Details of the Target

General Information of Target

Target ID LDTP05078
Target Name Platelet-activating factor acetylhydrolase IB subunit alpha2 (PAFAH1B2)
Gene Name PAFAH1B2
Gene ID 5049
Synonyms
PAFAHB; Platelet-activating factor acetylhydrolase IB subunit alpha2; EC 3.1.1.47; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLFVGDSMVQLMQQYEIWR
ELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWVGTNNHENTAEEVAGGIEA
IVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLLKVSLPKLANVQLLDTDGGFV
HSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLEETPEEKQTTIA
Target Bioclass
Enzyme
Family
'GDSL' lipolytic enzyme family, Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
Subcellular location
Cytoplasm
Function
Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE. May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis.
Uniprot ID
P68402
Ensemble ID
ENST00000419197.6
HGNC ID
HGNC:8575
ChEMBL ID
CHEMBL4463

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.V180A .
MCC13 SNV: p.S64F .
RKO SNV: p.D190Y .
RPMI8226 SNV: p.K86N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y56(17.03)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K155(5.88); K161(7.55); K36(10.00); K86(10.00)  LDD0277  [4]
DBIA
 Probe Info  		C35(2.99)  LDD3314  [5]
BTD
 Probe Info  		C35(1.17)  LDD2090  [6]
AHL-Pu-1
 Probe Info  		C35(2.62)  LDD0171  [7]
IPM
 Probe Info  		C35(0.84)  LDD1702  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C206(0.00); C188(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_H
 Probe Info  		C188(0.00); C206(0.00)  LDD0030  [11]
IPIAA_L
 Probe Info  		C206(0.00); C188(0.00)  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C206(0.00); C188(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
NHS
 Probe Info  		K161(0.00); K86(0.00)  LDD0010  [13]
PF-06672131
 Probe Info  		N.A.  LDD0152  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
NAIA_5
 Probe Info  		C206(0.00); C188(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C280
 Probe Info  		10.06  LDD1950  [18]
C282
 Probe Info  		14.12  LDD1952  [18]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C35(0.56)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C35(0.76)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C35(0.84)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C35(1.15)  LDD2117  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C35(0.92)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C35(0.56)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C35(0.70)  LDD2131  [6]
 LDCM0026  4SU-RNA+native RNA DM93 C35(2.62)  LDD0171  [7]
 LDCM0214  AC1 HEK-293T C188(0.85)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C188(1.00)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C188(1.09)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C188(1.09)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C188(1.08)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C188(1.13)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C188(1.24)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C188(0.96)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C188(0.80)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C188(1.24)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C188(1.23)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C188(0.98)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C188(1.34)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C188(1.29)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C188(1.29)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C188(0.88)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C188(1.01)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C188(0.96)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C188(1.07)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C188(1.07)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C188(0.84)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C188(0.97)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C188(1.07)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C188(1.14)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C188(1.20)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C188(1.14)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C188(1.14)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C188(1.32)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C188(1.14)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C188(1.23)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C188(1.43)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C188(1.04)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C188(1.09)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C188(1.14)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C188(0.97)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C188(1.12)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C188(1.13)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C188(1.06)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C188(0.99)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C188(1.25)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C188(1.31)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C188(0.99)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C188(1.10)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C188(1.09)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C188(1.09)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C188(1.15)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C188(1.16)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C188(1.13)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C188(1.10)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C188(1.13)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C188(0.94)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C188(1.13)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C188(1.05)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C188(0.85)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C188(1.11)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C188(0.94)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C188(1.05)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C188(1.14)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C188(0.93)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C188(1.07)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C188(0.86)  LDD1569  [20]
 LDCM0545  Acetamide MDA-MB-231 C35(0.65)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C35(0.90)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C188(1.05)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C188(1.07)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C188(1.05)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 13.08  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C188(0.97)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C188(0.91)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C188(1.00)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C188(0.98)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C188(0.90)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C188(1.34)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C188(0.95)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C188(1.00)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C188(0.95)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C188(1.21)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C188(1.01)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C188(0.96)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C188(1.06)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C188(0.89)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C188(1.10)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C188(0.98)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C188(1.24)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C188(0.88)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C188(1.04)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C188(1.16)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C188(1.09)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C188(0.96)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C188(1.07)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C188(0.96)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C188(1.14)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C188(0.99)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C188(0.91)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C188(0.98)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C188(0.86)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C188(0.72)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C188(0.79)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C188(0.80)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C188(0.85)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C188(0.91)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C188(0.95)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C188(0.99)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C188(1.00)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C188(1.05)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C188(0.97)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C188(0.92)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C188(0.90)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C188(1.08)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C188(0.99)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C188(1.06)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C188(1.21)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C188(0.95)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C188(0.92)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C188(1.10)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C188(1.15)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C188(0.94)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C188(1.14)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C188(1.07)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C188(1.14)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C188(0.94)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C188(1.02)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C188(0.76)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C188(0.91)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C188(1.06)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C188(1.05)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C188(0.95)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C188(1.06)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C188(0.82)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C188(1.32)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C188(0.91)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C188(1.00)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C188(0.96)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C188(1.04)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C188(0.93)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C188(0.87)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C188(1.01)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C188(1.04)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C188(0.95)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C188(0.75)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C188(1.00)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C188(1.06)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C188(0.91)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C188(0.90)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C188(1.03)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C188(1.01)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C188(0.93)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C188(0.88)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C188(1.11)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C188(0.90)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C188(1.17)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C188(1.20)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C188(1.03)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C188(1.15)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C188(1.10)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C188(1.08)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C188(0.99)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C188(1.01)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C188(0.98)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C188(0.93)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C188(0.82)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C188(1.07)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C188(1.05)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C188(1.27)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C188(0.86)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C188(0.78)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C188(0.91)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C188(0.78)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C188(1.02)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C188(0.84)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C188(0.60)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C188(0.85)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C188(0.95)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C188(0.78)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C188(0.89)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C188(0.82)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C188(0.82)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C188(0.74)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C188(0.77)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C188(0.85)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C188(0.85)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C188(0.85)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C188(0.74)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C188(0.78)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C188(1.09)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C188(0.87)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C188(0.91)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C188(0.92)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C188(0.66)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C188(0.93)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C188(0.84)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C188(1.09)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C188(1.29)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C35(0.84)  LDD1702  [6]
 LDCM0625  F8 Ramos C206(3.42); C188(0.89)  LDD2187  [21]
 LDCM0573  Fragment11 Ramos C188(1.54)  LDD2190  [21]
 LDCM0576  Fragment14 Ramos C206(1.02); C188(1.75)  LDD2193  [21]
 LDCM0586  Fragment28 Ramos C206(0.63)  LDD2198  [21]
 LDCM0468  Fragment33 HEK-293T C188(0.95)  LDD1671  [20]
 LDCM0566  Fragment4 Ramos C206(0.52)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C188(1.08)  LDD1631  [20]
 LDCM0569  Fragment7 Ramos C206(0.87)  LDD2186  [21]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C188(1.03)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C188(0.95)  LDD1497  [20]
 LDCM0024  KB05 IGR37 C35(2.99)  LDD3314  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C35(1.45)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C35(0.66)  LDD2121  [6]
 LDCM0109  NEM HeLa H67(0.00); H28(0.00)  LDD0224  [16]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C35(1.17)  LDD2090  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C35(1.68)  LDD2094  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C35(0.95)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C35(0.60)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C35(1.22)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C35(0.53)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C35(1.10)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C35(0.89)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C35(1.19)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C35(1.15)  LDD2107  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C35(0.54)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C35(2.37)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C35(0.82)  LDD2120  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C35(1.05)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C35(1.16)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C35(1.36)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C35(1.00)  LDD2128  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C35(0.60)  LDD2133  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C35(1.18)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C35(1.02)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C35(0.32)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C35(1.01)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C35(2.83)  LDD2144  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C35(1.81)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C35(0.90)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C35(0.50)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C35(1.14)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) GDSL lipolytic enzyme family Q15102
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Clavesin-2 (CLVS2) . Q5SYC1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578