Details of the Target

General Information of Target

Target ID LDTP05764
Target Name Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2)
Gene Name CALCOCO2
Gene ID 10241
Synonyms
NDP52; Calcium-binding and coiled-coil domain-containing protein 2; Antigen nuclear dot 52 kDa protein; Nuclear domain 10 protein NDP52; Nuclear domain 10 protein 52; Nuclear dot protein 52
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFR
VGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGAS
IPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKK
QEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQ
EKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQ
QELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQV
PTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCF
NCPICDKIFPATEKQIFEDHVFCHSL
Target Bioclass
Other
Family
CALCOCO family
Subcellular location
Cytoplasm, perinuclear region
Function
Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Uniprot ID
Q13137
Ensemble ID
ENST00000258947.8
HGNC ID
HGNC:29912

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.A95T DBIA    Probe Info 
HEC1B SNV: p.A95T .
MCC13 SNV: p.D352E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C467(1.77)  LDD3315  [2]
NAIA_5
 Probe Info  		C18(20.00); C321(2.74)  LDD2227  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		C108(0.00); C40(0.00)  LDD0166  [5]
Lodoacetamide azide
 Probe Info  		C163(0.00); C153(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
IPM
 Probe Info  		C321(0.00); C163(0.00)  LDD2156  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		12.30  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C130
 Probe Info  		7.46  LDD1812  [10]
C170
 Probe Info  		20.82  LDD1850  [10]
C208
 Probe Info  		8.63  LDD1883  [10]
C310
 Probe Info  		18.77  LDD1977  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C321(0.99); C443(0.95); C163(0.97); C406(1.13)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C321(1.07); C443(0.99); C163(1.01); C419(0.92)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C443(1.09); C163(1.04); C419(1.00)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C321(1.03); C443(0.95); C406(1.08); C419(1.15)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C321(0.97); C443(1.10); C163(1.02); C419(0.95)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C443(0.97); C163(1.00); C419(0.97)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C321(0.96); C443(0.98); C163(0.95); C406(1.22)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C321(0.94); C443(1.01); C163(1.04); C419(1.03)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C443(1.11); C163(1.46); C419(1.11)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C321(0.97); C443(1.12); C163(1.12); C419(1.01)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C321(0.88); C443(1.21); C406(0.99); C419(1.12)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C321(0.89); C443(1.06); C163(0.97); C419(0.99)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C321(0.99); C443(1.06); C163(0.95); C419(0.99)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C443(1.10); C163(0.95); C419(0.98)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C443(0.94); C163(1.05); C419(1.04)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C321(0.91); C443(0.94); C163(0.94); C406(1.17)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C321(0.99); C443(1.00); C163(0.98); C419(1.02)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C443(1.07); C163(1.03); C419(0.98)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C321(0.92); C443(1.00); C406(1.16); C419(1.06)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C321(0.89); C443(1.04); C163(0.99); C419(0.92)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C443(1.15); C163(1.00); C419(1.08)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C321(1.00); C443(1.11); C163(0.98); C419(0.92)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C443(0.93); C163(0.97); C419(0.99)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C443(1.12); C163(0.97); C419(0.92)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C321(0.94); C443(0.96); C163(1.04); C406(1.14)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C321(1.12); C443(1.13); C163(1.14); C419(1.09)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C443(1.14); C163(1.07); C419(1.01)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C321(0.98); C443(1.05); C406(1.07); C419(0.98)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C321(1.01); C443(0.99); C163(1.15); C419(0.92)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C321(0.92); C443(1.12); C163(1.00); C419(0.90)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C443(0.96); C163(0.98); C419(1.05)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C321(0.94); C443(1.02); C406(1.01); C419(1.02)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C443(1.03); C163(1.08); C419(1.04)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C321(0.95); C443(0.96); C163(1.01); C406(0.74)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C321(0.96); C443(0.97); C163(1.14); C419(0.89)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C443(1.07); C163(1.00); C419(1.01)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C321(1.11); C443(0.96); C406(1.18); C419(1.06)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C321(1.08); C443(1.07); C163(1.07); C419(1.00)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C321(0.90); C443(1.07); C163(1.03); C419(0.93)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C443(1.01); C163(0.99); C419(0.87)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C443(1.06); C163(1.11); C419(0.95)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C321(1.02); C443(1.03); C163(1.03); C406(0.86)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C321(0.97); C443(1.22); C163(1.08); C419(0.96)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C321(1.09); C443(1.01); C163(1.14); C419(0.94)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C443(1.18); C163(1.03); C419(1.02)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C321(0.96); C443(1.01); C406(1.00); C419(1.15)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C321(1.05); C443(1.04); C163(1.07); C419(0.95)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C321(1.04); C443(1.02); C163(1.03); C419(0.89)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C443(1.08); C163(0.95); C419(1.07)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C443(1.02); C163(1.08); C419(0.98)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C321(0.96); C443(0.98); C163(0.97); C406(1.05)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C321(1.08); C443(1.11); C163(1.08); C419(0.95)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C443(1.13); C163(0.99); C419(1.16)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C321(1.01); C443(1.17); C163(1.07); C419(0.99)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C321(0.99); C443(0.99); C406(1.19); C419(1.23)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C321(1.02); C443(0.99); C163(1.02); C419(1.04)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C321(0.99); C443(1.05); C163(1.00); C419(1.10)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C443(1.06); C163(0.98); C419(0.98)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C443(1.18); C163(1.11); C419(1.08)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C443(1.08); C163(0.96); C419(1.07)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C443(1.05); C163(1.05); C419(0.94)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C321(1.07); C443(1.06); C163(1.06); C419(0.93)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C321(1.00); C443(1.00); C163(1.00); C406(0.90)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C443(0.88); C163(1.10); C419(0.99)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C321(0.00); C163(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C18(20.00); C321(2.74)  LDD2227  [3]
 LDCM0367  CL1 HEK-293T C321(0.96); C443(1.05); C18(0.87); C419(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C321(0.97); C443(0.67); C163(0.91); C419(0.76)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C443(0.97); C163(0.94); C419(0.98)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C321(1.02); C443(1.03); C18(0.94); C419(1.07)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C321(0.91); C443(0.99); C163(0.94); C419(1.06)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C321(1.04); C443(1.09); C163(1.00); C419(1.03)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C443(1.15); C163(0.93); C419(0.91)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C321(0.90); C443(1.01); C18(0.86); C419(1.16)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C321(0.94); C443(0.98); C163(0.95); C419(0.99)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C321(0.97); C443(1.10); C163(0.96); C419(1.07)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C443(1.20); C163(0.87); C419(0.98)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C321(0.90); C443(0.97); C18(0.85); C419(1.08)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C443(0.71); C163(0.86); C419(0.81)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C321(0.90); C443(0.99); C163(0.91); C419(0.99)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C321(1.01); C443(1.07); C163(0.92); C419(1.08)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C443(0.95); C163(0.91); C419(0.95)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C321(0.91); C443(1.04); C18(1.02); C419(1.07)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C321(0.81); C443(1.04); C163(0.91); C419(0.97)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C321(1.09); C443(1.21); C163(0.98); C419(1.05)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C443(1.00); C163(0.86); C419(0.89)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C321(1.04); C443(1.02); C18(0.86); C419(1.08)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C321(0.97); C443(1.08); C163(1.07); C419(1.11)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C321(0.97); C443(1.04); C163(1.01); C419(1.06)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C443(0.69); C163(1.02); C419(0.74)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C443(1.05); C163(0.97); C419(0.91)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C321(0.98); C443(1.07); C18(0.86); C419(1.12)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C321(0.95); C443(1.03); C163(0.94); C419(0.93)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C321(1.02); C443(1.02); C163(0.90); C419(0.93)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C443(1.02); C163(1.03); C419(0.95)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C321(1.03); C443(1.10); C18(0.67); C419(1.14)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C321(1.00); C443(1.08); C163(0.98); C419(1.11)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C321(1.00); C443(1.19); C163(0.93); C419(1.06)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C443(1.13); C163(0.94); C419(1.00)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C321(1.04); C443(1.01); C18(0.88); C419(1.23)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C321(0.90); C443(1.07); C163(0.97); C419(1.09)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C321(1.09); C443(0.94); C163(1.01); C419(0.92)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C443(0.94); C163(0.99); C419(1.03)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C321(1.00); C443(0.77); C163(0.98); C406(1.36)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C321(1.12); C443(0.98); C163(1.12); C419(0.89)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C443(1.00); C163(1.03); C419(0.85)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C321(0.99); C443(1.03); C163(1.05); C419(1.13)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C321(1.08); C443(0.76); C406(0.96); C419(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C321(1.00); C443(0.65); C163(0.97); C419(0.83)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C321(1.12); C443(0.73); C163(0.97); C419(0.90)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C443(0.68); C163(0.95); C419(0.92)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C443(0.63); C163(1.09); C419(0.80)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C321(1.13); C443(0.98); C18(0.73); C419(1.05)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C321(0.96); C443(1.06); C163(1.04); C419(0.98)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C321(1.05); C443(1.10); C163(0.95); C419(1.17)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C443(1.06); C163(0.93); C419(1.06)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C321(1.06); C443(0.97); C163(1.06); C406(0.87)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C321(0.98); C443(1.03); C163(0.92); C419(1.23)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C321(1.05); C443(0.90); C163(1.06); C419(0.96)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C443(0.85); C163(1.07); C419(0.84)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C321(0.89); C443(0.84); C406(0.98); C419(0.84)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C321(0.86); C443(0.65); C163(0.91); C419(0.76)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C321(1.04); C443(0.80); C163(0.93); C419(0.84)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C443(0.66); C163(0.94); C419(0.83)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C443(0.66); C163(0.95); C419(0.80)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C321(1.07); C443(1.04); C18(0.76); C419(1.18)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C321(1.04); C443(1.03); C163(0.87); C419(1.13)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C443(1.00); C163(0.98); C419(1.08)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C443(1.04); C163(0.99); C419(0.86)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C321(1.03); C443(0.95); C163(0.94); C406(1.00)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C321(1.01); C443(1.05); C163(1.07); C419(0.97)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C443(0.89); C163(0.98); C419(0.77)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C321(0.94); C443(0.81); C406(0.96); C419(0.87)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C321(0.97); C443(0.65); C163(0.93); C419(0.79)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C321(1.04); C443(0.69); C163(0.97); C419(0.81)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C443(0.64); C163(0.95); C419(0.87)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C443(0.63); C163(0.98); C419(0.84)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C321(0.89); C443(1.18); C18(0.77); C419(1.13)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C321(1.10); C443(0.96); C163(0.97); C406(1.35)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C321(0.88); C443(1.07); C163(0.99); C419(1.08)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C443(1.02); C163(1.00); C419(0.87)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C321(0.89); C443(0.85); C163(0.96); C406(0.92)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C321(0.96); C443(0.84); C163(1.15); C419(0.87)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C443(0.89); C163(1.05); C419(0.79)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C321(1.09); C443(0.81); C406(1.01); C419(1.03)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C321(0.97); C443(0.73); C163(1.21); C419(0.75)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C321(0.95); C443(0.70); C163(1.02); C419(0.89)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C443(0.68); C163(0.91); C419(0.87)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C321(1.04); C443(0.93); C163(1.09); C419(0.84)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C443(0.62); C163(1.16); C419(0.84)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C321(1.22); C443(1.14); C18(0.73); C419(1.29)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C321(1.02); C443(1.07); C163(1.00); C419(0.88)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C321(1.06); C443(1.15); C163(0.99); C419(1.08)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C443(0.92); C163(0.92); C419(0.86)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C321(1.04); C443(0.96); C163(0.98); C406(1.20)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C321(1.04); C443(0.89); C163(1.15); C419(0.96)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C443(0.93); C163(1.05); C419(0.90)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C321(0.88); C443(0.77); C406(0.96); C419(0.96)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C321(0.97); C443(0.79); C163(1.04); C419(0.81)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C443(0.97); C163(0.99); C419(0.88)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C321(0.99); C443(0.75); C163(1.04); C419(0.83)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C443(0.71); C163(0.91); C419(0.86)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C443(0.64); C163(1.03); C419(0.79)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C321(0.86); C443(1.15); C18(0.77); C419(1.04)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C321(1.01); C443(1.12); C163(1.01); C419(1.00)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C443(1.07); C163(0.92); C419(0.98)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C321(0.89); C443(0.85); C163(0.94); C406(1.06)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C321(1.00); C443(0.93); C163(1.09); C419(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C443(1.00); C163(1.12); C419(0.87)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C321(0.86); C443(0.75); C406(0.95); C419(0.78)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C321(0.95); C443(0.87); C406(1.03); C419(0.87)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C321(1.03); C443(0.80); C163(0.99); C419(0.83)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C321(1.02); C443(0.76); C163(1.00); C419(0.79)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C443(0.74); C163(0.97); C419(0.85)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C443(0.70); C163(1.02); C419(0.83)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C321(1.03); C443(1.30); C18(0.65); C419(1.42)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C321(1.07); C443(1.23); C163(0.99); C419(1.20)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C321(1.10); C443(1.23); C163(1.01); C419(1.35)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C443(1.01); C163(0.95); C419(0.91)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C321(0.91); C443(1.10); C163(1.02); C406(0.98)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C321(1.05); C443(0.76); C163(0.95); C419(0.81)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C321(0.89); C443(0.86); C163(1.14); C419(0.89)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C443(1.07); C163(1.01); C419(0.94)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C321(1.08); C443(0.81); C406(1.01); C419(0.93)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C321(0.96); C443(0.78); C163(1.17); C419(0.85)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C321(0.96); C443(0.83); C163(0.98); C419(0.76)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C443(0.70); C163(0.88); C419(0.83)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C443(0.71); C163(1.17); C419(0.88)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C321(1.15); C443(0.95); C18(0.87); C419(1.08)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C321(0.84); C443(1.07); C163(0.92); C419(1.06)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C321(0.91); C443(1.13); C163(0.92); C419(1.24)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C321(1.00); C443(1.09); C163(0.99); C419(1.20)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C321(1.07); C443(1.15); C163(0.99); C419(1.14)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C321(0.96); C443(1.15); C163(1.06); C419(0.99)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C443(1.04); C321(1.06); C18(1.07); C406(1.00)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C443(1.01); C321(1.08); C18(1.10); C406(1.09)  LDD1497  [11]
 LDCM0024  KB05 IGR39 C467(1.77)  LDD3315  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 25 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 10 (NAA10) Acetyltransferase family P41227
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Valine--tRNA ligase (VARS1) Class-I aminoacyl-tRNA synthetase family P26640
Phenylalanine--tRNA ligase, mitochondrial (FARS2) Class-II aminoacyl-tRNA synthetase family O95363
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Poly(A) RNA polymerase, mitochondrial (MTPAP) DNA polymerase type-B-like family Q9NVV4
Poly(A) RNA polymerase GLD2 (TENT2) DNA polymerase type-B-like family Q6PIY7
FAST kinase domain-containing protein 4 (TBRG4) FAST kinase family Q969Z0
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Methyltransferase-like protein 17, mitochondrial (METTL17) Rsm22 family Q9H7H0
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
AMSH-like protease (STAMBPL1) Peptidase M67C family Q96FJ0
Chymotrypsin-like elastase family member 2B (CELA2B) Peptidase S1 family P08218
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
EKC/KEOPS complex subunit TP53RK (TP53RK) BUD32 family Q96S44
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Proto-oncogene serine/threonine-protein kinase mos (MOS) Ser/Thr protein kinase family P00540
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Cell division cycle 7-related protein kinase (CDC7) Ser/Thr protein kinase family O00311
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
Dual specificity protein phosphatase 26 (DUSP26) Protein-tyrosine phosphatase family Q9BV47
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Ubiquitin-associated domain-containing protein 2 (UBAC2) . Q8NBM4
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B9 (HOXB9) Abd-B homeobox family P17482
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger protein 337 (ZNF337) Krueppel C2H2-type zinc-finger protein family Q9Y3M9
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 564 (ZNF564) Krueppel C2H2-type zinc-finger protein family Q8TBZ8
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 696 (ZNF696) Krueppel C2H2-type zinc-finger protein family Q9H7X3
Zinc finger protein 774 (ZNF774) Krueppel C2H2-type zinc-finger protein family Q6NX45
Zinc finger protein 80 (ZNF80) Krueppel C2H2-type zinc-finger protein family P51504
PHD finger protein 1 (PHF1) Polycomblike family O43189
Forkhead box protein D4-like 3 (FOXD4L3) . Q6VB84
Max-interacting protein 1 (MXI1) . P50539
Transcriptional repressor p66-beta (GATAD2B) . Q8WXI9
Zinc finger and BTB domain-containing protein 4 (ZBTB4) . Q9P1Z0
Zinc finger protein 408 (ZNF408) . Q9H9D4
Zinc finger protein 581 (ZNF581) . Q9P0T4
Other
Click To Hide/Show 68 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Microtubule-associated proteins 1A/1B light chain 3C (MAP1LC3C) ATG8 family Q9BXW4
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Protein BEX2 (BEX2) BEX family Q9BXY8
Proteasome activator complex subunit 4 (PSME4) BLM10 family Q14997
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Cyclin-H (CCNH) Cyclin family P51946
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
Dynactin subunit 4 (DCTN4) Dynactin subunit 4 family Q9UJW0
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM168A (FAM168A) FAM168 family Q92567
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Lipase maturation factor 2 (LMF2) Lipase maturation factor family Q9BU23
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
MICOS complex subunit MIC19 (CHCHD3) MICOS complex subunit Mic19 family Q9NX63
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) NifU family Q9UMS0
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
RNA-binding protein 15 (RBM15) RRM Spen family Q96T37
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
U6 snRNA-associated Sm-like protein LSm4 (LSM4) SnRNP Sm proteins family Q9Y4Z0
Spermatogenesis-associated protein 24 (SPATA24) SPATA24 family Q86W54
Translational activator of cytochrome c oxidase 1 (TACO1) TACO1 family Q9BSH4
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
Tektin-3 (TEKT3) Tektin family Q9BXF9
Centrosomal protein CEP57L1 (CEP57L1) Translokin family Q8IYX8
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) Ubiquitin family; Eukaryotic ribosomal protein eS31 family P62979
Large ribosomal subunit protein uL6 (RPL9; RPL9P7; RPL9P8; RPL9P9) Universal ribosomal protein uL6 family P32969
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Axin-1 (AXIN1) . O15169
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
DAZ-associated protein 2 (DAZAP2) . Q15038
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1) . O43324
Fibronectin type III domain-containing protein 11 (FNDC11) . Q9BVV2
FK506-binding protein-like (FKBPL) . Q9UIM3
Galectin-8 (LGALS8) . O00214
Grancalcin (GCA) . P28676
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
Kelch-like protein 35 (KLHL35) . Q6PF15
Kelch-like protein 42 (KLHL42) . Q9P2K6
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
LIM domain transcription factor LMO4 (LMO4) . P61968
Mitochondrial antiviral-signaling protein (MAVS) . Q7Z434
Neuronal migration protein doublecortin (DCX) . O43602
Nuclear protein AMMECR1 (AMMECR1) . Q9Y4X0
Peflin (PEF1) . Q9UBV8
Phostensin (PPP1R18) . Q6NYC8
Receptor-transporting protein 5 (RTP5) . Q14D33
Retrotransposon-derived protein PEG10 (PEG10) . Q86TG7
Rho guanine nucleotide exchange factor 39 (ARHGEF39) . Q8N4T4
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
Rhombotin-2 (LMO2) . P25791
SCAN domain-containing protein 1 (SCAND1) . P57086
SHC-transforming protein 1 (SHC1) . P29353
Sorcin (SRI) . P30626
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402