Details of the Target

General Information of Target

Target ID LDTP12494
Target Name Carbohydrate sulfotransferase 12 (CHST12)
Gene Name CHST12
Gene ID 55501
Synonyms
Carbohydrate sulfotransferase 12; EC 2.8.2.5; Chondroitin 4-O-sulfotransferase 2; Chondroitin 4-sulfotransferase 2; C4ST-2; C4ST2; Sulfotransferase Hlo
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRRSMGETESGDAFLDLKKPPASKCPHRYTKEELLDIKELPHSKQRPSCLSEKYDSDGV
WDPEKWHASLYPASGRSSPVESLKKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRS
FGGGCHVTAAVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDL
RDRDRERDFKDKRFRREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFDD
KILEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQ
SPGDFDFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHE
ELERLAGLEQAILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANK
EKLKESSHSGVVLSVEEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGD
MTAFNKLVSTMKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPAS
SNLLSGLMGSLEPTTSLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLG
DPFQGMRKPMSPITAQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGF
RNRQQRVTKSPAPVHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGK
AALGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYTKE
QDYRPKATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVH
PQHLPSLLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQ
QLQRSVLHPPGSGSHAAAVSVQTTPQNVPSRSGLPHMHSQLEHRPSQRSSSPVGLAKWFG
SDVLQQPLPSMPAKVISVDELEYRQ
Target Bioclass
Enzyme
Family
Sulfotransferase 2 family
Subcellular location
Golgi apparatus membrane
Function
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Uniprot ID
Q9NRB3
Ensemble ID
ENST00000258711.7
HGNC ID
HGNC:17423

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		8.85  LDD0318  [1]
DBIA
 Probe Info  		C175(2.36)  LDD3338  [2]
BTD
 Probe Info  		C175(0.68)  LDD2117  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C135
 Probe Info  		9.78  LDD1817  [5]
C282
 Probe Info  		18.90  LDD1952  [5]
C284
 Probe Info  		21.56  LDD1954  [5]
C287
 Probe Info  		10.13  LDD1957  [5]
C288
 Probe Info  		6.19  LDD1958  [5]
C289
 Probe Info  		29.86  LDD1959  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C175(0.68)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C175(0.90)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C175(0.98)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C175(1.00)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C175(0.98); C329(1.11)  LDD1510  [6]
 LDCM0263  AC143 PaTu 8988t C175(1.07)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C175(1.09)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C175(0.97)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C175(0.94)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C175(1.00)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C175(1.24)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C175(1.42)  LDD1148  [7]
 LDCM0270  AC15 HEK-293T C175(1.12)  LDD1513  [6]
 LDCM0271  AC150 PaTu 8988t C175(1.20)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C175(1.51)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C175(1.16)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C175(1.43)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C175(1.36)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C175(1.28)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C175(1.23)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C175(1.29)  LDD2169  [7]
 LDCM0276  AC17 HEK-293T C175(0.97)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C175(0.98)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C175(1.08)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C175(0.93)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C175(0.99); C329(0.96)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C175(1.09); C329(1.06)  LDD1520  [6]
 LDCM0283  AC23 HEK-293T C175(1.08)  LDD1522  [6]
 LDCM0285  AC25 PaTu 8988t C175(0.96)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C175(0.84)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C175(1.37)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C175(1.35)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C175(0.90)  LDD1168  [7]
 LDCM0290  AC3 HEK-293T C175(0.97)  LDD1529  [6]
 LDCM0291  AC30 PaTu 8988t C175(0.79)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C175(1.00)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C175(1.72)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C175(1.12)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C175(1.06)  LDD1174  [7]
 LDCM0296  AC35 HEK-293T C175(0.99)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C175(0.96); C329(1.13)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C175(0.96); C329(1.10)  LDD1537  [6]
 LDCM0300  AC39 HEK-293T C175(1.11)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C175(0.96); C329(0.99)  LDD1540  [6]
 LDCM0303  AC41 HEK-293T C175(0.93)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C175(1.06)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C175(0.90)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C175(0.96); C329(0.97)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C175(1.01); C329(1.41)  LDD1546  [6]
 LDCM0309  AC47 HEK-293T C175(1.09)  LDD1548  [6]
 LDCM0311  AC49 HEK-293T C175(0.93)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C175(0.93); C329(0.96)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C175(0.96)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C175(0.91)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C175(1.00); C329(0.99)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C175(0.98); C329(1.15)  LDD1555  [6]
 LDCM0318  AC55 HEK-293T C175(1.08)  LDD1557  [6]
 LDCM0320  AC57 PaTu 8988t C175(1.22)  LDD1199  [7]
 LDCM0321  AC58 PaTu 8988t C175(1.48)  LDD1200  [7]
 LDCM0322  AC59 PaTu 8988t C175(1.18)  LDD1201  [7]
 LDCM0324  AC60 PaTu 8988t C175(1.56)  LDD1203  [7]
 LDCM0325  AC61 PaTu 8988t C175(1.33)  LDD1204  [7]
 LDCM0326  AC62 PaTu 8988t C175(1.14)  LDD1205  [7]
 LDCM0327  AC63 PaTu 8988t C175(1.30)  LDD1206  [7]
 LDCM0328  AC64 PaTu 8988t C175(1.33)  LDD1207  [7]
 LDCM0329  AC65 PaTu 8988t C175(1.22)  LDD1208  [7]
 LDCM0330  AC66 PaTu 8988t C175(1.30)  LDD1209  [7]
 LDCM0331  AC67 PaTu 8988t C175(1.37)  LDD1210  [7]
 LDCM0334  AC7 HEK-293T C175(1.07)  LDD1568  [6]
 LDCM0349  AC83 PaTu 8988t C175(0.97)  LDD1228  [7]
 LDCM0350  AC84 PaTu 8988t C175(0.91)  LDD1229  [7]
 LDCM0351  AC85 PaTu 8988t C175(1.09)  LDD1230  [7]
 LDCM0352  AC86 PaTu 8988t C175(1.05)  LDD1231  [7]
 LDCM0353  AC87 PaTu 8988t C175(0.86)  LDD1232  [7]
 LDCM0354  AC88 PaTu 8988t C175(0.87)  LDD1233  [7]
 LDCM0355  AC89 PaTu 8988t C175(1.16)  LDD1234  [7]
 LDCM0357  AC90 PaTu 8988t C175(0.94)  LDD1236  [7]
 LDCM0358  AC91 PaTu 8988t C175(0.81)  LDD1237  [7]
 LDCM0359  AC92 PaTu 8988t C175(1.05)  LDD1238  [7]
 LDCM0360  AC93 PaTu 8988t C175(1.04)  LDD1239  [7]
 LDCM0361  AC94 PaTu 8988t C175(0.96)  LDD1240  [7]
 LDCM0362  AC95 PaTu 8988t C175(1.04)  LDD1241  [7]
 LDCM0363  AC96 PaTu 8988t C175(0.95)  LDD1242  [7]
 LDCM0364  AC97 PaTu 8988t C175(0.96)  LDD1243  [7]
 LDCM0248  AKOS034007472 HEK-293T C175(1.15); C329(1.05)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C175(0.98)  LDD1570  [6]
 LDCM0367  CL1 PaTu 8988t C175(1.25)  LDD1246  [7]
 LDCM0368  CL10 PaTu 8988t C175(1.43)  LDD1247  [7]
 LDCM0369  CL100 HEK-293T C175(1.03)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C175(1.10); C332(1.08); C329(0.92)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C175(1.03)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C175(1.06)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C175(1.00)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C175(0.97); C332(1.03); C329(1.06)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C175(1.03)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C175(1.13)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C175(1.04)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C175(1.08); C332(1.13); C329(1.02)  LDD1582  [6]
 LDCM0379  CL11 PaTu 8988t C175(1.35)  LDD1258  [7]
 LDCM0380  CL110 HEK-293T C175(1.10)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C175(1.14)  LDD1585  [6]
 LDCM0382  CL112 PaTu 8988t C175(0.91)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C175(1.23)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C175(1.06)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C175(0.89)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C175(1.00)  LDD1265  [7]
 LDCM0387  CL117 HEK-293T C175(1.01); C332(1.16); C329(0.94)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C175(0.98)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C175(0.95)  LDD1593  [6]
 LDCM0390  CL12 PaTu 8988t C175(1.48)  LDD1269  [7]
 LDCM0391  CL120 HEK-293T C175(1.06)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C175(0.99); C332(1.00); C329(1.14)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C175(0.91)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C175(1.02)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C175(1.10)  LDD1599  [6]
 LDCM0396  CL125 PaTu 8988t C175(1.29)  LDD1275  [7]
 LDCM0397  CL126 PaTu 8988t C175(1.17)  LDD1276  [7]
 LDCM0398  CL127 PaTu 8988t C175(1.37)  LDD1277  [7]
 LDCM0399  CL128 PaTu 8988t C175(1.24)  LDD1278  [7]
 LDCM0400  CL13 PaTu 8988t C175(1.40)  LDD1279  [7]
 LDCM0401  CL14 PaTu 8988t C175(1.43)  LDD1280  [7]
 LDCM0402  CL15 PaTu 8988t C175(1.19)  LDD1281  [7]
 LDCM0403  CL16 HEK-293T C175(1.02)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C175(0.98)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C175(0.94)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C175(0.89)  LDD1610  [6]
 LDCM0407  CL2 PaTu 8988t C175(1.20)  LDD1286  [7]
 LDCM0408  CL20 HEK-293T C175(0.89); C329(1.06)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C175(1.28); C329(1.55)  LDD1613  [6]
 LDCM0411  CL23 HEK-293T C175(1.27)  LDD1615  [6]
 LDCM0413  CL25 HEK-293T C175(1.21); C332(1.31); C329(0.96)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C175(0.99)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C175(0.98)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C175(1.07)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C175(0.97)  LDD1621  [6]
 LDCM0418  CL3 PaTu 8988t C175(1.34)  LDD1297  [7]
 LDCM0419  CL30 HEK-293T C175(1.03)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C175(1.22)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C175(1.12); C329(1.11)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C175(1.33); C329(1.20)  LDD1626  [6]
 LDCM0424  CL35 HEK-293T C175(1.22)  LDD1628  [6]
 LDCM0426  CL37 HEK-293T C175(0.97); C332(1.01); C329(0.99)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C175(1.13)  LDD1632  [6]
 LDCM0429  CL4 PaTu 8988t C175(1.06)  LDD1308  [7]
 LDCM0430  CL40 HEK-293T C175(0.93)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C175(0.97)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C175(0.96)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C175(1.06)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C175(1.01); C329(0.90)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C175(1.22); C329(1.43)  LDD1639  [6]
 LDCM0437  CL47 HEK-293T C175(1.14)  LDD1641  [6]
 LDCM0439  CL49 HEK-293T C175(1.05); C332(1.16); C329(1.14)  LDD1643  [6]
 LDCM0440  CL5 PaTu 8988t C175(1.50)  LDD1319  [7]
 LDCM0441  CL50 HEK-293T C175(1.12)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C175(1.04)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C175(1.06)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C175(1.18)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C175(1.00)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C175(1.04); C329(1.02)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C175(1.25); C329(1.42)  LDD1651  [6]
 LDCM0450  CL59 HEK-293T C175(1.14)  LDD1653  [6]
 LDCM0451  CL6 PaTu 8988t C175(1.42)  LDD1330  [7]
 LDCM0453  CL61 HEK-293T C175(1.03); C332(0.99); C329(1.17)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C175(1.00)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C175(0.92)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C175(1.26)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C175(1.05)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C175(1.06)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C175(0.94)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C175(1.12); C329(1.00)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C175(1.09); C329(1.34)  LDD1664  [6]
 LDCM0462  CL7 PaTu 8988t C175(1.07)  LDD1341  [7]
 LDCM0464  CL71 HEK-293T C175(1.19)  LDD1667  [6]
 LDCM0466  CL73 HEK-293T C175(1.18); C332(1.10); C329(1.02)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C175(0.89)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C175(1.14)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C175(1.17)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C175(1.00)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C175(0.93)  LDD1675  [6]
 LDCM0473  CL8 PaTu 8988t C175(1.56)  LDD1352  [7]
 LDCM0474  CL80 HEK-293T C175(0.95); C329(1.26)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C175(1.12); C329(1.06)  LDD1678  [6]
 LDCM0477  CL83 HEK-293T C175(1.27)  LDD1680  [6]
 LDCM0479  CL85 HEK-293T C175(0.90); C332(1.09); C329(1.05)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C175(0.93)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C175(0.91)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C175(1.02)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C175(0.89)  LDD1686  [6]
 LDCM0484  CL9 PaTu 8988t C175(1.46)  LDD1363  [7]
 LDCM0485  CL90 HEK-293T C175(1.58)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C175(1.00)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C175(1.12); C329(1.09)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C175(1.08); C329(1.06)  LDD1691  [6]
 LDCM0490  CL95 HEK-293T C175(1.32)  LDD1693  [6]
 LDCM0492  CL97 HEK-293T C175(1.28); C332(1.03); C329(1.07)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C175(0.98)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C175(0.95)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C175(0.99)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C175(1.01)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C175(0.87)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C332(0.83)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C332(1.27)  LDD1497  [6]
 LDCM0024  KB05 MV4-11 C175(2.36)  LDD3338  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C175(0.85)  LDD2137  [3]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.