Details of the Target

General Information of Target

Target ID LDTP12154
Target Name MYG1 exonuclease (MYG1)
Gene Name MYG1
Gene ID 60314
Synonyms
C12orf10; MYG1 exonuclease; EC 3.1.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKG
FNLQGPLILWSFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVF
LLSKVIELGDTAFIILRKRPLIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAI
MYTYYTLKAANVKPPKMLPMLITSLQILQMFVGAIVSILTYIWRQDQGCHTTMEHLFWSF
ILYMTYFILFAHFFCQTYIRPKVKAKTKSQ
Target Bioclass
Enzyme
Family
MYG1 family
Subcellular location
Nucleus, nucleoplasm
Function
3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable).
Uniprot ID
Q9HB07
Ensemble ID
ENST00000267103.10
HGNC ID
HGNC:17590

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y189(17.50)  LDD3495  [1]
BTD
 Probe Info  		C305(0.86)  LDD2089  [2]
AHL-Pu-1
 Probe Info  		C305(4.46)  LDD0170  [3]
DBIA
 Probe Info  		C56(0.54); C62(0.54)  LDD0533  [4]
5E-2FA
 Probe Info  		H237(0.00); H208(0.00)  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
IA-alkyne
 Probe Info  		C305(0.00); C56(0.00); C62(0.00)  LDD0036  [6]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [7]
Lodoacetamide azide
 Probe Info  		C305(0.00); C88(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
NAIA_5
 Probe Info  		C340(0.00); C305(0.00); C62(0.00); C56(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C299
 Probe Info  		6.41  LDD1968  [11]
C355
 Probe Info  		22.94  LDD2016  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C305(0.24)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C305(0.35)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C305(0.45)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C305(0.96)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C305(0.70)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C305(1.00)  LDD2152  [2]
 LDCM0025  4SU-RNA DM93 C305(4.46)  LDD0170  [3]
 LDCM0214  AC1 HEK-293T C56(0.84)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C56(0.76)  LDD1508  [13]
 LDCM0216  AC100 HCT 116 C56(0.54); C62(0.54)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C56(0.60); C62(0.60)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C56(0.50); C62(0.50)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C56(0.32); C62(0.32)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C56(0.48); C62(0.48)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C56(0.37); C62(0.37)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C56(0.33); C62(0.33)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C56(0.36); C62(0.34)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C56(0.44); C62(0.47)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C56(0.57); C62(0.70)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C56(0.76)  LDD1509  [13]
 LDCM0227  AC110 HCT 116 C56(0.44); C62(0.42)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C56(0.51); C62(0.50)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C56(0.37); C62(0.43)  LDD0546  [4]
 LDCM0237  AC12 HEK-293T C56(0.91)  LDD1510  [13]
 LDCM0246  AC128 HCT 116 C56(0.84); C62(0.84)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C56(1.04); C62(1.04)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C56(0.85); C62(0.85)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C56(1.87); C62(1.87)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C56(0.78); C62(0.78)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C56(0.88); C62(0.88)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C56(0.55); C62(0.55)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C56(0.60); C62(0.60)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C56(0.75); C62(0.75)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C56(0.84); C62(0.84)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C56(0.38); C62(0.38)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C56(0.47); C62(0.47)  LDD0575  [4]
 LDCM0259  AC14 HEK-293T C56(1.35)  LDD1512  [13]
 LDCM0260  AC140 HCT 116 C56(0.33); C62(0.33)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C56(0.42); C62(0.42)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C56(1.95); C62(1.95)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C56(0.64); C62(0.64)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C56(0.12); C62(0.12)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C56(0.28); C62(0.28)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C56(0.22); C62(0.22)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C56(0.08); C62(0.08)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C56(0.04); C62(0.04)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C56(0.09); C62(0.09)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C56(0.97)  LDD1513  [13]
 LDCM0271  AC150 HCT 116 C56(0.92); C62(0.92)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C56(0.53); C62(0.53)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C56(0.08); C62(0.08)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C56(0.05); C62(0.05)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C56(0.15); C62(0.15)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C56(0.18); C62(0.18)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C56(0.59); C62(0.59)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C56(0.77); C62(0.77)  LDD2161  [4]
 LDCM0276  AC17 HEK-293T C56(1.03)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C56(0.71)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C56(0.83)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C56(0.79)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C56(0.96)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C62(1.00); C56(0.93)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C56(1.02)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C56(0.89)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C56(0.74)  LDD1523  [13]
 LDCM0285  AC25 HCT 116 C56(1.14); C62(1.14)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C56(0.77); C62(0.77)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C56(0.87); C62(0.87)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C56(0.76); C62(0.76)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C56(0.61); C62(0.61)  LDD0606  [4]
 LDCM0290  AC3 HEK-293T C56(0.78)  LDD1529  [13]
 LDCM0291  AC30 HCT 116 C56(0.50); C62(0.50)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C56(0.64); C62(0.64)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C56(0.37); C62(0.37)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C56(0.97); C62(0.97)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C56(0.88); C62(0.88)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C56(1.98); C62(1.98)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C56(1.20); C62(1.20)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C56(0.87); C62(0.87)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C56(1.24); C62(1.24)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C56(0.52); C62(0.52)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C56(1.07)  LDD1540  [13]
 LDCM0302  AC40 HCT 116 C56(0.48); C62(0.48)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C56(0.82); C62(0.82)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C56(0.59); C62(0.59)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C56(0.68); C62(0.68)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C56(0.54); C62(0.54)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C56(0.38); C62(0.38)  LDD0624  [4]
 LDCM0308  AC46 HEK-293T C56(0.99)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C56(0.73)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C56(0.73)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C56(0.69)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C62(0.97); C56(1.05)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C56(0.98)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C56(0.86)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C56(1.09)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C62(0.90); C56(0.88)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C56(0.78)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C56(1.09)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C56(0.92)  LDD1558  [13]
 LDCM0320  AC57 HCT 116 C56(0.37); C62(0.37)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C56(0.38); C62(0.38)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C56(0.22); C62(0.22)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C56(1.03)  LDD1562  [13]
 LDCM0324  AC60 HCT 116 C56(0.43); C62(0.43)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C56(0.67); C62(0.67)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C56(0.17); C62(0.17)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C56(0.45); C62(0.45)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C56(0.17); C62(0.17)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C56(0.18); C62(0.18)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C56(0.24); C62(0.24)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C56(0.07); C62(0.07)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C56(0.77); C62(0.77)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C56(0.62); C62(0.62)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C56(0.93)  LDD1568  [13]
 LDCM0335  AC70 HCT 116 C56(0.53); C62(0.53)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C56(0.91); C62(0.91)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C56(0.64); C62(0.64)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C56(0.57); C62(0.57)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C56(0.60); C62(0.60)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C56(0.47); C62(0.47)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C56(0.56); C62(0.56)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C56(0.54); C62(0.54)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C56(1.07); C62(1.07)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C56(0.69); C62(0.69)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C56(1.24)  LDD1569  [13]
 LDCM0346  AC80 HCT 116 C56(0.74); C62(0.74)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C56(1.47); C62(1.47)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C56(0.41); C62(0.41)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C56(0.56); C62(0.56)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C56(0.54); C62(0.54)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C56(0.71); C62(0.71)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C56(0.60); C62(0.60)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C56(0.77); C62(0.77)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C56(0.76); C62(0.76)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C56(0.67); C62(0.67)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C56(1.42); C62(1.42)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C56(0.55); C62(0.55)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C56(0.64); C62(0.64)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C56(0.80); C62(0.80)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C56(1.17); C62(1.17)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C56(1.08); C62(1.08)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C56(0.79); C62(0.79)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C56(0.46); C62(0.46)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C56(0.18); C62(0.18)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C56(0.51); C62(0.51)  LDD0683  [4]
 LDCM0545  Acetamide MDA-MB-231 C305(0.42)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C305(1.52)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C62(1.03); C56(0.99)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C56(0.79)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C56(0.77)  LDD1514  [13]
 LDCM0498  BS-3668 MDA-MB-231 C305(0.50)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C56(0.93)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C56(0.95)  LDD1572  [13]
 LDCM0370  CL101 HEK-293T C56(0.82)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C56(0.68)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C56(0.87)  LDD1576  [13]
 LDCM0374  CL105 HEK-293T C56(0.95)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C56(0.79)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C56(0.92)  LDD1580  [13]
 LDCM0378  CL109 HEK-293T C56(1.14)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C56(0.74)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C56(0.84)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C56(0.88)  LDD1585  [13]
 LDCM0382  CL112 HCT 116 C56(0.95); C62(0.95)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C56(0.54); C62(0.54)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C56(0.77); C62(0.77)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C56(0.84); C62(0.84)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C56(0.89); C62(0.89)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C56(0.29); C62(0.29)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C56(0.65); C62(0.65)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C56(0.57); C62(0.57)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C56(0.89)  LDD1594  [13]
 LDCM0391  CL120 HCT 116 C56(0.81); C62(0.81)  LDD0708  [4]
 LDCM0392  CL121 HEK-293T C56(1.11)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C56(0.79)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C56(0.89)  LDD1598  [13]
 LDCM0396  CL125 HCT 116 C56(0.76); C62(0.76)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C56(0.53); C62(0.53)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C56(0.70); C62(0.70)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C56(0.25); C62(0.25)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C56(0.78)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C56(0.88)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C56(0.95)  LDD1606  [13]
 LDCM0403  CL16 HCT 116 C56(0.80); C62(0.80)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C56(0.84); C62(0.84)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C56(1.27); C62(1.27)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C56(0.55); C62(0.55)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C56(0.76)  LDD1611  [13]
 LDCM0408  CL20 HCT 116 C56(0.30); C62(0.30)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C56(0.27); C62(0.27)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C56(0.16); C62(0.16)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C56(0.45); C62(0.45)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C56(0.23); C62(0.23)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C56(0.28); C62(0.28)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C56(0.47); C62(0.47)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C56(0.42); C62(0.42)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C56(0.46); C62(0.46)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C56(0.27); C62(0.27)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C56(0.88)  LDD1622  [13]
 LDCM0419  CL30 HCT 116 C56(0.69); C62(0.69)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C56(0.88)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C56(1.01)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C62(0.90); C56(0.88)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C56(1.01)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C56(0.84)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C56(0.83)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C56(0.67)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C56(0.98)  LDD1632  [13]
 LDCM0431  CL41 HEK-293T C56(0.73)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C56(0.89)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C56(0.73)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C56(0.88)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C62(1.00); C56(0.78)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C56(0.75)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C56(0.80)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C56(0.83)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C56(0.87)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C56(0.71)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C56(0.80)  LDD1645  [13]
 LDCM0444  CL53 HEK-293T C56(0.86)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C56(0.53)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C56(0.80)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C56(0.87)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C62(1.00); C56(0.68)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C56(0.87)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C56(0.79)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C56(0.72)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C56(0.94)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C56(0.99)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C56(0.69)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C56(0.93)  LDD1658  [13]
 LDCM0457  CL65 HEK-293T C56(0.77)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C56(0.80)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C56(0.81)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C56(0.84)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C62(0.92); C56(0.93)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C56(0.78)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C56(0.97)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C56(0.81)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C56(0.83)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C56(0.85)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C56(0.99)  LDD1670  [13]
 LDCM0470  CL77 HEK-293T C56(0.58)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C56(0.82)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C56(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C56(0.73)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C56(1.03)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C62(0.98); C56(0.77)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C56(0.92)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C56(0.81)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C56(0.72)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C56(0.92)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C56(0.67)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C56(0.94)  LDD1684  [13]
 LDCM0483  CL89 HEK-293T C56(0.71)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C62(1.14); C56(0.89)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C56(0.58)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C56(0.74)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C56(0.85)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C62(1.10); C56(0.72)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C56(0.92)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C56(0.74)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C56(0.89)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C56(0.93)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C56(0.83)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C56(0.95)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C56(0.84)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C305(1.42)  LDD1702  [2]
 LDCM0625  F8 Ramos C305(0.62)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C305(0.96)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C305(1.18)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C305(0.96)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C305(0.87)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C305(0.76)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C305(0.72)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C305(0.65)  LDD2195  [14]
 LDCM0578  Fragment27 Ramos C305(0.82)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C305(0.80)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C305(1.55)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C305(0.82)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C305(0.87)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C56(0.94)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C305(1.81)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C305(0.78)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C56(0.81)  LDD1631  [13]
 LDCM0569  Fragment7 Ramos C305(0.72)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C305(0.94)  LDD2188  [14]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 Ramos C305(0.65)  LDD2182  [14]
 LDCM0023  KB03 Ramos C305(0.83)  LDD2183  [14]
 LDCM0024  KB05 COLO792 C305(3.02)  LDD3310  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C305(0.45)  LDD2121  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C305(0.86)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C305(0.97)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C305(0.13)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C305(0.77)  LDD2097  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C305(0.24)  LDD2100  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C305(2.64)  LDD2105  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C305(0.46)  LDD2109  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C305(0.40)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C305(0.39)  LDD2115  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C305(0.38)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C305(0.87)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C305(0.27)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C305(0.61)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C305(0.61)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C305(0.15)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C305(0.81)  LDD2127  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C305(0.83)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C305(0.91)  LDD2129  [2]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C305(0.51)  LDD2133  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C305(0.36)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C305(0.99)  LDD2135  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C305(1.05)  LDD2137  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C305(0.38)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C305(0.75)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C305(3.33)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C305(0.28)  LDD2145  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C305(3.18)  LDD2147  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C305(0.22)  LDD2149  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C305(0.50)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Deubiquitinase DESI2 (DESI2) DeSI family Q9BSY9
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC (MAN1C1) Glycosyl hydrolase 47 family Q9NR34
Protein-L-histidine N-pros-methyltransferase (METTL9) METTL9 family Q9H1A3
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-gated purine nucleotide uniporter SLC17A9 (SLC17A9) Sodium/anion cotransporter family Q9BYT1
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) Tim17/Tim22/Tim23 family O60830
Barttin (BSND) . Q8WZ55
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinoic acid receptor RXR-beta (RXRB) Nuclear hormone receptor family P28702
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 5 (CMTM5) Chemokine-like factor family Q96DZ9
Other
Click To Hide/Show 22 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein A-V (APOA5) Apolipoprotein A1/A4/E family Q6Q788
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Complexin-2 (CPLX2) Complexin/synaphin family Q6PUV4
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein pelota homolog (PELO) Eukaryotic release factor 1 family Q9BRX2
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein MAL2 (MAL2) MAL family Q969L2
Large ribosomal subunit protein mL64 (GADD45GIP1) Mitochondrion-specific ribosomal protein mL64 family Q8TAE8
Perilipin-3 (PLIN3) Perilipin family O60664
Rod outer segment membrane protein 1 (ROM1) PRPH2/ROM1 family Q03395
Vesicle transport protein SFT2A (SFT2D1) SFT2 family Q8WV19
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Protein YIF1A (YIF1A) YIF1 family O95070
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
Elongation factor 1-gamma (EEF1G) . P26641
HORMA domain-containing protein 1 (HORMAD1) . Q86X24
Mitochondrial nucleoid-associated protein 1 (MTNAP1) . Q9BSJ5
Splicing regulator RBM11 (RBM11) . P57052
Transmembrane protein 239 (TMEM239) . Q8WW34
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840