Details of the Target

General Information of Target

Target ID LDTP01213
Target Name Cell division control protein 45 homolog (CDC45)
Gene Name CDC45
Gene ID 8318
Synonyms
CDC45L; CDC45L2; Cell division control protein 45 homolog; PORC-PI-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELET
AFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIK
QDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEAR
RRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVT
DVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARF
KLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQT
FSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAK
KQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCS
TKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHN
HFDLSVIELKAEDRSKFLDALISLLS
Target Bioclass
Other
Family
CDC45 family
Subcellular location
Nucleus
Function
Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Uniprot ID
O75419
Ensemble ID
ENST00000263201.7
HGNC ID
HGNC:1739
ChEMBL ID
CHEMBL3040

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Insertion: p.G366WfsTer43 .
HCT116 Deletion: p.P511QfsTer36 .
HCT15 SNV: p.D275E .
MOLT4 SNV: p.E259K IA-alkyne    Probe Info 
NCIH1666 SNV: p.E166D .
SNU1 SNV: p.L469F .
TCCSUP SNV: p.D82H .
YSCCC SNV: p.M353I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y238(16.06); Y413(6.30)  LDD0257  [1]
AHL-Pu-1
 Probe Info  		C267(3.52)  LDD0168  [2]
DBIA
 Probe Info  		C479(702.25)  LDD0209  [3]
ATP probe
 Probe Info  		K482(0.00); K420(0.00); K421(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
AOyne
 Probe Info  		14.10  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.11  LDD1740  [8]
C288
 Probe Info  		6.28  LDD1958  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C267(3.52)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C267(2.86)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C479(0.94); C33(0.97)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C479(0.99); C33(0.91)  LDD1508  [9]
 LDCM0226  AC11 HEK-293T C479(0.95)  LDD1509  [9]
 LDCM0237  AC12 HEK-293T C479(0.95); C33(1.01)  LDD1510  [9]
 LDCM0259  AC14 HEK-293T C479(0.96)  LDD1512  [9]
 LDCM0270  AC15 HEK-293T C479(0.98); C33(0.82)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C479(0.94); C33(0.86)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C479(1.01); C33(0.96)  LDD1516  [9]
 LDCM0278  AC19 HEK-293T C479(1.27)  LDD1517  [9]
 LDCM0279  AC2 HEK-293T C479(1.00); C33(1.05)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C479(0.93); C33(0.97)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C479(1.02)  LDD1520  [9]
 LDCM0282  AC22 HEK-293T C479(0.98)  LDD1521  [9]
 LDCM0283  AC23 HEK-293T C479(0.93); C33(0.81)  LDD1522  [9]
 LDCM0284  AC24 HEK-293T C479(1.00); C33(0.87)  LDD1523  [9]
 LDCM0285  AC25 HEK-293T C479(0.98); C33(0.94)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C479(1.00); C33(0.87)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C479(1.00)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C479(0.98); C33(1.05)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C479(1.01)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C479(1.01)  LDD1529  [9]
 LDCM0291  AC30 HEK-293T C479(0.99)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C479(0.93); C33(0.89)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C479(1.02); C33(0.93)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C479(0.93); C33(1.04)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C479(0.93); C33(1.07)  LDD1534  [9]
 LDCM0296  AC35 HEK-293T C479(0.93)  LDD1535  [9]
 LDCM0297  AC36 HEK-293T C479(0.91); C33(0.99)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C479(0.97)  LDD1537  [9]
 LDCM0299  AC38 HEK-293T C479(0.89)  LDD1538  [9]
 LDCM0300  AC39 HEK-293T C479(0.88); C33(0.79)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C479(0.94); C33(0.97)  LDD1540  [9]
 LDCM0302  AC40 HEK-293T C479(0.96); C33(0.90)  LDD1541  [9]
 LDCM0303  AC41 HEK-293T C479(0.96); C33(1.01)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C479(0.97); C33(0.86)  LDD1543  [9]
 LDCM0305  AC43 HEK-293T C479(0.98)  LDD1544  [9]
 LDCM0306  AC44 HEK-293T C479(0.92); C33(1.07)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C479(0.96)  LDD1546  [9]
 LDCM0308  AC46 HEK-293T C479(0.91)  LDD1547  [9]
 LDCM0309  AC47 HEK-293T C479(0.92); C33(1.02)  LDD1548  [9]
 LDCM0310  AC48 HEK-293T C479(0.95); C33(0.87)  LDD1549  [9]
 LDCM0311  AC49 HEK-293T C479(0.93); C33(0.94)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C479(1.01)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C479(0.93); C33(0.94)  LDD1552  [9]
 LDCM0314  AC51 HEK-293T C479(0.96)  LDD1553  [9]
 LDCM0315  AC52 HEK-293T C479(0.92); C33(0.99)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C479(0.96)  LDD1555  [9]
 LDCM0317  AC54 HEK-293T C479(0.91)  LDD1556  [9]
 LDCM0318  AC55 HEK-293T C479(0.90); C33(0.81)  LDD1557  [9]
 LDCM0319  AC56 HEK-293T C479(0.95); C33(0.92)  LDD1558  [9]
 LDCM0320  AC57 HEK-293T C479(1.03); C33(0.99)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C479(0.97); C33(0.96)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C479(0.98)  LDD1561  [9]
 LDCM0323  AC6 HEK-293T C479(0.97)  LDD1562  [9]
 LDCM0324  AC60 HEK-293T C479(0.95); C33(1.02)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C479(0.96)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C479(0.95)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C479(0.97); C33(0.87)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C479(0.96); C33(0.99)  LDD1567  [9]
 LDCM0334  AC7 HEK-293T C479(0.93); C33(0.86)  LDD1568  [9]
 LDCM0345  AC8 HEK-293T C479(0.95); C33(1.03)  LDD1569  [9]
 LDCM0248  AKOS034007472 HEK-293T C479(1.01)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C479(1.01); C33(0.97)  LDD1570  [9]
 LDCM0275  AKOS034007705 HEK-293T C479(0.96); C33(0.88)  LDD1514  [9]
 LDCM0367  CL1 HEK-293T C479(0.93); C33(0.91)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C479(1.05)  LDD1572  [9]
 LDCM0369  CL100 HEK-293T C479(0.96); C33(0.93)  LDD1573  [9]
 LDCM0370  CL101 HEK-293T C479(0.91); C33(0.96)  LDD1574  [9]
 LDCM0371  CL102 HEK-293T C479(0.97); C33(0.97)  LDD1575  [9]
 LDCM0372  CL103 HEK-293T C479(0.97); C33(0.98)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C479(0.92); C33(0.85)  LDD1577  [9]
 LDCM0374  CL105 HEK-293T C479(0.92); C33(0.95)  LDD1578  [9]
 LDCM0375  CL106 HEK-293T C479(0.97); C33(1.02)  LDD1579  [9]
 LDCM0376  CL107 HEK-293T C479(0.96); C33(1.07)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C479(0.94); C33(1.00)  LDD1581  [9]
 LDCM0378  CL109 HEK-293T C479(0.89); C33(0.77)  LDD1582  [9]
 LDCM0379  CL11 HEK-293T C479(0.98); C33(1.40)  LDD1583  [9]
 LDCM0380  CL110 HEK-293T C479(1.00); C33(1.03)  LDD1584  [9]
 LDCM0381  CL111 HEK-293T C479(0.96); C33(0.93)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C479(1.05); C33(0.84)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C479(0.88); C33(0.91)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C479(0.94); C33(0.86)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C479(0.91); C33(0.98)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C479(0.94); C33(1.04)  LDD1590  [9]
 LDCM0387  CL117 HEK-293T C479(0.88); C33(0.92)  LDD1591  [9]
 LDCM0388  CL118 HEK-293T C479(0.93); C33(1.09)  LDD1592  [9]
 LDCM0389  CL119 HEK-293T C479(0.90); C33(1.05)  LDD1593  [9]
 LDCM0390  CL12 HEK-293T C479(0.99); C33(1.39)  LDD1594  [9]
 LDCM0391  CL120 HEK-293T C479(0.95); C33(0.93)  LDD1595  [9]
 LDCM0392  CL121 HEK-293T C479(0.90); C33(0.94)  LDD1596  [9]
 LDCM0393  CL122 HEK-293T C479(0.93); C33(0.92)  LDD1597  [9]
 LDCM0394  CL123 HEK-293T C479(0.95); C33(0.92)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C479(1.01); C33(0.81)  LDD1599  [9]
 LDCM0396  CL125 HEK-293T C479(0.96); C33(1.19)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C479(0.96); C33(1.16)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C479(0.94); C33(1.15)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C479(1.01); C33(0.94)  LDD1603  [9]
 LDCM0400  CL13 HEK-293T C479(0.93); C33(0.98)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C479(0.84); C33(1.09)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C479(0.93); C33(1.05)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C479(0.88); C33(0.86)  LDD1607  [9]
 LDCM0404  CL17 HEK-293T C479(1.06); C33(0.93)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C479(1.03); C33(1.13)  LDD1609  [9]
 LDCM0406  CL19 HEK-293T C479(0.93)  LDD1610  [9]
 LDCM0407  CL2 HEK-293T C479(0.90); C33(0.93)  LDD1611  [9]
 LDCM0408  CL20 HEK-293T C479(0.96); C33(1.18)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C479(0.96)  LDD1613  [9]
 LDCM0410  CL22 HEK-293T C479(0.97)  LDD1614  [9]
 LDCM0411  CL23 HEK-293T C479(0.96); C33(1.25)  LDD1615  [9]
 LDCM0412  CL24 HEK-293T C479(1.02); C33(1.26)  LDD1616  [9]
 LDCM0413  CL25 HEK-293T C479(0.95); C33(0.93)  LDD1617  [9]
 LDCM0414  CL26 HEK-293T C479(0.97); C33(0.96)  LDD1618  [9]
 LDCM0415  CL27 HEK-293T C479(0.93); C33(1.05)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C479(0.90); C33(0.87)  LDD1620  [9]
 LDCM0417  CL29 HEK-293T C479(0.94); C33(0.99)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C479(0.89); C33(0.96)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C479(1.00); C33(0.88)  LDD1623  [9]
 LDCM0420  CL31 HEK-293T C479(1.08)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C479(0.97); C33(1.11)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C479(1.10)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C479(1.06)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C479(1.09); C33(1.25)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C479(1.09); C33(1.25)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C479(0.89); C33(1.07)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C479(0.93); C33(0.82)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C479(0.96); C33(0.99)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C479(0.99); C33(1.06)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C479(0.95); C33(0.94)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C479(0.97); C33(1.04)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C479(1.04)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C479(1.06); C33(1.14)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C479(1.01)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C479(1.17)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C479(1.06); C33(1.24)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C479(1.08); C33(1.20)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C479(0.89); C33(1.09)  LDD1643  [9]
 LDCM0440  CL5 HEK-293T C479(0.95); C33(1.11)  LDD1644  [9]
 LDCM0441  CL50 HEK-293T C479(0.88); C33(0.95)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C479(1.00); C33(0.95)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C479(0.91); C33(1.00)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C479(1.00); C33(0.97)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C479(0.99)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C479(0.95); C33(1.21)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C479(1.00)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C479(0.98)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C479(1.00); C33(1.06)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C479(1.01); C33(1.11)  LDD1654  [9]
 LDCM0452  CL60 HEK-293T C479(1.02); C33(1.21)  LDD1655  [9]
 LDCM0453  CL61 HEK-293T C479(0.91); C33(1.02)  LDD1656  [9]
 LDCM0454  CL62 HEK-293T C479(0.93); C33(0.98)  LDD1657  [9]
 LDCM0455  CL63 HEK-293T C479(0.92); C33(0.92)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C479(0.96); C33(0.61)  LDD1659  [9]
 LDCM0457  CL65 HEK-293T C479(0.95); C33(0.95)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C479(1.04); C33(1.17)  LDD1661  [9]
 LDCM0459  CL67 HEK-293T C479(0.96)  LDD1662  [9]
 LDCM0460  CL68 HEK-293T C479(0.95); C33(1.18)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C479(0.99)  LDD1664  [9]
 LDCM0462  CL7 HEK-293T C479(0.96)  LDD1665  [9]
 LDCM0463  CL70 HEK-293T C479(1.01)  LDD1666  [9]
 LDCM0464  CL71 HEK-293T C479(1.02); C33(1.12)  LDD1667  [9]
 LDCM0465  CL72 HEK-293T C479(1.03); C33(1.13)  LDD1668  [9]
 LDCM0466  CL73 HEK-293T C479(0.88); C33(1.02)  LDD1669  [9]
 LDCM0467  CL74 HEK-293T C479(0.93); C33(1.08)  LDD1670  [9]
 LDCM0469  CL76 HEK-293T C479(0.96); C33(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C479(1.09); C33(1.02)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C479(0.93); C33(0.92)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C479(0.97)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C479(1.10); C33(1.33)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C479(0.94); C33(1.18)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C479(1.01)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C479(1.01)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C479(1.00); C33(1.10)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C479(1.01); C33(1.14)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C479(0.85); C33(1.06)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C479(0.89); C33(1.20)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C479(0.92); C33(1.08)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C479(0.97); C33(0.96)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C479(1.02); C33(1.02)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C479(1.00)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C479(1.00); C33(0.91)  LDD1688  [9]
 LDCM0486  CL91 HEK-293T C479(0.98)  LDD1689  [9]
 LDCM0487  CL92 HEK-293T C479(0.95); C33(1.18)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C479(0.99)  LDD1691  [9]
 LDCM0489  CL94 HEK-293T C479(0.95)  LDD1692  [9]
 LDCM0490  CL95 HEK-293T C479(1.16); C33(1.13)  LDD1693  [9]
 LDCM0491  CL96 HEK-293T C479(0.99); C33(1.04)  LDD1694  [9]
 LDCM0492  CL97 HEK-293T C479(0.94); C33(0.95)  LDD1695  [9]
 LDCM0493  CL98 HEK-293T C479(1.00); C33(0.94)  LDD1696  [9]
 LDCM0494  CL99 HEK-293T C479(0.99); C33(0.94)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C479(0.86); C33(0.97)  LDD1698  [9]
 LDCM0625  F8 Ramos C479(0.62)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C479(1.91)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C479(0.09); C267(20.00)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C479(1.81)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C479(0.88)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C479(0.44); C267(0.78)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C479(2.80)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C479(1.14)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C479(1.56)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C479(0.79)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C479(0.67); C267(0.82)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C479(1.00)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C479(0.93)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C479(1.90)  LDD2201  [10]
 LDCM0468  Fragment33 HEK-293T C479(0.96); C33(0.94)  LDD1671  [9]
 LDCM0596  Fragment38 Ramos C479(1.10)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C479(0.90); C267(2.40)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C479(0.97); C33(0.96)  LDD1631  [9]
 LDCM0610  Fragment52 Ramos C479(0.96)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C479(0.99)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C479(1.96); C267(1.18)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C479(3.12)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C479(0.98); C267(1.12)  LDD1492  [9]
 LDCM0023  KB03 Jurkat C479(702.25)  LDD0209  [3]
 LDCM0024  KB05 NCI-H1703 C511(9.20)  LDD3347  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA replication licensing factor MCM2 (MCM2) MCM family P49736
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Ras-related protein Rab-4B (RAB4B) Rab family P61018
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Claspin (CLSPN) Claspin family Q9HAW4
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Replication protein A 32 kDa subunit (RPA2) Replication factor A protein 2 family P15927
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
DNA topoisomerase 2-binding protein 1 (TOPBP1) . Q92547

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840