Details of the Target

General Information of Target

Target ID LDTP13140
Target Name tRNA (guanine-N(7)-)-methyltransferase (METTL1)
Gene Name METTL1
Gene ID 4234
Synonyms
C12orf1; tRNA; guanine-N(7)-)-methyltransferase; EC 2.1.1.33; Methyltransferase-like protein 1; mRNA; guanine-N(7)-)-methyltransferase; EC 2.1.1.-; miRNA; guanine-N(7)-)-methyltransferase; EC 2.1.1.-; tRNA; guanine(46)-N(7))-methyltransferase; tRNA(m7G46)-methyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRPCEETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRR
RDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMD
FMSIGFRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPL
HPHHWAAAFHHLPAALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADSALRM
PSTGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAA
TAISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, TrmB family
Subcellular location
Nucleus
Function
Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop . M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. {|HAMAP-Rule:MF_03055}.
Uniprot ID
Q9UBP6
Ensemble ID
ENST00000257848.7
HGNC ID
HGNC:7030

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC26 SNV: p.E12Q DBIA    Probe Info 
OVK18 SNV: p.Y20Ter DBIA    Probe Info 
SW1116 SNV: p.A3G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C136(1.46)  LDD2099  [1]
DBIA
 Probe Info  		C136(4.33)  LDD0209  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
NAIA_5
 Probe Info  		C136(0.00); C208(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		65.80  LDD1948  [8]
C282
 Probe Info  		15.24  LDD1952  [8]
C293
 Probe Info  		20.25  LDD1963  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C136(1.24)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C136(1.33)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C136(0.38)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C136(0.31)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C136(0.23)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C136(0.19)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C136(0.18)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C136(0.20)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C136(0.21)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C136(0.38)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C136(0.20)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C136(0.18)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C136(1.30)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C136(0.22)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C136(0.21)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C136(0.27)  LDD0546  [10]
 LDCM0237  AC12 HCT 116 C136(1.25)  LDD0554  [10]
 LDCM0259  AC14 HCT 116 C136(1.19)  LDD0576  [10]
 LDCM0263  AC143 HCT 116 C136(1.00)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C136(0.31)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C136(0.41)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C136(0.38)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C136(0.33)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C136(0.21)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C136(0.29)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C136(1.08)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C136(0.54)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C136(0.58)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C136(0.29)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C136(0.17)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C136(0.34)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C136(0.34)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C136(0.84)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C136(0.67)  LDD2161  [10]
 LDCM0276  AC17 HEK-293T C136(0.83)  LDD1515  [11]
 LDCM0279  AC2 HCT 116 C136(1.05)  LDD0596  [10]
 LDCM0280  AC20 HEK-293T C136(0.96)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C136(1.07)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C136(1.16)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C136(0.91)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C136(1.08)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C136(0.73)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C136(0.52)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C136(0.76)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C136(1.00)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C136(0.68)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C136(1.08)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C136(0.62)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C136(0.76)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C136(0.62)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C136(0.70)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C136(0.72)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C136(1.14)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C136(1.26)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C136(1.67)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C136(1.04)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C136(1.23)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C136(1.35)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C136(1.26)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C136(1.20)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C136(1.13)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C136(1.00)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C136(1.50)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C136(1.66)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C136(1.10)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C136(1.05)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C136(1.22)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C136(0.68)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C136(1.85)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C136(0.72)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C136(1.38)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C136(0.99)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C136(0.93)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C136(0.81)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C136(0.63)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C136(0.48)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C136(0.63)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C136(0.67)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C136(0.60)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C136(1.00)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C136(0.61)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C136(0.79)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C136(0.54)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C136(0.61)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C136(0.53)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C136(0.70)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C136(0.71)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C136(0.39)  LDD0648  [10]
 LDCM0334  AC7 HCT 116 C136(0.99)  LDD0651  [10]
 LDCM0345  AC8 HCT 116 C136(1.11)  LDD0662  [10]
 LDCM0349  AC83 HCT 116 C136(0.25)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C136(0.28)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C136(0.52)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C136(0.41)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C136(0.73)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C136(0.43)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C136(0.33)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C136(1.01)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C136(0.29)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C136(0.29)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C136(0.40)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C136(0.54)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C136(0.68)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C136(0.35)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C136(0.34)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C136(0.07)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C136(0.40)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C136(1.01)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C136(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C136(1.11)  LDD0592  [10]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C136(1.00); C208(0.80)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C136(0.85)  LDD1572  [11]
 LDCM0369  CL100 HCT 116 C136(1.09)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C136(1.03)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C136(1.26)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C136(1.16)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C136(1.16)  LDD0690  [10]
 LDCM0374  CL105 HEK-293T C136(0.93); C208(0.98)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C136(0.93)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C136(1.00); C208(0.84)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C136(1.07)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C136(0.97); C208(1.08)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C136(1.05)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C136(0.84)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C136(0.97); C208(0.77)  LDD1585  [11]
 LDCM0382  CL112 HCT 116 C136(1.38)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C136(0.89)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C136(0.75)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C136(0.61)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C136(0.61)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C136(0.95)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C136(1.07)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C136(0.93)  LDD0706  [10]
 LDCM0390  CL12 HEK-293T C136(0.97)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C136(1.10)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C136(0.74)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C136(0.80)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C136(0.82)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C136(0.73)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C136(0.83)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C136(0.77)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C136(0.84)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C136(0.69)  LDD0716  [10]
 LDCM0400  CL13 HEK-293T C136(0.89); C208(1.39)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C136(0.86)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C136(1.05); C208(0.61)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C136(0.98)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C136(0.90)  LDD1608  [11]
 LDCM0407  CL2 HEK-293T C136(0.90)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C136(1.14)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C136(1.01)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C136(1.03)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C136(1.12)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C136(1.02)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C136(0.96); C208(0.91)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C136(0.92)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C136(1.10); C208(0.90)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C136(0.95)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C136(0.91)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C136(1.06); C208(0.78)  LDD1622  [11]
 LDCM0421  CL32 HEK-293T C136(1.07)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C136(0.96)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C136(0.98)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C136(1.04)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C136(0.94)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C136(0.96); C208(1.01)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C136(1.04); C208(0.89)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C136(0.90)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C136(1.03)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C136(1.01)  LDD1635  [11]
 LDCM0434  CL44 HEK-293T C136(1.08)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C136(0.92)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C136(1.06)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C136(1.14)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C136(0.95)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C136(1.16); C208(0.99)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C136(0.94)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C136(1.01)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C136(0.99)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C136(0.92)  LDD1647  [11]
 LDCM0447  CL56 HEK-293T C136(1.15)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C136(1.03)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C136(1.08)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C136(1.04)  LDD1653  [11]
 LDCM0452  CL60 HEK-293T C136(0.99)  LDD1655  [11]
 LDCM0453  CL61 HCT 116 C136(0.85)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C136(0.85)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C136(0.75)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C136(0.75)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C136(0.81)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C136(0.52)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C136(0.68)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C136(0.72)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C136(0.94)  LDD0778  [10]
 LDCM0463  CL70 HCT 116 C136(0.73)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C136(0.66)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C136(0.95)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C136(0.69)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C136(0.74)  LDD0784  [10]
 LDCM0469  CL76 HEK-293T C136(0.98)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C136(0.81)  LDD1673  [11]
 LDCM0473  CL8 HEK-293T C136(0.82)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C136(1.32)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C136(1.07)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C136(1.12)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C136(1.02)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C136(1.04)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C136(0.95); C208(0.89)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C136(0.99)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C136(1.02); C208(0.87)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C136(0.99)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C136(1.00)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C136(1.07)  LDD1687  [11]
 LDCM0486  CL91 HCT 116 C136(0.98)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C136(0.88)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C136(0.80)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C136(0.91)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C136(0.76)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C136(1.02)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C136(1.16)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C136(1.17)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C136(1.13)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C136(1.03); C208(0.71)  LDD1698  [11]
 LDCM0625  F8 Ramos C136(0.73)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C136(0.40)  LDD2189  [12]
 LDCM0574  Fragment12 Ramos C136(0.44)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C136(0.95)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C136(0.81)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C136(0.35)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C136(0.75)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C136(0.90)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C136(0.81)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C136(0.63)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C136(0.84)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C136(1.22)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C136(0.45)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C136(0.60)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C136(0.50)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C136(0.65)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C136(1.08)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C136(1.06)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C136(1.03)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C136(0.47)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C136(0.41)  LDD2188  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C136(1.07)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C136(4.33)  LDD0209  [2]
 LDCM0024  KB05 G361 C136(3.18)  LDD3311  [13]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C136(1.46)  LDD2099  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C136(0.92)  LDD2107  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C136(0.67)  LDD2109  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C136(0.66)  LDD2127  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C136(0.72)  LDD2137  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WDR4) WD repeat TRM82 family P57081

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840