Details of the Target

General Information of Target

Target ID LDTP11670
Target Name Mitochondrial fission factor (MFF)
Gene Name MFF
Gene ID 56947
Synonyms
C2orf33; Mitochondrial fission factor
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSSGTELLWPGAALLVLLGVAASLCVRCSRPGAKRSEKIYQQRSLREDQQSFTGSRTYSL
VGQAWPGPLADMAPTRKDKLLQFYPSLEDPASSRYQNFSKGSRHGSEEAYIDPIAMEYYN
WGRFSKPPEDDDANSYENVLICKQKTTETGAQQEGIGGLCRGDLSLSLALKTGPTSGLCP
SASPEEDEESEDYQNSASIHQWRESRKVMGQLQREASPGPVGSPDEEDGEPDYVNGEVAA
TEA
Target Bioclass
Other
Family
Tango11 family
Subcellular location
Mitochondrion outer membrane
Function
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Uniprot ID
Q9GZY8
Ensemble ID
ENST00000304593.14
HGNC ID
HGNC:24858

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K302(5.00)  LDD0277  [2]
DBIA
 Probe Info  		C209(3.49)  LDD3321  [3]
AHL-Pu-1
 Probe Info  		C209(3.04)  LDD0171  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		H212(0.00); H266(0.00)  LDD0219  [9]
Methacrolein
 Probe Info  		C209(0.00); H212(0.00)  LDD0218  [9]
AOyne
 Probe Info  		9.60  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.46  LDD1728  [11]
C027
 Probe Info  		8.46  LDD1733  [11]
C040
 Probe Info  		8.51  LDD1740  [11]
C055
 Probe Info  		22.78  LDD1752  [11]
C056
 Probe Info  		42.81  LDD1753  [11]
C064
 Probe Info  		6.82  LDD1761  [11]
C112
 Probe Info  		30.06  LDD1799  [11]
C390
 Probe Info  		23.26  LDD2049  [11]
C403
 Probe Info  		13.83  LDD2061  [11]
FFF probe11
 Probe Info  		20.00  LDD0471  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C209(2.22)  LDD0172  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C209(3.04)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C209(0.91)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C209(0.98)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C209(1.01)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C209(1.01)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C209(1.00)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C209(0.96)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C209(0.92)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C209(1.03)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C209(1.04)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C209(1.02)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C209(0.95)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C209(1.04)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C209(0.98)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C209(1.01)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C209(0.92)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C209(0.96)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C209(1.03)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C209(0.95)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C209(1.01)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C209(0.96)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C209(1.04)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C209(1.01)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C209(1.03)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C209(0.96)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C209(0.98)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C209(1.07)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C209(1.00)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C209(1.01)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C209(1.00)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C209(1.01)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C209(0.99)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C209(1.02)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C209(0.99)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C209(1.03)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C209(1.08)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C209(0.95)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C209(1.03)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C209(0.95)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C209(1.04)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C209(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C209(0.92)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C209(0.89)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C209(0.99)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C209(1.07)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C209(1.01)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C209(0.99)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C209(1.01)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C209(0.99)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C209(1.01)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C209(0.91)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C209(0.94)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C209(1.08)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C209(1.07)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C209(0.94)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C209(1.00)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C209(1.03)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C209(1.01)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C209(1.05)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C209(1.02)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C209(1.04)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C209(0.97)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C209(0.97)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C209(0.93)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C209(0.96)  LDD1514  [13]
 LDCM0630  CCW28-3 231MFP C209(1.11)  LDD2214  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C209(0.92)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C209(1.00)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C209(1.00)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C209(1.00)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C209(0.96)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C209(1.02)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C209(0.99)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C209(0.96)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C209(0.96)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C209(1.00)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C209(0.94)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C209(0.96)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C209(1.05)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C209(0.96)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C209(1.01)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C209(1.03)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C209(1.02)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C209(1.06)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C209(1.05)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C209(1.01)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C209(1.00)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C209(0.98)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C209(1.02)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C209(0.78)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C209(1.02)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C209(1.00)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C209(1.01)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C209(0.94)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C209(1.03)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C209(0.96)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C209(1.02)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C209(0.97)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C209(0.97)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C209(1.01)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C209(0.97)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C209(1.03)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C209(0.98)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C209(0.95)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C209(1.03)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C209(0.97)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C209(1.00)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C209(0.92)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C209(1.02)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C209(0.96)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C209(1.06)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C209(0.79)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C209(0.93)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C209(0.99)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C209(0.97)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C209(0.98)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C209(0.87)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C209(0.96)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C209(1.05)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C209(1.05)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C209(0.91)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C209(0.95)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C209(0.93)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C209(0.99)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C209(0.72)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C209(0.95)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C209(0.95)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C209(1.04)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C209(1.07)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C209(0.89)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C209(1.03)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C209(1.02)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C209(1.00)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C209(1.02)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C209(0.99)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C209(1.09)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C209(0.79)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C209(0.95)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C209(0.98)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C209(0.93)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C209(1.02)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C209(0.95)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C209(1.01)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C209(1.10)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C209(0.88)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C209(0.96)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C209(0.93)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C209(1.05)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C209(0.97)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C209(0.78)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C209(0.97)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C209(0.98)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C209(1.05)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C209(1.05)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C209(0.99)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C209(1.07)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C209(1.00)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C209(0.94)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C209(0.96)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C209(1.06)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C209(0.99)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C209(1.04)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C209(0.77)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C209(0.97)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C209(0.96)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C209(1.06)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C209(0.93)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C209(1.07)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C209(1.00)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C209(1.00)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C209(0.90)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C209(0.96)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C209(0.98)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C209(1.01)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C209(0.83)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C209(0.96)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C209(1.00)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C209(0.98)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C209(1.01)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C209(1.03)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C209(0.94)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C209(1.05)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C209(0.97)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C209(0.91)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C209(0.98)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C209(1.00)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C209(1.04)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C209(0.97)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C209(0.93)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C209(0.99)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C209(0.96)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C209(0.97)  LDD1698  [13]
 LDCM0625  F8 Ramos C209(1.17)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C209(1.95)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C209(0.39)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C209(1.38)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C209(1.06)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C209(0.57)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C209(3.39)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C209(0.88)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C209(1.21)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C209(0.90)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C209(0.81)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C209(1.36)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C209(1.03)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C209(1.91)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C209(0.95)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C209(1.42)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C209(1.47)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C209(0.99)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C209(1.27)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C209(1.06)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C209(3.78)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C209(2.27)  LDD2188  [15]
 LDCM0107  IAA HeLa H212(0.00); H267(0.00)  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C209(0.96)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C209(1.00)  LDD1497  [13]
 LDCM0024  KB05 SH4 C209(3.49)  LDD3321  [3]
 LDCM0109  NEM HeLa H266(0.00); H267(0.00)  LDD0224  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4) 1-acyl-sn-glycerol-3-phosphate acyltransferase family Q9NRZ5
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) CDP-alcohol phosphatidyltransferase class-I family O14735
Cytochrome b5 type B (CYB5B) Cytochrome b5 family O43169
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
Rhomboid-related protein 1 (RHBDL1) Peptidase S54 family O75783
Serine/threonine-protein kinase PLK3 (PLK3) Ser/Thr protein kinase family Q9H4B4
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Dynamin-1-like protein (DNM1L) Dynamin/Fzo/YdjA family O00429
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) V-ATPase proteolipid subunit family Q99437
Phosphatidylinositol-3-phosphatase SAC1 (SACM1L) . Q9NTJ5
Transporter and channel
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Gap junction beta-1 protein (GJB1) Connexin family P08034
Protein cornichon homolog 1 (CNIH1) Cornichon family O95406
FXYD domain-containing ion transport regulator 6 (FXYD6) FXYD family Q9H0Q3
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Vesicular acetylcholine transporter (SLC18A3) Vesicular transporter family Q16572
ER membrane protein complex subunit 5 (MMGT1) Membrane magnesium transporter (TC 1.A.67) family Q8N4V1
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Lens fiber major intrinsic protein (MIP) MIP/aquaporin (TC 1.A.8) family P30301
NIPA-like protein 3 (NIPAL3) NIPA family Q6P499
Solute carrier family 35 member B1 (SLC35B1) Nucleotide-sugar transporter family P78383
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Cardiac phospholamban (PLN) Phospholamban family P26678
Solute carrier family 41 member 2 (SLC41A2) SLC41A transporter family Q96JW4
Small integral membrane protein 1 (SMIM1) SMIM1 family B2RUZ4
Tetraspanin-33 (TSPAN33) Tetraspanin (TM4SF) family Q86UF1
Uroplakin-1b (UPK1B) Tetraspanin (TM4SF) family O75841
Transmembrane protein 14C (TMEM14C) TMEM14 family Q9P0S9
Transmembrane protein 218 (TMEM218) TMEM218 family A2RU14
Sigma intracellular receptor 2 (TMEM97) TMEM97/sigma-2 receptor family Q5BJF2
Translocating chain-associated membrane protein 1-like 1 (TRAM1L1) TRAM family Q8N609
Translocator protein 2 (TSPO2) TspO/BZRP family Q5TGU0
Protein unc-93 homolog B1 (UNC93B1) Unc-93 family Q9H1C4
Adiponectin (ADIPOQ) . Q15848
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (STRIT1) . P0DN84
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysophosphatidic acid receptor 3 (LPAR3) G-protein coupled receptor 1 family Q9UBY5
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Short-wave-sensitive opsin 1 (OPN1SW) G-protein coupled receptor 1 family P03999
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin protein zero-like protein 1 (MPZL1) Myelin P0 protein family O95297
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 41 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L2 (APOL2) Apolipoprotein L family Q9BQE5
BET1 homolog (BET1) BET1 family O15155
Apolipoprotein D (APOD) Lipocalin family P05090
Cell cycle exit and neuronal differentiation protein 1 (CEND1) CEND1 family Q8N111
Cortexin-3 (CTXN3) Cortexin family Q4LDR2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Protein FAM3C (FAM3C) FAM3 family Q92520
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Plasmolipin (PLLP) MAL family Q9Y342
UL16-binding protein 6 (RAET1L) MHC class I family Q5VY80
Neurotensin/neuromedin N (NTS) Neurotensin family P30990
Nurim (NRM) Nurim family Q8IXM6
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Protein transport protein Sec23A (SEC23A) SEC23/SEC24 family Q15436
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Syntaxin-7 (STX7) Syntaxin family O15400
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Transmembrane protein 88 (TMEM88) TMEM88 family Q6PEY1
Protein unc-50 homolog (UNC50) Unc-50 family Q53HI1
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Complement C1q-like protein 4 (C1QL4) . Q86Z23
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Follicular dendritic cell secreted peptide (FDCSP) . Q8NFU4
Insulin-like growth factor-binding protein 5 (IGFBP5) . P24593
Motile sperm domain-containing protein 3 (MOSPD3) . O75425
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
Testis-expressed protein 264 (TEX264) . Q9Y6I9
TPA-induced transmembrane protein (TTMP) . Q5BVD1
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
Transmembrane protein 140 (TMEM140) . Q9NV12
Transmembrane protein 254 (TMEM254) . Q8TBM7
Transmembrane protein 42 (TMEM42) . Q69YG0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578