Details of the Target

General Information of Target

Target ID LDTP04256
Target Name Glutamate dehydrogenase 2, mitochondrial (GLUD2)
Gene Name GLUD2
Gene ID 2747
Synonyms
GLUDP1; Glutamate dehydrogenase 2, mitochondrial; GDH 2; EC 1.4.1.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADR
EDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSF
PIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFG
GAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTY
ASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFR
DKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILG
FPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLER
NILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGK
HGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYV
NAIEKVFKVYSEAGVTFT
Target Bioclass
Enzyme
Family
Glu/Leu/Phe/Val dehydrogenases family
Subcellular location
Mitochondrion matrix
Function Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.
Uniprot ID
P49448
Ensemble ID
ENST00000328078.3
HGNC ID
HGNC:4336

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C5(1.89)  LDD3311  [2]
AHL-Pu-1
 Probe Info  		C327(2.12)  LDD0172  [3]
IA-alkyne
 Probe Info  		C172(0.56)  LDD2206  [4]
Compound 10
 Probe Info  		C112(0.00); C172(0.00)  LDD2216  [5]
Compound 11
 Probe Info  		C112(0.00); C172(0.00)  LDD2213  [5]
PF-06672131
 Probe Info  		N.A.  LDD0152  [6]
Acrolein
 Probe Info  		C172(0.00); C327(0.00)  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		18.73  LDD0463  [8]
FFF probe3
 Probe Info  		18.89  LDD0465  [8]
FFF probe6
 Probe Info  		5.89  LDD0468  [8]
STS-1
 Probe Info  		N.A.  LDD0137  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C327(2.12)  LDD0172  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C327(3.00)  LDD0173  [3]
 LDCM0108  Chloroacetamide HeLa C254(0.00); H355(0.00)  LDD0222  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 22RV1 C5(1.95)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C5(2.77)  LDD2660  [2]
 LDCM0024  KB05 G361 C5(1.89)  LDD3311  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C172(0.56)  LDD2206  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C172(0.88)  LDD2207  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142
Nadh Small molecular drug DB00157

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.