116 C205(0.36)  LDD0583  [19]
 LDCM0267  AC147 HCT 116 C205(0.50)  LDD0584  [19]
 LDCM0268  AC148 HCT 116 C205(0.36)  LDD0585  [19]
 LDCM0269  AC149 HCT 116 C205(0.33)  LDD0586  [19]
 LDCM0270  AC15 HCT 116 C55(0.58); C205(0.78)  LDD0587  [19]
 LDCM0271  AC150 HCT 116 C205(0.69)  LDD0588  [19]
 LDCM0272  AC151 HCT 116 C205(0.65)  LDD0589  [19]
 LDCM0273  AC152 HCT 116 C205(0.39)  LDD0590  [19]
 LDCM0274  AC153 HCT 116 C205(0.29)  LDD0591  [19]
 LDCM0621  AC154 HCT 116 C205(0.49)  LDD2158  [19]
 LDCM0622  AC155 HCT 116 C205(0.44)  LDD2159  [19]
 LDCM0623  AC156 HCT 116 C205(0.73)  LDD2160  [19]
 LDCM0624  AC157 HCT 116 C205(0.65)  LDD2161  [19]
 LDCM0276  AC17 HCT 116 C205(1.08)  LDD0593  [19]
 LDCM0277  AC18 HCT 116 C205(0.87)  LDD0594  [19]
 LDCM0278  AC19 HCT 116 C205(1.09)  LDD0595  [19]
 LDCM0279  AC2 HCT 116 C205(0.66); C55(1.04)  LDD0596  [19]
 LDCM0280  AC20 HCT 116 C205(1.21)  LDD0597  [19]
 LDCM0281  AC21 HCT 116 C205(1.13)  LDD0598  [19]
 LDCM0282  AC22 HCT 116 C205(1.31)  LDD0599  [19]
 LDCM0283  AC23 HCT 116 C205(1.28)  LDD0600  [19]
 LDCM0284  AC24 HCT 116 C205(1.32)  LDD0601  [19]
 LDCM0285  AC25 HCT 116 C205(1.06)  LDD0602  [19]
 LDCM0286  AC26 HCT 116 C205(0.64)  LDD0603  [19]
 LDCM0287  AC27 HCT 116 C205(0.63)  LDD0604  [19]
 LDCM0288  AC28 HCT 116 C205(0.61)  LDD0605  [19]
 LDCM0289  AC29 HCT 116 C205(0.58)  LDD0606  [19]
 LDCM0290  AC3 HCT 116 C205(0.75); C55(0.81)  LDD0607  [19]
 LDCM0291  AC30 HCT 116 C205(0.52)  LDD0608  [19]
 LDCM0292  AC31 HCT 116 C205(0.46)  LDD0609  [19]
 LDCM0293  AC32 HCT 116 C205(0.42)  LDD0610  [19]
 LDCM0294  AC33 HCT 116 C205(0.64)  LDD0611  [19]
 LDCM0295  AC34 HCT 116 C205(0.74)  LDD0612  [19]
 LDCM0296  AC35 HCT 116 C205(1.74)  LDD0613  [19]
 LDCM0297  AC36 HCT 116 C205(1.14)  LDD0614  [19]
 LDCM0298  AC37 HCT 116 C205(1.27)  LDD0615  [19]
 LDCM0299  AC38 HCT 116 C205(1.36)  LDD0616  [19]
 LDCM0300  AC39 HCT 116 C205(1.01)  LDD0617  [19]
 LDCM0301  AC4 HCT 116 C55(0.63); C205(0.84)  LDD0618  [19]
 LDCM0302  AC40 HCT 116 C205(0.93)  LDD0619  [19]
 LDCM0303  AC41 HCT 116 C205(1.15)  LDD0620  [19]
 LDCM0304  AC42 HCT 116 C205(1.07)  LDD0621  [19]
 LDCM0305  AC43 HCT 116 C205(0.80)  LDD0622  [19]
 LDCM0306  AC44 HCT 116 C205(1.30)  LDD0623  [19]
 LDCM0307  AC45 HCT 116 C205(1.10)  LDD0624  [19]
 LDCM0308  AC46 HCT 116 C205(0.30); C55(0.96)  LDD0625  [19]
 LDCM0309  AC47 HCT 116 C205(0.30); C55(0.85)  LDD0626  [19]
 LDCM0310  AC48 HCT 116 C55(0.46); C205(0.67)  LDD0627  [19]
 LDCM0311  AC49 HCT 116 C55(0.42); C205(0.65)  LDD0628  [19]
 LDCM0312  AC5 HCT 116 C55(0.63); C205(0.72)  LDD0629  [19]
 LDCM0313  AC50 HCT 116 C55(0.46); C205(0.55)  LDD0630  [19]
 LDCM0314  AC51 HCT 116 C205(0.67); C55(0.99)  LDD0631  [19]
 LDCM0315  AC52 HCT 116 C205(0.70); C55(0.86)  LDD0632  [19]
 LDCM0316  AC53 HCT 116 C55(0.59); C205(0.89)  LDD0633  [19]
 LDCM0317  AC54 HCT 116 C55(0.64); C205(0.75)  LDD0634  [19]
 LDCM0318  AC55 HCT 116 C55(0.41); C205(0.66)  LDD0635  [19]
 LDCM0319  AC56 HCT 116 C55(0.29); C205(1.47)  LDD0636  [19]
 LDCM0320  AC57 HCT 116 C55(0.60); C205(2.03)  LDD0637  [19]
 LDCM0321  AC58 HCT 116 C55(0.54); C205(2.54)  LDD0638  [19]
 LDCM0322  AC59 HCT 116 C55(0.55); C205(1.88)  LDD0639  [19]
 LDCM0323  AC6 HCT 116 C55(0.66); C205(0.81)  LDD0640  [19]
 LDCM0324  AC60 HCT 116 C55(0.45); C205(0.88)  LDD0641  [19]
 LDCM0325  AC61 HCT 116 C55(0.37); C205(1.25)  LDD0642  [19]
 LDCM0326  AC62 HCT 116 C55(0.53); C205(1.13)  LDD0643  [19]
 LDCM0327  AC63 HCT 116 C55(0.51); C205(1.09)  LDD0644  [19]
 LDCM0328  AC64 HCT 116 C55(0.48); C205(1.34)  LDD0645  [19]
 LDCM0329  AC65 HCT 116 C55(0.58); C205(1.50)  LDD0646  [19]
 LDCM0330  AC66 HCT 116 C55(0.59); C205(1.11)  LDD0647  [19]
 LDCM0331  AC67 HCT 116 C55(0.27); C205(1.40)  LDD0648  [19]
 LDCM0332  AC68 HCT 116 C205(0.56); C55(0.58)  LDD0649  [19]
 LDCM0333  AC69 HCT 116 C55(0.45); C205(0.51)  LDD0650  [19]
 LDCM0334  AC7 HCT 116 C55(0.62); C205(0.88)  LDD0651  [19]
 LDCM0335  AC70 HCT 116 C55(0.30); C205(0.63)  LDD0652  [19]
 LDCM0336  AC71 HCT 116 C55(0.80); C205(0.84)  LDD0653  [19]
 LDCM0337  AC72 HCT 116 C55(0.65); C205(0.88)  LDD0654  [19]
 LDCM0338  AC73 HCT 116 C55(0.31); C205(0.40)  LDD0655  [19]
 LDCM0339  AC74 HCT 116 C55(0.28); C205(0.78)  LDD0656  [19]
 LDCM0340  AC75 HCT 116 C55(0.25); C205(0.52)  LDD0657  [19]
 LDCM0341  AC76 HCT 116 C55(0.45); C205(0.65)  LDD0658  [19]
 LDCM0342  AC77 HCT 116 C55(0.48); C205(0.65)  LDD0659  [19]
 LDCM0343  AC78 HCT 116 C55(0.59); C205(0.74)  LDD0660  [19]
 LDCM0344  AC79 HCT 116 C55(0.77); C205(1.06)  LDD0661  [19]
 LDCM0345  AC8 HCT 116 C55(0.67); C205(0.84)  LDD0662  [19]
 LDCM0346  AC80 HCT 116 C55(0.55); C205(0.76)  LDD0663  [19]
 LDCM0347  AC81 HCT 116 C55(0.51); C205(0.70)  LDD0664  [19]
 LDCM0348  AC82 HCT 116 C55(0.21); C205(0.34)  LDD0665  [19]
 LDCM0349  AC83 HCT 116 C205(0.78)  LDD0666  [19]
 LDCM0350  AC84 HCT 116 C205(1.06)  LDD0667  [19]
 LDCM0351  AC85 HCT 116 C205(0.75)  LDD0668  [19]
 LDCM0352  AC86 HCT 116 C205(0.76)  LDD0669  [19]
 LDCM0353  AC87 HCT 116 C205(0.97)  LDD0670  [19]
 LDCM0354  AC88 HCT 116 C205(1.01)  LDD0671  [19]
 LDCM0355  AC89 HCT 116 C205(0.59)  LDD0672  [19]
 LDCM0357  AC90 HCT 116 C205(0.87)  LDD0674  [19]
 LDCM0358  AC91 HCT 116 C205(0.59)  LDD0675  [19]
 LDCM0359  AC92 HCT 116 C205(0.70)  LDD0676  [19]
 LDCM0360  AC93 HCT 116 C205(0.77)  LDD0677  [19]
 LDCM0361  AC94 HCT 116 C205(0.62)  LDD0678  [19]
 LDCM0362  AC95 HCT 116 C205(0.90)  LDD0679  [19]
 LDCM0363  AC96 HCT 116 C205(0.83)  LDD0680  [19]
 LDCM0364  AC97 HCT 116 C205(0.62)  LDD0681  [19]
 LDCM0365  AC98 HCT 116 C205(0.35)  LDD0682  [19]
 LDCM0366  AC99 HCT 116 C205(1.10)  LDD0683  [19]
 LDCM0520  AKOS000195272 MDA-MB-231 C205(0.83)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C205(0.89); C55(0.74)  LDD0565  [19]
 LDCM0356  AKOS034007680 HCT 116 C55(0.60); C205(0.80)  LDD0673  [19]
 LDCM0275  AKOS034007705 HCT 116 C55(0.32); C205(0.66)  LDD0592  [19]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C205(0.49)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C55(4.38)  LDD2214  [20]
 LDCM0108  Chloroacetamide HeLa C55(0.00); H166(0.00)  LDD0222  [17]
 LDCM0367  CL1 HCT 116 C205(0.87)  LDD0684  [19]
 LDCM0368  CL10 HCT 116 C205(0.65)  LDD0685  [19]
 LDCM0369  CL100 HCT 116 C205(0.69); C55(0.74)  LDD0686  [19]
 LDCM0370  CL101 HCT 116 C55(0.53); C205(0.80)  LDD0687  [19]
 LDCM0371  CL102 HCT 116 C205(0.86); C55(0.94)  LDD0688  [19]
 LDCM0372  CL103 HCT 116 C55(0.82); C205(1.00)  LDD0689  [19]
 LDCM0373  CL104 HCT 116 C55(0.75); C205(1.18)  LDD0690  [19]
 LDCM0374  CL105 HCT 116 C205(0.72)  LDD0691  [19]
 LDCM0375  CL106 HCT 116 C205(0.63)  LDD0692  [19]
 LDCM0376  CL107 HCT 116 C205(0.84)  LDD0693  [19]
 LDCM0377  CL108 HCT 116 C205(0.79)  LDD0694  [19]
 LDCM0378  CL109 HCT 116 C205(0.87)  LDD0695  [19]
 LDCM0379  CL11 HCT 116 C205(1.30)  LDD0696  [19]
 LDCM0380  CL110 HCT 116 C205(0.73)  LDD0697  [19]
 LDCM0381  CL111 HCT 116 C205(0.98)  LDD0698  [19]
 LDCM0382  CL112 HCT 116 C205(1.05)  LDD0699  [19]
 LDCM0383  CL113 HCT 116 C205(0.55)  LDD0700  [19]
 LDCM0384  CL114 HCT 116 C205(0.65)  LDD0701  [19]
 LDCM0385  CL115 HCT 116 C205(0.72)  LDD0702  [19]
 LDCM0386  CL116 HCT 116 C205(0.75)  LDD0703  [19]
 LDCM0387  CL117 HCT 116 C205(0.66)  LDD0704  [19]
 LDCM0388  CL118 HCT 116 C205(0.94)  LDD0705  [19]
 LDCM0389  CL119 HCT 116 C205(0.94)  LDD0706  [19]
 LDCM0390  CL12 HCT 116 C205(0.87)  LDD0707  [19]
 LDCM0391  CL120 HCT 116 C205(1.15)  LDD0708  [19]
 LDCM0392  CL121 HCT 116 C205(0.58); C55(0.64)  LDD0709  [19]
 LDCM0393  CL122 HCT 116 C205(0.43); C55(0.56)  LDD0710  [19]
 LDCM0394  CL123 HCT 116 C55(0.54); C205(0.72)  LDD0711  [19]
 LDCM0395  CL124 HCT 116 C55(0.48); C205(0.86)  LDD0712  [19]
 LDCM0396  CL125 HCT 116 C55(0.90); C205(4.12)  LDD0713  [19]
 LDCM0397  CL126 HCT 116 C55(0.85); C205(1.43)  LDD0714  [19]
 LDCM0398  CL127 HCT 116 C55(0.81); C205(1.35)  LDD0715  [19]
 LDCM0399  CL128 HCT 116 C55(0.63); C205(1.74)  LDD0716  [19]
 LDCM0400  CL13 HCT 116 C205(0.97)  LDD0717  [19]
 LDCM0401  CL14 HCT 116 C205(0.68)  LDD0718  [19]
 LDCM0402  CL15 HCT 116 C205(1.19)  LDD0719  [19]
 LDCM0403  CL16 HEK-293T C55(1.07)  LDD1001  [19]
 LDCM0404  CL17 HCT 116 C205(1.15)  LDD0721  [19]
 LDCM0405  CL18 HCT 116 C205(1.39)  LDD0722  [19]
 LDCM0406  CL19 HCT 116 C205(1.30)  LDD0723  [19]
 LDCM0407  CL2 HCT 116 C205(0.79)  LDD0724  [19]
 LDCM0408  CL20 HCT 116 C205(0.73)  LDD0725  [19]
 LDCM0409  CL21 HCT 116 C205(1.03)  LDD0726  [19]
 LDCM0410  CL22 HCT 116 C205(1.06)  LDD0727  [19]
 LDCM0411  CL23 HCT 116 C205(2.54)  LDD0728  [19]
 LDCM0412  CL24 HCT 116 C205(1.60)  LDD0729  [19]
 LDCM0413  CL25 HCT 116 C205(0.85)  LDD0730  [19]
 LDCM0414  CL26 HCT 116 C205(1.22)  LDD0731  [19]
 LDCM0415  CL27 HCT 116 C205(1.40)  LDD0732  [19]
 LDCM0416  CL28 HCT 116 C205(0.94)  LDD0733  [19]
 LDCM0417  CL29 HCT 116 C205(0.95)  LDD0734  [19]
 LDCM0418  CL3 HCT 116 C205(0.70)  LDD0735  [19]
 LDCM0419  CL30 HCT 116 C205(1.72)  LDD0736  [19]
 LDCM0420  CL31 HCT 116 C205(0.94); C55(0.98)  LDD0737  [19]
 LDCM0421  CL32 HCT 116 C205(0.64); C55(0.45)  LDD0738  [19]
 LDCM0422  CL33 HCT 116 C205(0.60); C55(0.59)  LDD0739  [19]
 LDCM0423  CL34 HCT 116 C205(0.78); C55(0.57)  LDD0740  [19]
 LDCM0424  CL35 HCT 116 C205(0.69); C55(0.62)  LDD0741  [19]
 LDCM0425  CL36 HCT 116 C205(0.71); C55(0.64)  LDD0742  [19]
 LDCM0426  CL37 HCT 116 C205(0.78); C55(0.61)  LDD0743  [19]
 LDCM0428  CL39 HCT 116 C205(0.79); C55(0.58)  LDD0745  [19]
 LDCM0429  CL4 HCT 116 C205(1.01)  LDD0746  [19]
 LDCM0430  CL40 HCT 116 C205(0.77); C55(0.70)  LDD0747  [19]
 LDCM0431  CL41 HCT 116 C205(1.07); C55(0.79)  LDD0748  [19]
 LDCM0432  CL42 HCT 116 C205(0.91); C55(0.38)  LDD0749  [19]
 LDCM0433  CL43 HCT 116 C205(0.86); C55(0.48)  LDD0750  [19]
 LDCM0434  CL44 HCT 116 C205(0.72); C55(0.49)  LDD0751  [19]
 LDCM0435  CL45 HCT 116 C205(0.61); C55(0.41)  LDD0752  [19]
 LDCM0436  CL46 HCT 116 C205(1.74)  LDD0753  [19]
 LDCM0437  CL47 HCT 116 C205(2.13)  LDD0754  [19]
 LDCM0438  CL48 HCT 116 C205(2.05)  LDD0755  [19]
 LDCM0439  CL49 HCT 116 C205(1.17)  LDD0756  [19]
 LDCM0440  CL5 HCT 116 C205(1.01)  LDD0757  [19]
 LDCM0441  CL50 HCT 116 C205(1.71)  LDD0758  [19]
 LDCM0442  CL51 HCT 116 C205(2.26)  LDD0759  [19]
 LDCM0443  CL52 HCT 116 C205(1.67)  LDD0760  [19]
 LDCM0444  CL53 HCT 116 C205(1.65)  LDD0761  [19]
 LDCM0445  CL54 HCT 116 C205(1.44)  LDD0762  [19]
 LDCM0446  CL55 HCT 116 C205(1.97)  LDD0763  [19]
 LDCM0447  CL56 HCT 116 C205(1.56)  LDD0764  [19]
 LDCM0448  CL57 HCT 116 C205(1.40)  LDD0765  [19]
 LDCM0449  CL58 HCT 116 C205(1.63)  LDD0766  [19]
 LDCM0450  CL59 HCT 116 C205(1.58)  LDD0767  [19]
 LDCM0451  CL6 HCT 116 C205(0.71)  LDD0768  [19]
 LDCM0452  CL60 HCT 116 C205(1.48)  LDD0769  [19]
 LDCM0453  CL61 HCT 116 C205(0.89)  LDD0770  [19]
 LDCM0454  CL62 HCT 116 C205(1.09)  LDD0771  [19]
 LDCM0455  CL63 HCT 116 C205(1.10)  LDD0772  [19]
 LDCM0456  CL64 HCT 116 C205(0.89)  LDD0773  [19]
 LDCM0457  CL65 HCT 116 C205(1.53)  LDD0774  [19]
 LDCM0458  CL66 HCT 116 C205(0.79)  LDD0775  [19]
 LDCM0459  CL67 HCT 116 C205(1.74)  LDD0776  [19]
 LDCM0460  CL68 HCT 116 C205(1.20)  LDD0777  [19]
 LDCM0461  CL69 HCT 116 C205(0.83)  LDD0778  [19]
 LDCM0462  CL7 HCT 116 C205(0.89)  LDD0779  [19]
 LDCM0463  CL70 HCT 116 C205(1.34)  LDD0780  [19]
 LDCM0464  CL71 HCT 116 C205(0.86)  LDD0781  [19]
 LDCM0465  CL72 HCT 116 C205(0.95)  LDD0782  [19]
 LDCM0466  CL73 HCT 116 C205(1.56)  LDD0783  [19]
 LDCM0467  CL74 HCT 116 C205(1.07)  LDD0784  [19]
 LDCM0469  CL76 HCT 116 C205(0.91); C55(0.52)  LDD0786  [19]
 LDCM0470  CL77 HCT 116 C205(0.87); C55(1.37)  LDD0787  [19]
 LDCM0471  CL78 HCT 116 C205(1.30); C55(0.72)  LDD0788  [19]
 LDCM0472  CL79 HCT 116 C205(0.99); C55(0.50)  LDD0789  [19]
 LDCM0473  CL8 HCT 116 C205(0.76)  LDD0790  [19]
 LDCM0474  CL80 HCT 116 C205(0.97); C55(0.42)  LDD0791  [19]
 LDCM0475  CL81 HCT 116 C205(0.89); C55(0.71)  LDD0792  [19]
 LDCM0476  CL82 HCT 116 C205(1.18); C55(0.29)  LDD0793  [19]
 LDCM0477  CL83 HCT 116 C205(0.89); C55(0.40)  LDD0794  [19]
 LDCM0478  CL84 HCT 116 C205(0.83); C55(0.25)  LDD0795  [19]
 LDCM0479  CL85 HCT 116 C205(0.96); C55(0.81)  LDD0796  [19]
 LDCM0480  CL86 HCT 116 C205(1.07); C55(1.19)  LDD0797  [19]
 LDCM0481  CL87 HCT 116 C205(1.04); C55(0.87)  LDD0798  [19]
 LDCM0482  CL88 HCT 116 C205(1.35); C55(0.40)  LDD0799  [19]
 LDCM0483  CL89 HCT 116 C205(1.09); C55(0.23)  LDD0800  [19]
 LDCM0484  CL9 HCT 116 C205(0.62)  LDD0801  [19]
 LDCM0485  CL90 HCT 116 C205(1.10); C55(1.39)  LDD0802  [19]
 LDCM0486  CL91 HCT 116 C205(0.70); C55(0.83)  LDD0803  [19]
 LDCM0487  CL92 HCT 116 C205(0.85); C55(0.79)  LDD0804  [19]
 LDCM0488  CL93 HCT 116 C205(0.83); C55(0.87)  LDD0805  [19]
 LDCM0489  CL94 HCT 116 C205(0.75); C55(0.68)  LDD0806  [19]
 LDCM0490  CL95 HCT 116 C205(0.83); C55(0.62)  LDD0807  [19]
 LDCM0491  CL96 HCT 116 C205(0.72); C55(0.63)  LDD0808  [19]
 LDCM0492  CL97 HCT 116 C205(0.63); C55(0.73)  LDD0809  [19]
 LDCM0493  CL98 HCT 116 C205(0.61); C55(0.74)  LDD0810  [19]
 LDCM0494  CL99 HCT 116 C205(0.63); C55(0.73)  LDD0811  [19]
 LDCM0495  E2913 HEK-293T C55(0.95); C205(1.06)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C205(7.15)  LDD1702  [5]
 LDCM0625  F8 Ramos C205(0.80)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C205(0.43)  LDD2189  [22]
 LDCM0574  Fragment12 Ramos C205(0.55)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C205(0.66)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C205(0.87)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C205(0.42)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C205(0.78)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C205(0.46)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C205(0.77)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C205(0.60)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C205(0.80)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C205(1.28)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C205(0.42)  LDD2201  [22]
 LDCM0468  Fragment33 HCT 116 C205(1.04)  LDD0785  [19]
 LDCM0596  Fragment38 Ramos C205(0.77)  LDD2203  [22]
 LDCM0566  Fragment4 Ramos C205(0.76)  LDD2184  [22]
 LDCM0427  Fragment51 HCT 116 C205(0.50); C55(0.40)  LDD0744  [19]
 LDCM0610  Fragment52 Ramos C205(0.85)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C205(1.28)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C205(0.44)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C205(0.46)  LDD2188  [22]
 LDCM0022  KB02 HEK-293T C205(0.89); C55(0.90)  LDD1492  [21]
 LDCM0023  KB03 Jurkat C205(4.05)  LDD0209  [7]
 LDCM0024  KB05 COLO792 C205(1.90)  LDD3310  [23]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C205(0.58)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C205(0.68)  LDD2089  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C205(0.88)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C205(1.93)  LDD2093  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C205(0.62)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C205(0.96)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C205(0.90)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C205(1.04)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C205(1.35)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C205(0.75)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C205(4.10)  LDD2119  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C205(0.96)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C205(1.14)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C205(1.58)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C205(0.93)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C205(0.50)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C205(0.87)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C205(1.00)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C205(1.08)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C205(1.95)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C205(0.96)  LDD2140  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C205(0.89)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C205(4.92)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C205(1.14)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C205(1.03)  LDD2148  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) GDSL lipolytic enzyme family Q15102
Platelet-activating factor acetylhydrolase IB subunit alpha2 (PAFAH1B2) GDSL lipolytic enzyme family P68402
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
PRKCA-binding protein (PICK1) . Q9NRD5
Syntenin-2 (SDCBP2) . Q9H190

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(1r)-122-trimethylpropyl (R)-methylphosphinate Small molecular drug DB07821

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
20 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840