Details of the Target

General Information of Target

Target ID LDTP09679
Target Name Negative elongation factor B (NELFB)
Gene Name NELFB
Gene ID 25920
Synonyms
COBRA1; KIAA1182; Negative elongation factor B; NELF-B; Cofactor of BRCA1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLE
FHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHL
PKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTE
LSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAE
LLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGD
LSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVF
KEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRM
ACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALED
FCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKEL
YSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAPL
Target Bioclass
Other
Family
NELF-B family
Subcellular location
Nucleus
Function
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules. Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
Uniprot ID
Q8WX92
Ensemble ID
ENST00000343053.6
HGNC ID
HGNC:24324

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.93  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
ONAyne
 Probe Info  		K146(0.65)  LDD0274  [3]
STPyne
 Probe Info  		K135(10.00); K146(5.82); K438(0.54); K519(3.97)  LDD0277  [3]
Probe 1
 Probe Info  		Y541(32.83)  LDD3495  [4]
BTD
 Probe Info  		C235(0.95)  LDD1700  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
DBIA
 Probe Info  		C235(1.05)  LDD0078  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		N.A.  LDD0022  [10]
IPM
 Probe Info  		N.A.  LDD0147  [9]
NHS
 Probe Info  		N.A.  LDD0010  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		C23(0.00); C115(0.00)  LDD0236  [11]
AOyne
 Probe Info  		14.70  LDD0443  [12]
NAIA_5
 Probe Info  		C141(0.00); C115(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		18.90  LDD1740  [14]
C134
 Probe Info  		20.68  LDD1816  [14]
STS-1
 Probe Info  		N.A.  LDD0137  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C235(1.18); C141(0.94)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C235(1.33)  LDD2152  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C141(0.43)  LDD2131  [5]
 LDCM0214  AC1 HCT 116 C115(0.89); C141(1.02); C23(0.83); C235(1.07)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C115(0.94); C141(1.09); C23(0.87); C235(0.85)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C115(0.79); C141(0.88); C23(0.86); C235(0.87)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C115(0.80); C141(0.93); C23(0.86); C235(0.97)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C115(0.87); C141(0.87); C23(0.81); C235(0.78)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C115(0.99); C141(1.19); C23(1.07); C235(0.86)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C115(0.95); C141(1.07); C23(1.07); C235(0.81)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C115(0.83); C141(1.03); C23(0.89); C235(0.89)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C115(0.83); C141(1.10); C23(1.05); C235(0.91)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C115(0.60); C141(1.21); C23(1.14); C235(0.91)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C115(0.59); C141(0.82); C23(0.80); C235(0.87)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C115(0.56); C141(0.83); C23(0.77); C235(0.90)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C115(1.02); C141(1.07); C23(0.97); C235(0.88)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C115(0.63); C141(0.77); C23(0.80); C235(0.89)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C115(0.64); C141(0.85); C23(0.75); C235(0.86)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C115(0.55); C141(0.99); C23(0.98); C235(0.87)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C141(0.91); C23(0.84); C235(1.14); C265(0.84)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C141(0.93); C23(0.75); C235(1.19); C265(0.75)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C141(0.91); C23(0.96); C235(1.54); C265(1.01)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C141(0.92); C23(0.83); C235(1.17); C265(0.90)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C141(1.00); C23(0.87); C235(1.01); C265(0.92)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C141(1.00); C23(0.89); C235(1.19); C265(0.87)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C141(1.04); C23(0.85); C235(1.05); C265(0.75)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C115(0.99); C141(0.99); C23(0.92); C235(0.82)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C141(0.78); C23(0.72); C235(0.92); C265(0.92)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C141(0.94); C23(0.91); C235(1.09); C265(1.11)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C141(1.01); C23(0.87); C235(1.12); C265(0.82)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C141(1.02); C23(1.05); C235(0.99); C265(0.95)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C141(1.03); C23(0.99); C235(1.06); C265(0.94)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C141(0.87); C23(0.82); C235(1.26); C265(0.73)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C141(0.99); C23(0.86); C235(1.24); C265(1.02)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C141(1.00); C23(0.84); C235(1.06); C265(0.93)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C115(1.17); C141(1.49); C23(0.85); C235(1.50)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C115(1.18); C141(0.84); C23(0.92); C235(1.21)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C115(1.11); C141(1.13); C23(1.05); C235(1.27)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C115(1.39); C141(0.81); C23(0.98); C235(1.06)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C115(0.76); C141(0.97); C23(1.06); C235(1.22)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C115(0.92); C141(1.19); C23(1.02); C235(1.24)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C115(1.07); C141(1.19); C23(1.10); C235(1.41)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C115(1.03); C141(1.18); C23(0.99); C235(1.67)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C115(0.84); C141(1.12); C23(1.10); C235(1.04)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C115(0.77); C141(0.99); C23(1.01); C235(1.04)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C115(0.82); C141(1.14); C23(1.23); C235(1.24)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C115(0.97); C141(1.14); C23(1.48); C235(1.18)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C115(0.82); C141(1.00); C23(0.77); C235(0.90)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C115(0.90); C141(1.24); C23(1.30); C235(1.57)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C115(0.89); C141(1.12); C23(1.28); C235(1.27)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C115(0.77); C141(0.94); C23(1.09); C235(1.19)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C269(0.65); C235(0.91); C265(0.95); C141(1.10)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C269(0.81); C265(0.91); C235(1.03); C141(1.38)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C269(0.84); C265(0.93); C235(0.96); C141(1.18)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C269(0.85); C235(0.99); C265(1.05); C141(1.34)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C269(0.94); C265(0.94); C235(1.10); C141(1.46)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C269(1.18); C265(1.36); C235(1.45); C141(2.15)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C269(0.95); C235(1.13); C265(1.23); C141(1.53)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C269(0.80); C23(0.83); C235(0.85); C265(0.95)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C269(0.88); C235(0.95); C265(0.98); C141(1.11)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C269(0.69); C265(0.82); C235(0.92); C141(1.06)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C269(1.04); C265(1.07); C235(1.08); C141(1.51)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C269(1.25); C235(1.59); C265(1.64); C141(2.39)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C141(1.23); C235(1.05); C265(0.98); C269(0.88)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C141(1.26); C235(1.02); C265(1.00); C269(0.83)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C141(0.92); C235(0.94); C265(1.07); C269(0.79)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C141(0.82); C235(0.94); C265(1.04); C269(0.84)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C141(0.99); C235(1.00); C23(1.01); C269(1.06)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C23(0.88); C235(0.96); C265(1.05); C269(1.07)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C235(0.94); C269(0.94); C23(0.98); C141(1.05)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C115(0.73); C254(0.84); C259(0.84); C265(0.93)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C235(0.88); C23(0.88); C141(1.01); C269(1.25)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C235(0.94); C23(0.96); C269(1.00); C141(1.07)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C23(0.85); C235(0.89); C269(1.04); C141(1.04)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C23(0.84); C235(0.88); C269(0.95); C141(1.02)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C235(0.80); C141(0.93); C269(0.95); C23(0.99)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C235(0.94); C23(0.98); C269(1.08); C265(1.10)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C235(0.99); C269(1.10); C265(1.11); C23(1.13)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C23(0.97); C235(1.02); C265(1.04); C269(1.07)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C235(0.91); C23(1.00); C269(1.16); C265(1.18)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C235(1.00); C23(1.08); C269(1.16); C265(1.18)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C115(0.74); C254(0.82); C259(0.82); C23(0.96)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C235(0.90); C23(1.02); C269(1.08); C141(1.23)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C235(0.91); C23(0.97); C265(1.12); C269(1.13)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C23(1.06); C235(1.10); C269(1.23); C265(1.31)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C23(0.87); C235(0.90); C269(0.99); C265(1.00)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C23(0.83); C235(0.95); C265(1.11); C269(1.22)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C141(0.85); C235(0.98); C254(1.07); C259(1.07)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C141(0.91); C235(0.98); C269(1.01); C254(1.03)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C269(0.89); C265(0.93); C141(0.96); C235(0.97)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C235(0.93); C141(0.99); C269(1.17); C254(1.27)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C235(0.90); C141(1.07); C269(1.12); C265(1.26)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C254(0.85); C259(0.85); C115(0.87); C269(1.00)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C235(0.85); C254(1.06); C259(1.06); C141(1.08)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C235(0.73); C141(1.01); C254(1.07); C259(1.07)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C254(0.93); C259(0.93); C235(0.97); C141(1.03)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C235(0.74); C254(1.10); C259(1.10); C141(1.10)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C235(0.83); C254(0.96); C259(0.96); C141(1.01)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C235(0.77); C265(1.06); C269(1.07); C141(1.15)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C235(0.95); C265(1.02); C141(1.04); C269(1.07)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C235(0.96); C269(1.04); C141(1.05); C265(1.13)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C235(0.88); C269(0.98); C265(1.02); C141(1.06)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C235(1.16); C265(1.21); C269(1.24); C141(1.34)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C115(0.74); C254(0.90); C259(0.90); C265(1.01)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C235(1.08); C269(1.16); C141(1.21); C265(1.22)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C235(0.83); C269(0.93); C141(0.95); C265(1.00)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C235(0.94); C269(1.01); C141(1.03); C265(1.04)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C235(0.95); C269(1.08); C265(1.11); C141(1.13)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C235(0.91); C269(1.17); C265(1.20); C141(1.24)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C235(1.00); C269(1.21); C141(1.31); C265(1.32)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C235(1.22); C269(1.27); C141(1.52); C265(1.52)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C115(0.87); C265(1.03); C235(1.08); C269(1.14)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C235(1.02); C115(1.02); C265(1.06); C269(1.10)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C115(0.81); C235(1.09); C269(1.13); C141(1.17)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C235(0.81); C269(0.85); C23(0.98); C265(1.00)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C115(0.74); C265(0.97); C235(0.99); C269(1.07)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C115(0.76); C265(0.95); C269(0.98); C235(1.00)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C265(1.01); C115(1.06); C269(1.11); C235(1.25)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C115(0.85); C235(0.99); C265(1.01); C269(1.02)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C115(0.84); C265(1.17); C235(1.18); C141(1.21)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C115(0.71); C265(1.03); C269(1.13); C235(1.18)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C115(0.70); C235(1.07); C265(1.12); C269(1.13)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C115(0.66); C269(1.20); C265(1.22); C235(1.30)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C115(0.99); C141(1.03); C265(1.05); C269(1.07)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C235(1.17); C265(1.21); C115(1.21); C141(1.22)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C269(0.76); C115(0.83); C23(0.92); C265(0.97)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C265(0.96); C269(0.97); C115(1.12); C141(1.24)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C115(0.84); C265(1.14); C235(1.15); C269(1.17)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C265(0.98); C269(1.00); C235(1.00); C141(1.18)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C141(1.12); C265(1.16); C269(1.18); C115(1.25)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C141(1.15); C265(1.32); C269(1.34); C235(1.42)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C141(1.11); C265(1.36); C269(1.39); C235(1.54)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C265(1.08); C269(1.11); C115(1.12); C235(1.19)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C141(0.96); C115(1.00); C235(1.17); C265(1.17)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C235(0.88); C115(0.91); C141(1.01); C265(1.08)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C235(0.97); C115(0.99); C141(1.20); C265(1.31)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C269(0.81); C23(0.87); C265(0.93); C115(0.93)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C141(1.01); C235(1.05); C265(1.10); C269(1.17)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C235(0.82); C115(0.85); C265(1.04); C269(1.08)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C141(1.12); C265(1.14); C269(1.16); C235(1.21)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C23(1.14); C235(1.16); C265(1.20); C269(1.26)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C235(1.00); C23(1.13); C269(1.28); C265(1.33)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C235(0.88); C23(1.01); C141(1.03); C269(1.20)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C235(0.92); C265(1.11); C269(1.11); C141(1.15)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C235(0.95); C141(1.03); C269(1.16); C265(1.26)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C235(0.93); C269(1.06); C265(1.08); C141(1.08)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C235(1.01); C269(1.17); C23(1.24); C141(1.27)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C235(0.92); C269(1.00); C265(1.08); C141(1.14)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C235(0.93); C23(1.04); C265(1.27); C269(1.30)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C23(1.04); C269(1.13); C265(1.17); C235(1.19)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C235(0.83); C23(0.99); C141(1.09); C269(1.09)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C235(0.79); C141(1.03); C23(1.24); C269(1.27)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C235(0.79); C269(0.84); C265(0.86); C141(0.98)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C235(0.93); C23(1.10); C269(1.22); C141(1.26)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C235(0.84); C269(1.17); C265(1.19); C23(1.21)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C115(0.88); C265(0.89); C269(0.89); C235(1.01)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C115(0.72); C23(0.72); C265(0.85); C269(0.85)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C141(0.62)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C115(0.76); C141(1.04); C23(0.92); C235(0.87)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C269(0.82); C115(0.88); C235(0.89); C265(0.94)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C269(0.81); C23(0.85); C265(0.91); C235(0.95)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.52  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C235(1.05)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa H321(0.00); C23(0.00)  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C115(1.37)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C141(0.90); C235(0.95); C269(0.99); C265(1.01)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C141(0.95); C235(0.96); C23(0.99); C269(1.06)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C254(0.75); C259(0.75); C23(0.86); C115(0.88)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C23(0.75); C235(0.84); C265(0.90); C115(0.91)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C23(0.74); C269(0.77); C235(0.81); C115(0.82)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C23(0.77); C269(0.80); C235(0.88); C265(0.88)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C23(0.73); C235(0.79); C269(0.80); C265(0.91)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C23(0.82); C235(0.95); C141(1.08); C269(1.09)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C23(0.86); C265(0.95); C235(1.03); C269(1.08)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C23(0.82); C235(1.00); C265(1.11); C269(1.20)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C23(0.93); C235(0.99); C141(1.29); C269(1.39)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C235(0.92); C23(0.94); C269(0.97); C141(1.08)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C23(0.97); C141(0.99); C235(1.06); C269(1.15)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C235(0.98); C269(1.03); C23(1.12); C141(1.14)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C235(0.87); C269(0.95); C141(1.06); C265(1.08)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C23(0.95); C235(0.98); C269(1.07); C141(1.08)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C235(0.95); C23(1.04); C265(1.04); C269(1.11)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C235(0.89); C23(0.93); C269(1.02); C265(1.08)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C235(0.90); C23(0.99); C269(1.12); C265(1.15)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C235(0.93); C23(0.94); C265(1.11); C269(1.12)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C235(0.82); C254(1.16); C259(1.16); C269(1.34)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C235(0.93); C141(1.03); C254(1.16); C259(1.16)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C235(0.90); C141(1.04); C265(1.06); C269(1.07)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C141(1.07); C23(1.12); C235(1.15); C265(1.17)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C235(0.84); C254(0.86); C259(0.86); C141(1.04)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C235(0.80); C269(0.83); C141(1.04); C265(1.57)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C235(0.91); C141(1.11); C265(1.13); C269(1.16)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C235(0.87); C269(1.06); C265(1.10); C141(1.14)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C235(0.99); C269(1.15); C265(1.16); C141(1.28)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C115(0.63); C265(0.93); C141(0.98); C269(1.00)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C115(0.66); C141(0.98); C269(1.04); C235(1.09)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C115(0.66); C235(0.91); C269(0.92); C141(0.96)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C115(0.85); C269(1.07); C265(1.08); C235(1.14)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C141(0.94); C23(0.96); C265(0.98); C269(0.99)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C23(0.92); C265(0.93); C141(0.95); C269(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C141(0.92); C265(0.92); C235(0.95); C269(0.95)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C235(0.85); C269(0.95); C265(0.95); C141(0.97)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C269(0.86); C265(0.86); C141(0.97); C235(1.00)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C265(0.82); C235(0.88); C269(0.88); C141(0.96)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C141(0.93); C269(0.95); C235(0.96); C265(1.03)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C265(0.91); C141(0.92); C269(0.92); C235(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C141(0.90); C265(1.05); C269(1.08); C235(1.08)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C141(0.90); C235(1.01); C269(1.04); C265(1.18)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C141(0.85); C235(1.29); C269(1.36); C265(1.91)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C235(0.86); C269(0.92); C141(0.97); C265(1.00)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C141(1.01); C269(1.02); C235(1.17); C265(1.21)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C141(1.09); C235(0.97); C265(1.11); C269(0.93)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C141(0.97); C235(0.83); C265(1.03); C269(0.93)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C141(0.92); C235(1.04); C265(1.00); C269(0.97)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C141(1.00); C235(0.99); C265(1.05); C269(0.93)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C141(0.83); C235(0.96); C265(1.15); C269(0.98)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C141(0.97); C23(1.13); C235(1.12); C265(0.96)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C141(1.11); C235(0.97); C265(0.97); C269(0.93)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C141(1.08); C235(0.93); C265(0.93); C269(0.96)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C141(1.20); C235(0.87); C265(0.97); C269(0.99)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C141(1.12); C235(0.87); C265(0.90); C269(1.15)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C141(1.31); C235(1.03); C265(1.14); C269(1.17)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C141(1.23); C235(1.04); C265(1.09); C269(1.12)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C141(1.22); C235(1.00); C265(1.03); C269(1.18)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C141(1.47); C235(1.04); C265(1.19); C269(1.19)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C141(1.30); C235(1.05); C265(1.08); C269(1.31)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C141(0.88); C23(1.04); C235(0.95); C265(0.89)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C141(1.24); C235(0.88); C265(1.03); C269(1.05)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C141(1.23); C235(0.94); C265(1.09); C269(1.23)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C141(1.55); C235(0.92); C265(1.43); C269(1.48)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C141(1.38); C235(0.94); C265(1.09); C269(1.28)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C141(1.32); C235(0.90); C265(0.91); C269(1.16)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C141(1.33); C235(0.92); C265(1.11); C269(1.19)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C141(0.76); C23(0.98); C235(0.94); C254(0.96)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C141(0.78); C23(0.92); C235(0.91); C254(1.05)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C141(0.76); C23(0.91); C235(0.97); C254(1.46)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C141(0.92); C23(1.23); C235(1.05); C254(0.78)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C141(0.94); C23(1.06); C235(1.03); C265(1.04)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C141(0.87); C23(0.97); C235(1.01); C254(1.50)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C141(0.89); C23(0.98); C235(1.15); C254(1.31)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C141(0.92); C23(1.07); C235(1.10); C254(1.30)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C141(0.74); C23(0.88); C235(1.00); C254(1.14)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C141(0.80); C23(0.92); C235(0.97); C254(1.35)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C141(0.80); C23(1.03); C235(1.06); C254(0.90)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C141(0.77); C23(0.95); C235(0.97); C254(1.16)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C141(0.75); C23(0.87); C235(0.98); C254(1.07)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C141(0.80); C23(1.03); C235(0.91); C254(1.57)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C141(0.86); C23(0.91); C235(0.97); C254(0.76)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C141(0.88); C23(1.08); C235(0.99); C265(0.92)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C141(0.88); C23(0.96); C235(0.93); C254(1.05)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C141(0.93); C23(0.94); C235(1.08); C265(0.99)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C141(1.03); C23(0.96); C235(0.93); C265(0.80)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C141(0.83); C23(0.81); C235(1.02); C265(0.78)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C141(1.17); C23(0.99); C235(1.12); C265(0.80)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C141(1.04); C23(0.97); C235(1.39); C265(0.79)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C141(1.03); C23(0.92); C235(1.12); C265(1.11)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C141(0.93); C23(0.93); C235(1.24); C265(0.85)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C141(0.85); C23(0.79); C235(1.18); C265(0.80)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C141(0.98); C23(0.92); C235(1.06); C265(0.75)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C141(1.00); C23(0.91); C235(1.10); C265(1.09)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C141(1.11); C23(0.88); C235(1.20); C265(0.94)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C141(1.03); C23(0.82); C235(1.02); C265(0.87)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C141(0.96); C23(1.01); C235(1.17); C265(1.00)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C141(0.92); C23(1.04); C235(1.12); C265(0.89)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C141(1.08); C23(0.94); C235(1.17); C265(0.82)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C141(0.89); C235(1.06); C254(1.03); C259(1.03)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C141(0.79); C235(0.96); C254(1.22); C259(1.22)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C141(0.85); C235(1.14); C254(0.99); C259(0.99)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C141(0.95); C235(1.12); C254(1.06); C259(1.06)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C141(0.88); C23(1.04); C235(1.15); C265(1.13)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C141(0.94); C235(1.09); C254(1.01); C259(1.01)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C141(0.97); C235(1.17); C254(1.13); C259(1.13)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C141(1.10); C235(1.11); C254(1.39); C259(1.39)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C141(1.13); C235(1.07); C254(1.27); C259(1.27)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C141(1.32); C235(0.95); C254(1.48); C259(1.48)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C141(0.91); C235(1.10); C254(1.06); C259(1.06)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C141(0.87); C235(1.04); C254(1.08); C259(1.08)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C141(1.04); C235(0.98); C254(1.04); C259(1.04)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C141(1.18); C235(1.10); C254(1.37); C259(1.37)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C141(1.56); C235(1.16); C254(1.60); C259(1.60)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C141(0.97); C23(0.94); C235(1.05); C265(0.92)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C141(0.87); C235(0.92); C254(1.13); C259(1.13)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C115(0.76); C141(1.07); C23(1.14); C235(1.19)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C115(0.66); C141(1.10); C23(0.94); C235(1.12)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C115(0.93); C141(1.08); C23(0.82); C235(1.10)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C115(0.81); C141(1.02); C23(0.82); C235(0.96)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C115(0.83); C141(1.07); C23(0.90); C235(1.30)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C115(0.72); C141(1.08); C23(0.98); C235(1.23)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C115(0.95); C141(1.04); C23(1.12); C235(1.10)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C115(0.80); C141(1.10); C23(1.03); C235(0.98)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C115(0.87); C141(1.05); C23(0.98); C235(1.15)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C141(0.98); C23(1.01); C422(0.93); C115(0.96)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C235(2.60); C141(1.95)  LDD1702  [5]
 LDCM0625  F8 Ramos C141(1.31); C115(1.37)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C141(0.93)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C141(0.09); C115(0.12)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C141(0.92)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C141(1.09); C115(0.83)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C141(1.13); C115(1.77)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C141(0.91)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C141(0.88); C115(0.71)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C141(1.75); C115(1.38)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C141(0.91); C115(0.62)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C141(1.35); C115(1.32)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C141(1.25); C115(0.84)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C141(1.01); C115(1.07)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C141(1.05); C115(0.91)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C141(1.05); C23(0.92); C235(1.29); C265(0.87)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C141(0.90); C115(0.83)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C141(1.05); C115(1.96)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C141(1.42); C235(0.96); C265(1.50); C269(1.29)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C141(1.21); C115(0.78)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C141(1.17); C115(0.53)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C141(0.97); C115(2.37)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C141(1.04)  LDD2188  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C235(0.82); C141(0.88); C23(1.00); C115(0.92)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C235(0.97); C141(0.92); C23(1.04); C115(1.00)  LDD1497  [16]
 LDCM0024  KB05 HMCB C71(4.33); C283(2.70)  LDD3312  [18]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C235(1.09)  LDD2121  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C235(0.78)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C235(1.23)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C141(1.23); C23(0.92)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C141(0.31)  LDD2101  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C235(1.35)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C235(1.00); C141(0.98)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C235(0.86); C141(1.05)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C235(1.18); C141(1.00)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C235(1.18)  LDD2115  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C235(1.57)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C235(1.02); C141(0.88)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C235(1.03); C141(1.01); C23(1.17)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C235(1.29); C141(0.98)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C235(1.43)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C235(1.52)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C235(1.30); C141(1.19); C23(1.24)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C235(1.14); C141(0.92)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C235(0.95)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C235(0.86); C141(0.79)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C235(1.58); C141(1.87)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C235(1.35)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C235(0.73)  LDD2150  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C141(0.86)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C141(0.65)  LDD2207  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microsomal glutathione S-transferase 1 (MGST1) MAPEG family P10620
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Density-regulated protein (DENR) DENR family O43583
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Stress-70 protein, mitochondrial (HSPA9) Heat shock protein 70 family P38646
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Negative elongation factor C/D (NELFCD) NELF-D family Q8IXH7
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Negative elongation factor E (NELFE) RRM NELF-E family P18615
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.