Details of the Target

General Information of Target

Target ID LDTP02703
Target Name General transcription factor IIF subunit 2 (GTF2F2)
Gene Name GTF2F2
Gene ID 2963
Synonyms
RAP30; General transcription factor IIF subunit 2; General transcription factor IIF 30 kDa subunit; Transcription initiation factor IIF subunit beta; TFIIF-beta; Transcription initiation factor RAP30
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNE
DLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAA
SENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADK
QHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYR
HYQGEEKSD
Target Bioclass
Other
Family
TFIIF beta subunit family
Subcellular location
Nucleus
Function TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB.
Uniprot ID
P13984
Ensemble ID
ENST00000340473.8
HGNC ID
HGNC:4653

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.45  LDD0402  [1]
TH211
 Probe Info  		Y161(20.00)  LDD0257  [2]
STPyne
 Probe Info  		K154(10.00); K22(5.63); K230(7.88); K25(1.04)  LDD0277  [3]
Probe 1
 Probe Info  		Y124(27.05)  LDD3495  [4]
DBIA
 Probe Info  		C116(2.21)  LDD3311  [5]
HHS-482
 Probe Info  		Y153(0.73); Y161(0.74)  LDD0285  [6]
HHS-475
 Probe Info  		Y26(0.68); Y153(0.74); Y161(0.86); Y239(0.92)  LDD0264  [7]
5E-2FA
 Probe Info  		H66(0.00); H159(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K33(0.00); K137(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
IPM
 Probe Info  		N.A.  LDD2156  [12]
SF
 Probe Info  		K154(0.00); Y153(0.00); Y165(0.00)  LDD0028  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
HHS-465
 Probe Info  		K154(0.00); Y153(0.00); Y161(0.00); K236(0.00)  LDD2240  [18]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C282
 Probe Info  		14.72  LDD1952  [19]
C284
 Probe Info  		22.78  LDD1954  [19]
C364
 Probe Info  		18.25  LDD2025  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C116(1.02)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C116(1.03)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C116(1.02)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C116(0.97)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C116(0.88)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C116(0.89)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C116(0.94)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C116(1.10)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C116(0.87)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C116(1.06)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C116(0.99)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C116(1.02)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C116(0.95)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C116(0.92)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C116(0.97)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C116(0.93)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C116(0.99)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C116(1.01)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C116(1.02)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C116(1.02)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C116(1.06)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C116(0.97)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C116(0.98)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C116(1.03)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C116(0.92)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C116(0.90)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C116(0.98)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C116(1.06)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C116(1.04)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C116(0.95)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C116(1.07)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C116(1.14)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C116(1.18)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C116(0.95)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C116(0.93)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C116(0.96)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C116(0.98)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C116(0.99)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C116(1.03)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C116(0.94)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C116(1.04)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C116(0.98)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C116(1.11)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C116(1.03)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C116(0.95)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C116(0.99)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C116(1.04)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C116(0.96)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C116(0.96)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C116(1.00)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C116(0.95)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C116(1.07)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C116(0.99)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C116(1.00)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C116(0.98)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C116(1.00)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C116(0.91)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C116(1.00)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C116(1.08)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C116(1.02)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C116(1.07)  LDD1569  [20]
 LDCM0248  AKOS034007472 HEK-293T C116(1.02)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C116(0.98)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C116(1.03)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 12.62  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C116(0.00); H241(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C116(20.00)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C116(0.95)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C116(0.68)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C116(1.10)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C116(0.96)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C116(0.94)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C116(0.97)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C116(1.04)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C116(1.01)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C116(0.99)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C116(1.04)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C116(1.02)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C116(1.00)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C116(0.73)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C116(0.93)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C116(1.00)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C116(1.01)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C116(0.98)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C116(0.95)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C116(0.99)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C116(1.09)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C116(0.99)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C116(1.00)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C116(1.04)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C116(0.81)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C116(1.00)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C116(0.99)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C116(1.01)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C116(0.92)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C116(1.03)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C116(1.20)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C116(1.00)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C116(1.07)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C116(1.10)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C116(0.94)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C116(0.95)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C116(0.78)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C116(0.94)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C116(0.70)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C116(0.82)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C116(0.88)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C116(0.95)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C116(0.91)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C116(0.76)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C116(0.84)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C116(0.77)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C116(0.86)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C116(1.02)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C116(1.07)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C116(1.03)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C116(0.99)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C116(0.89)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C116(0.88)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C116(0.89)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C116(0.81)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C116(0.99)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C116(0.70)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C116(0.86)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C116(0.74)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C116(0.86)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C116(1.02)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C116(1.02)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C116(0.95)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C116(1.01)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C116(0.86)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C116(1.03)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C116(0.88)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C116(0.97)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C116(0.78)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C116(0.83)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C116(0.74)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C116(0.90)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C116(1.23)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C116(0.84)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C116(0.93)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C116(0.98)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C116(0.80)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C116(0.76)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C116(0.88)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C116(0.92)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C116(0.80)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C116(0.88)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C116(0.84)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C116(0.76)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C116(0.87)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C116(1.22)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C116(1.00)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C116(1.02)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C116(0.93)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C116(0.89)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C116(0.91)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C116(0.91)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C116(0.98)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C116(0.92)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C116(0.87)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C116(0.86)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C116(0.82)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C116(0.88)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C116(1.06)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C116(1.12)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C116(1.05)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C116(0.84)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C116(0.87)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C116(0.94)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C116(0.72)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C116(1.03)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C116(0.87)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C116(0.86)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C116(0.76)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C116(0.85)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C116(1.31)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C116(1.26)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C116(1.18)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C116(1.13)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C116(1.03)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C116(0.86)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C116(0.74)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C116(1.04)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C116(0.92)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C116(0.86)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C116(0.93)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C116(0.67)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C116(0.99)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C116(0.99)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C116(1.01)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C116(1.09)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C116(0.99)  LDD1698  [20]
 LDCM0625  F8 Ramos C116(1.48)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C116(0.89)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C116(4.39)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C116(1.10)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C116(1.23)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C116(0.75)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C116(0.75)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C116(1.06)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C116(1.39)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C116(1.34)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C116(0.68)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C116(1.47)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C116(1.37)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C116(1.07)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C116(1.00)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C116(1.04)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C116(0.74)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C116(1.04)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C116(2.12)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C116(1.42)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C116(0.71)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C116(1.20)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y26(0.68); Y153(0.74); Y161(0.86); Y239(0.92)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y242(0.59); Y153(0.78); Y161(0.82); Y26(0.91)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y242(0.55); Y26(0.55); Y239(0.69); Y153(0.77)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y153(0.68); Y161(0.74); Y239(0.93); Y26(1.13)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y26(0.57); Y242(0.70); Y153(0.75); Y161(0.93)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y153(0.73); Y161(0.74)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y153(0.71); Y161(0.69)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y153(0.94); Y161(0.94)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y153(2.31); Y161(1.92)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y153(1.54); Y161(1.91)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y153(0.94); Y161(0.87)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y153(0.50); Y161(0.50)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y153(0.91); Y161(0.89)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C116(0.99)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C116(1.02)  LDD1497  [20]
 LDCM0024  KB05 G361 C116(2.21)  LDD3311  [5]
 LDCM0109  NEM HeLa H159(0.00); H241(0.00)  LDD0223  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Unconventional prefoldin RPB5 interactor 1 (URI1) RNA polymerase II subunit 5-mediating protein family O94763
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain Tctex-type protein 2B (DYNLT2B) Dynein light chain Tctex-type family Q8WW35
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
General transcription factor IIF subunit 1 (GTF2F1) TFIIF alpha subunit family P35269
Large ribosomal subunit protein uL15 (RPL27A) Universal ribosomal protein uL15 family P46776
Four and a half LIM domains protein 2 (FHL2) . Q14192
Zinc finger MYND domain-containing protein 19 (ZMYND19) . Q96E35

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578