Details of the Target

General Information of Target

Target ID LDTP13093
Target Name Neurochondrin (NCDN)
Gene Name NCDN
Gene ID 23154
Synonyms
KIAA0607; Neurochondrin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRG
RGRWKQAGRGGGVCGRGRGRGRGRGRGRGRGRGRGRPPSGGSGLGGDGGGCGGGGSGGGG
APRREPVPFPSGSAGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYF
SPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLN
TTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQII
KTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCK
AFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA
Target Bioclass
Other
Family
Neurochondrin family
Subcellular location
Cytoplasm, cytosol
Function
Probably involved in signal transduction in the nervous system, via increasing cell surface localization of GRM5/mGluR5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (Probable).
Uniprot ID
Q9UBB6
Ensemble ID
ENST00000356090.8
HGNC ID
HGNC:17597

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 SNV: p.G646S DBIA    Probe Info 
A3KAW SNV: p.T543A DBIA    Probe Info 
HCT15 SNV: p.R397W .
MCC13 Insertion: p.L671AfsTer90 DBIA    Probe Info 
MOLT4 SNV: p.W468Ter IA-alkyne    Probe Info 
REH SNV: p.Q708L DBIA    Probe Info 
RL952 SNV: p.R662C DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.59  LDD0402  [1]
STPyne
 Probe Info  		K272(6.61); K283(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
BTD
 Probe Info  		C491(0.92)  LDD2093  [3]
AHL-Pu-1
 Probe Info  		C22(2.72)  LDD0169  [4]
DBIA
 Probe Info  		C98(297.53)  LDD0209  [5]
IA-alkyne
 Probe Info  		C98(0.00); C541(0.00); C415(0.00); C469(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C415(0.00); C98(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		C98(0.00); C22(0.00)  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
IPM
 Probe Info  		C469(0.00); C491(0.00); C415(0.00)  LDD0005  [9]
VSF
 Probe Info  		C415(0.00); C98(0.00); C491(0.00)  LDD0007  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
Methacrolein
 Probe Info  		C22(0.00); C292(0.00)  LDD0218  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		12.30  LDD0443  [12]
NAIA_5
 Probe Info  		C541(0.00); C415(0.00); C469(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C228
 Probe Info  		16.68  LDD1901  [13]
C282
 Probe Info  		15.78  LDD1952  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C22(2.72)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C98(0.97); C351(1.03); C292(0.98); C491(0.92)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C98(1.00); C292(0.92); C491(1.00); C725(0.98)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C98(0.99); C351(1.18); C292(0.91); C491(0.97)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C98(1.04); C292(0.95); C491(1.03); C725(1.10)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C98(0.95); C351(1.06); C292(0.98); C491(0.99)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C98(1.04); C292(1.00); C491(1.06); C725(1.04)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C98(0.90); C351(1.16); C292(0.93); C491(1.00)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C98(0.96); C292(1.01); C491(0.98); C725(1.05)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C98(0.89); C351(1.56); C292(1.21); C491(1.44)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C98(1.00); C292(0.97); C491(0.92); C725(1.02)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C98(0.97); C292(0.92); C491(1.04); C725(1.08)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C98(0.91); C351(1.05); C292(0.93); C491(1.00)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C98(0.91); C351(1.00); C292(0.96); C491(0.93)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C98(1.03); C292(1.01); C491(0.95); C725(0.97)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C98(1.00); C351(1.05); C292(1.04); C491(0.96)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C98(0.88); C351(1.05); C292(0.95); C491(0.99)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C98(1.01); C292(0.98); C491(1.00); C725(1.04)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C98(0.98); C351(1.05); C292(0.93); C491(1.04)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C98(1.08); C292(0.96); C491(1.06); C725(1.09)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C98(0.95); C351(1.07); C292(1.04); C491(0.98)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C98(0.97); C351(1.07); C292(0.97); C491(1.00)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C98(1.10); C351(1.17); C292(0.98); C491(1.03)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C98(1.02); C292(1.02); C491(1.02); C725(0.97)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C98(1.00); C351(1.12); C292(0.98); C491(0.97)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C98(0.94); C351(0.99); C292(0.95); C491(0.91)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C98(0.98); C292(1.01); C491(0.94); C725(1.11)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C98(0.97); C351(1.06); C292(0.96); C491(1.00)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C98(1.03); C292(0.94); C491(1.00); C725(1.07)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C98(0.96); C351(1.00); C292(0.88); C491(0.95)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C98(1.03); C351(1.17); C292(0.93); C491(0.92)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C98(1.10); C292(1.05); C491(0.99); C725(1.09)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C98(1.02); C292(0.96); C491(1.00); C725(1.15)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C98(1.14); C351(1.15); C292(1.01); C491(0.99)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C98(0.93); C351(1.12); C292(0.96); C491(0.97)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C98(0.97); C292(1.04); C491(1.01); C725(1.13)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C98(0.91); C351(1.11); C292(0.90); C491(1.03)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C98(1.05); C292(0.98); C491(0.99); C725(1.14)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C98(0.92); C351(1.03); C292(0.90); C491(1.01)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C98(1.02); C351(1.08); C292(0.99); C491(0.93)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C98(1.05); C292(1.05); C491(1.04); C725(1.10)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C98(1.04); C351(1.23); C292(1.08); C491(0.94)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C98(0.95); C351(1.09); C292(0.92); C491(0.91)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C98(0.95); C351(1.00); C292(0.96); C491(0.98)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C98(1.00); C292(1.01); C491(0.97); C725(1.00)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C98(0.96); C351(1.09); C292(1.01); C491(0.90)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C98(1.04); C292(0.99); C491(1.01); C725(1.13)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C98(0.92); C351(1.02); C292(0.94); C491(0.99)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C98(0.96); C351(1.07); C292(0.99); C491(0.93)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C98(1.09); C292(1.01); C491(0.97); C725(0.96)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C98(1.06); C351(1.16); C292(0.99); C491(1.02)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C98(0.94); C351(0.99); C292(0.98); C491(0.92)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C98(1.00); C292(0.97); C491(0.99); C725(0.99)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C98(0.94); C351(1.04); C292(0.96); C491(0.97)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C98(1.00); C351(1.04); C292(1.01); C491(1.04)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C98(0.97); C292(1.00); C491(1.01); C725(1.11)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C98(0.99); C351(1.06); C292(0.87); C491(0.99)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C98(0.99); C351(1.05); C292(1.00); C491(1.04)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C98(1.04); C292(1.03); C491(1.01); C725(1.00)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C98(1.04); C351(1.08); C292(1.04); C491(0.99)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C98(1.06); C292(1.06); C491(0.99); C725(1.08)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C98(1.01); C351(1.10); C292(1.07); C491(1.02)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C98(1.00); C351(1.04); C292(1.03); C491(0.97)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C98(0.96); C351(1.07); C292(1.00); C491(0.95)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C98(1.02); C351(1.22); C292(1.04); C491(1.00)  LDD1514  [15]
 LDCM0108  Chloroacetamide HeLa C469(0.00); C98(0.00); H716(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C3(2.26); C351(0.98); C415(0.91); C415(0.75)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C98(0.92); C351(1.11); C292(1.05); C491(1.04)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C98(1.93); C351(2.32); C292(1.26); C491(1.82)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C98(0.91); C292(0.83); C491(0.98); C725(0.90)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C98(1.03); C351(1.06); C292(0.95); C491(1.04)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C98(0.87); C351(1.26); C292(0.97); C491(1.13)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C98(0.97); C351(1.06); C292(0.93); C491(0.98)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C98(0.98); C292(0.83); C491(0.93); C725(0.87)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C98(0.99); C351(1.03); C292(0.96); C491(1.00)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C98(1.00); C351(1.08); C292(0.92); C491(1.03)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C98(0.91); C351(1.01); C292(0.95); C491(0.93)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C98(1.02); C292(0.85); C491(0.93); C725(0.99)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C98(0.99); C351(1.14); C292(0.94); C491(1.11)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C98(1.26); C292(1.42); C491(1.11); C725(1.05)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C98(0.93); C351(1.22); C292(0.98); C491(1.32)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C98(0.98); C351(1.09); C292(0.92); C491(1.04)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C98(1.05); C292(0.93); C491(0.95); C725(1.12)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C98(1.12); C351(0.97); C292(0.92); C491(0.88)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C98(1.00); C351(1.32); C292(0.96); C491(1.17)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C98(0.96); C351(1.05); C292(1.06); C491(0.91)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C98(1.02); C292(0.97); C491(0.88); C725(1.02)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C98(1.09); C351(1.06); C292(0.96); C491(0.94)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C98(0.90); C351(1.15); C292(0.92); C491(0.96)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C98(1.00); C351(1.07); C292(0.98); C491(0.94)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C98(1.14); C351(1.23); C292(1.34); C491(1.15)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C98(0.90); C292(0.95); C491(0.92); C725(0.93)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C98(1.07); C351(1.06); C292(0.94); C491(0.97)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C98(0.91); C351(1.34); C292(0.96); C491(0.98)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C98(1.05); C351(1.13); C292(1.00); C491(1.29)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C98(0.89); C292(0.84); C491(1.07); C725(0.90)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C98(1.04); C351(1.00); C292(0.93); C491(1.01)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C98(1.10); C351(1.07); C292(0.85); C491(0.97)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C98(0.93); C351(1.01); C292(1.00); C491(0.99)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C98(0.99); C292(0.95); C491(0.91); C725(0.97)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C98(0.89); C351(1.05); C292(1.03); C491(1.00)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C98(0.93); C351(1.06); C292(0.87); C491(0.92)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C98(0.97); C351(1.18); C292(0.98); C491(1.46)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C98(0.92); C292(1.01); C491(0.81); C725(0.92)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C98(0.97); C351(1.28); C292(1.05); C491(1.35)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C98(1.02); C292(1.02); C491(1.03); C725(1.05)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C98(1.00); C351(1.15); C292(0.94); C491(0.96)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C98(0.99); C351(1.11); C292(0.90); C491(0.92)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C98(1.08); C292(1.09); C491(1.06); C725(1.04)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C98(1.05); C351(1.39); C292(1.16); C491(1.61)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C98(1.05); C351(1.28); C292(1.08); C491(1.00)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C98(1.34); C292(1.33); C491(1.02); C725(0.99)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C98(1.25); C351(1.38); C292(1.21); C491(1.02)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C98(0.95); C351(1.19); C292(1.06); C491(1.21)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C98(0.88); C351(0.98); C292(0.89); C491(1.01)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C98(0.98); C351(1.03); C292(0.93); C491(1.00)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C98(1.01); C292(0.86); C491(0.90); C725(0.98)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C98(0.99); C351(1.08); C292(1.01); C491(0.89)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C98(0.98); C351(1.09); C292(1.03); C491(0.96)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C98(0.99); C292(1.00); C491(0.98); C725(1.01)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C98(1.14); C351(1.27); C292(1.09); C491(1.01)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C98(1.02); C292(0.99); C491(1.02); C725(1.13)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C98(1.39); C351(1.70); C292(1.44); C491(2.57)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C98(0.96); C351(1.26); C292(1.01); C491(1.09)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C98(1.44); C292(1.27); C491(1.04); C725(1.13)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C98(1.37); C351(1.30); C292(1.24); C491(1.12)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C98(1.01); C351(1.03); C292(0.98); C491(0.98)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C98(0.95); C351(1.06); C292(0.89); C491(0.99)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C98(0.94); C292(0.99); C491(0.94); C725(0.97)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C98(0.93); C292(0.91); C491(0.98); C725(1.12)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C98(1.03); C351(1.08); C292(1.00); C491(1.01)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C98(1.02); C292(1.01); C491(1.02); C725(1.06)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C98(1.01); C351(1.06); C292(1.08); C491(1.08)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C98(1.10); C292(0.97); C491(1.12); C725(1.12)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C98(0.99); C351(1.29); C292(1.14); C491(1.13)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C98(0.99); C351(1.45); C292(1.07); C491(1.11)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C98(1.39); C292(1.14); C491(1.05); C725(1.18)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C98(1.45); C351(1.24); C292(1.30); C491(1.04)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C98(1.12); C351(1.04); C292(0.99); C491(0.96)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C98(0.99); C351(1.03); C292(0.99); C491(0.98)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C98(0.90); C351(1.15); C292(0.92); C491(1.08)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C98(1.01); C292(0.95); C491(0.89); C725(1.11)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C98(0.98); C351(1.24); C292(1.03); C491(1.28)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C98(1.37); C292(1.02); C491(1.38); C725(0.96)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C98(0.98); C351(1.24); C292(1.02); C491(1.03)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C98(1.10); C292(1.05); C491(1.01); C725(1.02)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C98(0.95); C351(1.28); C292(1.07); C491(1.33)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C98(1.00); C351(1.46); C292(0.95); C491(1.00)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C98(1.45); C292(1.14); C491(1.03); C725(1.06)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C98(1.08); C292(1.14); C491(1.32); C725(1.11)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C98(1.41); C351(1.39); C292(1.20); C491(1.08)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C98(1.09); C351(0.97); C292(1.10); C491(0.93)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C98(1.10); C351(0.99); C292(0.95); C491(0.94)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C98(0.93); C351(0.97); C292(0.93); C491(1.02)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C98(1.04); C292(0.95); C491(1.18); C725(0.91)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C98(0.99); C351(1.02); C292(1.00); C491(0.98)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C98(0.99); C292(0.95); C491(1.10); C725(1.11)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C98(1.00); C351(1.25); C292(0.99); C491(1.09)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C98(1.12); C292(1.01); C491(1.05); C725(1.05)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C98(0.97); C351(1.22); C292(1.10); C491(1.08)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C98(0.96); C351(1.14); C292(0.97); C491(1.09)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C98(0.86); C351(1.27); C292(1.02); C491(1.00)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C98(1.38); C292(1.03); C491(1.04); C725(1.01)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C98(1.29); C351(1.23); C292(1.16); C491(1.12)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C98(1.07); C351(1.07); C292(0.95); C491(0.96)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C98(0.85); C351(1.08); C292(0.84); C491(0.98)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C98(1.00); C292(0.89); C491(0.91); C725(1.11)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C98(0.93); C351(1.15); C292(0.95); C491(1.16)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C98(1.03); C292(1.05); C491(0.99); C725(1.09)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C98(1.02); C351(1.14); C292(1.00); C491(1.03)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C98(1.42); C292(1.68); C491(5.15); C725(0.99)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C98(1.12); C292(1.02); C491(1.04); C725(1.05)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C98(1.03); C351(1.13); C292(1.00); C491(1.00)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C98(1.04); C351(1.22); C292(1.04); C491(1.05)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C98(1.26); C292(1.08); C491(1.07); C725(0.99)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C98(1.16); C351(1.25); C292(1.11); C491(1.11)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C98(1.06); C351(0.98); C292(1.02); C491(0.96)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C98(1.00); C351(1.02); C292(0.98); C491(0.98)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C98(0.91); C351(1.04); C292(0.95); C491(0.92)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C98(0.98); C292(0.88); C491(0.91); C725(1.12)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C98(0.98); C351(1.10); C292(0.98); C491(0.96)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C98(0.93); C351(1.12); C292(1.19); C491(1.13)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C98(1.45); C292(1.25); C491(2.35); C725(0.99)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C98(0.98); C351(1.12); C292(1.01); C491(1.05)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C98(1.22); C292(1.03); C491(1.23); C725(1.07)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C98(0.99); C351(1.23); C292(1.05); C491(1.30)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C98(0.98); C351(1.15); C292(1.02); C491(1.02)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C98(1.13); C292(1.27); C491(2.16); C725(1.05)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C98(1.07); C351(1.38); C292(1.17); C491(1.24)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C98(1.00); C351(1.04); C292(0.99); C491(1.19)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C98(1.10); C351(1.05); C292(0.92); C491(0.99)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C98(0.94); C351(1.03); C292(0.93); C491(0.94)  LDD1697  [15]
 LDCM0634  CY-0357 Hep-G2 C98(0.74); C22(0.56)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C98(0.92); C351(0.98); C292(0.94); C491(0.88)  LDD1698  [15]
 LDCM0625  F8 Ramos C491(0.93); C415(4.75); C98(1.21); C469(1.41)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C98(1.61); C292(0.80)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C491(4.77); C415(1.50); C98(0.29); C469(0.55)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C98(6.17); C292(1.21)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C491(0.96); C415(0.37); C98(0.91); C469(0.85)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C98(6.99)  LDD2193  [16]
 LDCM0580  Fragment21 Ramos C415(3.89); C98(1.01); C469(0.94); C292(1.62)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C491(1.02); C415(2.39); C98(1.24); C469(0.95)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C491(0.79); C415(0.64); C98(0.89); C469(0.73)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C491(0.86); C415(1.53); C98(0.76); C469(1.21)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C491(1.43); C415(3.95); C98(1.17); C469(0.96)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C491(2.15); C415(4.02); C98(1.15); C469(1.23)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C98(3.91); C469(1.41); C292(0.78)  LDD2201  [16]
 LDCM0468  Fragment33 HEK-293T C98(0.92); C351(1.05); C292(0.94); C491(0.91)  LDD1671  [15]
 LDCM0596  Fragment38 Ramos C491(1.82); C415(2.25); C98(1.09); C469(1.08)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C98(1.89); C292(1.43)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C98(1.04); C351(0.98); C292(0.97); C491(0.97)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C491(1.74); C98(1.95); C292(1.82)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C491(1.28); C415(3.64); C98(1.41); C469(0.69)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C98(3.01); C292(1.29)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C469(2.22)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C98(0.90); C292(0.98); C491(0.96); C725(0.93)  LDD1492  [15]
 LDCM0023  KB03 Jurkat C98(297.53)  LDD0209  [5]
 LDCM0024  KB05 MKN-1 C543(1.47); C98(3.09); C417(3.25); C471(1.99)  LDD3331  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C491(0.92)  LDD2093  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C491(1.06)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C491(1.43)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C491(0.71)  LDD2137  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C292(1.25); C469(0.85); C491(0.64); C415(0.62)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C98(1.00); C3(1.00); C469(0.82); C415(0.80)  LDD2207  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 398 (ZNF398) Krueppel C2H2-type zinc-finger protein family Q8TD17
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
TERF1-interacting nuclear factor 2 (TINF2) . Q9BSI4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.