Details of the Target

General Information of Target

Target ID LDTP11648
Target Name NIF3-like protein 1 (NIF3L1)
Gene Name NIF3L1
Gene ID 60491
Synonyms
ALS2CR1; NIF3-like protein 1; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTV
CLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYES
PIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLD
ALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHA
RMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLI
RPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGR
LCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK
Target Bioclass
Enzyme
Family
GTP cyclohydrolase I type 2/NIF3 family
Subcellular location
Cytoplasm
Function May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.
Uniprot ID
Q9GZT8
Ensemble ID
ENST00000359683.8
HGNC ID
HGNC:13390

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S304G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K109(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y161(10.16); Y175(8.10)  LDD3495  [2]
BTD
 Probe Info  		C213(1.58)  LDD1700  [3]
DBIA
 Probe Info  		C148(0.85); C21(1.07)  LDD0532  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C148(0.00); C213(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C254(0.00); C213(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C148(0.00); C213(0.00); C254(0.00)  LDD0037  [5]
ENE
 Probe Info  		N.A.  LDD0006  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		57.68  LDD1948  [8]
C280
 Probe Info  		10.27  LDD1950  [8]
C282
 Probe Info  		14.93  LDD1952  [8]
C284
 Probe Info  		24.25  LDD1954  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C148(1.66)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C213(1.42)  LDD2152  [3]
 LDCM0214  AC1 HEK-293T C213(0.89); C148(0.90)  LDD1507  [9]
 LDCM0215  AC10 HCT 116 C148(0.85); C21(1.07)  LDD0532  [4]
 LDCM0226  AC11 HCT 116 C148(0.68); C21(1.19)  LDD0543  [4]
 LDCM0230  AC113 HCT 116 C148(1.13)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C148(1.27)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C148(1.42)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C148(1.31)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C148(1.50)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C148(1.12)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C148(1.08)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C148(0.89); C21(1.14)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C148(1.31)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C148(1.32)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C148(1.17)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C148(1.29)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C148(1.39)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C148(1.40)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C148(1.26)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C148(1.40)  LDD0562  [4]
 LDCM0259  AC14 HCT 116 C148(0.71); C21(0.86)  LDD0576  [4]
 LDCM0270  AC15 HCT 116 C148(0.66); C21(0.78)  LDD0587  [4]
 LDCM0276  AC17 HCT 116 C148(0.88); C21(1.09)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C21(1.11); C148(4.65)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C148(0.81); C21(1.11)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C213(1.04); C148(1.00)  LDD1518  [9]
 LDCM0280  AC20 HCT 116 C148(0.82); C21(1.08)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C148(0.89); C21(1.00)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C148(0.55); C21(0.94)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C148(0.73); C21(1.01)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C148(0.66); C21(1.03)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C213(0.89); C148(0.86)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C213(1.04); C148(1.06)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C213(0.97); C148(1.03)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C213(1.07); C148(0.99)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C213(1.01); C148(0.88)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C213(1.04); C148(0.99)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C148(0.93)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C213(1.01); C148(1.00)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C213(1.05); C148(0.96)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C213(0.89); C148(0.84)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C213(1.06); C148(0.96)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C21(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C21(0.87)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C21(0.76)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C21(1.00)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C21(0.93)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C213(0.91); C148(1.01)  LDD1540  [9]
 LDCM0302  AC40 HCT 116 C21(1.07)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C21(0.98)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C21(0.94)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C21(0.95)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C21(0.84)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C21(0.84)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C148(0.96)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C213(0.91); C148(1.03)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C213(0.99); C148(0.97)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C213(0.87); C148(0.88)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C213(0.99); C148(0.92)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C213(1.09); C148(1.01)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C213(1.02); C148(1.05)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C213(0.90); C148(1.02)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C213(0.99); C148(0.91)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C148(1.00)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C213(0.92); C148(0.95)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C213(0.94); C148(1.02)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C213(0.93); C148(0.86)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C213(1.10); C148(0.96)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C213(1.08); C148(0.98)  LDD1561  [9]
 LDCM0323  AC6 HCT 116 C148(0.85); C21(1.02)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C213(0.97); C148(0.93)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C213(0.98); C148(0.86)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C148(0.90)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C213(0.90); C148(0.89)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C213(1.00); C148(0.97)  LDD1567  [9]
 LDCM0332  AC68 HCT 116 C21(0.86)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C21(0.84)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C148(0.88); C21(0.94)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C21(1.06)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C21(0.85)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C21(0.95)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C21(0.88)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C21(0.80)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C21(0.86)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C21(0.68)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C21(0.79)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C21(0.64)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C21(0.80)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C21(0.89); C148(0.97)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C21(0.80)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C21(0.76)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C21(0.71)  LDD0665  [4]
 LDCM0248  AKOS034007472 HCT 116 C148(0.94); C21(1.11)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C148(0.91); C21(1.13)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C148(1.03); C21(1.03)  LDD0592  [4]
 LDCM0108  Chloroacetamide HeLa C213(0.00); H167(0.00); C148(0.00)  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C148(0.89)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C148(0.76)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C213(0.96); C148(0.95)  LDD1573  [9]
 LDCM0370  CL101 HCT 116 C148(0.89); C21(1.00)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C148(0.89); C21(1.03)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C148(0.83); C21(1.26)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C21(0.93); C148(1.04)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C21(1.25); C148(1.40)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C148(0.79); C21(1.47)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C148(0.71); C21(1.41)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C148(0.64); C21(1.45)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C148(0.55); C21(1.30)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C148(0.89)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C148(1.23); C21(1.47)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C148(0.86); C21(1.28)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C213(0.92); C148(0.79)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C213(0.98); C148(0.94)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C213(0.89); C148(0.91)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C213(0.83); C148(0.96)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C213(0.96); C148(0.88)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C21(1.08)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C21(1.00)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C21(0.96)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C148(0.89)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C21(0.90)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C213(0.97); C148(0.93)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C213(0.98); C148(0.91)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C213(0.90); C148(0.85)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C213(0.88); C148(0.98)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C213(1.11); C148(0.86)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C213(1.00); C148(0.92)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C213(0.93); C148(0.97)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C213(1.00); C148(1.00)  LDD1603  [9]
 LDCM0400  CL13 HCT 116 C148(0.92)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C148(0.79)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C148(0.98)  LDD0719  [4]
 LDCM0403  CL16 HEK-293T C213(0.99); C148(1.18)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C213(0.73); C148(0.83)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C213(1.11); C148(1.13)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C213(0.93); C148(1.14)  LDD1610  [9]
 LDCM0407  CL2 HCT 116 C148(0.75)  LDD0724  [4]
 LDCM0408  CL20 HEK-293T C213(0.86); C148(1.15)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C213(0.88); C148(0.93)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C148(1.19)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C213(0.86); C148(1.19)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C213(1.01); C148(1.09)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C213(0.85); C148(0.94)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C213(0.91); C148(0.89)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C213(0.89); C148(1.08)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C213(0.98); C148(1.09)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C213(0.97); C148(1.08)  LDD1621  [9]
 LDCM0418  CL3 HCT 116 C148(1.23)  LDD0735  [4]
 LDCM0419  CL30 HEK-293T C213(1.00); C148(1.06)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C213(0.96); C148(1.11)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C213(0.95); C148(1.11)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C213(0.87); C148(0.96)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C148(1.08)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C213(0.88); C148(1.20)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C213(0.95); C148(1.09)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C213(0.96); C148(0.93)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C213(0.90); C148(1.02)  LDD1632  [9]
 LDCM0429  CL4 HCT 116 C148(1.06)  LDD0746  [4]
 LDCM0430  CL40 HEK-293T C213(0.96); C148(0.97)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C213(0.89); C148(0.96)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C213(1.04); C148(1.11)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C213(1.02); C148(1.14)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C213(1.01); C148(1.11)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C213(0.92); C148(0.89)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C148(1.09)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C213(0.83); C148(1.11)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C213(0.97); C148(1.15)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C213(1.02); C148(1.00)  LDD1643  [9]
 LDCM0440  CL5 HCT 116 C148(0.92)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C213(0.86); C148(0.96)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C213(0.92); C148(0.93)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C213(0.79); C148(0.93)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C213(0.98); C148(0.99)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C213(1.03); C148(1.23)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C213(0.94); C148(1.13)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C213(0.88); C148(0.88)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C148(1.09)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C213(0.79); C148(1.16)  LDD1653  [9]
 LDCM0451  CL6 HCT 116 C148(1.02)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C213(1.03); C148(1.10)  LDD1655  [9]
 LDCM0453  CL61 HCT 116 C148(0.96)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C148(1.34)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C148(0.95)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C148(0.94)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C148(0.70)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C148(0.98)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C148(0.62)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C148(0.64)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C148(0.84)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C148(0.96)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C148(0.81)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C148(0.62)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C148(0.97)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C148(0.86)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C148(0.79)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C213(0.93); C148(0.91)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C213(0.83); C148(0.83)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C213(1.02); C148(1.00)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C213(1.01); C148(1.20)  LDD1675  [9]
 LDCM0473  CL8 HCT 116 C148(0.88)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C213(0.96); C148(1.07)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C213(0.99); C148(0.99)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C148(1.05)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C213(0.97); C148(1.16)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C213(1.01); C148(1.00)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C213(0.98); C148(0.96)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C213(0.98); C148(0.89)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C213(0.93); C148(0.88)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C213(1.04); C148(0.86)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C213(0.89); C148(0.91)  LDD1686  [9]
 LDCM0484  CL9 HCT 116 C148(1.05)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C213(0.92); C148(0.82)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C213(1.08); C148(1.09)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C213(0.89); C148(0.96)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C213(0.92); C148(0.88)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C148(1.01)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C213(0.77); C148(0.86)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C213(0.84); C148(0.96)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C213(0.93); C148(0.88)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C213(0.95); C148(0.92)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C213(0.93); C148(0.91)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C213(0.88); C148(1.00)  LDD1698  [9]
 LDCM0625  F8 Ramos C213(0.07)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C213(7.11)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C213(0.45)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C213(6.17)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C213(1.05)  LDD2192  [10]
 LDCM0579  Fragment20 Ramos C213(7.03)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C213(1.16)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C213(1.03)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C213(0.80)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C213(0.87)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C213(1.15)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C213(0.95)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C213(2.89)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C148(0.85)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C213(1.01)  LDD2203  [10]
 LDCM0427  Fragment51 HEK-293T C213(0.98); C148(0.92)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C213(1.36)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C213(1.04)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C213(0.64)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C213(11.80)  LDD2188  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C148(0.95); C213(1.11)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C148(0.91); C213(0.98)  LDD1497  [9]
 LDCM0024  KB05 UACC257 C213(1.63)  LDD3325  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C213(0.80)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C213(0.60); C148(0.77)  LDD2101  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C213(0.99); C148(0.89)  LDD2109  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C213(0.79)  LDD2115  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C213(1.29)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C213(2.73)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C213(0.91)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C213(0.71)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C213(0.92)  LDD2125  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C148(0.37)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C213(1.78)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C213(0.88)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C213(1.58)  LDD1700  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C213(1.07)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C213(3.07)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C213(0.81)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C213(0.45)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) GDSL lipolytic enzyme family Q15102
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
Peptidyl-prolyl cis-trans isomerase H (PPIH) Cyclophilin-type PPIase family O43447
Eukaryotic initiation factor 4A-III (EIF4A3) DEAD box helicase family P38919
Probable E3 ubiquitin-protein ligase DTX2 (DTX2) Deltex family Q86UW9
Deoxyhypusine synthase (DHPS) Deoxyhypusine synthase family P49366
Neuroglobin (NGB) Globin family Q9NPG2
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Inositol hexakisphosphate kinase 3 (IP6K3) Inositol phosphokinase (IPK) family Q96PC2
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Uridine diphosphate glucose pyrophosphatase NUDT14 (NUDT14) Nudix hydrolase family O95848
Caspase-7 (CASP7) Peptidase C14A family P55210
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Dual specificity phosphatase 29 (DUSP29) Protein-tyrosine phosphatase family Q68J44
Dual specificity protein phosphatase 23 (DUSP23) Protein-tyrosine phosphatase family Q9BVJ7
Sulfotransferase 1A2 (SULT1A2) Sulfotransferase 1 family P50226
Sulfotransferase 1A3 (SULT1A3) Sulfotransferase 1 family P0DMM9
Sulfotransferase 2A1 (SULT2A1) Sulfotransferase 1 family Q06520
Thioredoxin (TXN) Thioredoxin family P10599
Septin-1 (SEPTIN1) Septin GTPase family Q8WYJ6
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Eukaryotic translation initiation factor 5A-2 (EIF5A2) EIF-5A family Q9GZV4
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arpin (ARPIN) Arpin family Q7Z6K5
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) CDKN2 cyclin-dependent kinase inhibitor family P42772
Cyclin-dependent kinase 4 inhibitor C (CDKN2C) CDKN2 cyclin-dependent kinase inhibitor family P42773
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
CYFIP-related Rac1 interactor B (CYRIB) CYRI family Q9NUQ9
Dynein light chain Tctex-type 3 (DYNLT3) Dynein light chain Tctex-type family P51808
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Ragulator complex protein LAMTOR3 (LAMTOR3) LAMTOR3 family Q9UHA4
Protein NATD1 (NATD1) NATD1 family Q8N6N6
Meiotic recombination protein DMC1/LIM15 homolog (DMC1) RecA family Q14565
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
T-cell leukemia/lymphoma protein 1A (TCL1A) TCL1 family P56279
AP-5 complex subunit beta-1 (AP5B1) . Q2VPB7
BEN domain-containing protein 7 (BEND7) . Q8N7W2
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
Rhombotin-2 (LMO2) . P25791
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840