Details of the Target

General Information of Target

Target ID LDTP12725
Target Name Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB)
Gene Name MCUB
Gene ID 55013
Synonyms
CCDC109B; Calcium uniporter regulatory subunit MCUb, mitochondrial; MCUb; Coiled-coil domain-containing protein 109B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPLESSSSMPLSFPSLLPSVPHNTNPSPPLMSYITSQEMKCILHWFANWSGPQRERFLED
LVAKAVPEKLQPLLDSLEQLSVSGADRPPSIFECQLHLWDQWFRGWAEQERNEFVRQLEF
SEPDFVAKFYQAVAATAGKD
Target Bioclass
Transporter and channel
Family
MCU (TC 1.A.77) family
Subcellular location
Mitochondrion inner membrane
Function
Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
Uniprot ID
Q9NWR8
Ensemble ID
ENST00000394650.7
HGNC ID
HGNC:26076

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C147(1.26)  LDD3312  [2]
BTD
 Probe Info  		C147(0.55)  LDD2125  [3]
AHL-Pu-1
 Probe Info  		C324(7.09)  LDD0169  [4]
IA-alkyne
 Probe Info  		C82(0.00); C147(0.00)  LDD0165  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		16.00  LDD1793  [7]
C134
 Probe Info  		20.97  LDD1816  [7]
C140
 Probe Info  		8.00  LDD1822  [7]
C278
 Probe Info  		67.18  LDD1948  [7]
C282
 Probe Info  		15.89  LDD1952  [7]
C284
 Probe Info  		23.26  LDD1954  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C324(7.09)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C147(0.97); C324(0.97)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C147(0.88); C324(0.91)  LDD1508  [8]
 LDCM0216  AC100 HEK-293T C147(1.87); C324(1.23)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C147(1.22); C324(1.29)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C147(1.54); C324(1.36)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C147(1.77); C324(1.23)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C147(1.95); C324(1.28)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C147(1.30); C324(1.29)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C147(1.16); C324(0.84)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C147(1.55); C324(1.08)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C147(1.14); C324(0.90)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C147(1.33); C324(1.13)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C147(1.08); C324(0.97)  LDD1509  [8]
 LDCM0227  AC110 HEK-293T C147(2.51); C324(1.59)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C147(2.83); C324(1.80)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C147(3.29); C324(1.43)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C324(1.29)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C324(1.28)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C324(1.34)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C324(1.11)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C324(1.41)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C324(1.30)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C324(1.77)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C147(0.92); C324(1.00)  LDD1510  [8]
 LDCM0238  AC120 HEK-293T C324(1.32)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C324(1.86)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C324(2.10)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C324(2.04)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C324(1.32)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C324(1.67)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C324(2.40)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C324(2.53)  LDD0843  [9]
 LDCM0259  AC14 HEK-293T C147(0.94); C324(1.01)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C147(0.95); C324(1.12)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C147(2.91); C324(2.71)  LDD0874  [9]
 LDCM0277  AC18 HEK-293T C147(1.93); C324(1.46)  LDD0875  [9]
 LDCM0278  AC19 HEK-293T C147(1.99); C324(2.25)  LDD0876  [9]
 LDCM0279  AC2 HEK-293T C147(0.85); C324(0.94)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C147(2.59); C324(2.21)  LDD0878  [9]
 LDCM0281  AC21 HEK-293T C147(2.40); C324(1.72)  LDD0879  [9]
 LDCM0282  AC22 HEK-293T C147(2.66); C324(1.61)  LDD0880  [9]
 LDCM0283  AC23 HEK-293T C147(3.30); C324(2.85)  LDD0881  [9]
 LDCM0284  AC24 HEK-293T C147(1.80); C324(1.48)  LDD0882  [9]
 LDCM0285  AC25 HEK-293T C147(1.46); C324(1.39)  LDD0883  [9]
 LDCM0286  AC26 HEK-293T C147(1.53); C324(1.23)  LDD0884  [9]
 LDCM0287  AC27 HEK-293T C147(1.50); C324(1.46)  LDD0885  [9]
 LDCM0288  AC28 HEK-293T C147(1.59); C324(1.55)  LDD0886  [9]
 LDCM0289  AC29 HEK-293T C147(1.89); C324(1.56)  LDD0887  [9]
 LDCM0290  AC3 HEK-293T C147(1.05); C324(0.92)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C147(1.72); C324(1.65)  LDD0889  [9]
 LDCM0292  AC31 HEK-293T C147(1.47); C324(1.73)  LDD0890  [9]
 LDCM0293  AC32 HEK-293T C147(1.74); C324(1.48)  LDD0891  [9]
 LDCM0294  AC33 HEK-293T C147(1.92); C324(2.01)  LDD0892  [9]
 LDCM0295  AC34 HEK-293T C147(2.12); C324(1.95)  LDD0893  [9]
 LDCM0296  AC35 HEK-293T C147(1.02); C324(0.95)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C147(0.93); C324(1.00)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C147(0.96); C324(0.87)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C147(0.98); C324(1.05)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C147(0.95); C324(1.16)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C147(0.87); C324(1.04)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C147(1.07); C324(0.96)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C147(0.97); C324(0.96)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C147(0.79); C324(1.11)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C147(1.00); C324(0.98)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C147(0.97); C324(0.99)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C147(0.97); C324(0.96)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C147(0.70); C324(0.90)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C147(0.94); C324(1.28)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C147(1.12); C324(0.92)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C147(1.53); C324(2.31)  LDD0909  [9]
 LDCM0312  AC5 HEK-293T C147(1.00); C324(0.92)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C147(1.60); C324(1.51)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C147(1.15); C324(1.50)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C147(1.50); C324(1.14)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C147(1.13); C324(1.52)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C147(1.16); C324(1.68)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C147(1.14); C324(1.49)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C147(0.97); C324(1.08)  LDD0917  [9]
 LDCM0320  AC57 HEK-293T C147(1.02); C324(1.10)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C147(0.95); C324(0.94)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C147(1.11); C324(0.89)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C147(0.89); C324(1.04)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C147(0.95); C324(1.00)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C147(1.01); C324(0.91)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C147(0.98); C324(0.97)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C147(1.05); C324(1.10)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C147(1.06); C324(1.01)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C147(0.94); C324(1.10)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C147(1.08); C324(0.95)  LDD1569  [8]
 LDCM0349  AC83 HEK-293T C147(0.99); C324(1.53)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C147(2.28); C324(1.93)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C147(1.21); C324(1.16)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C147(1.36); C324(1.24)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C147(1.57); C324(1.38)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C147(1.21); C324(2.13)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C147(2.31); C324(2.73)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C147(2.29); C324(2.54)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C147(1.55); C324(1.44)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C147(1.72); C324(1.81)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C147(2.05); C324(1.74)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C147(2.50); C324(2.41)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C147(1.64); C324(1.21)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C147(2.05); C324(1.46)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C147(3.84); C324(2.30)  LDD0962  [9]
 LDCM0365  AC98 HEK-293T C147(1.20); C324(1.01)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C147(1.19); C324(1.15)  LDD0964  [9]
 LDCM0248  AKOS034007472 HEK-293T C147(1.00); C324(0.97)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C147(0.98); C324(1.00)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C147(1.11); C324(1.02)  LDD1514  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C147(0.96); C324(1.10)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C147(1.07); C324(0.99)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C147(0.97); C324(1.01)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C147(0.86); C324(0.93)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C147(0.98); C324(0.94)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C147(0.97); C324(1.00)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C147(0.96); C324(0.94)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C147(2.02); C324(2.04)  LDD0972  [9]
 LDCM0375  CL106 HEK-293T C147(1.88); C324(1.81)  LDD0973  [9]
 LDCM0376  CL107 HEK-293T C147(1.55); C324(1.52)  LDD0974  [9]
 LDCM0377  CL108 HEK-293T C147(1.93); C324(1.61)  LDD0975  [9]
 LDCM0378  CL109 HEK-293T C147(2.06); C324(1.49)  LDD0976  [9]
 LDCM0379  CL11 HEK-293T C147(0.98); C324(1.14)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C147(2.74); C324(1.93)  LDD0978  [9]
 LDCM0381  CL111 HEK-293T C147(2.28); C324(1.68)  LDD0979  [9]
 LDCM0382  CL112 HEK-293T C147(2.10); C324(1.75)  LDD0980  [9]
 LDCM0383  CL113 HEK-293T C147(1.68); C324(1.55)  LDD0981  [9]
 LDCM0384  CL114 HEK-293T C147(2.92); C324(2.56)  LDD0982  [9]
 LDCM0385  CL115 HEK-293T C147(2.91); C324(2.86)  LDD0983  [9]
 LDCM0386  CL116 HEK-293T C147(2.48); C324(2.60)  LDD0984  [9]
 LDCM0387  CL117 HEK-293T C147(1.02); C324(0.95)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C147(0.97); C324(0.93)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C147(1.04); C324(1.00)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C147(1.12); C324(1.21)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C147(1.04); C324(0.96)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C147(1.28); C324(1.91)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C147(1.10); C324(1.27)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C147(1.32); C324(1.50)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C147(1.42); C324(1.82)  LDD0993  [9]
 LDCM0396  CL125 HEK-293T C147(1.03); C324(0.90)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C147(0.99); C324(0.98)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C147(0.94); C324(0.86)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C147(1.00); C324(0.92)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C147(0.97); C324(1.05)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C147(1.03); C324(0.91)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C147(0.94); C324(0.89)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C324(0.93)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C324(1.84)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C324(1.59)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C324(1.34)  LDD1004  [9]
 LDCM0407  CL2 HEK-293T C147(1.05); C324(0.93)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C324(1.13)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C324(1.00)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C324(1.53)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C324(1.23)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C324(1.03)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C324(1.24)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C324(1.39)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C324(1.10)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C324(1.46)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C324(1.11)  LDD1015  [9]
 LDCM0418  CL3 HEK-293T C147(0.91); C324(0.98)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C324(2.18)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C324(1.84)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C324(1.14)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C324(1.60)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C324(1.25)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C324(2.02)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C324(1.34)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C324(1.62)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C324(3.58)  LDD1026  [9]
 LDCM0429  CL4 HEK-293T C147(0.99); C324(0.96)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C324(1.51)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C324(1.96)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C324(1.97)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C324(1.75)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C324(1.34)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C324(2.56)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C147(1.04); C324(1.18)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C147(1.04); C324(1.17)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C147(1.26); C324(1.22)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C147(0.96); C324(1.01)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C147(1.09); C324(1.00)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C147(0.97); C324(0.86)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C147(1.02); C324(0.87)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C147(0.97); C324(0.97)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C147(1.10); C324(0.91)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C147(1.13); C324(1.09)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C147(0.97); C324(1.07)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C147(1.16); C324(1.18)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C147(1.09); C324(1.12)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C147(1.00); C324(1.34)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C147(0.90); C324(1.06)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C147(1.23); C324(1.16)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C147(0.87); C324(0.95)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C147(0.91); C324(0.87)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C147(1.02); C324(0.93)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C147(1.00); C324(0.84)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C147(1.01); C324(1.06)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C147(0.91); C324(1.11)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C147(0.98); C324(1.00)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C147(1.00); C324(1.07)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C147(0.97); C324(1.13)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C147(0.99); C324(1.08)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C147(1.07); C324(1.06)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C147(1.01); C324(1.12)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C147(1.21); C324(1.03)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C147(1.01); C324(0.92)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C147(0.98); C324(0.80)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C147(0.98); C324(0.95)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C147(1.09); C324(1.06)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C147(0.77); C324(0.98)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C147(0.99); C324(1.02)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C147(1.01); C324(1.54)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C147(0.99); C324(1.20)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C147(1.00); C324(1.10)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C147(0.91); C324(1.09)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C147(1.01); C324(1.19)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C147(1.25); C324(1.11)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C147(1.10); C324(0.90)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C147(0.97); C324(0.88)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C147(1.09); C324(0.99)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C147(0.94); C324(0.96)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C147(1.07); C324(0.99)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C147(1.05); C324(1.11)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C147(0.98); C324(1.13)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C147(1.09); C324(0.99)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C147(0.95); C324(1.03)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C147(1.09); C324(1.06)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C147(0.96); C324(1.01)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C147(1.02); C324(1.18)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C147(1.05); C324(0.95)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C147(1.07); C324(1.06)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C147(1.01); C324(0.88)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C147(0.38); C324(1.04)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C147(1.13); C324(0.99)  LDD1698  [8]
 LDCM0625  F8 Ramos C147(2.89)  LDD2187  [10]
 LDCM0586  Fragment28 Ramos C147(0.75)  LDD2198  [10]
 LDCM0468  Fragment33 HEK-293T C147(0.85); C324(0.94)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C324(1.35)  LDD1025  [9]
 LDCM0569  Fragment7 Ramos C147(0.59)  LDD2186  [10]
 LDCM0022  KB02 HEK-293T C147(1.04); C324(0.89)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C147(0.91); C324(0.89)  LDD1497  [8]
 LDCM0024  KB05 HMCB C147(1.26)  LDD3312  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C147(0.55)  LDD2125  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578