Details of the Target

General Information of Target

Target ID LDTP17659
Target Name ELMO domain-containing protein 2 (ELMOD2)
Gene Name ELMOD2
Gene ID 255520
Synonyms
ELMO domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSVMEKPSAGSGILSRSRAKTVPNGGQPHSEDDSSEEEHSHDSMIRVGTNYQAVIPECK
PESPARYSNKELKGMLVWSPNHCVSDAKLDKYIAMAKEKHGYNIEQALGMLLWHKHDVEK
SLADLANFTPFPDEWTVEDKVLFEQAFGFHGKCFQRIQQMLPDKLIPSLVKYYYSWKKTR
SRTSVMDRQARRLGGRKDKEDSDELEEGRGGVSEGEPDPADPKREPLPSRPLNARPGPGK
KEVQVSQYRHHPLRTRRRPPKGMYLSPEGLTAVSGSPDLANLTLRGLDSQLISLKRQVQS
MKQTNSSLRQALEGGIDPLRPPEANTKFNSRWTTDEQLLAVQAIRRYGKDFGAIAEVIGN
KTLTQVKTFFVSYRRRFNLEEVLQEWEAEQDGAPGAPVPMEEARRGAPLPAPALEEDDEV
QITSVSTSVPRSVPPAPPPPPPPTSLSQPPPLLRPPLPTAPTLLRQPPPLQQGRFLQPRL
APNQPPPPLIRPALAAPRHSARPGPQPPPTLIGTPLEPPAPSL
Target Bioclass
Other
Function
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
Uniprot ID
Q8IZ81
Ensemble ID
ENST00000323570.8
HGNC ID
HGNC:28111

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.83  LDD0402  [1]
BTD
 Probe Info  		C29(1.09)  LDD2090  [2]
DBIA
 Probe Info  		C285(1.21)  LDD0080  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD0005  [7]
AOyne
 Probe Info  		13.70  LDD0443  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.69  LDD1740  [10]
C091
 Probe Info  		13.00  LDD1782  [10]
C092
 Probe Info  		17.63  LDD1783  [10]
C094
 Probe Info  		23.26  LDD1785  [10]
C218
 Probe Info  		13.00  LDD1892  [10]
C278
 Probe Info  		93.05  LDD1948  [10]
C280
 Probe Info  		9.58  LDD1950  [10]
C282
 Probe Info  		18.64  LDD1952  [10]
C284
 Probe Info  		22.94  LDD1954  [10]
C289
 Probe Info  		29.04  LDD1959  [10]
FFF probe11
 Probe Info  		17.98  LDD0471  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe14
 Probe Info  		20.00  LDD0477  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.85)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C29(0.95)  LDD2112  [2]
 LDCM0214  AC1 HCT 116 C285(1.26)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C285(1.55)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C285(1.29)  LDD1105  [3]
 LDCM0230  AC113 PaTu 8988t C285(0.80)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C285(0.88)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C285(0.78)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C285(0.93)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C285(0.83)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C285(1.10)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C285(1.12)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C285(1.28)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C285(0.94)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C285(1.04)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C285(0.89)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C285(0.91)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C285(1.15)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C285(1.02)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C285(0.80)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C285(1.08)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C285(0.97)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C285(0.97)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C285(0.88)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C285(0.93)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C285(0.93)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C285(1.00)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C285(1.06)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C285(0.94)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C285(1.01)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C285(0.97)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C285(1.10)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C285(0.93)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C285(1.10)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C285(1.11)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C285(0.94)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C285(1.07)  LDD1141  [3]
 LDCM0263  AC143 HCT 116 C285(1.13)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C285(1.25)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C285(1.17)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C285(1.35)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C285(1.60)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C285(2.04)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C285(1.54)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C285(1.30)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C285(1.19)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C285(1.06)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C285(1.63)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C285(2.69)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C285(1.37)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C285(1.40)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C285(1.04)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C285(0.96)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C98(1.00); C285(0.94)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C98(0.97); C285(0.94)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C98(0.88); C285(0.81)  LDD1517  [12]
 LDCM0279  AC2 HCT 116 C285(1.12)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C98(0.95); C285(0.93)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C98(1.05); C285(0.91)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C98(1.03); C285(0.88)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C98(0.97); C285(0.86)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C98(0.97); C285(0.96)  LDD1523  [12]
 LDCM0285  AC25 HCT 116 C285(1.12)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C285(1.19)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C285(1.35)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C285(1.35)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C285(1.20)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C285(1.11)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C285(1.43)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C285(1.38)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C285(1.61)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C285(1.46)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C285(1.66)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C285(0.80)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C285(0.89)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C285(0.90)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C285(1.00)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C285(1.12)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C285(1.30)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C285(1.19)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C285(0.94)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C285(1.10)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C285(1.11)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C285(1.17)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C285(1.37)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C285(1.11)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C285(1.04)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C285(1.04)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C285(1.47)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C285(1.29)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C285(1.48)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C285(0.86)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C285(1.02)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C285(1.15)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C285(1.28)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C285(1.53)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C285(2.16)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C285(0.95)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C285(1.08)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C285(0.93)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C285(1.12)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C285(0.91)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C285(0.90)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C285(0.90)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C285(0.89)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C285(0.89)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C285(1.22)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C285(1.16)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C285(1.07)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C285(0.81)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C285(0.80)  LDD0650  [3]
 LDCM0334  AC7 PaTu 8988t C285(0.92)  LDD1213  [3]
 LDCM0335  AC70 HCT 116 C285(1.00)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C285(0.77)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C285(0.92)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C285(0.95)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C285(0.80)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C285(1.08)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C285(0.81)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C285(0.90)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C285(0.90)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C285(0.97)  LDD0661  [3]
 LDCM0345  AC8 PaTu 8988t C285(0.93)  LDD1224  [3]
 LDCM0346  AC80 HCT 116 C285(0.79)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C285(0.81)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C285(0.82)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C285(1.45)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C285(1.29)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C285(1.27)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C285(1.18)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C285(1.01)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C285(1.21)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C285(1.11)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C285(0.92)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C285(1.43)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C285(1.38)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C285(1.11)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C285(1.16)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C285(1.02)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C285(1.37)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C285(1.22)  LDD0681  [3]
 LDCM0545  Acetamide MDA-MB-231 C29(0.34)  LDD2138  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C285(1.33)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C285(1.26)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C285(1.31)  LDD1154  [3]
 LDCM0156  Aniline NCI-H1299 8.25  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C285(1.24)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C285(0.81)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C285(1.38)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C285(1.21)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C285(1.06)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C285(1.02)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C285(1.54)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C285(1.18)  LDD1252  [3]
 LDCM0374  CL105 HEK-293T C98(0.97); C285(0.98)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C98(0.88); C285(0.96)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C98(1.00); C285(0.97)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C98(0.98); C285(0.95)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C98(0.95); C285(1.02)  LDD1582  [12]
 LDCM0379  CL11 HCT 116 C285(1.47)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C98(0.87); C285(1.01)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C98(0.95); C285(0.95)  LDD1585  [12]
 LDCM0382  CL112 HCT 116 C285(1.13)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C285(1.44)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C285(1.11)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C285(1.34)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C285(1.41)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C285(1.73)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C285(1.06)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C285(1.08)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C285(1.46)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C285(0.96)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C285(1.54)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C285(1.21)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C285(1.14)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C285(1.40)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C285(1.14)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C285(1.01)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C285(1.03)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C285(1.04)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C285(1.45)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C285(1.11)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C285(1.32)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C285(0.59)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C285(1.00)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C285(0.92)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C285(0.92)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C285(0.91)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C285(0.89)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C285(1.66)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C285(1.06)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C285(1.12)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C285(0.83)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C285(0.94)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C285(0.93)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C285(1.05)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C285(1.04)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C285(1.02)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C285(0.93)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C285(1.16)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C285(1.04)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C285(1.14)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C285(0.96)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C285(1.48)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C285(1.32)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C285(1.26)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C285(1.53)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C285(1.25)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C285(1.13)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C285(1.29)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C285(1.31)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C285(2.10)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C285(1.67)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C285(1.25)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C285(1.66)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C285(0.72)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C285(0.77)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C285(0.73)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C285(0.86)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C285(1.14)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C285(0.69)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C285(0.74)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C285(0.74)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C285(0.72)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C285(0.69)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C285(0.69)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C285(0.89)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C285(0.73)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C285(0.75)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C285(0.79)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C285(1.23)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C285(0.82)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C285(1.01)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C285(1.06)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C285(1.10)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C285(1.26)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C285(1.20)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C285(1.66)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C285(1.41)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C285(1.27)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C285(1.01)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C285(1.44)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C285(1.09)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C285(1.09)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C285(1.01)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C285(1.16)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C285(1.16)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C285(1.02)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C285(1.01)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C285(1.14)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C285(1.26)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C285(1.33)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C285(1.12)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C285(1.21)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C285(1.91)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C285(1.51)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C285(2.17)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C285(1.25)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C285(1.07)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C285(1.22)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C285(1.73)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C285(2.66)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C285(1.13)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C285(0.81)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C285(1.02)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C285(0.86)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C285(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C285(1.03)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C285(0.98)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C285(1.06)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C285(1.20)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C285(1.13)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C285(1.25)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C98(1.01); C285(0.87)  LDD1698  [12]
 LDCM0625  F8 Ramos C98(0.71)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C98(0.54)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C98(2.94)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C98(0.66)  LDD2191  [13]
 LDCM0579  Fragment20 Ramos C98(0.50)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C98(1.02)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C98(0.86)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C98(0.95)  LDD2197  [13]
 LDCM0588  Fragment30 Ramos C98(0.70)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C98(1.19)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C98(0.42)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C285(1.16)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C98(0.99)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C98(0.92)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C285(1.97)  LDD0744  [3]
 LDCM0614  Fragment56 Ramos C98(0.71)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C98(0.92)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C98(0.47)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C285(1.21)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C285(0.93)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C285(0.98)  LDD0082  [3]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C29(0.75)  LDD2102  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C29(0.44)  LDD2121  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C29(1.09)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C29(0.80)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C29(0.94)  LDD2094  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C29(2.48)  LDD2098  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C29(0.78)  LDD2099  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C29(1.43)  LDD2100  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C29(0.88)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C29(1.06)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C29(0.93)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C29(0.90)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C29(1.02)  LDD2108  [2]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C29(1.40)  LDD2110  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C29(0.57)  LDD2114  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C29(0.85)  LDD2129  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C29(0.81)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C29(1.22)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C29(0.86)  LDD2141  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C29(1.70)  LDD2153  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C285(1.01); C285(0.57)  LDD2206  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C285(0.96)  LDD2207  [14]
 LDCM0021  THZ1 HCT 116 C285(1.24)  LDD2173  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.