Details of the Target

General Information of Target

Target ID LDTP14427
Target Name Cytochrome c oxidase subunit 7A-related protein, mitochondrial (COX7A2L)
Gene Name COX7A2L
Gene ID 9167
Synonyms
COX7AR; COX7RP; Cytochrome c oxidase subunit 7A-related protein, mitochondrial; COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAEFLDDQETRLCDNCKKEIPVFNFTIHEIHCQRNIGMCPTCKEPFPKSDMETHMAAEHC
QVTCKCNKKLEKRLLKKHEETECPLRLAVCQHCDLELSILKLKEHEDYCGARTELCGNCG
RNVLVKDLKTHPEVCGREGEEKRNEVAIPPNAYDESWGQDGIWIASQLLRQIEALDPPMR
LPRRPLRAFESDVFHNRTTNQRNITAQVSIQNNLFEEQERQERNRGQQPPKEGGEESANL
DFMLALSLQNEGQASSVAEQDFWRAVCEADQSHGGPRSLSDIKGAADEIMLPCEFCEELY
PEELLIDHQTSCNPSRALPSLNTGSSSPRGVEEPDVIFQNFLQQAASNQLDSLMGLSNSH
PVEESIIIPCEFCGVQLEEEVLFHHQDQCDQRPATATNHVTEGIPRLDSQPQETSPELPR
RRVRHQGDLSSGYLDDTKQETANGPTSCLPPSRPINNMTATYNQLSRSTSGPRPGCQPSS
PCVPKLSNSDSQDIQGRNRDSQNGAIAPGHVSVIRPPQNLYPENIVPSFSPGPSGRYGAS
GRSEGGRNSRVTPAAANYRSRTAKAKPSKQQGAGDAEEEEEE
Target Bioclass
Enzyme
Family
Cytochrome c oxidase VIIa family
Subcellular location
Mitochondrion inner membrane
Function Involved in the regulation of oxidative phosphorylation and energy metabolism. Necessary for the assembly of mitochondrial respiratory supercomplex.
Uniprot ID
O14548
Ensemble ID
ENST00000234301.3
HGNC ID
HGNC:2289

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K57(5.88); K59(7.69); K65(10.00); K69(2.72)  LDD0277  [2]
Probe 1
 Probe Info  		Y52(10.22)  LDD3495  [3]
Jackson_14
 Probe Info  		2.56  LDD0123  [4]
NHS
 Probe Info  		N.A.  LDD0010  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		6.59  LDD1733  [8]
C056
 Probe Info  		21.71  LDD1753  [8]
C094
 Probe Info  		26.72  LDD1785  [8]
C106
 Probe Info  		17.03  LDD1793  [8]
C143
 Probe Info  		13.27  LDD1825  [8]
C201
 Probe Info  		38.85  LDD1877  [8]
C228
 Probe Info  		19.43  LDD1901  [8]
C231
 Probe Info  		13.64  LDD1904  [8]
C235
 Probe Info  		25.11  LDD1908  [8]
C278
 Probe Info  		48.50  LDD1948  [8]
C289
 Probe Info  		31.56  LDD1959  [8]
C299
 Probe Info  		6.32  LDD1968  [8]
C350
 Probe Info  		29.24  LDD2011  [8]
C355
 Probe Info  		23.10  LDD2016  [8]
C362
 Probe Info  		25.81  LDD2023  [8]
C388
 Probe Info  		48.17  LDD2047  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.56  LDD0123  [4]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587