Details of the Target

General Information of Target

Target ID LDTP12803
Target Name Dipeptidyl peptidase 3 (DPP3)
Gene Name DPP3
Gene ID 10072
Synonyms
Dipeptidyl peptidase 3; EC 3.4.14.4; Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III; Enkephalinase B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRDEIATTVFFVTRLVKKHDKLSKQQIEDFAEKLMTILFETYRSHWHSDCPSKGQAFRCI
RINNNQNKDPILERACVESNVDFSHLGLPKEMTIWVDPFEVCCRYGEKNHPFTVASFKGR
WEEWELYQQISYAVSRASSDVSSGTSCDEESCSKEPRVIPKVSNPKSIYQVENLKQPFQS
WLQIPRKKNVVDGRVGLLGNTYHGSQKHPKCYRPAMHRLDRIL
Target Bioclass
Enzyme
Family
Peptidase M49 family
Subcellular location
Cytoplasm, cytosol
Function Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).
Uniprot ID
Q9NY33
Ensemble ID
ENST00000530165.5
HGNC ID
HGNC:3008
ChEMBL ID
CHEMBL4520

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.E263Ter DBIA    Probe Info 
HEC1B SNV: p.Q287R .
Ishikawa (Heraklio) 02 ER SNV: p.V99A DBIA    Probe Info 
J82 SNV: p.E512K DBIA    Probe Info 
JURKAT SNV: p.G458D .
PANC1 SNV: p.R248L DBIA    Probe Info 
PF382 SNV: p.R623Q DBIA    Probe Info 
RPMI8226 SNV: p.I282V DBIA    Probe Info 
SUPT1 Insertion: p.E493GfsTer5 DBIA    Probe Info 
WM2664 Insertion: p.A533GfsTer2 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		5.00  LDD0389  [1]
Alkylaryl probe 3
 Probe Info  		20.00  LDD0381  [1]
TH211
 Probe Info  		Y417(5.48)  LDD0257  [2]
TH216
 Probe Info  		Y417(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K615(10.00); K670(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y171(9.96); Y211(48.28); Y417(15.76)  LDD3495  [4]
BTD
 Probe Info  		C509(1.31)  LDD2109  [5]
Jackson_14
 Probe Info  		2.00  LDD0123  [6]
DBIA
 Probe Info  		C509(102.29)  LDD0209  [7]
HHS-482
 Probe Info  		Y417(1.02)  LDD0285  [8]
HHS-475
 Probe Info  		Y417(1.07)  LDD0264  [9]
IPM
 Probe Info  		C509(1.70)  LDD1702  [5]
HHS-465
 Probe Info  		Y417(6.30)  LDD2237  [10]
Acrolein
 Probe Info  		N.A.  LDD0222  [11]
5E-2FA
 Probe Info  		H273(0.00); H136(0.00)  LDD2235  [12]
m-APA
 Probe Info  		N.A.  LDD2231  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C654(0.00); C176(0.00); C509(0.00); C147(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C654(0.00); C176(0.00); C509(0.00); C147(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C654(0.00); C176(0.00); C509(0.00); C147(0.00)  LDD0037  [13]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
KY-26
 Probe Info  		N.A.  LDD0301  [15]
SF
 Probe Info  		N.A.  LDD0028  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
NAIA_5
 Probe Info  		C654(0.00); C509(0.00); C19(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		12.88  LDD0465  [18]
STS-1
 Probe Info  		N.A.  LDD0068  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C509(0.99)  LDD0531  [20]
 LDCM0215  AC10 HCT 116 C509(0.99)  LDD0532  [20]
 LDCM0216  AC100 HCT 116 C509(1.25)  LDD0533  [20]
 LDCM0217  AC101 HCT 116 C509(1.05)  LDD0534  [20]
 LDCM0218  AC102 HCT 116 C509(1.05)  LDD0535  [20]
 LDCM0219  AC103 HCT 116 C509(1.04)  LDD0536  [20]
 LDCM0220  AC104 HCT 116 C509(1.04)  LDD0537  [20]
 LDCM0221  AC105 HCT 116 C509(1.03)  LDD0538  [20]
 LDCM0222  AC106 HCT 116 C509(1.11)  LDD0539  [20]
 LDCM0223  AC107 HCT 116 C509(1.12)  LDD0540  [20]
 LDCM0224  AC108 HCT 116 C509(1.10)  LDD0541  [20]
 LDCM0225  AC109 HCT 116 C509(1.01)  LDD0542  [20]
 LDCM0226  AC11 HCT 116 C509(1.04)  LDD0543  [20]
 LDCM0227  AC110 HCT 116 C509(1.03)  LDD0544  [20]
 LDCM0228  AC111 HCT 116 C509(1.09)  LDD0545  [20]
 LDCM0229  AC112 HCT 116 C509(1.10)  LDD0546  [20]
 LDCM0230  AC113 HCT 116 C509(0.98)  LDD0547  [20]
 LDCM0231  AC114 HCT 116 C509(1.03)  LDD0548  [20]
 LDCM0232  AC115 HCT 116 C509(0.97)  LDD0549  [20]
 LDCM0233  AC116 HCT 116 C509(1.06)  LDD0550  [20]
 LDCM0234  AC117 HCT 116 C509(0.96)  LDD0551  [20]
 LDCM0235  AC118 HCT 116 C509(1.50)  LDD0552  [20]
 LDCM0236  AC119 HCT 116 C509(1.32)  LDD0553  [20]
 LDCM0237  AC12 HCT 116 C509(0.99)  LDD0554  [20]
 LDCM0238  AC120 HCT 116 C509(1.08)  LDD0555  [20]
 LDCM0239  AC121 HCT 116 C509(0.99)  LDD0556  [20]
 LDCM0240  AC122 HCT 116 C509(1.09)  LDD0557  [20]
 LDCM0241  AC123 HCT 116 C509(1.38)  LDD0558  [20]
 LDCM0242  AC124 HCT 116 C509(1.05)  LDD0559  [20]
 LDCM0243  AC125 HCT 116 C509(0.94)  LDD0560  [20]
 LDCM0244  AC126 HCT 116 C509(1.15)  LDD0561  [20]
 LDCM0245  AC127 HCT 116 C509(1.15)  LDD0562  [20]
 LDCM0246  AC128 HCT 116 C509(0.47)  LDD0563  [20]
 LDCM0247  AC129 HCT 116 C509(1.12)  LDD0564  [20]
 LDCM0249  AC130 HCT 116 C509(0.68)  LDD0566  [20]
 LDCM0250  AC131 HCT 116 C509(1.10)  LDD0567  [20]
 LDCM0251  AC132 HCT 116 C509(0.80)  LDD0568  [20]
 LDCM0252  AC133 HCT 116 C509(0.78)  LDD0569  [20]
 LDCM0253  AC134 HCT 116 C509(0.69)  LDD0570  [20]
 LDCM0254  AC135 HCT 116 C509(0.64)  LDD0571  [20]
 LDCM0255  AC136 HCT 116 C509(0.68)  LDD0572  [20]
 LDCM0256  AC137 HCT 116 C509(0.72)  LDD0573  [20]
 LDCM0257  AC138 HCT 116 C509(0.65)  LDD0574  [20]
 LDCM0258  AC139 HCT 116 C509(0.66)  LDD0575  [20]
 LDCM0259  AC14 HCT 116 C509(1.10)  LDD0576  [20]
 LDCM0260  AC140 HCT 116 C509(0.64)  LDD0577  [20]
 LDCM0261  AC141 HCT 116 C509(0.89)  LDD0578  [20]
 LDCM0262  AC142 HCT 116 C509(0.71)  LDD0579  [20]
 LDCM0263  AC143 HCT 116 C509(1.13)  LDD0580  [20]
 LDCM0264  AC144 HCT 116 C509(1.60)  LDD0581  [20]
 LDCM0265  AC145 HCT 116 C509(1.56)  LDD0582  [20]
 LDCM0266  AC146 HCT 116 C509(0.89)  LDD0583  [20]
 LDCM0267  AC147 HCT 116 C509(1.23)  LDD0584  [20]
 LDCM0268  AC148 HCT 116 C509(0.32)  LDD0585  [20]
 LDCM0269  AC149 HCT 116 C509(1.10)  LDD0586  [20]
 LDCM0270  AC15 HCT 116 C509(1.07)  LDD0587  [20]
 LDCM0271  AC150 HCT 116 C509(2.73)  LDD0588  [20]
 LDCM0272  AC151 HCT 116 C509(1.79)  LDD0589  [20]
 LDCM0273  AC152 HCT 116 C509(0.92)  LDD0590  [20]
 LDCM0274  AC153 HCT 116 C509(0.24)  LDD0591  [20]
 LDCM0621  AC154 HCT 116 C509(1.25)  LDD2158  [20]
 LDCM0622  AC155 HCT 116 C509(1.45)  LDD2159  [20]
 LDCM0623  AC156 HCT 116 C509(1.32)  LDD2160  [20]
 LDCM0624  AC157 HCT 116 C509(0.99)  LDD2161  [20]
 LDCM0276  AC17 HCT 116 C509(0.97)  LDD0593  [20]
 LDCM0277  AC18 HCT 116 C509(1.25)  LDD0594  [20]
 LDCM0278  AC19 HCT 116 C509(0.99)  LDD0595  [20]
 LDCM0279  AC2 HCT 116 C509(0.98)  LDD0596  [20]
 LDCM0280  AC20 HCT 116 C509(1.00)  LDD0597  [20]
 LDCM0281  AC21 HCT 116 C509(0.93)  LDD0598  [20]
 LDCM0282  AC22 HCT 116 C509(0.87)  LDD0599  [20]
 LDCM0283  AC23 HCT 116 C509(0.90)  LDD0600  [20]
 LDCM0284  AC24 HCT 116 C509(0.99)  LDD0601  [20]
 LDCM0285  AC25 HCT 116 C509(1.09)  LDD0602  [20]
 LDCM0286  AC26 HCT 116 C509(1.10)  LDD0603  [20]
 LDCM0287  AC27 HCT 116 C509(1.13)  LDD0604  [20]
 LDCM0288  AC28 HCT 116 C509(1.13)  LDD0605  [20]
 LDCM0289  AC29 HCT 116 C509(1.05)  LDD0606  [20]
 LDCM0290  AC3 HCT 116 C509(1.04)  LDD0607  [20]
 LDCM0291  AC30 HCT 116 C509(1.22)  LDD0608  [20]
 LDCM0292  AC31 HCT 116 C509(1.16)  LDD0609  [20]
 LDCM0293  AC32 HCT 116 C509(1.12)  LDD0610  [20]
 LDCM0294  AC33 HCT 116 C509(1.08)  LDD0611  [20]
 LDCM0295  AC34 HCT 116 C509(0.99)  LDD0612  [20]
 LDCM0296  AC35 HCT 116 C509(1.03)  LDD0613  [20]
 LDCM0297  AC36 HCT 116 C509(1.05)  LDD0614  [20]
 LDCM0298  AC37 HCT 116 C509(1.27)  LDD0615  [20]
 LDCM0299  AC38 HCT 116 C509(1.19)  LDD0616  [20]
 LDCM0300  AC39 HCT 116 C509(1.23)  LDD0617  [20]
 LDCM0301  AC4 HCT 116 C509(1.07)  LDD0618  [20]
 LDCM0302  AC40 HCT 116 C509(0.87)  LDD0619  [20]
 LDCM0303  AC41 HCT 116 C509(1.11)  LDD0620  [20]
 LDCM0304  AC42 HCT 116 C509(0.97)  LDD0621  [20]
 LDCM0305  AC43 HCT 116 C509(1.17)  LDD0622  [20]
 LDCM0306  AC44 HCT 116 C509(0.98)  LDD0623  [20]
 LDCM0307  AC45 HCT 116 C509(0.69)  LDD0624  [20]
 LDCM0308  AC46 HCT 116 C509(0.99)  LDD0625  [20]
 LDCM0309  AC47 HCT 116 C509(1.00)  LDD0626  [20]
 LDCM0310  AC48 HCT 116 C509(1.26)  LDD0627  [20]
 LDCM0311  AC49 HCT 116 C509(0.48)  LDD0628  [20]
 LDCM0312  AC5 HCT 116 C509(1.07)  LDD0629  [20]
 LDCM0313  AC50 HCT 116 C509(0.66)  LDD0630  [20]
 LDCM0314  AC51 HCT 116 C509(0.94)  LDD0631  [20]
 LDCM0315  AC52 HCT 116 C509(0.94)  LDD0632  [20]
 LDCM0316  AC53 HCT 116 C509(0.76)  LDD0633  [20]
 LDCM0317  AC54 HCT 116 C509(0.76)  LDD0634  [20]
 LDCM0318  AC55 HCT 116 C509(0.52)  LDD0635  [20]
 LDCM0319  AC56 HCT 116 C509(0.33)  LDD0636  [20]
 LDCM0320  AC57 HCT 116 C509(1.00)  LDD0637  [20]
 LDCM0321  AC58 HCT 116 C509(1.08)  LDD0638  [20]
 LDCM0322  AC59 HCT 116 C509(1.12)  LDD0639  [20]
 LDCM0323  AC6 HCT 116 C509(0.92)  LDD0640  [20]
 LDCM0324  AC60 HCT 116 C509(1.28)  LDD0641  [20]
 LDCM0325  AC61 HCT 116 C509(1.15)  LDD0642  [20]
 LDCM0326  AC62 HCT 116 C509(1.12)  LDD0643  [20]
 LDCM0327  AC63 HCT 116 C509(1.19)  LDD0644  [20]
 LDCM0328  AC64 HCT 116 C509(0.92)  LDD0645  [20]
 LDCM0329  AC65 HCT 116 C509(1.33)  LDD0646  [20]
 LDCM0330  AC66 HCT 116 C509(1.25)  LDD0647  [20]
 LDCM0331  AC67 HCT 116 C509(0.77)  LDD0648  [20]
 LDCM0332  AC68 HCT 116 C509(0.83)  LDD0649  [20]
 LDCM0333  AC69 HCT 116 C509(0.78)  LDD0650  [20]
 LDCM0334  AC7 HCT 116 C509(0.96)  LDD0651  [20]
 LDCM0335  AC70 HCT 116 C509(0.63)  LDD0652  [20]
 LDCM0336  AC71 HCT 116 C509(0.85)  LDD0653  [20]
 LDCM0337  AC72 HCT 116 C509(0.83)  LDD0654  [20]
 LDCM0338  AC73 HCT 116 C509(0.47)  LDD0655  [20]
 LDCM0339  AC74 HCT 116 C509(0.48)  LDD0656  [20]
 LDCM0340  AC75 HCT 116 C509(0.50)  LDD0657  [20]
 LDCM0341  AC76 HCT 116 C509(0.74)  LDD0658  [20]
 LDCM0342  AC77 HCT 116 C509(0.64)  LDD0659  [20]
 LDCM0343  AC78 HCT 116 C509(0.86)  LDD0660  [20]
 LDCM0344  AC79 HCT 116 C509(1.02)  LDD0661  [20]
 LDCM0345  AC8 HCT 116 C509(0.94)  LDD0662  [20]
 LDCM0346  AC80 HCT 116 C509(0.81)  LDD0663  [20]
 LDCM0347  AC81 HCT 116 C509(0.78)  LDD0664  [20]
 LDCM0348  AC82 HCT 116 C509(0.50)  LDD0665  [20]
 LDCM0349  AC83 HCT 116 C509(0.55)  LDD0666  [20]
 LDCM0350  AC84 HCT 116 C509(0.90)  LDD0667  [20]
 LDCM0351  AC85 HCT 116 C509(1.67)  LDD0668  [20]
 LDCM0352  AC86 HCT 116 C509(1.53)  LDD0669  [20]
 LDCM0353  AC87 HCT 116 C509(1.20)  LDD0670  [20]
 LDCM0354  AC88 HCT 116 C509(1.31)  LDD0671  [20]
 LDCM0355  AC89 HCT 116 C509(1.09)  LDD0672  [20]
 LDCM0357  AC90 HCT 116 C509(1.50)  LDD0674  [20]
 LDCM0358  AC91 HCT 116 C509(0.80)  LDD0675  [20]
 LDCM0359  AC92 HCT 116 C509(1.14)  LDD0676  [20]
 LDCM0360  AC93 HCT 116 C509(1.45)  LDD0677  [20]
 LDCM0361  AC94 HCT 116 C509(1.29)  LDD0678  [20]
 LDCM0362  AC95 HCT 116 C509(1.25)  LDD0679  [20]
 LDCM0363  AC96 HCT 116 C509(1.09)  LDD0680  [20]
 LDCM0364  AC97 HCT 116 C509(0.91)  LDD0681  [20]
 LDCM0365  AC98 HCT 116 C509(1.14)  LDD0682  [20]
 LDCM0366  AC99 HCT 116 C509(1.12)  LDD0683  [20]
 LDCM0248  AKOS034007472 HCT 116 C509(0.97)  LDD0565  [20]
 LDCM0356  AKOS034007680 HCT 116 C509(0.86)  LDD0673  [20]
 LDCM0275  AKOS034007705 HCT 116 C509(0.89)  LDD0592  [20]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HCT 116 C509(1.00)  LDD0684  [20]
 LDCM0368  CL10 HCT 116 C509(1.00)  LDD0685  [20]
 LDCM0369  CL100 HCT 116 C509(0.97)  LDD0686  [20]
 LDCM0370  CL101 HCT 116 C509(1.08)  LDD0687  [20]
 LDCM0371  CL102 HCT 116 C509(1.11)  LDD0688  [20]
 LDCM0372  CL103 HCT 116 C509(0.94)  LDD0689  [20]
 LDCM0373  CL104 HCT 116 C509(0.94)  LDD0690  [20]
 LDCM0374  CL105 HCT 116 C509(1.10)  LDD0691  [20]
 LDCM0375  CL106 HCT 116 C509(0.99)  LDD0692  [20]
 LDCM0376  CL107 HCT 116 C509(1.11)  LDD0693  [20]
 LDCM0377  CL108 HCT 116 C509(0.97)  LDD0694  [20]
 LDCM0378  CL109 HCT 116 C509(1.14)  LDD0695  [20]
 LDCM0379  CL11 HCT 116 C509(0.60)  LDD0696  [20]
 LDCM0380  CL110 HCT 116 C509(1.17)  LDD0697  [20]
 LDCM0381  CL111 HCT 116 C509(1.22)  LDD0698  [20]
 LDCM0382  CL112 HCT 116 C509(1.02)  LDD0699  [20]
 LDCM0383  CL113 HCT 116 C509(1.09)  LDD0700  [20]
 LDCM0384  CL114 HCT 116 C509(0.99)  LDD0701  [20]
 LDCM0385  CL115 HCT 116 C509(1.19)  LDD0702  [20]
 LDCM0386  CL116 HCT 116 C509(1.01)  LDD0703  [20]
 LDCM0387  CL117 HCT 116 C509(0.22)  LDD0704  [20]
 LDCM0388  CL118 HCT 116 C509(1.00)  LDD0705  [20]
 LDCM0389  CL119 HCT 116 C509(1.19)  LDD0706  [20]
 LDCM0390  CL12 HCT 116 C509(0.62)  LDD0707  [20]
 LDCM0391  CL120 HCT 116 C509(1.23)  LDD0708  [20]
 LDCM0392  CL121 HCT 116 C509(0.82)  LDD0709  [20]
 LDCM0393  CL122 HCT 116 C509(1.04)  LDD0710  [20]
 LDCM0394  CL123 HCT 116 C509(0.78)  LDD0711  [20]
 LDCM0395  CL124 HCT 116 C509(0.61)  LDD0712  [20]
 LDCM0396  CL125 HCT 116 C509(1.09)  LDD0713  [20]
 LDCM0397  CL126 HCT 116 C509(1.29)  LDD0714  [20]
 LDCM0398  CL127 HCT 116 C509(1.13)  LDD0715  [20]
 LDCM0399  CL128 HCT 116 C509(1.06)  LDD0716  [20]
 LDCM0400  CL13 HCT 116 C509(0.88)  LDD0717  [20]
 LDCM0401  CL14 HCT 116 C509(0.95)  LDD0718  [20]
 LDCM0402  CL15 HCT 116 C509(0.99)  LDD0719  [20]
 LDCM0403  CL16 HCT 116 C509(1.01)  LDD0720  [20]
 LDCM0404  CL17 HCT 116 C509(1.16)  LDD0721  [20]
 LDCM0405  CL18 HCT 116 C509(1.17)  LDD0722  [20]
 LDCM0406  CL19 HCT 116 C509(1.12)  LDD0723  [20]
 LDCM0407  CL2 HCT 116 C509(1.11)  LDD0724  [20]
 LDCM0408  CL20 HCT 116 C509(1.03)  LDD0725  [20]
 LDCM0409  CL21 HCT 116 C509(0.90)  LDD0726  [20]
 LDCM0410  CL22 HCT 116 C509(0.52)  LDD0727  [20]
 LDCM0411  CL23 HCT 116 C509(1.04)  LDD0728  [20]
 LDCM0412  CL24 HCT 116 C509(0.92)  LDD0729  [20]
 LDCM0413  CL25 HCT 116 C509(0.94)  LDD0730  [20]
 LDCM0414  CL26 HCT 116 C509(1.05)  LDD0731  [20]
 LDCM0415  CL27 HCT 116 C509(1.13)  LDD0732  [20]
 LDCM0416  CL28 HCT 116 C509(1.15)  LDD0733  [20]
 LDCM0417  CL29 HCT 116 C509(1.06)  LDD0734  [20]
 LDCM0418  CL3 HCT 116 C509(1.08)  LDD0735  [20]
 LDCM0419  CL30 HCT 116 C509(1.13)  LDD0736  [20]
 LDCM0420  CL31 HCT 116 C509(0.87)  LDD0737  [20]
 LDCM0421  CL32 HCT 116 C509(1.14)  LDD0738  [20]
 LDCM0422  CL33 HCT 116 C509(0.80)  LDD0739  [20]
 LDCM0423  CL34 HCT 116 C509(0.63)  LDD0740  [20]
 LDCM0424  CL35 HCT 116 C509(0.55)  LDD0741  [20]
 LDCM0425  CL36 HCT 116 C509(0.82)  LDD0742  [20]
 LDCM0426  CL37 HCT 116 C509(0.59)  LDD0743  [20]
 LDCM0428  CL39 HCT 116 C509(0.55)  LDD0745  [20]
 LDCM0429  CL4 HCT 116 C509(1.21)  LDD0746  [20]
 LDCM0430  CL40 HCT 116 C509(0.88)  LDD0747  [20]
 LDCM0431  CL41 HCT 116 C509(0.74)  LDD0748  [20]
 LDCM0432  CL42 HCT 116 C509(0.15)  LDD0749  [20]
 LDCM0433  CL43 HCT 116 C509(0.39)  LDD0750  [20]
 LDCM0434  CL44 HCT 116 C509(0.87)  LDD0751  [20]
 LDCM0435  CL45 HCT 116 C509(0.54)  LDD0752  [20]
 LDCM0436  CL46 HCT 116 C509(1.16)  LDD0753  [20]
 LDCM0437  CL47 HCT 116 C509(0.90)  LDD0754  [20]
 LDCM0438  CL48 HCT 116 C509(0.85)  LDD0755  [20]
 LDCM0439  CL49 HCT 116 C509(0.93)  LDD0756  [20]
 LDCM0440  CL5 HCT 116 C509(1.03)  LDD0757  [20]
 LDCM0441  CL50 HCT 116 C509(1.06)  LDD0758  [20]
 LDCM0442  CL51 HCT 116 C509(0.95)  LDD0759  [20]
 LDCM0443  CL52 HCT 116 C509(2.08)  LDD0760  [20]
 LDCM0444  CL53 HCT 116 C509(0.81)  LDD0761  [20]
 LDCM0445  CL54 HCT 116 C509(0.81)  LDD0762  [20]
 LDCM0446  CL55 HCT 116 C509(0.91)  LDD0763  [20]
 LDCM0447  CL56 HCT 116 C509(0.98)  LDD0764  [20]
 LDCM0448  CL57 HCT 116 C509(1.07)  LDD0765  [20]
 LDCM0449  CL58 HCT 116 C509(1.09)  LDD0766  [20]
 LDCM0450  CL59 HCT 116 C509(1.07)  LDD0767  [20]
 LDCM0451  CL6 HCT 116 C509(1.01)  LDD0768  [20]
 LDCM0452  CL60 HCT 116 C509(1.47)  LDD0769  [20]
 LDCM0453  CL61 HCT 116 C509(1.08)  LDD0770  [20]
 LDCM0454  CL62 HCT 116 C509(1.07)  LDD0771  [20]
 LDCM0455  CL63 HCT 116 C509(1.01)  LDD0772  [20]
 LDCM0456  CL64 HCT 116 C509(1.02)  LDD0773  [20]
 LDCM0457  CL65 HCT 116 C509(1.02)  LDD0774  [20]
 LDCM0458  CL66 HCT 116 C509(0.75)  LDD0775  [20]
 LDCM0459  CL67 HCT 116 C509(1.02)  LDD0776  [20]
 LDCM0460  CL68 HCT 116 C509(1.08)  LDD0777  [20]
 LDCM0461  CL69 HCT 116 C509(1.22)  LDD0778  [20]
 LDCM0462  CL7 HCT 116 C509(0.84)  LDD0779  [20]
 LDCM0463  CL70 HCT 116 C509(1.30)  LDD0780  [20]
 LDCM0464  CL71 HCT 116 C509(1.04)  LDD0781  [20]
 LDCM0465  CL72 HCT 116 C509(1.03)  LDD0782  [20]
 LDCM0466  CL73 HCT 116 C509(1.13)  LDD0783  [20]
 LDCM0467  CL74 HCT 116 C509(1.00)  LDD0784  [20]
 LDCM0469  CL76 HCT 116 C509(0.92)  LDD0786  [20]
 LDCM0470  CL77 HCT 116 C509(0.98)  LDD0787  [20]
 LDCM0471  CL78 HCT 116 C509(1.02)  LDD0788  [20]
 LDCM0472  CL79 HCT 116 C509(0.92)  LDD0789  [20]
 LDCM0473  CL8 HCT 116 C509(0.67)  LDD0790  [20]
 LDCM0474  CL80 HCT 116 C509(0.81)  LDD0791  [20]
 LDCM0475  CL81 HCT 116 C509(1.13)  LDD0792  [20]
 LDCM0476  CL82 HCT 116 C509(0.71)  LDD0793  [20]
 LDCM0477  CL83 HCT 116 C509(0.81)  LDD0794  [20]
 LDCM0478  CL84 HCT 116 C509(0.55)  LDD0795  [20]
 LDCM0479  CL85 HCT 116 C509(1.06)  LDD0796  [20]
 LDCM0480  CL86 HCT 116 C509(1.08)  LDD0797  [20]
 LDCM0481  CL87 HCT 116 C509(1.36)  LDD0798  [20]
 LDCM0482  CL88 HCT 116 C509(0.71)  LDD0799  [20]
 LDCM0483  CL89 HCT 116 C509(0.52)  LDD0800  [20]
 LDCM0484  CL9 HCT 116 C509(1.06)  LDD0801  [20]
 LDCM0485  CL90 HCT 116 C509(1.00)  LDD0802  [20]
 LDCM0486  CL91 HCT 116 C509(1.04)  LDD0803  [20]
 LDCM0487  CL92 HCT 116 C509(1.01)  LDD0804  [20]
 LDCM0488  CL93 HCT 116 C509(1.03)  LDD0805  [20]
 LDCM0489  CL94 HCT 116 C509(1.02)  LDD0806  [20]
 LDCM0490  CL95 HCT 116 C509(1.09)  LDD0807  [20]
 LDCM0491  CL96 HCT 116 C509(1.04)  LDD0808  [20]
 LDCM0492  CL97 HCT 116 C509(1.08)  LDD0809  [20]
 LDCM0493  CL98 HCT 116 C509(1.09)  LDD0810  [20]
 LDCM0494  CL99 HCT 116 C509(0.95)  LDD0811  [20]
 LDCM0495  E2913 HEK-293T C654(0.92)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C509(1.70)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C509(1.03)  LDD0785  [20]
 LDCM0427  Fragment51 HCT 116 C509(0.21)  LDD0744  [20]
 LDCM0116  HHS-0101 DM93 Y417(1.07)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y417(0.96)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y417(1.01)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y417(1.01)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y417(1.23)  LDD0268  [9]
 LDCM0123  JWB131 DM93 Y417(1.02)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y417(0.68)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y417(1.24)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y417(1.46)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y417(1.26)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y417(0.88)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y417(0.45)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y417(1.00)  LDD0292  [8]
 LDCM0022  KB02 HEK-293T C176(1.40)  LDD1492  [21]
 LDCM0023  KB03 Jurkat C509(102.29)  LDD0209  [7]
 LDCM0024  KB05 HMCB C654(12.42); C509(1.28)  LDD3312  [22]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C509(1.31)  LDD2109  [5]
 LDCM0131  RA190 MM1.R C509(1.37)  LDD0304  [23]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.00  LDD0123  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.